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Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers.

Ogden A, Bhattarai S, Sahoo B, Mongan NP, Alsaleem M, Green AR, Aleskandarany M, Ellis IO, Pattni S, Li XB, Moreno CS, Krishnamurti U, Janssen EA, Jonsdottir K, Rakha E, Rida P, Aneja R.

Sci Rep. 2020 Feb 20;10(1):3009. doi: 10.1038/s41598-020-59514-1.


Quadruple-Negative Breast Cancer: An Uneven Playing Field.

Saini G, Bhattarai S, Gogineni K, Aneja R.

JCO Glob Oncol. 2020 Feb;6:233-237. doi: 10.1200/JGO.19.00366. No abstract available.


Spotlighting the hypoxia-centrosome amplification axis.

Mittal K, Aneja R.

Med Res Rev. 2020 Feb 10. doi: 10.1002/med.21663. [Epub ahead of print]


A quantitative centrosomal amplification score predicts local recurrence in ductal carcinoma in situ.

Mittal K, Toss MS, Wei G, Kaur J, Choi DH, Melton BD, Osan RM, Milligy IM, Green AR, Janssen EAM, Søiland H, Gogineni K, Manne U, Rida P, Rakha EA, Aneja R.

Clin Cancer Res. 2020 Jan 14. pii: clincanres.1272.2019. doi: 10.1158/1078-0432.CCR-19-1272. [Epub ahead of print]


Clinicopathologic Factors Associated With Response to Neoadjuvant Anti-HER2-Directed Chemotherapy in HER2-Positive Breast Cancer.

Meisel JL, Zhao J, Suo A, Zhang C, Wei Z, Taylor C, Aneja R, Krishnamurti U, Li Z, Nahta R, O'Regan R, Li X.

Clin Breast Cancer. 2020 Feb;20(1):19-24. doi: 10.1016/j.clbc.2019.09.003. Epub 2019 Sep 18.


Effect of dietary cellulose supplementation on gut barrier function and apoptosis in a murine model of endotoxemia.

Di Caro V, Alcamo AM, Cummings JL, Clark RSB, Novak EA, Mollen KP, Morowitz MJ, Aneja RK.

PLoS One. 2019 Dec 2;14(12):e0224838. doi: 10.1371/journal.pone.0224838. eCollection 2019.


The authors reply.

Alcamo AM, Alessi LJ, Vehovic SN, Bansal N, Bond GJ, Carcillo JA, Green M, Michaels MG, Aneja RK.

Pediatr Crit Care Med. 2019 Nov;20(11):1103-1104. doi: 10.1097/PCC.0000000000002140. No abstract available.


Roles of p38α and p38β mitogen‑activated protein kinase isoforms in human malignant melanoma A375 cells.

Wen SY, Cheng SY, Ng SC, Aneja R, Chen CJ, Huang CY, Kuo WW.

Int J Mol Med. 2019 Dec;44(6):2123-2132. doi: 10.3892/ijmm.2019.4383. Epub 2019 Oct 24.


Early Axonal Injury and Delayed Cytotoxic Cerebral Edema are Associated With Microglial Activation in a Mouse Model of Sepsis.

Pang D, Wu YL, Alcamo AM, Cummings J, Di Caro V, Walko T 3rd, Hsue V, Clark RSB, Panigrahy A, Kochanek PM, Aneja RK.

Shock. 2019 Sep 10. doi: 10.1097/SHK.0000000000001446. [Epub ahead of print]


Panoptic View of Prognostic Models for Personalized Breast Cancer Management.

Saini G, Mittal K, Rida P, Janssen EAM, Gogineni K, Aneja R.

Cancers (Basel). 2019 Sep 7;11(9). pii: E1325. doi: 10.3390/cancers11091325. Review.


Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.

Toss M, Miligy I, Gorringe K, Mittal K, Aneja R, Ellis I, Green A, Rakha E.

J Clin Pathol. 2020 Feb;73(2):76-82. doi: 10.1136/jclinpath-2019-205939. Epub 2019 Aug 23.


Machine learning-based prediction of breast cancer growth rate in vivo.

Bhattarai S, Klimov S, Aleskandarany MA, Burrell H, Wormall A, Green AR, Rida P, Ellis IO, Osan RM, Rakha EA, Aneja R.

Br J Cancer. 2019 Sep;121(6):497-504. doi: 10.1038/s41416-019-0539-x. Epub 2019 Aug 9.


A whole slide image-based machine learning approach to predict ductal carcinoma in situ (DCIS) recurrence risk.

Klimov S, Miligy IM, Gertych A, Jiang Y, Toss MS, Rida P, Ellis IO, Green A, Krishnamurti U, Rakha EA, Aneja R.

Breast Cancer Res. 2019 Jul 29;21(1):83. doi: 10.1186/s13058-019-1165-5.


Prognostic Role of Androgen Receptor in Triple Negative Breast Cancer: A Multi-Institutional Study.

Bhattarai S, Klimov S, Mittal K, Krishnamurti U, Li XB, Oprea-Ilies G, Wetherilt CS, Riaz A, Aleskandarany MA, Green AR, Ellis IO, Cantuaria G, Gupta M, Manne U, Agboola J, Baskovich B, Janssen EAM, Callagy G, Walsh EM, Mehta A, Dogra A, Shet T, Gajaria P, Traina T, Nggada HA, Omonisi A, Ahmed SA, Rakha EA, Rida P, Aneja R.

Cancers (Basel). 2019 Jul 17;11(7). pii: E995. doi: 10.3390/cancers11070995.


Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription.

Mousseau G, Aneja R, Clementz MA, Mediouni S, Lima NS, Haregot A, Kessing CF, Jablonski JA, Thenin-Houssier S, Nagarsheth N, Trautmann L, Valente ST.

mBio. 2019 Jul 2;10(4). pii: e01750-18. doi: 10.1128/mBio.01750-18.


Monitoring the dynamics of hemeoxygenase-1 activation in head and neck cancer cells in real-time using plasmonically enhanced Raman spectroscopy.

Panikkanvalappil SR, Garlapati C, Hooshmand N, Aneja R, El-Sayed MA.

Chem Sci. 2019 Mar 22;10(18):4876-4882. doi: 10.1039/c9sc00093c. eCollection 2019 May 14.


Collagen (XI) alpha-1 chain is an independent prognostic factor in breast ductal carcinoma in situ.

Toss MS, Miligy IM, Gorringe KL, Aleskandarany MA, Alkawaz A, Mittal K, Aneja R, Ellis IO, Green AR, Rakha EA.

Mod Pathol. 2019 Oct;32(10):1460-1472. doi: 10.1038/s41379-019-0286-9. Epub 2019 Jun 7.


Geometric characteristics of collagen have independent prognostic significance in breast ductal carcinoma in situ: an image analysis study.

Toss MS, Miligy IM, Gorringe KL, AlKawaz A, Mittal K, Aneja R, Ellis IO, Green AR, Roxanis I, Rakha EA.

Mod Pathol. 2019 Oct;32(10):1473-1485. doi: 10.1038/s41379-019-0296-7. Epub 2019 Jun 7.


Disadvantaged neighborhoods and racial disparity in breast cancer outcomes: the biological link.

Saini G, Ogden A, McCullough LE, Torres M, Rida P, Aneja R.

Cancer Causes Control. 2019 Jul;30(7):677-686. doi: 10.1007/s10552-019-01180-4. Epub 2019 May 20. Review.


Severe Sepsis in Pediatric Liver Transplant Patients: The Emergence of Multidrug-Resistant Organisms.

Alcamo AM, Alessi LJ, Vehovic SN, Bansal N, Bond GJ, Carcillo JA, Green M, Michaels MG, Aneja RK.

Pediatr Crit Care Med. 2019 Jul;20(7):e326-e332. doi: 10.1097/PCC.0000000000001983.


Role of Damage-Associated Molecular Patterns and Uncontrolled Inflammation in Pediatric Sepsis-Induced Multiple Organ Dysfunction Syndrome.

Alcamo AM, Pang D, Bashir DA, Carcillo JA, Nguyen TC, Aneja RK.

J Pediatr Intensive Care. 2019 Mar;8(1):25-31. doi: 10.1055/s-0038-1675639. Epub 2018 Nov 20. Review.


Time will tell: Circadian clock dysregulation in triple negative breast cancer.

Rida P, Syed MI, Aneja R.

Front Biosci (Schol Ed). 2019 Mar 1;11:178-192. Review.


Targeting risk factors for reducing the racially disparate burden in breast cancer.

Wright N, Akinyemiju T, Subhedar P, Rida P, Aneja R.

Front Biosci (Schol Ed). 2019 Mar 1;11:136-160. Review.


The persisting puzzle of racial disparity in triple negative breast cancer: looking through a new lens.

Garlapati C, Joshi S, Sahoo B, Kapoor S, Aneja R.

Front Biosci (Schol Ed). 2019 Mar 1;11:75-88. Review.


Pharmacokinetic stability of macrocyclic peptide triazole HIV-1 inactivators alone and in liposomes.

Aneja R, Grigoletto A, Nangarlia A, Rashad AA, Wrenn S, Jacobson JM, Pasut G, Chaiken I.

J Pept Sci. 2019 Apr;25(4):e3155. doi: 10.1002/psc.3155. Epub 2019 Feb 27.


The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts.

Alsaleem M, Toss MS, Joseph C, Aleskandarany M, Kurozumi S, Alshankyty I, Ogden A, Rida PCG, Ellis IO, Aneja R, Green AR, Mongan NP, Rakha EA.

Mod Pathol. 2019 Jul;32(7):967-976. doi: 10.1038/s41379-019-0209-9. Epub 2019 Feb 13.


ROS- and HIF1α-dependent IGFBP3 upregulation blocks IGF1 survival signaling and thereby mediates high-glucose-induced cardiomyocyte apoptosis.

Huang YT, Liu CH, Yang YC, Aneja R, Wen SY, Huang CY, Kuo WW.

J Cell Physiol. 2019 Aug;234(8):13557-13570. doi: 10.1002/jcp.28034. Epub 2019 Jan 19.


Therapeutic Plasma Exchange in Children With Thrombocytopenia-Associated Multiple Organ Failure: The Thrombocytopenia-Associated Multiple Organ Failure Network Prospective Experience.

Fortenberry JD, Nguyen T, Grunwell JR, Aneja RK, Wheeler D, Hall M, Fleming G, Tarrago R, Buttram S, Dalton H, Han Y, Easley KA, Knezevic A, Dai T, Paden M, Carcillo JA; Thrombocytopenia-Associated Multiple Organ Failure (TAMOF) Network Study Group.

Crit Care Med. 2019 Mar;47(3):e173-e181. doi: 10.1097/CCM.0000000000003559.


Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.

Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Büttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J.

EMBO J. 2019 Jan 15;38(2). pii: e99876. doi: 10.15252/embj.201899876. Epub 2018 Dec 10.


Comparing breast biomarker status between routine immunohistochemistry and FISH studies and Oncotype DX testing, a study of 610 cases.

Neely C, You S, Mendoza PM, Aneja R, Sahin AA, Li X.

Breast J. 2018 Nov;24(6):889-893. doi: 10.1111/tbj.13110. Epub 2018 Sep 19.


Pkcδ Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products (Ages).

Yang YC, Tsai CY, Chen CL, Kuo CH, Hou CW, Cheng SY, Aneja R, Huang CY, Kuo WW.

Aging Dis. 2018 Aug 1;9(4):647-663. doi: 10.14336/AD.2017.0924. eCollection 2018 Aug.


Panoptic Overview of Triple-Negative Breast Cancer in Nigeria: Current Challenges and Promising Global Initiatives.

Wright N, Rida P, Rakha E, Agboola A, Aneja R.

J Glob Oncol. 2018 Jul;4:1-20. doi: 10.1200/JGO.17.00116. Review.


Dietary Cellulose Supplementation Modulates the Immune Response in a Murine Endotoxemia Model.

Di Caro V, Cummings JL, Alcamo AM, Piganelli JD, Clark RSB, Morowitz MJ, Aneja RK.

Shock. 2019 Apr;51(4):526-534. doi: 10.1097/SHK.0000000000001180.


Lack of Benefit on Brain Edema, Blood-Brain Barrier Permeability, or Cognitive Outcome in Global Inducible High Mobility Group Box 1 Knockout Mice Despite Tissue Sparing after Experimental Traumatic Brain Injury.

Aneja RK, Alcamo AM, Cummings J, Vagni V, Feldman K, Wang Q, Dixon CE, Billiar TR, Kochanek PM.

J Neurotrauma. 2019 Jan 15;36(2):360-369. doi: 10.1089/neu.2018.5664. Epub 2018 Sep 5.


Presenting predictors and temporal trends of treatment-related outcomes in diabetic ketoacidosis.

Horvat CM, Ismail HM, Au AK, Garibaldi L, Siripong N, Kantawala S, Aneja RK, Hupp DS, Kochanek PM, Clark RS.

Pediatr Diabetes. 2018 Aug;19(5):985-992. doi: 10.1111/pedi.12663. Epub 2018 Apr 26.


Prognostic significance of tumor-infiltrating lymphocytes in ductal carcinoma in situ of the breast.

Toss MS, Miligy I, Al-Kawaz A, Alsleem M, Khout H, Rida PC, Aneja R, Green AR, Ellis IO, Rakha EA.

Mod Pathol. 2018 Aug;31(8):1226-1236. doi: 10.1038/s41379-018-0040-8. Epub 2018 Mar 20.


Pharmacokinetic-pharmacodynamic correlations in the development of ginger extract as an anticancer agent.

Mukkavilli R, Yang C, Tanwar RS, Saxena R, Gundala SR, Zhang Y, Ghareeb A, Floyd SD, Vangala S, Kuo WW, Rida PCG, Aneja R.

Sci Rep. 2018 Feb 14;8(1):3056. doi: 10.1038/s41598-018-21125-2.


First international TNBC conference meeting report.

Rida P, Ogden A, Ellis IO, Varga Z, Wolff AC, Traina TA, Hatzis C, Palmer JR, Ambrosone CB, Lehmann BD, Nanda R, Montgomery Rice V, Brawley OW, Torres MA, Rakha E, Aneja R.

Breast Cancer Res Treat. 2018 Jun;169(3):407-412. doi: 10.1007/s10549-018-4692-3. Epub 2018 Feb 8.


Pediatric Sepsis Update: How Are Children Different?

Emr BM, Alcamo AM, Carcillo JA, Aneja RK, Mollen KP.

Surg Infect (Larchmt). 2018 Feb/Mar;19(2):176-183. doi: 10.1089/sur.2017.316. Epub 2018 Feb 2. Review.


Diallyl trisulfide suppresses doxorubicin-induced cardiomyocyte apoptosis by inhibiting MAPK/NF-κB signaling through attenuation of ROS generation.

Wen SY, Tsai CY, Pai PY, Chen YW, Yang YC, Aneja R, Huang CY, Kuo WW.

Environ Toxicol. 2018 Jan;33(1):93-103. doi: 10.1002/tox.22500. Epub 2017 Oct 31.


Rationale for Adjunctive Therapies for Pediatric Sepsis Induced Multiple Organ Failure.

Podd BS, Simon DW, Lopez S, Nowalk A, Aneja R, Carcillo JA.

Pediatr Clin North Am. 2017 Oct;64(5):1071-1088. doi: 10.1016/j.pcl.2017.06.007. Epub 2017 Aug 18. Review.


Galangin suppresses H2 O2 -induced aging in human dermal fibroblasts.

Wen SY, Chen JY, Weng YS, Aneja R, Chen CJ, Huang CY, Kuo WW.

Environ Toxicol. 2017 Dec;32(12):2419-2427. doi: 10.1002/tox.22455. Epub 2017 Aug 18.


Rho-GTPase activating-protein 18: a biomarker associated with good prognosis in invasive breast cancer.

Aleskandarany MA, Sonbul S, Surridge R, Mukherjee A, Caldas C, Diez-Rodriguez M, Ashankyty I, Albrahim KI, Elmouna AM, Aneja R, Martin SG, Ellis IO, Green AR, Rakha EA.

Br J Cancer. 2017 Oct 10;117(8):1176-1184. doi: 10.1038/bjc.2017.261. Epub 2017 Aug 22.


50 years on … the discovery of tubulin continues to advance cancer treatment.

Crasta K, Aneja R.

Endocr Relat Cancer. 2017 Sep;24(9):E3-E5. doi: 10.1530/ERC-17-0273. No abstract available.


Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring.

Rashad AA, Acharya K, Haftl A, Aneja R, Dick A, Holmes AP, Chaiken I.

Org Biomol Chem. 2017 Sep 26;15(37):7770-7782. doi: 10.1039/c7ob01448a.


The American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock: Executive Summary.

Davis AL, Carcillo JA, Aneja RK, Deymann AJ, Lin JC, Nguyen TC, Okhuysen-Cawley RS, Relvas MS, Rozenfeld RA, Skippen PW, Stojadinovic BJ, Williams EA, Yeh TS, Balamuth F, Brierley J, de Caen AR, Cheifetz IM, Choong K, Conway E Jr, Cornell T, Doctor A, Dugas MA, Feldman JD, Fitzgerald JC, Flori HR, Fortenberry JD, Graciano AL, Greenwald BM, Hall MW, Han YY, Hernan LJ, Irazuzta JE, Iselin E, van der Jagt EW, Jeffries HE, Kache S, Katyal C, Kissoon N, Kon AA, Kutko MC, MacLaren G, Maul T, Mehta R, Odetola F, Parbuoni K, Paul R, Peters MJ, Ranjit S, Reuter-Rice KE, Schnitzler EJ, Scott HF, Torres A Jr, Weingarten-Abrams J, Weiss SL, Zimmerman JJ, Zuckerberg AL.

Pediatr Crit Care Med. 2017 Sep;18(9):884-890. doi: 10.1097/PCC.0000000000001259. No abstract available.


Novel immunohistochemistry-based signatures to predict metastatic site of triple-negative breast cancers.

Klimov S, Rida PC, Aleskandarany MA, Green AR, Ellis IO, Janssen EA, Rakha EA, Aneja R.

Br J Cancer. 2017 Sep 5;117(6):826-834. doi: 10.1038/bjc.2017.224. Epub 2017 Jul 18.


Minocycline Attenuates High Mobility Group Box 1 Translocation, Microglial Activation, and Thalamic Neurodegeneration after Traumatic Brain Injury in Post-Natal Day 17 Rats.

Simon DW, Aneja RK, Alexander H, Bell MJ, Bayır H, Kochanek PM, Clark RSB.

J Neurotrauma. 2018 Jan 1;35(1):130-138. doi: 10.1089/neu.2017.5093. Epub 2017 Aug 22.


Detecting and Quantifying pADPr In Vivo.

Lai YC, Aneja RK, Satchell MA, Clark RSB.

Methods Mol Biol. 2017;1608:27-43. doi: 10.1007/978-1-4939-6993-7_3.


Brain-Specific Serum Biomarkers Predict Neurological Morbidity in Diagnostically Diverse Pediatric Intensive Care Unit Patients.

Au AK, Bell MJ, Fink EL, Aneja RK, Kochanek PM, Clark RSB.

Neurocrit Care. 2018 Feb;28(1):26-34. doi: 10.1007/s12028-017-0414-7.


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