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Items: 1 to 50 of 128

1.

In vivo CYP3A4 activity does not predict the magnitude of interaction between itraconazole and tacrolimus from an extended release formulation.

Vanhove T, Annaert P, Knops N, de Loor H, de Hoon J, Kuypers DRJ.

Basic Clin Pharmacol Toxicol. 2018 Jul 10. doi: 10.1111/bcpt.13092. [Epub ahead of print]

PMID:
29989304
2.

Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures.

Rodrigues RM, Kollipara L, Chaudhari U, Sachinidis A, Zahedi RP, Sickmann A, Kopp-Schneider A, Jiang X, Keun H, Hengstler J, Oorts M, Annaert P, Hoeben E, Gijbels E, De Kock J, Vanhaecke T, Rogiers V, Vinken M.

Arch Toxicol. 2018 May 14. doi: 10.1007/s00204-018-2214-z. [Epub ahead of print]

PMID:
29761207
3.

Drug-induced cholestasis: mechanisms, models, and markers.

Chatterjee S, Annaert P.

Curr Drug Metab. 2018 Apr 27. doi: 10.2174/1389200219666180427165035. [Epub ahead of print]

PMID:
29708070
4.

Metabolism of the synthetic cannabinoids AMB-CHMICA and 5C-AKB48 in pooled human hepatocytes and rat hepatocytes analyzed by UHPLC-(IMS)-HR-MSE.

Mardal M, Dalsgaard PW, Qi B, Mollerup CB, Annaert P, Linnet K.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 15;1083:189-197. doi: 10.1016/j.jchromb.2018.03.016. Epub 2018 Mar 10.

PMID:
29549742
5.

MRP2 Inhibition by HIV Protease Inhibitors in Rat and Human Hepatocytes: A Quantitative Confocal Microscopy Study.

Holmstock N, Oorts M, Snoeys J, Annaert P.

Drug Metab Dispos. 2018 May;46(5):697-703. doi: 10.1124/dmd.117.079467. Epub 2018 Mar 9.

PMID:
29523599
6.

Effect of Cryopreservation on Enzyme and Transporter Activities in Suspended and Sandwich Cultured Rat Hepatocytes.

Keemink J, Deferm N, De Bruyn T, Augustijns P, Bouillon T, Annaert P.

AAPS J. 2018 Feb 21;20(2):33. doi: 10.1208/s12248-018-0188-7.

PMID:
29468289
7.

Higher versus standard amikacin single dose in emergency department patients with severe sepsis and septic shock: a randomised controlled trial.

De Winter S, Wauters J, Meersseman W, Verhaegen J, Van Wijngaerden E, Peetermans W, Annaert P, Verelst S, Spriet I.

Int J Antimicrob Agents. 2018 Apr;51(4):562-570. doi: 10.1016/j.ijantimicag.2017.11.009. Epub 2017 Nov 24.

PMID:
29180278
8.

Metabolism of the synthetic cannabinoid 5F-PY-PICA by human and rat hepatocytes and identification of biliary analytical targets by directional efflux in sandwich-cultured rat hepatocytes using UHPLC-HR-MS/MS.

Mardal M, Annaert P, Noble C, Oorts M, Linnet K.

J Pharm Biomed Anal. 2018 Feb 5;149:296-307. doi: 10.1016/j.jpba.2017.11.027. Epub 2017 Nov 7.

PMID:
29128830
9.

Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes.

Oorts M, Keemink J, Deferm N, Adriaensen R, Richert L, Augustijns P, Annaert P.

J Pharmacol Toxicol Methods. 2018 Mar - Apr;90:31-38. doi: 10.1016/j.vascn.2017.10.007. Epub 2017 Oct 25.

PMID:
29079456
10.

On the Role of Illness Duration and Nutrient Restriction in Cholestatic Alterations that Occur During Critical Illness.

Jenniskens M, Güiza F, Oorts M, Vander Perre S, Derde S, Dufour T, Thiessen S, Annaert P, Van den Berghe G, Langouche L.

Shock. 2018 Aug;50(2):187-198. doi: 10.1097/SHK.0000000000001001.

11.

Biomarkers of propofol metabolism in neonates: the quest beyond ontogeny.

Smits A, Annaert P, Allegaert K.

Biomark Med. 2017 Nov;11(11):933-936. doi: 10.2217/bmm-2017-0184. Epub 2017 Oct 23. No abstract available.

12.

Role of the OATP Transporter Family and a Benzbromarone-SensitiveEfflux Transporter in the Hepatocellular Disposition of Vincristine.

Nicolaï J, Thevelin L, Bing Q, Stieger B, Chanteux H, Augustijns P, Annaert P.

Pharm Res. 2017 Nov;34(11):2336-2348. doi: 10.1007/s11095-017-2241-0. Epub 2017 Aug 21.

PMID:
28828541
13.

Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation.

Vanhove T, Hasan M, Annaert P, Oswald S, Kuypers DRJ.

Br J Clin Pharmacol. 2017 Nov;83(11):2406-2415. doi: 10.1111/bcp.13343. Epub 2017 Jul 14.

PMID:
28603840
14.

Integration and validation of the ex vivo human placenta perfusion model.

Conings S, Amant F, Annaert P, Van Calsteren K.

J Pharmacol Toxicol Methods. 2017 Nov;88(Pt 1):25-31. doi: 10.1016/j.vascn.2017.05.002. Epub 2017 May 15.

PMID:
28522142
15.

Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients.

Vanhove T, Bouillon T, de Loor H, Annaert P, Kuypers D.

Clin Pharmacol Ther. 2017 Dec;102(6):989-996. doi: 10.1002/cpt.718. Epub 2017 May 27.

PMID:
28437851
16.

Inter-Subject Variability in OCT1 Activity in 27 Batches of Cryopreserved Human Hepatocytes and Association with OCT1 mRNA Expression and Genotype.

Fattah S, Shinde AB, Matic M, Baes M, van Schaik RHN, Allegaert K, Parmentier C, Richert L, Augustijns P, Annaert P.

Pharm Res. 2017 Jun;34(6):1309-1319. doi: 10.1007/s11095-017-2148-9. Epub 2017 Mar 31.

PMID:
28364304
17.

Determinants of the Magnitude of Interaction Between Tacrolimus and Voriconazole/Posaconazole in Solid Organ Recipients.

Vanhove T, Bouwsma H, Hilbrands L, Swen JJ, Spriet I, Annaert P, Vanaudenaerde B, Verleden G, Vos R, Kuypers DRJ.

Am J Transplant. 2017 Sep;17(9):2372-2380. doi: 10.1111/ajt.14232. Epub 2017 Apr 8.

PMID:
28224698
18.

Cell Imaging Counting as a Novel Ex Vivo Approach for Investigating Drug-Induced Hepatotoxicity in Zebrafish Larvae.

Nguyen XB, Kislyuk S, Pham DH, Kecskés A, Maes J, Cabooter D, Annaert P, De Witte P, Ny A.

Int J Mol Sci. 2017 Feb 8;18(2). pii: E356. doi: 10.3390/ijms18020356.

19.

Response to: 'Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'.

Vanhove T, Annaert P, Kuypers DRJ.

Br J Clin Pharmacol. 2017 Jun;83(6):1353-1356. doi: 10.1111/bcp.13249. Epub 2017 Feb 20. No abstract available.

20.

Effect of the Direct Oral Anticoagulants Rivaroxaban and Apixaban on the Disposition of Calcineurin Inhibitors in Transplant Recipients.

Vanhove T, Spriet I, Annaert P, Maertens J, Van Cleemput J, Vos R, Kuypers D.

Ther Drug Monit. 2017 Feb;39(1):77-82. doi: 10.1097/FTD.0000000000000356.

PMID:
27861314
21.

Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study.

Boets E, Gomand SV, Deroover L, Preston T, Vermeulen K, De Preter V, Hamer HM, Van den Mooter G, De Vuyst L, Courtin CM, Annaert P, Delcour JA, Verbeke KA.

J Physiol. 2017 Jan 15;595(2):541-555. doi: 10.1113/JP272613. Epub 2016 Sep 18.

22.

Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance.

Vanhove T, de Jonge H, de Loor H, Annaert P, Diczfalusy U, Kuypers DR.

Br J Clin Pharmacol. 2016 Dec;82(6):1539-1549. doi: 10.1111/bcp.13083. Epub 2016 Sep 20.

23.

Effect of ABCB1 diplotype on tacrolimus disposition in renal recipients depends on CYP3A5 and CYP3A4 genotype.

Vanhove T, Annaert P, Lambrechts D, Kuypers DRJ.

Pharmacogenomics J. 2017 Dec;17(6):556-562. doi: 10.1038/tpj.2016.49. Epub 2016 Jul 5.

PMID:
27378609
24.

In vitro and in vivo investigation of the gastrointestinal behavior of simvastatin.

Geboers S, Stappaerts J, Tack J, Annaert P, Augustijns P.

Int J Pharm. 2016 Aug 20;510(1):296-303. doi: 10.1016/j.ijpharm.2016.06.048. Epub 2016 Jun 20.

PMID:
27340029
25.

Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.

T'jollyn H, Snoeys J, Van Bocxlaer J, De Bock L, Annaert P, Van Peer A, Allegaert K, Mannens G, Vermeulen A, Boussery K.

Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):537-543. doi: 10.1007/s13318-016-0355-0.

PMID:
27317395
26.

Lipophilic nalmefene prodrugs to achieve a one-month sustained release.

Gaekens T, Guillaume M, Borghys H, De Zwart LL, de Vries R, Embrechts RC, Vermeulen A, Megens AA, Leysen JE, Herdewijn P, Annaert PP, Atack JR.

J Control Release. 2016 Jun 28;232:196-202. doi: 10.1016/j.jconrel.2016.04.029. Epub 2016 Apr 21.

PMID:
27107723
27.

SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants.

Matic M, de Wildt SN, Elens L, de Hoon JN, Annaert P, Tibboel D, van Schaik RH, Allegaert K.

Ther Drug Monit. 2016 Aug;38(4):487-92. doi: 10.1097/FTD.0000000000000307.

PMID:
27082504
28.

The effect of macrophage and angiogenesis inhibition on the drug release and absorption from an intramuscular sustained-release paliperidone palmitate suspension.

Darville N, van Heerden M, Mariën D, De Meulder M, Rossenu S, Vermeulen A, Vynckier A, De Jonghe S, Sterkens P, Annaert P, Van den Mooter G.

J Control Release. 2016 May 28;230:95-108. doi: 10.1016/j.jconrel.2016.03.041. Epub 2016 Apr 9.

PMID:
27067365
29.

Posaconazole plasma exposure correlated to intestinal mucositis in allogeneic stem cell transplant patients.

Vanstraelen K, Prattes J, Maertens J, Lagrou K, Schoemans H, Peersman N, Vermeersch P, Theunissen K, Mols R, Augustijns P, Annaert P, Hoenigl M, Spriet I.

Eur J Clin Pharmacol. 2016 Aug;72(8):953-63. doi: 10.1007/s00228-016-2057-6. Epub 2016 Apr 11.

PMID:
27066958
30.

The Effect of Food on the Intraluminal Behavior of Abiraterone Acetate in Man.

Geboers S, Stappaerts J, Mols R, Snoeys J, Tack J, Annaert P, Augustijns P.

J Pharm Sci. 2016 Sep;105(9):2974-2981. doi: 10.1016/j.xphs.2016.03.008. Epub 2016 Apr 7.

PMID:
27061460
31.

Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes.

Oorts M, Baze A, Bachellier P, Heyd B, Zacharias T, Annaert P, Richert L.

Toxicol In Vitro. 2016 Aug;34:179-86. doi: 10.1016/j.tiv.2016.03.008. Epub 2016 Apr 2.

PMID:
27046439
32.

High Intrapatient Variability of Tacrolimus Concentrations Predicts Accelerated Progression of Chronic Histologic Lesions in Renal Recipients.

Vanhove T, Vermeulen T, Annaert P, Lerut E, Kuypers DRJ.

Am J Transplant. 2016 Oct;16(10):2954-2963. doi: 10.1111/ajt.13803. Epub 2016 Apr 21.

33.

Clinical determinants of calcineurin inhibitor disposition: a mechanistic review.

Vanhove T, Annaert P, Kuypers DR.

Drug Metab Rev. 2016;48(1):88-112. doi: 10.3109/03602532.2016.1151037. Epub 2016 Feb 25. Review.

PMID:
26912097
34.

Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes.

Nicolaï J, De Bruyn T, Thevelin L, Augustijns P, Annaert P.

Drug Metab Dispos. 2016 Mar;44(3):389-97. doi: 10.1124/dmd.115.068114. Epub 2015 Dec 28.

35.

Effect of Age on The Hepatocellularity Number for Wistar rats.

Fattah S, Augustijns P, Annaert P.

Drug Metab Dispos. 2016 Mar;44(3):366-9. doi: 10.1124/dmd.115.066381. Epub 2015 Dec 23. Erratum in: Drug Metab Dispos. 2016 Mar;44(3):417.

36.

Modeling the Time Course of the Tissue Responses to Intramuscular Long-acting Paliperidone Palmitate Nano-/Microcrystals and Polystyrene Microspheres in the Rat.

Darville N, van Heerden M, Erkens T, De Jonghe S, Vynckier A, De Meulder M, Vermeulen A, Sterkens P, Annaert P, Van den Mooter G.

Toxicol Pathol. 2016 Feb;44(2):189-210. doi: 10.1177/0192623315618291. Epub 2015 Dec 23.

PMID:
26698322
37.

Pharmacokinetics of Posaconazole Oral Suspension in Children Dosed According to Body Surface Area.

Vanstraelen K, Colita A, Bica AM, Mols R, Augustijns P, Peersman N, Vermeersch P, Annaert P, Spriet I.

Pediatr Infect Dis J. 2016 Feb;35(2):183-8. doi: 10.1097/INF.0000000000000963.

PMID:
26544987
38.

Multimodal non-linear optical imaging for the investigation of drug nano-/microcrystal-cell interactions.

Darville N, Saarinen J, Isomäki A, Khriachtchev L, Cleeren D, Sterkens P, van Heerden M, Annaert P, Peltonen L, Santos HA, Strachan CJ, Van den Mooter G.

Eur J Pharm Biopharm. 2015 Oct;96:338-48. doi: 10.1016/j.ejpb.2015.09.003. Epub 2015 Sep 5.

PMID:
26347923
39.

Primary Hepatocytes in Sandwich Culture.

Keemink J, Oorts M, Annaert P.

Methods Mol Biol. 2015;1250:175-88. doi: 10.1007/978-1-4939-2074-7_12.

PMID:
26272142
40.

Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake.

De Bruyn T, Stieger B, Augustijns PF, Annaert PP.

J Pharm Sci. 2016 Feb;105(2):854-863. doi: 10.1002/jps.24564. Epub 2016 Jan 11.

41.

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.

T'jollyn H, Snoeys J, Vermeulen A, Michelet R, Cuyckens F, Mannens G, Van Peer A, Annaert P, Allegaert K, Van Bocxlaer J, Boussery K.

AAPS J. 2015 Nov;17(6):1376-87. doi: 10.1208/s12248-015-9803-z. Epub 2015 Jul 25.

42.

Hepatic Clearance Prediction of Nine Human Immunodeficiency Virus Protease Inhibitors in Rat.

De Bruyn T, Augustijns PF, Annaert PP.

J Pharm Sci. 2016 Feb;105(2):846-853. doi: 10.1002/jps.24559. Epub 2016 Jan 12.

PMID:
26202434
43.

In vitro disposition profiling of heterocyclic compounds.

Keemink J, Wuyts B, Nicolaï J, Jonghe SD, Stella A, Herdewijn P, Augustijns P, Annaert P.

Int J Pharm. 2015 Aug 1;491(1-2):78-90. doi: 10.1016/j.ijpharm.2015.05.080. Epub 2015 Jun 1.

PMID:
26043826
44.

Unbound ritonavir concentrations in rat and human hepatocytes.

Keemink J, Augustijns P, Annaert P.

J Pharm Sci. 2015 Jul;104(7):2378-87. doi: 10.1002/jps.24477. Epub 2015 May 18.

PMID:
25989229
45.

Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling.

Nicolaï J, De Bruyn T, Van Veldhoven PP, Keemink J, Augustijns P, Annaert P.

Biopharm Drug Dispos. 2015 Oct;36(7):462-80. doi: 10.1002/bdd.1959. Epub 2015 Jun 11.

PMID:
25963583
46.

Investigation of Saliva as an Alternative to Plasma Monitoring of Voriconazole.

Vanstraelen K, Maertens J, Augustijns P, Lagrou K, de Loor H, Mols R, Annaert P, Malfroot A, Spriet I.

Clin Pharmacokinet. 2015 Nov;54(11):1151-60. doi: 10.1007/s40262-015-0269-z.

PMID:
25910879
47.

Drug-induced cholestasis detection in cryopreserved rat hepatocytes in sandwich culture.

Oorts M, Richert L, Annaert P.

J Pharmacol Toxicol Methods. 2015 May-Jun;73:63-71. doi: 10.1016/j.vascn.2015.03.002. Epub 2015 Mar 28.

PMID:
25828992
48.

Intestinal behavior of the ester prodrug tenofovir DF in humans.

Geboers S, Haenen S, Mols R, Brouwers J, Tack J, Annaert P, Augustijns P.

Int J Pharm. 2015 May 15;485(1-2):131-7. doi: 10.1016/j.ijpharm.2015.03.002. Epub 2015 Mar 4.

PMID:
25747454
49.

Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: in vitro, rat in situ and human in vivo studies.

Stappaerts J, Geboers S, Snoeys J, Brouwers J, Tack J, Annaert P, Augustijns P.

Eur J Pharm Biopharm. 2015 Feb;90:1-7. doi: 10.1016/j.ejpb.2015.01.001. Epub 2015 Jan 12.

PMID:
25592324
50.

The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats.

Verbeke L, Farre R, Verbinnen B, Covens K, Vanuytsel T, Verhaegen J, Komuta M, Roskams T, Chatterjee S, Annaert P, Vander Elst I, Windmolders P, Trebicka J, Nevens F, Laleman W.

Am J Pathol. 2015 Feb;185(2):409-19. doi: 10.1016/j.ajpath.2014.10.009. Epub 2015 Jan 12.

PMID:
25592258

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