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Items: 8


A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer.

Lucki NC, Villa GR, Vergani N, Bollong MJ, Beyer BA, Lee JW, Anglin JL, Spangenberg SH, Chin EN, Sharma A, Johnson K, Sander PN, Gordon P, Skirboll SL, Wurdak H, Schultz PG, Mischel PS, Lairson LL.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440. doi: 10.1073/pnas.1816626116. Epub 2019 Mar 7.


Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics.

Lum KM, Sato Y, Beyer BA, Plaisted WC, Anglin JL, Lairson LL, Cravatt BF.

ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.


Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, Lyssiotis CA, Lairson LL, Cantley LC.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1778-83. doi: 10.1073/pnas.1521548113. Epub 2016 Feb 1. Erratum in: Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1585.


A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.

Anglin JL, Song Y.

J Med Chem. 2013 Nov 27;56(22):8972-83. doi: 10.1021/jm4007752. Epub 2013 Aug 14. Review.


Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.

Zheng B, Yao Y, Liu Z, Deng L, Anglin JL, Jiang H, Prasad BV, Song Y.

ACS Med Chem Lett. 2013 Jun 13;4(6):542-546.


Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L.

Anglin JL, Deng L, Yao Y, Cai G, Liu Z, Jiang H, Cheng G, Chen P, Dong S, Song Y.

J Med Chem. 2012 Sep 27;55(18):8066-74. Epub 2012 Sep 6.


Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies.

Yao Y, Chen P, Diao J, Cheng G, Deng L, Anglin JL, Prasad BV, Song Y.

J Am Chem Soc. 2011 Oct 26;133(42):16746-9. doi: 10.1021/ja206312b. Epub 2011 Oct 4. Erratum in: J Am Chem Soc. 2012 Oct 24;134(42):17834.


Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii.

Nair SC, Brooks CF, Goodman CD, Sturm A, McFadden GI, Sundriyal S, Anglin JL, Song Y, Moreno SN, Striepen B.

J Exp Med. 2011 Jul 4;208(7):1547-59. doi: 10.1084/jem.20110039. Epub 2011 Jun 20. Erratum in: J Exp Med. 2012 May 7;209(5):1051. Strurm, Angelika [corrected to Sturm, Angelika].

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