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Items: 1 to 50 of 62

1.

HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis.

Liu CH, Raj S, Chen CH, Hung KH, Chou CT, Chen IH, Chien JT, Lin IY, Yang SY, Angata T, Tsai WC, Wei JC, Tzeng IS, Hung SC, Lin KI.

J Clin Invest. 2019 Nov 4. pii: 125212. doi: 10.1172/JCI125212. [Epub ahead of print]

2.

Expedient assembly of Oligo-LacNAcs by a sugar nucleotide regeneration system: Finding the role of tandem LacNAc and sialic acid position towards siglec binding.

Wu HR, Anwar MT, Fan CY, Low PY, Angata T, Lin CC.

Eur J Med Chem. 2019 Oct 15;180:627-636. doi: 10.1016/j.ejmech.2019.07.046. Epub 2019 Jul 17.

PMID:
31351394
3.

Chemoenzymatic Synthesis of DSGb5 and Sialylated Globo-series Glycans.

Li PJ, Huang SY, Chiang PY, Fan CY, Guo LJ, Wu DY, Angata T, Lin CC.

Angew Chem Int Ed Engl. 2019 Aug 12;58(33):11273-11278. doi: 10.1002/anie.201903943. Epub 2019 Jul 4.

PMID:
31140679
4.

Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs.

Angata T.

Front Immunol. 2018 Dec 4;9:2885. doi: 10.3389/fimmu.2018.02885. eCollection 2018. Review.

5.

Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses.

Huang PJ, Low PY, Wang I, Hsu SD, Angata T.

J Biol Chem. 2018 Dec 21;293(51):19645-19658. doi: 10.1074/jbc.RA118.005676. Epub 2018 Oct 30.

PMID:
30377253
6.

High affinity sugar ligands of C-type lectin receptor langerin.

Ota F, Hirayama T, Kizuka Y, Yamaguchi Y, Fujinawa R, Nagata M, Ismanto HS, Lepenies B, Aretz J, Rademacher C, Seeberger PH, Angata T, Kitazume S, Yoshida K, Betsuyaku T, Kida K, Yamasaki S, Taniguchi N.

Biochim Biophys Acta Gen Subj. 2018 Jul;1862(7):1592-1601. doi: 10.1016/j.bbagen.2018.04.004. Epub 2018 Apr 7.

PMID:
29631057
7.

O-GlcNAcylation is required for B cell homeostasis and antibody responses.

Wu JL, Chiang MF, Hsu PH, Tsai DY, Hung KH, Wang YH, Angata T, Lin KI.

Nat Commun. 2017 Nov 30;8(1):1854. doi: 10.1038/s41467-017-01677-z.

8.

Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates.

Hayakawa T, Khedri Z, Schwarz F, Landig C, Liang SY, Yu H, Chen X, Fujito NT, Satta Y, Varki A, Angata T.

BMC Evol Biol. 2017 Nov 23;17(1):228. doi: 10.1186/s12862-017-1075-z.

9.

Identification of Siglec Ligands Using a Proximity Labeling Method.

Chang L, Chen YJ, Fan CY, Tang CJ, Chen YH, Low PY, Ventura A, Lin CC, Chen YJ, Angata T.

J Proteome Res. 2017 Oct 6;16(10):3929-3941. doi: 10.1021/acs.jproteome.7b00625. Epub 2017 Sep 22.

PMID:
28899088
10.

The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes.

Graustein AD, Horne DJ, Fong JJ, Schwarz F, Mefford HC, Peterson GJ, Wells RD, Musvosvi M, Shey M, Hanekom WA, Hatherill M, Scriba TJ, Thuong NTT, Mai NTH, Caws M, Bang ND, Dunstan SJ, Thwaites GE, Varki A, Angata T, Hawn TR.

Tuberculosis (Edinb). 2017 May;104:38-45. doi: 10.1016/j.tube.2017.02.005. Epub 2017 Feb 21.

PMID:
28454648
11.

Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.

Ishii T, Angata T, Wan ES, Cho MH, Motegi T, Gao C, Ohtsubo K, Kitazume S, Gemma A, ParÉ PD, Lomas DA, Silverman EK, Taniguchi N, Kida K.

Respirology. 2017 May;22(4):684-690. doi: 10.1111/resp.12952. Epub 2016 Nov 22.

PMID:
27878892
12.

Identification and characterization of sulfated glycoproteins from small cell lung carcinoma cells assisted by management of molecular charges.

Toyoda M, Kaji H, Sawaki H, Togayachi A, Angata T, Narimatsu H, Kameyama A.

Glycoconj J. 2016 Dec;33(6):917-926. Epub 2016 Jun 18.

PMID:
27318476
13.

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.

Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A.

EMBO J. 2015 Nov 12;34(22):2775-88. doi: 10.15252/embj.201591407. Epub 2015 Oct 12.

14.

Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.

Angata T, Nycholat CM, Macauley MS.

Trends Pharmacol Sci. 2015 Oct;36(10):645-660. doi: 10.1016/j.tips.2015.06.008. Review.

15.

Siglec-15 is a potential therapeutic target for postmenopausal osteoporosis.

Kameda Y, Takahata M, Mikuni S, Shimizu T, Hamano H, Angata T, Hatakeyama S, Kinjo M, Iwasaki N.

Bone. 2015 Feb;71:217-26. doi: 10.1016/j.bone.2014.10.027. Epub 2014 Nov 8.

PMID:
25460183
16.

Association of serum interleukin-27 with the exacerbation of chronic obstructive pulmonary disease.

Angata T, Ishii T, Gao C, Ohtsubo K, Kitazume S, Gemma A, Kida K, Taniguchi N.

Physiol Rep. 2014 Jul 3;2(7). pii: e12069. doi: 10.14814/phy2.12069. Print 2014 Jul 1.

17.

Associations of genetic polymorphisms of Siglecs with human diseases.

Angata T.

Glycobiology. 2014 Sep;24(9):785-93. doi: 10.1093/glycob/cwu043. Epub 2014 May 19. Review.

PMID:
24841380
18.

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.

Ali SR, Fong JJ, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A.

J Exp Med. 2014 Jun 2;211(6):1231-42. doi: 10.1084/jem.20131853. Epub 2014 May 5.

19.

Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates.

Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T.

FASEB J. 2014 Mar;28(3):1280-93. doi: 10.1096/fj.13-241497. Epub 2013 Dec 5.

20.

Metabolically programmed quality control system for dolichol-linked oligosaccharides.

Harada Y, Nakajima K, Masahara-Negishi Y, Freeze HH, Angata T, Taniguchi N, Suzuki T.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19366-71. doi: 10.1073/pnas.1312187110. Epub 2013 Nov 11.

21.

A single dose of lipopolysaccharide into mice with emphysema mimics human chronic obstructive pulmonary disease exacerbation as assessed by micro-computed tomography.

Kobayashi S, Fujinawa R, Ota F, Kobayashi S, Angata T, Ueno M, Maeno T, Kitazume S, Yoshida K, Ishii T, Gao C, Ohtsubo K, Yamaguchi Y, Betsuyaku T, Kida K, Taniguchi N.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):971-7. doi: 10.1165/rcmb.2013-0074OC.

PMID:
23822858
22.

Mass isotopomer analysis of metabolically labeled nucleotide sugars and N- and O-glycans for tracing nucleotide sugar metabolisms.

Nakajima K, Ito E, Ohtsubo K, Shirato K, Takamiya R, Kitazume S, Angata T, Taniguchi N.

Mol Cell Proteomics. 2013 Sep;12(9):2468-80. doi: 10.1074/mcp.M112.027151. Epub 2013 May 29.

23.

Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells.

Shirato K, Gao C, Ota F, Angata T, Shogomori H, Ohtsubo K, Yoshida K, Lepenies B, Taniguchi N.

Biochem Biophys Res Commun. 2013 Jun 7;435(3):460-5. doi: 10.1016/j.bbrc.2013.05.009. Epub 2013 May 14.

PMID:
23680662
24.

Siglec-15 regulates osteoclast differentiation by modulating RANKL-induced phosphatidylinositol 3-kinase/Akt and Erk pathways in association with signaling Adaptor DAP12.

Kameda Y, Takahata M, Komatsu M, Mikuni S, Hatakeyama S, Shimizu T, Angata T, Kinjo M, Minami A, Iwasaki N.

J Bone Miner Res. 2013 Dec;28(12):2463-75. doi: 10.1002/jbmr.1989.

25.

Glycoproteomic discovery of serological biomarker candidates for HCV/HBV infection-associated liver fibrosis and hepatocellular carcinoma.

Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, Hirabayashi J, Tanaka Y, Mizokami M, Ikehara Y, Narimatsu H.

J Proteome Res. 2013 Jun 7;12(6):2630-40. doi: 10.1021/pr301217b. Epub 2013 Apr 30.

PMID:
23586699
26.

Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation.

Angata T, Ishii T, Motegi T, Oka R, Taylor RE, Soto PC, Chang YC, Secundino I, Gao CX, Ohtsubo K, Kitazume S, Nizet V, Varki A, Gemma A, Kida K, Taniguchi N.

Cell Mol Life Sci. 2013 Sep;70(17):3199-210. doi: 10.1007/s00018-013-1311-7. Epub 2013 Mar 22.

27.

The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.

Takamiya R, Ohtsubo K, Takamatsu S, Taniguchi N, Angata T.

Glycobiology. 2013 Feb;23(2):178-87. doi: 10.1093/glycob/cws139. Epub 2012 Oct 3.

PMID:
23035012
28.

α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD).

Kamio K, Yoshida T, Gao C, Ishii T, Ota F, Motegi T, Kobayashi S, Fujinawa R, Ohtsubo K, Kitazume S, Angata T, Azuma A, Gemma A, Nishimura M, Betsuyaku T, Kida K, Taniguchi N.

Biochem Biophys Res Commun. 2012 Jul 20;424(1):112-7. doi: 10.1016/j.bbrc.2012.06.081. Epub 2012 Jun 23.

PMID:
22732410
29.

Evolution of siglec-11 and siglec-16 genes in hominins.

Wang X, Mitra N, Cruz P, Deng L; NISC Comparative Sequencing Program, Varki N, Angata T, Green ED, Mullikin J, Hayakawa T, Varki A.

Mol Biol Evol. 2012 Aug;29(8):2073-86. doi: 10.1093/molbev/mss077. Epub 2012 Mar 1.

30.

Integrated approach toward the discovery of glyco-biomarkers of inflammation-related diseases.

Angata T, Fujinawa R, Kurimoto A, Nakajima K, Kato M, Takamatsu S, Korekane H, Gao CX, Ohtsubo K, Kitazume S, Taniguchi N.

Ann N Y Acad Sci. 2012 Apr;1253:159-69. doi: 10.1111/j.1749-6632.2012.06469.x. Epub 2012 Mar 1. Review.

PMID:
22380786
31.

SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.

Mitra N, Banda K, Altheide TK, Schaffer L, Johnson-Pais TL, Beuten J, Leach RJ, Angata T, Varki N, Varki A.

J Biol Chem. 2011 Jul 1;286(26):23003-11. doi: 10.1074/jbc.M111.244152. Epub 2011 May 9.

32.

Detection of anti-Siglec-14 alloantibodies in blood components implicated in nonhaemolytic transfusion reactions.

Yasui K, Angata T, Matsuyama N, Furuta RA, Kimura T, Okazaki H, Tani Y, Nakano S, Narimatsu H, Hirayama F.

Br J Haematol. 2011 Jun;153(6):794-6. doi: 10.1111/j.1365-2141.2010.08488.x. Epub 2011 Apr 8. No abstract available.

PMID:
21477167
33.

Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle.

Shirato K, Nakajima K, Korekane H, Takamatsu S, Gao C, Angata T, Ohtsubo K, Taniguchi N.

J Clin Biochem Nutr. 2011 Jan;48(1):20-5. doi: 10.3164/jcbn.11-015FR. Epub 2010 Dec 29.

34.

Multilectin assay for detecting fibrosis-specific glyco-alteration by means of lectin microarray.

Kuno A, Ikehara Y, Tanaka Y, Angata T, Unno S, Sogabe M, Ozaki H, Ito K, Hirabayashi J, Mizokami M, Narimatsu H.

Clin Chem. 2011 Jan;57(1):48-56. doi: 10.1373/clinchem.2010.151340. Epub 2010 Nov 3.

35.

Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC.

Nakajima K, Kitazume S, Angata T, Fujinawa R, Ohtsubo K, Miyoshi E, Taniguchi N.

Glycobiology. 2010 Jul;20(7):865-71. doi: 10.1093/glycob/cwq044. Epub 2010 Apr 5.

PMID:
20371511
36.

Human C21orf63 is a heparin-binding protein.

Mitsunaga K, Harada-Itadani J, Shikanai T, Tateno H, Ikehara Y, Hirabayashi J, Narimatsu H, Angata T.

J Biochem. 2009 Sep;146(3):369-73. doi: 10.1093/jb/mvp079. Epub 2009 May 26.

PMID:
19470522
37.

Deletion polymorphism of SIGLEC14 and its functional implications.

Yamanaka M, Kato Y, Angata T, Narimatsu H.

Glycobiology. 2009 Aug;19(8):841-6. doi: 10.1093/glycob/cwp052. Epub 2009 Apr 15.

PMID:
19369701
38.

Strategy for glycoproteomics: identification of glyco-alteration using multiple glycan profiling tools.

Ito H, Kuno A, Sawaki H, Sogabe M, Ozaki H, Tanaka Y, Mizokami M, Shoda J, Angata T, Sato T, Hirabayashi J, Ikehara Y, Narimatsu H.

J Proteome Res. 2009 Mar;8(3):1358-67. doi: 10.1021/pr800735j.

PMID:
19178301
39.

Glycoconjugate microarray based on an evanescent-field fluorescence-assisted detection principle for investigation of glycan-binding proteins.

Tateno H, Mori A, Uchiyama N, Yabe R, Iwaki J, Shikanai T, Angata T, Narimatsu H, Hirabayashi J.

Glycobiology. 2008 Oct;18(10):789-98. doi: 10.1093/glycob/cwn068. Epub 2008 Jul 16.

PMID:
18633134
40.

[Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins].

Angata T.

Tanpakushitsu Kakusan Koso. 2008 May;53(6):733-8. Review. Japanese. No abstract available.

PMID:
18453149
41.

Siglec-15: an immune system Siglec conserved throughout vertebrate evolution.

Angata T, Tabuchi Y, Nakamura K, Nakamura M.

Glycobiology. 2007 Aug;17(8):838-46. Epub 2007 May 4.

PMID:
17483134
42.

Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.

Zhang M, Angata T, Cho JY, Miller M, Broide DH, Varki A.

Blood. 2007 May 15;109(10):4280-7. Epub 2007 Feb 1.

43.

Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.

Angata T, Hayakawa T, Yamanaka M, Varki A, Nakamura M.

FASEB J. 2006 Oct;20(12):1964-73.

PMID:
17012248
44.

Molecular diversity and evolution of the Siglec family of cell-surface lectins.

Angata T.

Mol Divers. 2006 Nov;10(4):555-66. Review.

PMID:
16972014
45.

Strategy for simulation of CID spectra of N-linked oligosaccharides toward glycomics.

Kameyama A, Nakaya S, Ito H, Kikuchi N, Angata T, Nakamura M, Ishida HK, Narimatsu H.

J Proteome Res. 2006 Apr;5(4):808-14.

PMID:
16602687
46.

A human-specific gene in microglia.

Hayakawa T, Angata T, Lewis AL, Mikkelsen TS, Varki NM, Varki A.

Science. 2005 Sep 9;309(5741):1693.

47.

Siglecs--the major subfamily of I-type lectins.

Varki A, Angata T.

Glycobiology. 2006 Jan;16(1):1R-27R. Epub 2005 Jul 13. Review.

PMID:
16014749
48.

[Functions and evolution of siglecs, a family of endogenous sialic acid receptors of vertebrates].

Angata T.

Seikagaku. 2004 Sep;76(9):1224-8. Review. Japanese. No abstract available.

PMID:
15524113
49.

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.

Angata T, Margulies EH, Green ED, Varki A.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13251-6. Epub 2004 Aug 26.

50.

CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice.

Brinkman-Van der Linden EC, Angata T, Reynolds SA, Powell LD, Hedrick SM, Varki A.

Mol Cell Biol. 2003 Jun;23(12):4199-206.

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