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Items: 1 to 50 of 147

1.

Integration of Placental Transfer in a Fetal-Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus.

Mian P, Allegaert K, Conings S, Annaert P, Tibboel D, Pfister M, van Calsteren K, van den Anker JN, Dallmann A.

Clin Pharmacokinet. 2020 Feb 12. doi: 10.1007/s40262-020-00861-7. [Epub ahead of print]

PMID:
32052378
2.

Current insights in the complexities underlying drug-induced cholestasis.

Deferm N, De Vocht T, Qi B, Van Brantegem P, Gijbels E, Vinken M, de Witte P, Bouillon T, Annaert P.

Crit Rev Toxicol. 2019 Jul;49(6):520-548. doi: 10.1080/10408444.2019.1635081. Epub 2019 Oct 7.

PMID:
31589080
3.

A sensitive liquid chromatography method for analysis of propofol in small volumes of neonatal blood.

Qi B, Nicolaï J, Smits A, De Vocht T, Deferm N, Van Brantegem P, Allegaert K, Annaert P.

J Clin Pharm Ther. 2020 Feb;45(1):128-133. doi: 10.1111/jcpt.13038. Epub 2019 Oct 3.

PMID:
31583723
4.

Novel natural and synthetic inhibitors of solute carriers SGLT1 and SGLT2.

Oranje P, Gouka R, Burggraaff L, Vermeer M, Chalet C, Duchateau G, van der Pijl P, Geldof M, de Roo N, Clauwaert F, Vanpaeschen T, Nicolaï J, de Bruyn T, Annaert P, IJzerman AP, van Westen GJP.

Pharmacol Res Perspect. 2019 Jul 30;7(4):e00504. doi: 10.1002/prp2.504. eCollection 2019 Aug.

5.

Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women.

Mian P, van den Anker JN, van Calsteren K, Annaert P, Tibboel D, Pfister M, Allegaert K, Dallmann A.

Clin Pharmacokinet. 2020 Jan;59(1):97-110. doi: 10.1007/s40262-019-00799-5.

6.

Primary hepatocytes and their cultures for the testing of drug-induced liver injury.

Vilas-Boas V, Cooreman A, Gijbels E, Van Campenhout R, Gustafson E, Ballet S, Annaert P, Cogliati B, Vinken M.

Adv Pharmacol. 2019;85:1-30. doi: 10.1016/bs.apha.2018.08.001. Epub 2018 Sep 1. Review.

PMID:
31307583
7.

Detection of Drug-Induced Cholestasis Potential in Sandwich-Cultured Human Hepatocytes.

Deferm N, Richert L, Van Brantegem P, De Vocht T, Qi B, de Witte P, Bouillon T, Annaert P.

Methods Mol Biol. 2019;1981:335-350. doi: 10.1007/978-1-4939-9420-5_22.

PMID:
31016665
8.

Vesicle- and Hepatocyte-Based Assays for Identification of Drug Candidates Inhibiting BSEP Function.

Van Brantegem P, Deferm N, Qi B, De Vocht T, Annaert P.

Methods Mol Biol. 2019;1981:55-73. doi: 10.1007/978-1-4939-9420-5_4.

PMID:
31016647
9.

LC-MS/MS Analysis of Bile Acids in In Vitro Samples.

Dewaele D, Annaert P, Hoeben E.

Methods Mol Biol. 2019;1981:15-23. doi: 10.1007/978-1-4939-9420-5_2.

PMID:
31016645
10.

Mechanisms and in vitro models of drug-induced cholestasis.

Gijbels E, Vilas-Boas V, Deferm N, Devisscher L, Jaeschke H, Annaert P, Vinken M.

Arch Toxicol. 2019 May;93(5):1169-1186. doi: 10.1007/s00204-019-02437-2. Epub 2019 Apr 10. Review.

PMID:
30972450
11.

Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos.

Giusti A, Nguyen XB, Kislyuk S, Mignot M, Ranieri C, Nicolaï J, Oorts M, Wu X, Annaert P, De Croze N, Léonard M, Ny A, Cabooter D, de Witte P.

Int J Mol Sci. 2019 Apr 6;20(7). pii: E1712. doi: 10.3390/ijms20071712.

12.

Non-clinical Models to Determine Drug Passage into Human Breast Milk.

Ventrella D, Forni M, Bacci ML, Annaert P.

Curr Pharm Des. 2019;25(5):534-548. doi: 10.2174/1381612825666190320165904. Review.

PMID:
30894104
13.

Transplacental transport of paracetamol and its phase II metabolites using the ex vivo placenta perfusion model.

Conings S, Tseke F, Van den Broeck A, Qi B, Paulus J, Amant F, Annaert P, Van Calsteren K.

Toxicol Appl Pharmacol. 2019 May 1;370:14-23. doi: 10.1016/j.taap.2019.03.004. Epub 2019 Mar 5.

PMID:
30849458
14.

Ontogeny of ADME Processes during Postnatal Development in Man and Preclinical Species: A Comprehensive Review.

De Schaepdrijver LM, Annaert PPJ, Chen CL.

Drug Metab Dispos. 2019 Mar;47(3):295. doi: 10.1124/dmd.118.084350. Review. No abstract available.

PMID:
30770345
15.

Connexin and Pannexin (Hemi)Channels: Emerging Targets in the Treatment of Liver Disease.

Cooreman A, Van Campenhout R, Ballet S, Annaert P, Van Den Bossche B, Colle I, Cogliati B, Vinken M.

Hepatology. 2019 Mar;69(3):1317-1323. doi: 10.1002/hep.30306. Epub 2019 Feb 23. Review.

PMID:
30300925
16.

Antenatal sildenafil administration to prevent pulmonary hypertension in congenital diaphragmatic hernia (SToP-PH): study protocol for a phase I/IIb placenta transfer and safety study.

Russo FM, Benachi A, Van Mieghem T, De Hoon J, Van Calsteren K, Annaert P, Tréluyer JM, Allegaert K, Deprest J.

Trials. 2018 Sep 27;19(1):524. doi: 10.1186/s13063-018-2897-8.

17.

Sildenafil crosses the placenta at therapeutic levels in a dually perfused human cotyledon model.

Russo FM, Conings S, Allegaert K, Van Mieghem T, Toelen J, Van Calsteren K, Annaert P, Deprest J.

Am J Obstet Gynecol. 2018 Dec;219(6):619.e1-619.e10. doi: 10.1016/j.ajog.2018.08.041. Epub 2018 Sep 5.

PMID:
30194048
18.

Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers.

Vanhove T, de Jonge H, de Loor H, Oorts M, de Hoon J, Pohanka A, Annaert P, Kuypers DRJ.

Drug Metab Dispos. 2018 Nov;46(11):1507-1513. doi: 10.1124/dmd.118.081935. Epub 2018 Aug 30.

PMID:
30166405
19.

Human tissue-engineered skeletal muscle: a novel 3D in vitro model for drug disposition and toxicity after intramuscular injection.

Gholobova D, Gerard M, Decroix L, Desender L, Callewaert N, Annaert P, Thorrez L.

Sci Rep. 2018 Aug 15;8(1):12206. doi: 10.1038/s41598-018-30123-3.

20.

In vivo CYP3A4 activity does not predict the magnitude of interaction between itraconazole and tacrolimus from an extended release formulation.

Vanhove T, Annaert P, Knops N, de Loor H, de Hoon J, Kuypers DRJ.

Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):50-55. doi: 10.1111/bcpt.13092. Epub 2018 Aug 14.

21.

Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures.

Rodrigues RM, Kollipara L, Chaudhari U, Sachinidis A, Zahedi RP, Sickmann A, Kopp-Schneider A, Jiang X, Keun H, Hengstler J, Oorts M, Annaert P, Hoeben E, Gijbels E, De Kock J, Vanhaecke T, Rogiers V, Vinken M.

Arch Toxicol. 2018 Jun;92(6):1939-1952. doi: 10.1007/s00204-018-2214-z. Epub 2018 May 14.

22.

Drug-induced Cholestasis: Mechanisms, Models, and Markers.

Chatterjee S, Annaert P.

Curr Drug Metab. 2018;19(10):808-818. doi: 10.2174/1389200219666180427165035. Review.

PMID:
29708070
23.

Metabolism of the synthetic cannabinoids AMB-CHMICA and 5C-AKB48 in pooled human hepatocytes and rat hepatocytes analyzed by UHPLC-(IMS)-HR-MSE.

Mardal M, Dalsgaard PW, Qi B, Mollerup CB, Annaert P, Linnet K.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 15;1083:189-197. doi: 10.1016/j.jchromb.2018.03.016. Epub 2018 Mar 10.

PMID:
29549742
24.

MRP2 Inhibition by HIV Protease Inhibitors in Rat and Human Hepatocytes: A Quantitative Confocal Microscopy Study.

Holmstock N, Oorts M, Snoeys J, Annaert P.

Drug Metab Dispos. 2018 May;46(5):697-703. doi: 10.1124/dmd.117.079467. Epub 2018 Mar 9.

PMID:
29523599
25.

Effect of Cryopreservation on Enzyme and Transporter Activities in Suspended and Sandwich Cultured Rat Hepatocytes.

Keemink J, Deferm N, De Bruyn T, Augustijns P, Bouillon T, Annaert P.

AAPS J. 2018 Feb 21;20(2):33. doi: 10.1208/s12248-018-0188-7.

PMID:
29468289
26.

Higher versus standard amikacin single dose in emergency department patients with severe sepsis and septic shock: a randomised controlled trial.

De Winter S, Wauters J, Meersseman W, Verhaegen J, Van Wijngaerden E, Peetermans W, Annaert P, Verelst S, Spriet I.

Int J Antimicrob Agents. 2018 Apr;51(4):562-570. doi: 10.1016/j.ijantimicag.2017.11.009. Epub 2017 Nov 24.

PMID:
29180278
27.

Metabolism of the synthetic cannabinoid 5F-PY-PICA by human and rat hepatocytes and identification of biliary analytical targets by directional efflux in sandwich-cultured rat hepatocytes using UHPLC-HR-MS/MS.

Mardal M, Annaert P, Noble C, Oorts M, Linnet K.

J Pharm Biomed Anal. 2018 Feb 5;149:296-307. doi: 10.1016/j.jpba.2017.11.027. Epub 2017 Nov 7.

PMID:
29128830
28.

Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes.

Oorts M, Keemink J, Deferm N, Adriaensen R, Richert L, Augustijns P, Annaert P.

J Pharmacol Toxicol Methods. 2018 Mar - Apr;90:31-38. doi: 10.1016/j.vascn.2017.10.007. Epub 2017 Oct 25.

PMID:
29079456
29.

On the Role of Illness Duration and Nutrient Restriction in Cholestatic Alterations that Occur During Critical Illness.

Jenniskens M, Güiza F, Oorts M, Vander Perre S, Derde S, Dufour T, Thiessen S, Annaert P, Van den Berghe G, Langouche L.

Shock. 2018 Aug;50(2):187-198. doi: 10.1097/SHK.0000000000001001.

30.

Biomarkers of propofol metabolism in neonates: the quest beyond ontogeny.

Smits A, Annaert P, Allegaert K.

Biomark Med. 2017 Nov;11(11):933-936. doi: 10.2217/bmm-2017-0184. Epub 2017 Oct 23. No abstract available.

31.

Role of the OATP Transporter Family and a Benzbromarone-SensitiveEfflux Transporter in the Hepatocellular Disposition of Vincristine.

Nicolaï J, Thevelin L, Bing Q, Stieger B, Chanteux H, Augustijns P, Annaert P.

Pharm Res. 2017 Nov;34(11):2336-2348. doi: 10.1007/s11095-017-2241-0. Epub 2017 Aug 21.

32.

Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation.

Vanhove T, Hasan M, Annaert P, Oswald S, Kuypers DRJ.

Br J Clin Pharmacol. 2017 Nov;83(11):2406-2415. doi: 10.1111/bcp.13343. Epub 2017 Jul 14.

33.

Integration and validation of the ex vivo human placenta perfusion model.

Conings S, Amant F, Annaert P, Van Calsteren K.

J Pharmacol Toxicol Methods. 2017 Nov;88(Pt 1):25-31. doi: 10.1016/j.vascn.2017.05.002. Epub 2017 May 15.

PMID:
28522142
34.

Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients.

Vanhove T, Bouillon T, de Loor H, Annaert P, Kuypers D.

Clin Pharmacol Ther. 2017 Dec;102(6):989-996. doi: 10.1002/cpt.718. Epub 2017 May 27.

PMID:
28437851
35.

Inter-Subject Variability in OCT1 Activity in 27 Batches of Cryopreserved Human Hepatocytes and Association with OCT1 mRNA Expression and Genotype.

Fattah S, Shinde AB, Matic M, Baes M, van Schaik RHN, Allegaert K, Parmentier C, Richert L, Augustijns P, Annaert P.

Pharm Res. 2017 Jun;34(6):1309-1319. doi: 10.1007/s11095-017-2148-9. Epub 2017 Mar 31.

PMID:
28364304
36.

Determinants of the Magnitude of Interaction Between Tacrolimus and Voriconazole/Posaconazole in Solid Organ Recipients.

Vanhove T, Bouwsma H, Hilbrands L, Swen JJ, Spriet I, Annaert P, Vanaudenaerde B, Verleden G, Vos R, Kuypers DRJ.

Am J Transplant. 2017 Sep;17(9):2372-2380. doi: 10.1111/ajt.14232. Epub 2017 Apr 8.

37.

Cell Imaging Counting as a Novel Ex Vivo Approach for Investigating Drug-Induced Hepatotoxicity in Zebrafish Larvae.

Nguyen XB, Kislyuk S, Pham DH, Kecskés A, Maes J, Cabooter D, Annaert P, De Witte P, Ny A.

Int J Mol Sci. 2017 Feb 8;18(2). pii: E356. doi: 10.3390/ijms18020356.

38.

Response to: 'Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'.

Vanhove T, Annaert P, Kuypers DRJ.

Br J Clin Pharmacol. 2017 Jun;83(6):1353-1356. doi: 10.1111/bcp.13249. Epub 2017 Feb 20. No abstract available.

39.

Effect of the Direct Oral Anticoagulants Rivaroxaban and Apixaban on the Disposition of Calcineurin Inhibitors in Transplant Recipients.

Vanhove T, Spriet I, Annaert P, Maertens J, Van Cleemput J, Vos R, Kuypers D.

Ther Drug Monit. 2017 Feb;39(1):77-82. doi: 10.1097/FTD.0000000000000356.

PMID:
27861314
40.

Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study.

Boets E, Gomand SV, Deroover L, Preston T, Vermeulen K, De Preter V, Hamer HM, Van den Mooter G, De Vuyst L, Courtin CM, Annaert P, Delcour JA, Verbeke KA.

J Physiol. 2017 Jan 15;595(2):541-555. doi: 10.1113/JP272613. Epub 2016 Sep 18.

41.

Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance.

Vanhove T, de Jonge H, de Loor H, Annaert P, Diczfalusy U, Kuypers DR.

Br J Clin Pharmacol. 2016 Dec;82(6):1539-1549. doi: 10.1111/bcp.13083. Epub 2016 Sep 20.

42.

Effect of ABCB1 diplotype on tacrolimus disposition in renal recipients depends on CYP3A5 and CYP3A4 genotype.

Vanhove T, Annaert P, Lambrechts D, Kuypers DRJ.

Pharmacogenomics J. 2017 Dec;17(6):556-562. doi: 10.1038/tpj.2016.49. Epub 2016 Jul 5.

PMID:
27378609
43.

In vitro and in vivo investigation of the gastrointestinal behavior of simvastatin.

Geboers S, Stappaerts J, Tack J, Annaert P, Augustijns P.

Int J Pharm. 2016 Aug 20;510(1):296-303. doi: 10.1016/j.ijpharm.2016.06.048. Epub 2016 Jun 20.

PMID:
27340029
44.

Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.

T'jollyn H, Snoeys J, Van Bocxlaer J, De Bock L, Annaert P, Van Peer A, Allegaert K, Mannens G, Vermeulen A, Boussery K.

Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):537-543. doi: 10.1007/s13318-016-0355-0.

PMID:
27317395
45.

Lipophilic nalmefene prodrugs to achieve a one-month sustained release.

Gaekens T, Guillaume M, Borghys H, De Zwart LL, de Vries R, Embrechts RC, Vermeulen A, Megens AA, Leysen JE, Herdewijn P, Annaert PP, Atack JR.

J Control Release. 2016 Jun 28;232:196-202. doi: 10.1016/j.jconrel.2016.04.029. Epub 2016 Apr 21.

PMID:
27107723
46.

SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants.

Matic M, de Wildt SN, Elens L, de Hoon JN, Annaert P, Tibboel D, van Schaik RH, Allegaert K.

Ther Drug Monit. 2016 Aug;38(4):487-92. doi: 10.1097/FTD.0000000000000307.

PMID:
27082504
47.

The effect of macrophage and angiogenesis inhibition on the drug release and absorption from an intramuscular sustained-release paliperidone palmitate suspension.

Darville N, van Heerden M, Mariën D, De Meulder M, Rossenu S, Vermeulen A, Vynckier A, De Jonghe S, Sterkens P, Annaert P, Van den Mooter G.

J Control Release. 2016 May 28;230:95-108. doi: 10.1016/j.jconrel.2016.03.041. Epub 2016 Apr 9.

PMID:
27067365
48.

Posaconazole plasma exposure correlated to intestinal mucositis in allogeneic stem cell transplant patients.

Vanstraelen K, Prattes J, Maertens J, Lagrou K, Schoemans H, Peersman N, Vermeersch P, Theunissen K, Mols R, Augustijns P, Annaert P, Hoenigl M, Spriet I.

Eur J Clin Pharmacol. 2016 Aug;72(8):953-63. doi: 10.1007/s00228-016-2057-6. Epub 2016 Apr 11.

PMID:
27066958
49.

The Effect of Food on the Intraluminal Behavior of Abiraterone Acetate in Man.

Geboers S, Stappaerts J, Mols R, Snoeys J, Tack J, Annaert P, Augustijns P.

J Pharm Sci. 2016 Sep;105(9):2974-2981. doi: 10.1016/j.xphs.2016.03.008. Epub 2016 Apr 7.

PMID:
27061460
50.

Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes.

Oorts M, Baze A, Bachellier P, Heyd B, Zacharias T, Annaert P, Richert L.

Toxicol In Vitro. 2016 Aug;34:179-186. doi: 10.1016/j.tiv.2016.03.008. Epub 2016 Apr 2.

PMID:
27046439

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