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Items: 1 to 50 of 86

1.

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

MacLeod G, Bozek DA, Rajakulendran N, Monteiro V, Ahmadi M, Steinhart Z, Kushida MM, Yu H, Coutinho FJ, Cavalli FMG, Restall I, Hao X, Hart T, Luchman HA, Weiss S, Dirks PB, Angers S.

Cell Rep. 2019 Apr 16;27(3):971-986.e9. doi: 10.1016/j.celrep.2019.03.047.

2.

Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.

Raman S, Beilschmidt M, To M, Lin K, Lui F, Jmeian Y, Ng M, Fernandez M, Fu Y, Mascall K, Duque A, Wang X, Pan G, Angers S, Moffat J, Sidhu SS, Magram J, Sinclair AM, Fransson J, Julien JP.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6812-6817. doi: 10.1073/pnas.1817246116. Epub 2019 Mar 20.

PMID:
30894493
3.

Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells.

Rajakulendran N, Rowland KJ, Selvadurai HJ, Ahmadi M, Park NI, Naumenko S, Dolma S, Ward RJ, So M, Lee L, MacLeod G, Pasiliao C, Brandon C, Clarke ID, Cusimano MD, Bernstein M, Batada N, Angers S, Dirks PB.

Genes Dev. 2019 May 1;33(9-10):498-510. doi: 10.1101/gad.321968.118. Epub 2019 Mar 6.

PMID:
30842215
4.

Agonist-induced desensitisation of β3 -adrenoceptors: Where, when, and how?

Okeke K, Angers S, Bouvier M, Michel MC.

Br J Pharmacol. 2019 Feb 27. doi: 10.1111/bph.14633. [Epub ahead of print] Review.

PMID:
30809805
5.

ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development.

Magomedova L, Tiefenbach J, Zilberman E, Le Billan F, Voisin V, Saikali M, Boivin V, Robitaille M, Gueroussov S, Irimia M, Ray D, Patel R, Xu C, Jeyasuria P, Bader GD, Hughes TR, Morris QD, Scott MS, Krause H, Angers S, Blencowe BJ, Cummins CL.

Nucleic Acids Res. 2019 Apr 8;47(6):2856-2870. doi: 10.1093/nar/gkz010.

6.

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.

Yin WC, Satkunendran T, Mo R, Morrissy S, Zhang X, Huang ES, Uusküla-Reimand L, Hou H, Son JE, Liu W, Liu YC, Zhang J, Parker J, Wang X, Farooq H, Selvadurai H, Chen X, Sau-Wai Ngan E, Cheng SY, Dirks PB, Angers S, Wilson MD, Taylor MD, Hui CC.

Dev Cell. 2019 Jan 28;48(2):167-183.e5. doi: 10.1016/j.devcel.2018.11.015. Epub 2018 Dec 13.

PMID:
30554998
7.

Three-Dimensional Nanostructured Architectures Enable Efficient Neural Differentiation of Mesenchymal Stem Cells via Mechanotransduction.

Poudineh M, Wang Z, Labib M, Ahmadi M, Zhang L, Das J, Ahmed S, Angers S, Kelley SO.

Nano Lett. 2018 Nov 14;18(11):7188-7193. doi: 10.1021/acs.nanolett.8b03313. Epub 2018 Oct 18.

PMID:
30335391
8.

A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties.

Pavlovic Z, Adams JJ, Blazer LL, Gakhal AK, Jarvik N, Steinhart Z, Robitaille M, Mascall K, Pan J, Angers S, Moffat J, Sidhu SS.

MAbs. 2018 Nov-Dec;10(8):1157-1167. doi: 10.1080/19420862.2018.1515565. Epub 2018 Sep 25.

PMID:
30183492
9.

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.

Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaitė Ž, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, Chandrashekhar M, Angers S, Moffat J, Brunton VG, Hart T, de Bono J, Stankovic T, Jackson AP, Durocher D.

Nature. 2018 Jul;559(7713):285-289. doi: 10.1038/s41586-018-0291-z. Epub 2018 Jul 4.

10.

Wnt signaling in development and tissue homeostasis.

Steinhart Z, Angers S.

Development. 2018 Jun 8;145(11). pii: dev146589. doi: 10.1242/dev.146589. Review.

11.

Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.

Nile AH, de Sousa E Melo F, Mukund S, Piskol R, Hansen S, Zhou L, Zhang Y, Fu Y, Gogol EB, Kömüves LG, Modrusan Z, Angers S, Franke Y, Koth C, Fairbrother WJ, Wang W, de Sauvage FJ, Hannoush RN.

Nat Chem Biol. 2018 Sep;14(9):902. doi: 10.1038/s41589-018-0069-5.

PMID:
29728602
12.

A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.

Nile AH, de Sousa E Melo F, Mukund S, Piskol R, Hansen S, Zhou L, Zhang Y, Fu Y, Gogol EB, Kömüves LG, Modrusan Z, Angers S, Franke Y, Koth C, Fairbrother WJ, Wang W, de Sauvage FJ, Hannoush RN.

Nat Chem Biol. 2018 Jun;14(6):582-590. doi: 10.1038/s41589-018-0035-2. Epub 2018 Apr 9. Erratum in: Nat Chem Biol. 2018 May 4;:.

PMID:
29632413
13.

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.

Youn JY, Dunham WH, Hong SJ, Knight JDR, Bashkurov M, Chen GI, Bagci H, Rathod B, MacLeod G, Eng SWM, Angers S, Morris Q, Fabian M, Côté JF, Gingras AC.

Mol Cell. 2018 Feb 1;69(3):517-532.e11. doi: 10.1016/j.molcel.2017.12.020. Epub 2018 Jan 25.

14.

Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.

Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, Moffat J, Angers S.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384d.

PMID:
29117169
15.

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.

Park NI, Guilhamon P, Desai K, McAdam RF, Langille E, O'Connor M, Lan X, Whetstone H, Coutinho FJ, Vanner RJ, Ling E, Prinos P, Lee L, Selvadurai H, Atwal G, Kushida M, Clarke ID, Voisin V, Cusimano MD, Bernstein M, Das S, Bader G, Arrowsmith CH, Angers S, Huang X, Lupien M, Dirks PB.

Cell Stem Cell. 2017 Sep 7;21(3):411. doi: 10.1016/j.stem.2017.08.008. No abstract available.

16.

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.

Park NI, Guilhamon P, Desai K, McAdam RF, Langille E, O'Connor M, Lan X, Whetstone H, Coutinho FJ, Vanner RJ, Ling E, Prinos P, Lee L, Selvadurai H, Atwal G, Kushida M, Clarke ID, Voisin V, Cusimano MD, Bernstein M, Das S, Bader G, Arrowsmith CH, Angers S, Huang X, Lupien M, Dirks PB.

Cell Stem Cell. 2017 Aug 3;21(2):209-224.e7. doi: 10.1016/j.stem.2017.06.004. Epub 2017 Jul 14. Erratum in: Cell Stem Cell. 2017 Sep 7;21(3):411.

17.

Separating the Anti-Inflammatory and Diabetogenic Effects of Glucocorticoids Through LXRβ Antagonism.

Patel R, Magomedova L, Tsai R, Angers S, Orellana A, Cummins CL.

Endocrinology. 2017 Apr 1;158(4):1034-1047. doi: 10.1210/en.2017-00094.

PMID:
28324010
18.

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandía J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morató X, Otasek D, Kobayashi H, Menendez J, Auerbach D, Angers S, Pržulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I, Stagljar I.

Mol Syst Biol. 2017 Mar 15;13(3):918. doi: 10.15252/msb.20167430.

19.

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.

Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, Moffat J, Angers S.

Nat Med. 2017 Jan;23(1):60-68. doi: 10.1038/nm.4219. Epub 2016 Nov 21. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.

PMID:
27869803
20.

Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.

Gammons MV, Rutherford TJ, Steinhart Z, Angers S, Bienz M.

J Cell Sci. 2016 Oct 15;129(20):3892-3902.

21.

Identification of Novel Smoothened Ligands Using Structure-Based Docking.

Lacroix C, Fish I, Torosyan H, Parathaman P, Irwin JJ, Shoichet BK, Angers S.

PLoS One. 2016 Aug 4;11(8):e0160365. doi: 10.1371/journal.pone.0160365. eCollection 2016.

22.

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins.

Cervenka I, Valnohova J, Bernatik O, Harnos J, Radsetoulal M, Sedova K, Hanakova K, Potesil D, Sedlackova M, Salasova A, Steinhart Z, Angers S, Schulte G, Hampl A, Zdrahal Z, Bryja V.

Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9304-9. doi: 10.1073/pnas.1608783113. Epub 2016 Aug 2.

23.

Role of Spinophilin in Group I Metabotropic Glutamate Receptor Endocytosis, Signaling, and Synaptic Plasticity.

Di Sebastiano AR, Fahim S, Dunn HA, Walther C, Ribeiro FM, Cregan SP, Angers S, Schmid S, Ferguson SS.

J Biol Chem. 2016 Aug 19;291(34):17602-15. doi: 10.1074/jbc.M116.722355. Epub 2016 Jun 29.

24.

PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2.

Daulat AM, Bertucci F, Audebert S, Sergé A, Finetti P, Josselin E, Castellano R, Birnbaum D, Angers S, Borg JP.

Dev Cell. 2016 May 23;37(4):311-325. doi: 10.1016/j.devcel.2016.04.011. Epub 2016 May 12.

25.

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.

Farin HF, Jordens I, Mosa MH, Basak O, Korving J, Tauriello DV, de Punder K, Angers S, Peters PJ, Maurice MM, Clevers H.

Nature. 2016 Feb 18;530(7590):340-3. doi: 10.1038/nature16937. Epub 2016 Feb 10.

PMID:
26863187
26.

SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex.

Chiu CWN, Monat C, Robitaille M, Lacomme M, Daulat AM, Macleod G, McNeill H, Cayouette M, Angers S.

Dev Cell. 2016 Jan 11;36(1):50-62. doi: 10.1016/j.devcel.2015.12.016.

27.

YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.

Dey A, Robitaille M, Remke M, Maier C, Malhotra A, Gregorieff A, Wrana JL, Taylor MD, Angers S, Kenney AM.

Oncogene. 2016 Aug 11;35(32):4256-68. doi: 10.1038/onc.2015.491. Epub 2016 Jan 4.

28.

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J.

Cell. 2015 Dec 3;163(6):1515-26. doi: 10.1016/j.cell.2015.11.015. Epub 2015 Nov 25.

29.

A Par-1-Par-3-Centrosome Cell Polarity Pathway and Its Tuning for Isotropic Cell Adhesion.

Jiang T, McKinley RF, McGill MA, Angers S, Harris TJ.

Curr Biol. 2015 Oct 19;25(20):2701-8. doi: 10.1016/j.cub.2015.08.063. Epub 2015 Oct 8.

30.

The Identification of Novel Protein-Protein Interactions in Liver that Affect Glucagon Receptor Activity.

Han J, Zhang M, Froese S, Dai FF, Robitaille M, Bhattacharjee A, Huang X, Jia W, Angers S, Wheeler MB, Wei L.

PLoS One. 2015 Jun 15;10(6):e0129226. doi: 10.1371/journal.pone.0129226. eCollection 2015.

31.

Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling.

Khan SM, Min A, Gora S, Houranieh GM, Campden R, Robitaille M, Trieu P, Pétrin D, Jacobi AM, Behlke MA, Angers S, Hébert TE.

Cell Signal. 2015 Aug;27(8):1597-608. doi: 10.1016/j.cellsig.2015.04.007. Epub 2015 Apr 23.

PMID:
25916507
32.

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.

Coyaud E, Mis M, Laurent EM, Dunham WH, Couzens AL, Robitaille M, Gingras AC, Angers S, Raught B.

Mol Cell Proteomics. 2015 Jul;14(7):1781-95. doi: 10.1074/mcp.M114.045658. Epub 2015 Apr 21.

33.

Ca(2+)/calmodulin-dependent protein kinase II interacts with group I metabotropic glutamate and facilitates receptor endocytosis and ERK1/2 signaling: role of β-amyloid.

Raka F, Di Sebastiano AR, Kulhawy SC, Ribeiro FM, Godin CM, Caetano FA, Angers S, Ferguson SS.

Mol Brain. 2015 Mar 26;8:21. doi: 10.1186/s13041-015-0111-4.

34.

Stepping stone: a cytohesin adaptor for membrane cytoskeleton restraint in the syncytial Drosophila embryo.

Liu J, Lee DM, Yu CG, Angers S, Harris TJ.

Mol Biol Cell. 2015 Feb 15;26(4):711-25. doi: 10.1091/mbc.E14-11-1554. Epub 2014 Dec 24.

35.

The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity.

Hurley B, Lee D, Mott A, Wilton M, Liu J, Liu YC, Angers S, Coaker G, Guttman DS, Desveaux D.

PLoS One. 2014 Dec 11;9(12):e114921. doi: 10.1371/journal.pone.0114921. eCollection 2014.

36.

The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.

Liu YC, Couzens AL, Deshwar AR, B McBroom-Cerajewski LD, Zhang X, Puviindran V, Scott IC, Gingras AC, Hui CC, Angers S.

Sci Signal. 2014 Dec 9;7(355):ra117. doi: 10.1126/scisignal.2005608.

PMID:
25492966
37.

Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development.

Zhulyn O, Nieuwenhuis E, Liu YC, Angers S, Hui CC.

Dev Biol. 2015 Jan 15;397(2):191-202. doi: 10.1016/j.ydbio.2014.10.023. Epub 2014 Nov 13.

38.

Tandem affinity purification to identify cytosolic and nuclear gβγ-interacting proteins.

Campden R, Pétrin D, Robitaille M, Audet N, Gora S, Angers S, Hébert TE.

Methods Mol Biol. 2015;1234:161-84. doi: 10.1007/978-1-4939-1755-6_14.

PMID:
25304356
39.

Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.

Zhang M, Robitaille M, Showalter AD, Huang X, Liu Y, Bhattacharjee A, Willard FS, Han J, Froese S, Wei L, Gaisano HY, Angers S, Sloop KW, Dai FF, Wheeler MB.

Mol Cell Proteomics. 2014 Nov;13(11):3049-62. doi: 10.1074/mcp.M114.040196. Epub 2014 Jul 20.

40.

New insights in the regulation of Rab GTPases by G protein-coupled receptors.

Lachance V, Angers S, Parent JL.

Small GTPases. 2014;5:e29039. doi: 10.4161/sgtp.29039. Epub 2014 May 9.

41.

Ubiquitylation and activation of a Rab GTPase is promoted by a β₂AR-HACE1 complex.

Lachance V, Degrandmaison J, Marois S, Robitaille M, Génier S, Nadeau S, Angers S, Parent JL.

J Cell Sci. 2014 Jan 1;127(Pt 1):111-23. doi: 10.1242/jcs.132944. Epub 2013 Nov 4.

42.

Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.

Roy SJ, Glazkova I, Fréchette L, Iorio-Morin C, Binda C, Pétrin D, Trieu P, Robitaille M, Angers S, Hébert TE, Parent JL.

Mol Endocrinol. 2013 Aug;27(8):1245-66. doi: 10.1210/me.2013-1091. Epub 2013 Jun 24.

43.

Evasion of p53 and G2/M checkpoints are characteristic of Hh-driven basal cell carcinoma.

Li ZJ, Mack SC, Mak TH, Angers S, Taylor MD, Hui CC.

Oncogene. 2014 May 15;33(20):2674-80. doi: 10.1038/onc.2013.212. Epub 2013 Jun 10.

PMID:
23752195
44.

The human PDZome: a gateway to PSD95-Disc large-zonula occludens (PDZ)-mediated functions.

Belotti E, Polanowska J, Daulat AM, Audebert S, Thomé V, Lissitzky JC, Lembo F, Blibek K, Omi S, Lenfant N, Gangar A, Montcouquiol M, Santoni MJ, Sebbagh M, Aurrand-Lions M, Angers S, Kodjabachian L, Reboul J, Borg JP.

Mol Cell Proteomics. 2013 Sep;12(9):2587-603. doi: 10.1074/mcp.O112.021022. Epub 2013 May 30.

45.

Emerging non-canonical functions for heterotrimeric G proteins in cellular signaling.

Ahmed SM, Angers S.

J Recept Signal Transduct Res. 2013 Jun;33(3):177-83. doi: 10.3109/10799893.2013.795972. Review.

PMID:
23721574
46.

A novel assay for measurement of membrane-protein surface expression using a β-lactamase.

Lam VM, Beerepoot P, Angers S, Salahpour A.

Traffic. 2013 Jul;14(7):778-84. doi: 10.1111/tra.12073. Epub 2013 May 5.

47.

Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate decisions during vertebrate development.

Hayes M, Naito M, Daulat A, Angers S, Ciruna B.

Development. 2013 Apr;140(8):1807-18. doi: 10.1242/dev.090183. Erratum in: Development. 2013 Apr;140(8):1807.

48.

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.

Ahmed SM, Thériault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S.

J Cell Biol. 2012 Dec 10;199(6):951-67. doi: 10.1083/jcb.201206051. Epub 2012 Dec 3.

49.

Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.

Bao R, Christova T, Song S, Angers S, Yan X, Attisano L.

PLoS One. 2012;7(11):e48670. doi: 10.1371/journal.pone.0048670. Epub 2012 Nov 7.

50.

Radil controls neutrophil adhesion and motility through β2-integrin activation.

Liu L, Aerbajinai W, Ahmed SM, Rodgers GP, Angers S, Parent CA.

Mol Biol Cell. 2012 Dec;23(24):4751-65. doi: 10.1091/mbc.E12-05-0408. Epub 2012 Oct 24.

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