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Items: 12


Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.

Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T.

Nature. 2019 May;569(7754):131-135. doi: 10.1038/s41586-019-1130-6. Epub 2019 Apr 17.


Protein kinase C mechanisms that contribute to cardiac remodelling.

Newton AC, Antal CE, Steinberg SF.

Clin Sci (Lond). 2016 Sep 1;130(17):1499-510. doi: 10.1042/CS20160036. Review.


Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.

Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R.

Sci Signal. 2016 May 10;9(427):ra47. doi: 10.1126/scisignal.aaf6209.


Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII.

Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC.

Cell Rep. 2015 Aug 25;12(8):1252-60. doi: 10.1016/j.celrep.2015.07.039. Epub 2015 Aug 13.


Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.

Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC.

Cell. 2015 Jan 29;160(3):489-502. doi: 10.1016/j.cell.2015.01.001. Epub 2015 Jan 22.


Tuning the signalling output of protein kinase C.

Antal CE, Newton AC.

Biochem Soc Trans. 2014 Dec;42(6):1477-83. doi: 10.1042/BST20140172. Review.


Intramolecular conformational changes optimize protein kinase C signaling.

Antal CE, Violin JD, Kunkel MT, Skovsø S, Newton AC.

Chem Biol. 2014 Apr 24;21(4):459-469. doi: 10.1016/j.chembiol.2014.02.008. Epub 2014 Mar 13.


Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling.

Antal CE, Newton AC.

Mol Cell Proteomics. 2013 Dec;12(12):3498-508. doi: 10.1074/mcp.R113.029819. Epub 2013 Jun 20. Review.


Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα.

Scott AM, Antal CE, Newton AC.

J Biol Chem. 2013 Jun 7;288(23):16905-15. doi: 10.1074/jbc.M113.467456. Epub 2013 Apr 15.


Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation.

de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton AC, Cooke MP, Schultz PG.

Chem Biol. 2012 Aug 24;19(8):994-1000. doi: 10.1016/j.chembiol.2012.06.010.


The effect of short-term hypoxic exposure on metabolic gene expression.

Everett MV, Antal CE, Crawford DL.

J Exp Zool A Ecol Genet Physiol. 2012 Jan 1;317(1):9-23. doi: 10.1002/jez.717. Epub 2011 Oct 21.


Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.

Gould CM, Antal CE, Reyes G, Kunkel MT, Adams RA, Ziyar A, Riveros T, Newton AC.

J Biol Chem. 2011 Aug 19;286(33):28922-30. doi: 10.1074/jbc.M111.272526. Epub 2011 Jun 29.

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