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Items: 1 to 50 of 53

1.

A novel ex vivo high-throughput assay reveals antiproliferative effects of idelalisib and ibrutinib in chronic lymphocytic leukemia.

Primo D, Scarfò L, Xochelli A, Mattsson M, Ranghetti P, Espinosa AB, Robles A, Gorrochategui J, Martínez-López J, de la Serna J, González M, Gil AC, Anguita E, Iraheta S, Munugalavadla V, Quéva C, Tannheimer S, Rosenquist R, Stamatopoulos K, Ballesteros J, Ghia P.

Oncotarget. 2018 May 25;9(40):26019-26031. doi: 10.18632/oncotarget.25419. eCollection 2018 May 25.

2.

Ca2+ signaling and Src-kinases-controlled cellular functions.

Anguita E, Villalobo A.

Arch Biochem Biophys. 2018 Jul 15;650:59-74. doi: 10.1016/j.abb.2018.05.005. Epub 2018 May 16. Review.

PMID:
29753725
3.

Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer.

Dopeso H, Rodrigues P, Bilic J, Bazzocco S, Cartón-García F, Macaya I, de Marcondes PG, Anguita E, Masanas M, Jiménez-Flores LM, Martínez-Barriocanal Á, Nieto R, Segura MF, Schwartz S Jr, Mariadason JM, Arango D.

Br J Cancer. 2018 Jan;118(1):106-116. doi: 10.1038/bjc.2017.420. Epub 2017 Dec 5.

PMID:
29206819
4.

PTCH1 is a reliable marker for predicting imatinib response in chronic myeloid leukemia patients in chronic phase.

Alonso-Dominguez JM, Casado LF, Anguita E, Gomez-Casares MT, Buño I, Ferrer-Marín F, Arenas A, Del Orbe R, Ayala R, Llamas P, Salgado RN, Osorio S, Sanchez-Godoy P, Burgaleta C, Mahíllo-Fernández I, Garcia-Gutierrez V, Steegmann JL, Martinez-Lopez J.

PLoS One. 2017 Jul 13;12(7):e0181366. doi: 10.1371/journal.pone.0181366. eCollection 2017.

5.

Detailed Characterization of Mesenchymal Stem/Stromal Cells from a Large Cohort of AML Patients Demonstrates a Definitive Link to Treatment Outcomes.

Diaz de la Guardia R, Lopez-Millan B, Lavoie JR, Bueno C, Castaño J, Gómez-Casares M, Vives S, Palomo L, Juan M, Delgado J, Blanco ML, Nomdedeu J, Chaparro A, Fuster JL, Anguita E, Rosu-Myles M, Menéndez P.

Stem Cell Reports. 2017 Jun 6;8(6):1573-1586. doi: 10.1016/j.stemcr.2017.04.019. Epub 2017 May 18.

6.

Amplification of mixed lineage leukemia gene perturbs hematopoiesis and cooperates with partial tandem duplication to induce acute myeloid leukemia.

Yip BH, Tsai CT, Rane JK, Vetharoy W, Anguita E, Dong S, Caligiuri MA, So CWE.

Haematologica. 2017 Aug;102(8):e300-e304. doi: 10.3324/haematol.2016.161406. Epub 2017 May 18. No abstract available.

7.

Increasing TIMP3 expression by hypomethylating agents diminishes soluble MICA, MICB and ULBP2 shedding in acute myeloid leukemia, facilitating NK cell-mediated immune recognition.

Raneros AB, Puras AM, Rodriguez RM, Colado E, Bernal T, Anguita E, Mogorron AV, Gil AC, Vidal-Castiñeira JR, Márquez-Kisinousky L, Bulnes PD, Marin AM, Garay MCG, Suarez-Alvarez B, Lopez-Larrea C.

Oncotarget. 2017 May 9;8(19):31959-31976. doi: 10.18632/oncotarget.16657.

8.

Transcription Factor GFI1B in Health and Disease.

Anguita E, Candel FJ, Chaparro A, Roldán-Etcheverry JJ.

Front Oncol. 2017 Mar 28;7:54. doi: 10.3389/fonc.2017.00054. eCollection 2017. Review.

9.

Wilms Tumor 1 gene expression levels improve risk stratification in AML patients. Results of a multicentre study within the Spanish Group for Molecular Biology in Haematology.

Martínez-Laperche C, Kwon M, Franco-Villegas AC, Chillón MC, Castro N, Anguita E, Dolz S, Rodríguez-Medina C, Hermosín L, Bellón JM, Prieto-Conde MI, Barragán E, Gómez-Casares M, Ayala R, Martínez-López J, González-Díaz M, Díez-Martin JL, Buño I; Cooperative Group for Molecular Biology in Haematology (GBMH).

Br J Haematol. 2018 May;181(4):542-546. doi: 10.1111/bjh.14635. Epub 2017 Apr 3. No abstract available.

PMID:
28369773
10.

Src-family tyrosine kinases and the Ca2+ signal.

Anguita E, Villalobo A.

Biochim Biophys Acta. 2017 Jun;1864(6):915-932. doi: 10.1016/j.bbamcr.2016.10.022. Epub 2016 Nov 4. Review.

11.

Splenectomy in ITP: we keep removing a healthy functional organ.

Anguita E, Candel FJ, González-Del Castillo J, Martín-Sánchez FJ.

Ann Hematol. 2016 Oct;95(11):1911-2. doi: 10.1007/s00277-016-2778-8. Epub 2016 Aug 31. No abstract available.

PMID:
27577110
12.

A somatic mutation of GFI1B identified in leukemia alters cell fate via a SPI1 (PU.1) centered genetic regulatory network.

Anguita E, Gupta R, Olariu V, Valk PJ, Peterson C, Delwel R, Enver T.

Dev Biol. 2016 Mar 15;411(2):277-286. doi: 10.1016/j.ydbio.2016.02.002. Epub 2016 Feb 3.

13.

The activating role of phospho-(Tyr)-calmodulin on the epidermal growth factor receptor.

Stateva SR, Salas V, Benguría A, Cossío I, Anguita E, Martín-Nieto J, Benaim G, Villalobo A.

Biochem J. 2015 Dec 1;472(2):195-204. doi: 10.1042/BJ20150851. Epub 2015 Sep 23.

PMID:
26399481
14.

Ca2+/Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activity of c-Src.

Stateva SR, Salas V, Anguita E, Benaim G, Villalobo A.

PLoS One. 2015 Jun 9;10(6):e0128783. doi: 10.1371/journal.pone.0128783. eCollection 2015.

15.

A new NPM1 gene mutation.

Illana FJ, Manrique A, Coria-Ramírez E, Anguita E.

Leuk Lymphoma. 2015;56(12):3449-51. doi: 10.3109/10428194.2015.1037761. Epub 2015 Jun 18. No abstract available.

PMID:
25927245
16.

Bone marrow mesenchymal stem cells from patients with aplastic anemia maintain functional and immune properties and do not contribute to the pathogenesis of the disease.

Bueno C, Roldan M, Anguita E, Romero-Moya D, Martín-Antonio B, Rosu-Myles M, del Cañizo C, Campos F, García R, Gómez-Casares M, Fuster JL, Jurado M, Delgado M, Menendez P.

Haematologica. 2014 Jul;99(7):1168-75. doi: 10.3324/haematol.2014.103580. Epub 2014 Apr 11.

17.

[Molecular characterization of two new mutations of α° thalassemia in two Spanish families (mutation --(ED) and --(GP))].

Villegas A, Ropero P, Anguita E, Hernández A, Polo M, Ataúlfo González F.

Med Clin (Barc). 2011 May 28;136(15):674-7. doi: 10.1016/j.medcli.2011.01.015. Epub 2011 Mar 31. Spanish.

PMID:
21453942
18.

Human promoter mutations unveil Oct-1 and GATA-1 opposite action on Gfi1b regulation.

Hernández A, Villegas A, Anguita E.

Ann Hematol. 2010 Aug;89(8):759-65. doi: 10.1007/s00277-009-0900-x. Epub 2010 Feb 9.

PMID:
20143233
19.

GFI1B controls its own expression binding to multiple sites.

Anguita E, Villegas A, Iborra F, Hernández A.

Haematologica. 2010 Jan;95(1):36-46. doi: 10.3324/haematol.2009.012351. Epub 2009 Sep 22.

20.

Haemoglobinopathies with high oxygen affinity. Experience of Erythropathology Cooperative Spanish Group.

González Fernández FA, Villegas A, Ropero P, Carreño MD, Anguita E, Polo M, Pascual A, Henández A.

Ann Hematol. 2009 Mar;88(3):235-8. doi: 10.1007/s00277-008-0581-x. Epub 2008 Sep 26.

PMID:
18818920
21.

Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.

De Gobbi M, Anguita E, Hughes J, Sloane-Stanley JA, Sharpe JA, Koch CM, Dunham I, Gibbons RJ, Wood WG, Higgs DR.

Blood. 2007 Dec 15;110(13):4503-10. Epub 2007 Aug 22. Erratum in: Blood. 2008 Feb 15;111(4):1773.

22.

How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation.

Higgs DR, Vernimmen D, De Gobbi M, Anguita E, Hughes J, Buckle V, Iborra F, Garrick D, Wood WG.

Biochem Soc Symp. 2006;(73):11-22.

PMID:
16626283
23.

Understanding alpha-globin gene regulation: Aiming to improve the management of thalassemia.

Higgs DR, Garrick D, Anguita E, De Gobbi M, Hughes J, Muers M, Vernimmen D, Lower K, Law M, Argentaro A, Deville MA, Gibbons R.

Ann N Y Acad Sci. 2005;1054:92-102. Review.

PMID:
16339655
24.

Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences.

Hughes JR, Cheng JF, Ventress N, Prabhakar S, Clark K, Anguita E, De Gobbi M, de Jong P, Rubin E, Higgs DR.

Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9830-5. Epub 2005 Jul 5.

25.

Differences in the chromatin structure and cis-element organization of the human and mouse GATA1 loci: implications for cis-element identification.

Valverde-Garduno V, Guyot B, Anguita E, Hamlett I, Porcher C, Vyas P.

Blood. 2004 Nov 15;104(10):3106-16. Epub 2004 Jul 20.

26.

Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2.

Anguita E, Hughes J, Heyworth C, Blobel GA, Wood WG, Higgs DR.

EMBO J. 2004 Jul 21;23(14):2841-52. Epub 2004 Jun 24.

27.

Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype.

Anguita E, Sharpe JA, Sloane-Stanley JA, Tufarelli C, Higgs DR, Wood WG.

Blood. 2002 Nov 15;100(10):3450-6. Epub 2002 Jul 5.

28.

Deletion of BCR region 3' in chronic myelogenous leukemia.

González FA, Anguita E, Mora A, Asenjo S, López I, Polo M, Villegas A.

Cancer Genet Cytogenet. 2001 Oct 1;130(1):68-74.

PMID:
11672777
29.

Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster.

Anguita E, Johnson CA, Wood WG, Turner BM, Higgs DR.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12114-9. Epub 2001 Oct 2.

30.

The thalassemia syndromes: molecular characterization in the Spanish population.

Villegas A, Ropero P, González FA, Anguita E, Espinós D.

Hemoglobin. 2001 Aug;25(3):273-83.

PMID:
11570720
31.

Monosomy for the most telomeric, gene-rich region of the short arm of human chromosome 16 causes minimal phenotypic effects.

Horsley SW, Daniels RJ, Anguita E, Raynham HA, Peden JF, Villegas A, Vickers MA, Green S, Waye JS, Chui DH, Ayyub H, MacCarthy AB, Buckle VJ, Gibbons RJ, Kearney L, Higgs DR.

Eur J Hum Genet. 2001 Mar;9(3):217-25.

32.

Hb Johnstown [beta 109 (G11) Val-->Leu]: second case described and associated for the first time with beta(0)-thalassemia in two Spanish families.

Ropero P, Villegas A, González AF, Anguita E, Sánchez J, Carreño DL, Arrizabalaga B, Atuxta L.

Am J Hematol. 2000 Dec;65(4):298-301.

PMID:
11074558
33.

A new polymorphim (G->A) in the psizeta1 globin gene.

Villegas A, Anguita E, Noguera N, González FA, Ropero P, Sánchez J, Milani AC, Espinos D, Monash DB, Higgs D.

Haematologica. 2000 Sep;85(9):899-901.

34.

Association of t(9;11)-MLL AF9 and trisomy 8 in an AML-M5 preceded by pancytopenia.

Anguita E, Barrio CG, González FA, Ferro MT, del Potro E, Ropero P, Villegas A.

Cancer Genet Cytogenet. 2000 Jul 15;120(2):144-7.

PMID:
10942806
35.

Homozygous Constant Spring: the first case described in the west.

Noguera NI, González FA, Ropero P, Anguita E, Milani AC, Villegas A.

Haematologica. 2000 Jun;85(6):667-9. No abstract available.

36.

Is the alpha(-)(cal) mutation prevalent in central Spain?

Villegas A, Ropero P, González FA, Anguita E, Sánchez J, Quevedo E, San Juan I.

Haematologica. 2000 Jan;85(1):100-1. No abstract available.

37.

Identification of the Hb Lepore phenotype by HPLC.

Ropero P, González FA, Sánchez J, Anguita E, Asenjo S, Del Arco A, Murga MJ, Ramos R, Fernández C, Villegas A.

Haematologica. 1999 Dec;84(12):1081-4.

38.

Cleavage of the ALL1 gene in acute lymphoid leukemia before treatment disappears in relapse.

Anguita E, Villegas A, Serra A, González FA, Ropero P, Contra T, Saglio G.

Haematologica. 1999 Aug;84(8):695-8.

39.

[The relationship between the persistence of the BCR/ABL gene and relapse in adult patients with acute lymphoblastic leukemia].

Anguita E, Villegas A, González FA, del Potro E, Martínez R, Alvarez A, Díaz-Mediavilla J, Ferro MT, Espinós D.

Med Clin (Barc). 1999 Apr 17;112(13):481-4. Spanish.

PMID:
10353112
40.

High incidence of the CD8/9 (+G) beta 0-thalassemia mutation in Spain.

Villegas A, Ropero P, Ataulfo González F, Martí E, Anguita E, de Blas JM.

Haematologica. 1998 Dec;83(12):1066-8.

41.

Acute promyelocytic leukemia relapse in the central nervous system during hematologic and molecular remission.

Anguita E, Villegas A, González FA, Díaz-Mediavilla J, Lo Coco F.

Am J Hematol. 1999 Feb;60(2):170-1. No abstract available.

42.

Preliminary experience in external quality control of RT-PCR PML-RAR alpha detection in promyelocytic leukemia.

Bolufer P, Barragán E, Sánz MA, Martín G, Bornstein R, Colomer D, Delgado MD, González M, Marugan I, Román J, Gómez MT, Anguita E, Diverio D, Chomienne C, Briz M.

Leukemia. 1998 Dec;12(12):2024-8.

PMID:
9844933
43.

Detection of bcr/abl mRNA in a case of chronic myelogenous leukemia in long-term remission: CML or sensitivity of detection?

Anguita E, Villegas A, Díaz-Mediavilla J, González FA, del Potro E, Espinós D.

Haematologica. 1998 Aug;83(8):744-7. Review.

44.

Late relapse in BCR/ABL-positive patients after non-intensive chemotherapy.

Anguita E, Ataulfo González F, del Potro E, Villegas A.

Leukemia. 1998 Jun;12(6):1006-7. No abstract available.

PMID:
9639438
45.

[Usefulness of molecular screening in childhood lymphoblastic leukemias].

Anguita E, González FA, Contra T, Martín N, Valverde F, Villegas A.

Sangre (Barc). 1998 Feb;43(1):7-11. Spanish.

PMID:
9577176
46.
47.

The first report of a Philadelphia chromosome and BCR/ABL rearrangement positive myeloproliferative disorder in a child with thrombocythemia.

Anguita E, Valverde F, González FA, Gil C, Mateo M, Ferro MT, Villegas A.

Leukemia. 1998 Mar;12(3):442-4. No abstract available.

PMID:
9529142
48.

[Value of analyzing reticulocyte subpopulations in polycythemia].

Ataulfo González F, Bermejo A, Sánchez J, Anguita E, Villegas A.

Sangre (Barc). 1997 Oct;42(5):383-6. Spanish.

PMID:
9424738
49.

Occurrence of BCR-ABL rearrangement in a Philadelphia chromosome-negative patient with 5q and 13q deletions and myeloproliferative syndrome.

Villegas A, Anguita E, González FA, Ferro MT, San Román C.

Cancer Genet Cytogenet. 1998 Jan 1;100(1):1-4.

PMID:
9406572
50.

TEL/AML1 transcript and p16 gene deletion in a patient with childhood acute lymphoblastic leukaemia.

Anguita E, González FA, López J, Villegas A.

Br J Haematol. 1997 Oct;99(1):240-1. No abstract available.

PMID:
9359534

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