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Items: 10

1.

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.

Chen ZC, Zhang W, Chua LL, Chai C, Li R, Lin L, Cao Z, Angeles DC, Stanton LW, Peng JH, Zhou ZD, Lim KL, Zeng L, Tan EK.

Sci Signal. 2017 Jul 18;10(488). pii: eaam6790. doi: 10.1126/scisignal.aam6790.

PMID:
28720718
2.

Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson's disease (PD).

Zhou ZD, Sathiyamoorthy S, Angeles DC, Tan EK.

Mol Brain. 2016 Apr 18;9:41. doi: 10.1186/s13041-016-0218-2. Review.

3.

Antioxidants inhibit neuronal toxicity in Parkinson's disease-linked LRRK2.

Angeles DC, Ho P, Dymock BW, Lim KL, Zhou ZD, Tan EK.

Ann Clin Transl Neurol. 2016 Mar 2;3(4):288-94. doi: 10.1002/acn3.282. eCollection 2016 Apr.

4.

F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy.

Zhou ZD, Xie SP, Sathiyamoorthy S, Saw WT, Sing TY, Ng SH, Chua HP, Tang AM, Shaffra F, Li Z, Wang H, Ho PG, Lai MK, Angeles DC, Lim TM, Tan EK.

Hum Mol Genet. 2015 Nov 15;24(22):6314-30. doi: 10.1093/hmg/ddv340. Epub 2015 Aug 26.

PMID:
26310625
5.

MAP1B rescues LRRK2 mutant-mediated cytotoxicity.

Chan SL, Chua LL, Angeles DC, Tan EK.

Mol Brain. 2014 Apr 22;7:29. doi: 10.1186/1756-6606-7-29.

6.

Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila.

Angeles DC, Ho P, Chua LL, Wang C, Yap YW, Ng C, Zhou Zd, Lim KL, Wszolek ZK, Wang HY, Tan EK.

Hum Mol Genet. 2014 Jun 15;23(12):3157-65. doi: 10.1093/hmg/ddu026. Epub 2014 Jan 23.

7.

Targeting leucine-rich repeat kinase 2 in Parkinson's disease.

Chan SL, Angeles DC, Tan EK.

Expert Opin Ther Targets. 2013 Dec;17(12):1471-82. doi: 10.1517/14728222.2013.842978. Epub 2013 Nov 9. Review.

PMID:
24206363
8.

Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death.

Angeles DC, Gan BH, Onstead L, Zhao Y, Lim KL, Dachsel J, Melrose H, Farrer M, Wszolek ZK, Dickson DW, Tan EK.

Hum Mutat. 2011 Dec;32(12):1390-7. doi: 10.1002/humu.21582. Epub 2011 Sep 12.

PMID:
21850687
9.

Peptide antibiotic and actin-binding protein as mixed-type inhibitors of Clostridium difficile CDT toxin activities.

Angeles DC, Song KP.

Biochem Biophys Res Commun. 2005 Feb 4;327(1):361-70.

PMID:
15629471

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