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Items: 14

1.

Ontogeny of ADME Processes during Postnatal Development in Man and Preclinical Species: A Comprehensive Review.

De Schaepdrijver LM, Annaert PPJ, Chen CL.

Drug Metab Dispos. 2019 Mar;47(3):295. doi: 10.1124/dmd.118.084350. Review. No abstract available.

PMID:
30770345
2.

Lipophilic nalmefene prodrugs to achieve a one-month sustained release.

Gaekens T, Guillaume M, Borghys H, De Zwart LL, de Vries R, Embrechts RC, Vermeulen A, Megens AA, Leysen JE, Herdewijn P, Annaert PP, Atack JR.

J Control Release. 2016 Jun 28;232:196-202. doi: 10.1016/j.jconrel.2016.04.029. Epub 2016 Apr 21.

PMID:
27107723
3.

Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake.

De Bruyn T, Stieger B, Augustijns PF, Annaert PP.

J Pharm Sci. 2016 Feb;105(2):854-863. doi: 10.1002/jps.24564. Epub 2016 Jan 11.

4.

Hepatic Clearance Prediction of Nine Human Immunodeficiency Virus Protease Inhibitors in Rat.

De Bruyn T, Augustijns PF, Annaert PP.

J Pharm Sci. 2016 Feb;105(2):846-853. doi: 10.1002/jps.24559. Epub 2016 Jan 12.

PMID:
26202434
5.

Structure-based identification of OATP1B1/3 inhibitors.

De Bruyn T, van Westen GJ, Ijzerman AP, Stieger B, de Witte P, Augustijns PF, Annaert PP.

Mol Pharmacol. 2013 Jun;83(6):1257-67. doi: 10.1124/mol.112.084152. Epub 2013 Apr 9.

PMID:
23571415
6.

Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes.

De Bruyn T, Ye ZW, Peeters A, Sahi J, Baes M, Augustijns PF, Annaert PP.

Eur J Pharm Sci. 2011 Jul 17;43(4):297-307. doi: 10.1016/j.ejps.2011.05.002. Epub 2011 May 14.

PMID:
21605667
7.

Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding.

Yanni SB, Smith PB, Benjamin DK Jr, Augustijns PF, Thakker DR, Annaert PP.

Biopharm Drug Dispos. 2011 May;32(4):222-32. doi: 10.1002/bdd.752. Epub 2011 Mar 30.

8.

In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats.

Yanni SB, Augustijns PF, Benjamin DK Jr, Brouwer KL, Thakker DR, Annaert PP.

Drug Metab Dispos. 2010 Oct;38(10):1848-56. doi: 10.1124/dmd.110.033811. Epub 2010 Jul 6.

9.

In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3.

Yanni SB, Annaert PP, Augustijns P, Ibrahim JG, Benjamin DK Jr, Thakker DR.

Drug Metab Dispos. 2010 Jan;38(1):25-31. doi: 10.1124/dmd.109.029769.

10.

The ontogeny of drug metabolizing enzymes and transporters in the rat.

de Zwart L, Scholten M, Monbaliu JG, Annaert PP, Van Houdt JM, Van den Wyngaert I, De Schaepdrijver LM, Bailey GP, Coogan TP, Coussement WC, Mannens GS.

Reprod Toxicol. 2008 Nov-Dec;26(3-4):220-30. doi: 10.1016/j.reprotox.2008.09.010. Epub 2008 Oct 7.

PMID:
18926897
11.

Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes.

Yanni SB, Annaert PP, Augustijns P, Bridges A, Gao Y, Benjamin DK Jr, Thakker DR.

Drug Metab Dispos. 2008 Jun;36(6):1119-25. doi: 10.1124/dmd.107.019646. Epub 2008 Mar 24.

12.

Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes.

Annaert PP, Brouwer KL.

Drug Metab Dispos. 2005 Mar;33(3):388-94. Epub 2004 Dec 17.

PMID:
15608134
13.

P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes.

Annaert PP, Turncliff RZ, Booth CL, Thakker DR, Brouwer KL.

Drug Metab Dispos. 2001 Oct;29(10):1277-83.

PMID:
11560870
14.

Hydration changes implicated in the remarkable temperature-dependent membrane permeation of cyclosporin A.

Augustijns PF, Brown SC, Willard DH, Consler TG, Annaert PP, Hendren RW, Bradshaw TP.

Biochemistry. 2000 Jun 27;39(25):7621-30.

PMID:
10858313

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