Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 58


Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.

Chan WK, Horvath TD, Tan L, Link T, Harutyunyan KG, Pontikos MA, Anishkin A, Du D, Martin LA, Yin E, Rempe SB, Sukharev S, Konopleva M, Weinstein JN, Lorenzi PL.

Mol Cancer Ther. 2019 Sep;18(9):1587-1592. doi: 10.1158/1535-7163.MCT-18-1329. Epub 2019 Jun 17.


Human mutations highlight an intersubunit cation-π bond that stabilizes the closed but not open or inactivated states of TRPV channels.

Teng J, Anishkin A, Kung C, Blount P.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9410-9416. doi: 10.1073/pnas.1820673116. Epub 2019 Apr 22.


Binding energies and the entry route of palmitic acid and palmitoylcarnitine into myoglobin.

Chintapalli SV, Anishkin A, Adams SH.

Data Brief. 2018 Oct 27;21:1106-1110. doi: 10.1016/j.dib.2018.10.118. eCollection 2018 Dec.


The S6 gate in regulatory Kv6 subunits restricts heteromeric K+ channel stoichiometry.

Pisupati A, Mickolajczyk KJ, Horton W, van Rossum DB, Anishkin A, Chintapalli SV, Li X, Chu-Luo J, Busey G, Hancock WO, Jegla T.

J Gen Physiol. 2018 Dec 3;150(12):1702-1721. doi: 10.1085/jgp.201812121. Epub 2018 Oct 15.


The voltage-dependence of MscL has dipolar and dielectric contributions and is governed by local intramembrane electric field.

Najem JS, Rowe I, Anishkin A, Leo DJ, Sukharev S.

Sci Rep. 2018 Sep 11;8(1):13607. doi: 10.1038/s41598-018-31945-x.


Crystal Structure of the Labile Complex of IL-24 with the Extracellular Domains of IL-22R1 and IL-20R2.

Lubkowski J, Sonmez C, Smirnov SV, Anishkin A, Kotenko SV, Wlodawer A.

J Immunol. 2018 Oct 1;201(7):2082-2093. doi: 10.4049/jimmunol.1800726. Epub 2018 Aug 15.


Exploring the entry route of palmitic acid and palmitoylcarnitine into myoglobin.

Chintapalli SV, Anishkin A, Adams SH.

Arch Biochem Biophys. 2018 Oct 1;655:56-66. doi: 10.1016/ Epub 2018 Aug 6.


Spatiotemporal relationships defining the adaptive gating of the bacterial mechanosensitive channel MscS.

Çetiner U, Anishkin A, Sukharev S.

Eur Biophys J. 2018 Sep;47(6):663-677. doi: 10.1007/s00249-018-1303-5. Epub 2018 Apr 23.


Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A-mediated phosphorylation.

Cao S, Anishkin A, Zinkevich NS, Nishijima Y, Korishettar A, Wang Z, Fang J, Wilcox DA, Zhang DX.

J Biol Chem. 2018 Apr 6;293(14):5307-5322. doi: 10.1074/jbc.M117.811075. Epub 2018 Feb 8.


High-Affinity Interactions of Beryllium(2+) with Phosphatidylserine Result in a Cross-Linking Effect Reducing Surface Recognition of the Lipid.

Ermakov YA, Kamaraju K, Dunina-Barkovskaya A, Vishnyakova KS, Yegorov YE, Anishkin A, Sukharev S.

Biochemistry. 2017 Oct 10;56(40):5457-5470. doi: 10.1021/acs.biochem.7b00644. Epub 2017 Sep 20.


Tension-activated channels in the mechanism of osmotic fitness in Pseudomonas aeruginosa.

Çetiner U, Rowe I, Schams A, Mayhew C, Rubin D, Anishkin A, Sukharev S.

J Gen Physiol. 2017 May 1;149(5):595-609. doi: 10.1085/jgp.201611699. Epub 2017 Apr 19.


Channel disassembled: Pick, tweak, and soak parts to soften.

Anishkin A, Sukharev S.

Channels (Austin). 2017 May 4;11(3):173-175. doi: 10.1080/19336950.2017.1291213. Epub 2017 Feb 6. No abstract available.


A competing hydrophobic tug on L596 to the membrane core unlatches S4-S5 linker elbow from TRP helix and allows TRPV4 channel to open.

Teng J, Loukin SH, Anishkin A, Kung C.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11847-11852. Epub 2016 Oct 3.


Novel Molecular Interactions of Acylcarnitines and Fatty Acids with Myoglobin.

Chintapalli SV, Jayanthi S, Mallipeddi PL, Gundampati R, Suresh Kumar TK, van Rossum DB, Anishkin A, Adams SH.

J Biol Chem. 2016 Nov 25;291(48):25133-25143. Epub 2016 Oct 7.


Protein architecture and core residues in unwound α-helices provide insights to the transport function of plant AtCHX17.

Czerny DD, Padmanaban S, Anishkin A, Venema K, Riaz Z, Sze H.

Biochim Biophys Acta. 2016 Sep;1858(9):1983-1998. doi: 10.1016/j.bbamem.2016.05.008. Epub 2016 May 11.


Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.

Li X, Anishkin A, Liu H, van Rossum DB, Chintapalli SV, Sassic JK, Gallegos D, Pivaroff-Ward K, Jegla T.

J Gen Physiol. 2015 Nov;146(5):357-74. doi: 10.1085/jgp.201511491.


Ceramide channels: destabilization by Bcl-xL and role in apoptosis.

Chang KT, Anishkin A, Patwardhan GA, Beverly LJ, Siskind LJ, Colombini M.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2374-84. doi: 10.1016/j.bbamem.2015.07.013. Epub 2015 Jul 26.


Catalytic Role of the Substrate Defines Specificity of Therapeutic l-Asparaginase.

Anishkin A, Vanegas JM, Rogers DM, Lorenzi PL, Chan WK, Purwaha P, Weinstein JN, Sukharev S, Rempe SB.

J Mol Biol. 2015 Aug 28;427(17):2867-85. doi: 10.1016/j.jmb.2015.06.017. Epub 2015 Jul 2.


Molecular dynamic simulations reveal the structural determinants of Fatty Acid binding to oxy-myoglobin.

Chintapalli SV, Bhardwaj G, Patel R, Shah N, Patterson RL, van Rossum DB, Anishkin A, Adams SH.

PLoS One. 2015 Jun 1;10(6):e0128496. doi: 10.1371/journal.pone.0128496. eCollection 2015.


L596-W733 bond between the start of the S4-S5 linker and the TRP box stabilizes the closed state of TRPV4 channel.

Teng J, Loukin SH, Anishkin A, Kung C.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3386-91. doi: 10.1073/pnas.1502366112. Epub 2015 Mar 3.


Major diversification of voltage-gated K+ channels occurred in ancestral parahoxozoans.

Li X, Liu H, Chu Luo J, Rhodes SA, Trigg LM, van Rossum DB, Anishkin A, Diatta FH, Sassic JK, Simmons DK, Kamel B, Medina M, Martindale MQ, Jegla T.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E1010-9. doi: 10.1073/pnas.1422941112. Epub 2015 Feb 17.


TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.

Lindy AS, Parekh PK, Zhu R, Kanju P, Chintapalli SV, Tsvilovskyy V, Patterson RL, Anishkin A, van Rossum DB, Liedtke WB.

Nat Commun. 2014 Sep 2;5:4734. doi: 10.1038/ncomms5734.


The force-from-lipid (FFL) principle of mechanosensitivity, at large and in elements.

Teng J, Loukin S, Anishkin A, Kung C.

Pflugers Arch. 2015 Jan;467(1):27-37. doi: 10.1007/s00424-014-1530-2. Epub 2014 Jun 3. Review.


Feeling the hidden mechanical forces in lipid bilayer is an original sense.

Anishkin A, Loukin SH, Teng J, Kung C.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):7898-905. doi: 10.1073/pnas.1313364111. Epub 2014 May 21. Review.


The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding.

Rowe I, Anishkin A, Kamaraju K, Yoshimura K, Sukharev S.

J Gen Physiol. 2014 May;143(5):543-57. doi: 10.1085/jgp.201311114.


The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells.

Chan WK, Lorenzi PL, Anishkin A, Purwaha P, Rogers DM, Sukharev S, Rempe SB, Weinstein JN.

Blood. 2014 Jun 5;123(23):3596-606. doi: 10.1182/blood-2013-10-535112. Epub 2014 Mar 21.


Clarifying the positive association between education and prostate cancer: a Monte Carlo simulation approach.

Pudrovska T, Anishkin A.

J Appl Gerontol. 2015 Apr;34(3):293-316. doi: 10.1177/0733464812473798. Epub 2013 Mar 21.


Reevaluation of the evolutionary events within recA/RAD51 phylogeny.

Chintapalli SV, Bhardwaj G, Babu J, Hadjiyianni L, Hong Y, Todd GK, Boosalis CA, Zhang Z, Zhou X, Ma H, Anishkin A, van Rossum DB, Patterson RL.

BMC Genomics. 2013 Apr 10;14:240. doi: 10.1186/1471-2164-14-240.


Stiffened lipid platforms at molecular force foci.

Anishkin A, Kung C.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):4886-92. doi: 10.1073/pnas.1302018110. Epub 2013 Mar 8. Review.


Early-life socioeconomic status and physical activity in later life: evidence from structural equation models.

Pudrovska T, Anishkin A.

J Aging Health. 2013 Apr;25(3):383-404. doi: 10.1177/0898264312468601. Epub 2012 Dec 16.


Early-Life Socioeconomic Status and the Prevalence of Breast Cancer in Later Life.

Pudrovska T, Anishkin A, Shen Y.

Res Aging. 2012 May;34(3):302-320. Epub 2011 Aug 18.


The core domain as the force sensor of the yeast mechanosensitive TRP channel.

Su Z, Anishkin A, Kung C, Saimi Y.

J Gen Physiol. 2011 Dec;138(6):627-40. doi: 10.1085/jgp.201110693.


The pathway and spatial scale for MscS inactivation.

Kamaraju K, Belyy V, Rowe I, Anishkin A, Sukharev S.

J Gen Physiol. 2011 Jul;138(1):49-57. doi: 10.1085/jgp.201110606. Epub 2011 Jun 13.


Adaptive MscS gating in the osmotic permeability response in E. coli: the question of time.

Boer M, Anishkin A, Sukharev S.

Biochemistry. 2011 May 17;50(19):4087-96. doi: 10.1021/bi1019435. Epub 2011 Apr 20.


Hydration properties of mechanosensitive channel pores define the energetics of gating.

Anishkin A, Akitake B, Kamaraju K, Chiang CS, Sukharev S.

J Phys Condens Matter. 2010 Nov 17;22(45):454120. doi: 10.1088/0953-8984/22/45/454120. Epub 2010 Oct 29.


Structural models of TREK channels and their gating mechanism.

Milac A, Anishkin A, Fatakia SN, Chow CC, Sukharev S, Guy HR.

Channels (Austin). 2011 Jan-Feb;5(1):23-33. Epub 2011 Jan 1.


Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models.

Maksaev G, Milac A, Anishkin A, Guy HR, Sukharev S.

Channels (Austin). 2011 Jan-Feb;5(1):34-42. Epub 2011 Jan 1.


Beta-barrel models of soluble amyloid beta oligomers and annular protofibrils.

Shafrir Y, Durell SR, Anishkin A, Guy HR.

Proteins. 2010 Dec;78(16):3458-72. doi: 10.1002/prot.22832.


Adaptive behavior of bacterial mechanosensitive channels is coupled to membrane mechanics.

Belyy V, Kamaraju K, Akitake B, Anishkin A, Sukharev S.

J Gen Physiol. 2010 Jun;135(6):641-52. doi: 10.1085/jgp.200910371.


The tension-transmitting 'clutch' in the mechanosensitive channel MscS.

Belyy V, Anishkin A, Kamaraju K, Liu N, Sukharev S.

Nat Struct Mol Biol. 2010 Apr;17(4):451-8. doi: 10.1038/nsmb.1775. Epub 2010 Mar 7.


Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels.

Anishkin A, Milac AL, Guy HR.

Proteins. 2010 Mar;78(4):932-49. doi: 10.1002/prot.22618.


State-stabilizing Interactions in Bacterial Mechanosensitive Channel Gating and Adaptation.

Anishkin A, Sukharev S.

J Biol Chem. 2009 Jul 17;284(29):19153-7. doi: 10.1074/jbc.R109.009357. Epub 2009 Apr 21. Review.


Yeast gain-of-function mutations reveal structure-function relationships conserved among different subfamilies of transient receptor potential channels.

Su Z, Zhou X, Haynes WJ, Loukin SH, Anishkin A, Saimi Y, Kung C.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19607-12. Epub 2007 Nov 27.


Straightening and sequential buckling of the pore-lining helices define the gating cycle of MscS.

Akitake B, Anishkin A, Liu N, Sukharev S.

Nat Struct Mol Biol. 2007 Dec;14(12):1141-9. Epub 2007 Nov 25.


Yeast screens show aromatic residues at the end of the sixth helix anchor transient receptor potential channel gate.

Zhou X, Su Z, Anishkin A, Haynes WJ, Friske EM, Loukin SH, Kung C, Saimi Y.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15555-9. Epub 2007 Sep 18.


2,2,2-Trifluoroethanol changes the transition kinetics and subunit interactions in the small bacterial mechanosensitive channel MscS.

Akitake B, Spelbrink RE, Anishkin A, Killian JA, de Kruijff B, Sukharev S.

Biophys J. 2007 Apr 15;92(8):2771-84. Epub 2007 Feb 2.


Searching for the molecular arrangement of transmembrane ceramide channels.

Anishkin A, Sukharev S, Colombini M.

Biophys J. 2006 Apr 1;90(7):2414-26. Epub 2006 Jan 13.


Microbial mechanosensation.

Anishkin A, Kung C.

Curr Opin Neurobiol. 2005 Aug;15(4):397-405. Review.


Supplemental Content

Loading ...
Support Center