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Items: 1 to 50 of 68

1.

A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1.

McNulty DE, Bonnette WG, Qi H, Wang L, Ho TF, Waszkiewicz A, Kallal LA, Nagarajan RP, Stern M, Quinn AM, Creasy CL, Su DS, Graves AP, Annan RS, Sweitzer SM, Holbert MA.

SLAS Discov. 2018 Jan;23(1):34-46. doi: 10.1177/2472555217732014. Epub 2017 Sep 28.

PMID:
28957646
2.

Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets.

Van Aller GS, Graves AP, Elkins PA, Bonnette WG, McDevitt PJ, Zappacosta F, Annan RS, Dean TW, Su DS, Carpenter CL, Mohammad HP, Kruger RG.

Structure. 2016 May 3;24(5):774-781. doi: 10.1016/j.str.2016.03.010. Epub 2016 Apr 7.

3.

An optimized platform for hydrophilic interaction chromatography-immobilized metal affinity chromatography enables deep coverage of the rat liver phosphoproteome.

Zappacosta F, Scott GF, Huddleston MJ, Annan RS.

J Proteome Res. 2015 Feb 6;14(2):997-1009. doi: 10.1021/pr501025e. Epub 2015 Jan 26.

PMID:
25575281
4.

Overview of peptide and protein analysis by mass spectrometry.

Zhang G, Annan RS, Carr SA, Neubert TA.

Curr Protoc Mol Biol. 2014 Oct 1;108:10.21.1-30. doi: 10.1002/0471142727.mb1021s108.

PMID:
25271712
5.

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells.

Billiard J, Dennison JB, Briand J, Annan RS, Chai D, Colón M, Dodson CS, Gilbert SA, Greshock J, Jing J, Lu H, McSurdy-Freed JE, Orband-Miller LA, Mills GB, Quinn CJ, Schneck JL, Scott GF, Shaw AN, Waitt GM, Wooster RF, Duffy KJ.

Cancer Metab. 2013 Sep 6;1(1):19. doi: 10.1186/2049-3002-1-19.

6.

Persistent Mycoplasma genitalium infection of human endocervical epithelial cells elicits chronic inflammatory cytokine secretion.

McGowin CL, Annan RS, Quayle AJ, Greene SJ, Ma L, Mancuso MM, Adegboye D, Martin DH.

Infect Immun. 2012 Nov;80(11):3842-9. doi: 10.1128/IAI.00819-12. Epub 2012 Aug 20.

7.

Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.

Pappalardi MB, McNulty DE, Martin JD, Fisher KE, Jiang Y, Burns MC, Zhao H, Ho T, Sweitzer S, Schwartz B, Annan RS, Copeland RA, Tummino PJ, Luo L.

Biochem J. 2011 Jun 1;436(2):363-9. doi: 10.1042/BJ20101201.

PMID:
21410436
8.

MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation.

McNulty DE, Li Z, White CD, Sacks DB, Annan RS.

J Biol Chem. 2011 Apr 29;286(17):15010-21. doi: 10.1074/jbc.M111.227694. Epub 2011 Feb 24.

9.

Overview of peptide and protein analysis by mass spectrometry.

Zhang G, Annan RS, Carr SA, Neubert TA.

Curr Protoc Protein Sci. 2010 Nov;Chapter 16:Unit16.1. doi: 10.1002/0471140864.ps1601s62.

PMID:
21104985
10.

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.

Wood KW, Lad L, Luo L, Qian X, Knight SD, Nevins N, Brejc K, Sutton D, Gilmartin AG, Chua PR, Desai R, Schauer SP, McNulty DE, Annan RS, Belmont LD, Garcia C, Lee Y, Diamond MA, Faucette LF, Giardiniere M, Zhang S, Sun CM, Vidal JD, Lichtsteiner S, Cornwell WD, Greshock JD, Wooster RF, Finer JT, Copeland RA, Huang PS, Morgans DJ Jr, Dhanak D, Bergnes G, Sakowicz R, Jackson JR.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5839-44. doi: 10.1073/pnas.0915068107. Epub 2010 Feb 18.

11.

Hydrophilic interaction chromatography for fractionation and enrichment of the phosphoproteome.

McNulty DE, Annan RS.

Methods Mol Biol. 2009;527:93-105, x. doi: 10.1007/978-1-60327-834-8_8. Review.

PMID:
19241008
12.

Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis.

Mohl DA, Huddleston MJ, Collingwood TS, Annan RS, Deshaies RJ.

J Cell Biol. 2009 Feb 23;184(4):527-39. doi: 10.1083/jcb.200812022. Epub 2009 Feb 16.

13.

Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.

Goodman KB, Bury MJ, Cheung M, Cichy-Knight MA, Dowdell SE, Dunn AK, Lee D, Lieby JA, Moore ML, Scherzer DA, Sha D, Suarez DP, Murphy DJ, Harpel MR, Manas ES, McNulty DE, Annan RS, Matico RE, Schwartz BK, Trill JJ, Sweitzer TD, Wang DY, Keller PM, Krawiec JA, Jaye MC.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):27-30. doi: 10.1016/j.bmcl.2008.11.033. Epub 2008 Nov 14.

PMID:
19058966
14.

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit.

Huang H, Hittle J, Zappacosta F, Annan RS, Hershko A, Yen TJ.

J Cell Biol. 2008 Nov 17;183(4):667-80. doi: 10.1083/jcb.200805163.

15.

The catalytic role of INCENP in Aurora B activation and the kinetic mechanism of Aurora B/INCENP.

Yang J, Zappacosta F, Annan RS, Nurse K, Tummino PJ, Copeland RA, Lai Z.

Biochem J. 2009 Jan 1;417(1):355-60. doi: 10.1042/BJ20081365.

PMID:
18767990
16.

Overview of peptide and protein analysis by mass spectrometry.

Carr SA, Annan RS.

Curr Protoc Protein Sci. 2001 May;Chapter 16:Unit 16.1. doi: 10.1002/0471140864.ps1601s04.

PMID:
18429127
17.

Overview of peptide and protein analysis by mass spectrometry.

Carr SA, Annan RS.

Curr Protoc Mol Biol. 2001 May;Chapter 10:Unit 10.21. doi: 10.1002/0471142727.mb1021s38.

PMID:
18265062
18.

Hydrophilic interaction chromatography reduces the complexity of the phosphoproteome and improves global phosphopeptide isolation and detection.

McNulty DE, Annan RS.

Mol Cell Proteomics. 2008 May;7(5):971-80. doi: 10.1074/mcp.M700543-MCP200. Epub 2008 Jan 22.

19.

TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion.

Smirnova EV, Collingwood TS, Bisbal C, Tsygankova OM, Bogush M, Meinkoth JL, Henderson EE, Annan RS, Tsygankov AY.

Virology. 2008 Mar 1;372(1):10-23. Epub 2007 Nov 19.

20.

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.

Luo L, Parrish CA, Nevins N, McNulty DE, Chaudhari AM, Carson JD, Sudakin V, Shaw AN, Lehr R, Zhao H, Sweitzer S, Lad L, Wood KW, Sakowicz R, Annan RS, Huang PS, Jackson JR, Dhanak D, Copeland RA, Auger KR.

Nat Chem Biol. 2007 Nov;3(11):722-6. Epub 2007 Oct 7.

PMID:
17922005
21.

T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis.

Collingwood TS, Smirnova EV, Bogush M, Carpino N, Annan RS, Tsygankov AY.

J Biol Chem. 2007 Oct 19;282(42):30920-8. Epub 2007 Aug 20.

22.

A quantitative results-driven approach to analyzing multisite protein phosphorylation: the phosphate-dependent phosphorylation profile of the transcription factor Pho4.

Zappacosta F, Collingwood TS, Huddleston MJ, Annan RS.

Mol Cell Proteomics. 2006 Nov;5(11):2019-30. Epub 2006 Jul 6.

23.

Mapping posttranslational modifications of proteins by MS-based selective detection: application to phosphoproteomics.

Carr SA, Annan RS, Huddleston MJ.

Methods Enzymol. 2005;405:82-115. Review.

PMID:
16413312
24.

Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck.

Yokoyama N, deBakker CD, Zappacosta F, Huddleston MJ, Annan RS, Ravichandran KS, Miller WT.

Biochemistry. 2005 Jun 21;44(24):8841-9.

25.

Interaction between Brk kinase and insulin receptor substrate-4.

Qiu H, Zappacosta F, Su W, Annan RS, Miller WT.

Oncogene. 2005 Aug 25;24(36):5656-64.

PMID:
15870689
26.

IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner.

Li Z, McNulty DE, Marler KJ, Lim L, Hall C, Annan RS, Sacks DB.

J Biol Chem. 2005 Apr 8;280(14):13871-8. Epub 2005 Jan 28.

27.

Protein posttranslational modifications: phosphorylation site analysis using mass spectrometry.

Annan RS, Zappacosta F.

Methods Biochem Anal. 2005;45:85-106. Review. No abstract available.

PMID:
19235292
28.
29.

Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.

Azzam R, Chen SL, Shou W, Mah AS, Alexandru G, Nasmyth K, Annan RS, Carr SA, Deshaies RJ.

Science. 2004 Jul 23;305(5683):516-9.

30.

Comparative phosphorylation site mapping from gel-derived proteins using a multidimensional ES/MS-based approach.

Zappacosta F, Huddleston MJ, Annan RS.

Methods Mol Biol. 2004;284:91-110.

PMID:
15173611
31.

TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.

Feshchenko EA, Smirnova EV, Swaminathan G, Teckchandani AM, Agrawal R, Band H, Zhang X, Annan RS, Carr SA, Tsygankov AY.

Oncogene. 2004 Jun 10;23(27):4690-706. Erratum in: Oncogene. 2004 Dec 16;23(58):9449.

PMID:
15107835
32.
33.
34.

Mass spectrometry-based methods for phosphorylation site mapping of hyperphosphorylated proteins applied to Net1, a regulator of exit from mitosis in yeast.

Loughrey Chen S, Huddleston MJ, Shou W, Deshaies RJ, Annan RS, Carr SA.

Mol Cell Proteomics. 2002 Mar;1(3):186-96.

35.

Mapping phosphorylation sites in proteins by mass spectrometry.

Shou W, Verma R, Annan RS, Huddleston MJ, Chen SL, Carr SA, Deshaies RJ.

Methods Enzymol. 2002;351:279-96. Review. No abstract available.

PMID:
12073350
36.

Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.

Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT.

J Biol Chem. 2002 Aug 2;277(31):28238-46. Epub 2002 May 23.

37.

Cdc5 influences phosphorylation of Net1 and disassembly of the RENT complex.

Shou W, Azzam R, Chen SL, Huddleston MJ, Baskerville C, Charbonneau H, Annan RS, Carr SA, Deshaies RJ.

BMC Mol Biol. 2002 Apr 17;3:3. Epub 2002 Apr 17.

38.

Phosphorylation of the Saccharomyces cerevisiae La protein does not appear to be required for its functions in tRNA maturation and nascent RNA stabilization.

Long KS, Cedervall T, Walch-Solimena C, Noe DA, Huddleston MJ, Annan RS, Wolin SL.

RNA. 2001 Nov;7(11):1589-602.

39.

The srhSR gene pair from Staphylococcus aureus: genomic and proteomic approaches to the identification and characterization of gene function.

Throup JP, Zappacosta F, Lunsford RD, Annan RS, Carr SA, Lonsdale JT, Bryant AP, McDevitt D, Rosenberg M, Burnham MK.

Biochemistry. 2001 Aug 28;40(34):10392-401.

PMID:
11513618
40.

Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II.

Karcher RL, Roland JT, Zappacosta F, Huddleston MJ, Annan RS, Carr SA, Gelfand VI.

Science. 2001 Aug 17;293(5533):1317-20.

41.

Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase.

Chi Y, Huddleston MJ, Zhang X, Young RA, Annan RS, Carr SA, Deshaies RJ.

Genes Dev. 2001 May 1;15(9):1078-92.

42.

A multidimensional electrospray MS-based approach to phosphopeptide mapping.

Annan RS, Huddleston MJ, Verma R, Deshaies RJ, Carr SA.

Anal Chem. 2001 Feb 1;73(3):393-404.

PMID:
11217738
43.
44.

Isolation and identification of a mouse brain protein recognized by antisera to heart fatty acid-binding protein.

Pu L, Annan RS, Carr SA, Frolov A, Wood WG, Spener F, Schroeder F.

Lipids. 1999 Apr;34(4):363-73.

PMID:
10443969
45.

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway.

Chaturvedi P, Eng WK, Zhu Y, Mattern MR, Mishra R, Hurle MR, Zhang X, Annan RS, Lu Q, Faucette LF, Scott GF, Li X, Carr SA, Johnson RK, Winkler JD, Zhou BB.

Oncogene. 1999 Jul 15;18(28):4047-54.

46.

Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain.

Liang Y, Annan RS, Carr SA, Popp S, Mevissen M, Margolis RK, Margolis RU.

J Biol Chem. 1999 Jun 18;274(25):17885-92.

47.

Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis.

Erdjument-Bromage H, Lui M, Lacomis L, Grewal A, Annan RS, McNulty DE, Carr SA, Tempst P.

J Chromatogr A. 1998 Nov 27;826(2):167-81.

PMID:
9871337
48.

Isolation and characterization of 26- and 30-kDa rat liver proteins immunoreactive to anti-sterol carrier protein-2 antibodies.

Pu L, Foxworth WB, Kier AB, Annan RS, Carr SA, Edmondson R, Russell D, Wood WG, Schroeder F.

Protein Expr Purif. 1998 Aug;13(3):337-48.

PMID:
9693058
49.

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M.

Cell. 1998 Mar 6;92(5):1 page following 696. No abstract available.

50.

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M.

Cell. 1998 Feb 20;92(4):573-85.

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