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Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation.

Segovia M, Russo S, Jeldres M, Mahmoud YD, Perez V, Duhalde M, Charnet P, Rousset M, Victoria S, Veigas F, Louvet C, Vanhove B, Floto RA, Anegon I, Cuturi MC, Girotti MR, Rabinovich GA, Hill M.

Cancer Cell. 2019 May 13;35(5):767-781.e6. doi: 10.1016/j.ccell.2019.04.003.


Genetic Restoration of Heme Oxygenase-1 Expression Protects from Type 1 Diabetes in NOD Mice.

Pogu J, Tzima S, Kollias G, Anegon I, Blancou P, Simon T.

Int J Mol Sci. 2019 Apr 3;20(7). pii: E1676. doi: 10.3390/ijms20071676.


Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies.

Clarke SC, Ma B, Trinklein ND, Schellenberger U, Osborn MJ, Ouisse LH, Boudreau A, Davison LM, Harris KE, Ugamraj HS, Balasubramani A, Dang KH, Jorgensen B, Ogana HAN, Pham DT, Pratap PP, Sankaran P, Anegon I, van Schooten WC, Brüggemann M, Buelow R, Force Aldred S.

Front Immunol. 2019 Jan 7;9:3037. doi: 10.3389/fimmu.2018.03037. eCollection 2018.


23rd Nantes Actualités Transplantation: "Genomics and Immunogenetics of Kidney and Inflammatory Diseases-Lessons for Transplantation".

Vince N, Poschmann J, Josien R, Anegon I, Limou S, Gourraud PA.

Transplantation. 2019 May;103(5):857-861. doi: 10.1097/TP.0000000000002517. No abstract available.


Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease.

Ossart J, Moreau A, Autrusseau E, Ménoret S, Martin JC, Besnard M, Ouisse LH, Tesson L, Flippe L, Kisand K, Peterson P, Hubert FX, Anegon I, Josien R, Guillonneau C.

J Immunol. 2018 Aug 1;201(3):874-887. doi: 10.4049/jimmunol.1701318. Epub 2018 Jun 29.


Advances on CD8+ Treg Cells and Their Potential in Transplantation.

Bézie S, Anegon I, Guillonneau C.

Transplantation. 2018 Sep;102(9):1467-1478. doi: 10.1097/TP.0000000000002258. Review.


Generation of Immunodeficient Rats With Rag1 and Il2rg Gene Deletions and Human Tissue Grafting Models.

Ménoret S, Ouisse LH, Tesson L, Delbos F, Garnier D, Remy S, Usal C, Concordet JP, Giovannangeli C, Chenouard V, Brusselle L, Merieau E, Nerrière-Daguin V, Duteille F, Bellier-Waast F, Fraichard A, Nguyen TH, Anegon I.

Transplantation. 2018 Aug;102(8):1271-1278. doi: 10.1097/TP.0000000000002251.


CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair.

Charpentier M, Khedher AHY, Menoret S, Brion A, Lamribet K, Dardillac E, Boix C, Perrouault L, Tesson L, Geny S, De Cian A, Itier JM, Anegon I, Lopez B, Giovannangeli C, Concordet JP.

Nat Commun. 2018 Mar 19;9(1):1133. doi: 10.1038/s41467-018-03475-7.


Multiplex CRISPR/Cas9 system impairs HCMV replication by excising an essential viral gene.

Gergen J, Coulon F, Creneguy A, Elain-Duret N, Gutierrez A, Pinkenburg O, Verhoeyen E, Anegon I, Nguyen TH, Halary FA, Haspot F.

PLoS One. 2018 Feb 15;13(2):e0192602. doi: 10.1371/journal.pone.0192602. eCollection 2018.


Ex Vivo Expanded Human Non-Cytotoxic CD8+CD45RClow/- Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice.

Bézie S, Meistermann D, Boucault L, Kilens S, Zoppi J, Autrusseau E, Donnart A, Nerrière-Daguin V, Bellier-Waast F, Charpentier E, Duteille F, David L, Anegon I, Guillonneau C.

Front Immunol. 2018 Jan 31;8:2014. doi: 10.3389/fimmu.2017.02014. eCollection 2017.


Immunotherapies in transplantation and cancer: 22nd NAT meeting/2nd NAT LabEx IGO joint meeting; 1-2 June 2017, Nantes, France.

Simon S, Charpentier M, Anegon I, Labarriere N.

Immunotherapy. 2017 Sep;9(11):867-870. doi: 10.2217/imt-2017-0094.


Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses.

Lopez Robles MD, Pallier A, Huchet V, Le Texier L, Remy S, Braudeau C, Delbos L, Moreau A, Louvet C, Brosseau C, Royer PJ, Magnan A, Halary F, Josien R, Cuturi MC, Anegon I, Chiffoleau E.

Blood Adv. 2017 Mar 22;1(9):557-568. doi: 10.1182/bloodadvances.2016002360. eCollection 2017 Mar 28.


Generation of gene-edited rats by delivery of CRISPR/Cas9 protein and donor DNA into intact zygotes using electroporation.

Remy S, Chenouard V, Tesson L, Usal C, Ménoret S, Brusselle L, Heslan JM, Nguyen TH, Bellien J, Merot J, De Cian A, Giovannangeli C, Concordet JP, Anegon I.

Sci Rep. 2017 Nov 29;7(1):16554. doi: 10.1038/s41598-017-16328-y.


FOCIS goes south: advances in translational and clinical immunology.

Kalergis AM, Anegon I, González PA.

Immunotherapy. 2017 Sep;9(10):789-792. doi: 10.2217/imt-2017-0079.


Heme-Oxygenase-1 Expression Contributes to the Immunoregulation Induced by Fasciola hepatica and Promotes Infection.

Carasi P, Rodríguez E, da Costa V, Frigerio S, Brossard N, Noya V, Robello C, Anegón I, Freire T.

Front Immunol. 2017 Jul 26;8:883. doi: 10.3389/fimmu.2017.00883. eCollection 2017.


Advances in transgenic animal models and techniques.

Ménoret S, Tesson L, Remy S, Usal C, Ouisse LH, Brusselle L, Chenouard V, Anegon I.

Transgenic Res. 2017 Oct;26(5):703-708. doi: 10.1007/s11248-017-0038-x. Epub 2017 Aug 5.


A New Marker for Regulatory Macrophages.

Anegon I.

Transplantation. 2017 Nov;101(11):2659-2660. doi: 10.1097/TP.0000000000001863. No abstract available.


Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection.

Espinoza JA, León MA, Céspedes PF, Gómez RS, Canedo-Marroquín G, Riquelme SA, Salazar-Echegarai FJ, Blancou P, Simon T, Anegon I, Lay MK, González PA, Riedel CA, Bueno SM, Kalergis AM.

J Immunol. 2017 Jul 1;199(1):212-223. doi: 10.4049/jimmunol.1601414. Epub 2017 May 31.


Inhibition of effector antigen-specific T cells by intradermal administration of heme oxygenase-1 inducers.

Simon T, Pogu J, Rémy S, Brau F, Pogu S, Maquigneau M, Fonteneau JF, Poirier N, Vanhove B, Blancho G, Piaggio E, Anegon I, Blancou P.

J Autoimmun. 2017 Jul;81:44-55. doi: 10.1016/j.jaut.2017.03.005. Epub 2017 Mar 23.


Immunoregulatory properties of the cytokine IL-34.

Guillonneau C, Bézie S, Anegon I.

Cell Mol Life Sci. 2017 Jul;74(14):2569-2586. doi: 10.1007/s00018-017-2482-4. Epub 2017 Mar 3. Review.


Transient antibody targeting of CD45RC induces transplant tolerance and potent antigen-specific regulatory T cells.

Picarda E, Bézie S, Boucault L, Autrusseau E, Kilens S, Meistermann D, Martinet B, Daguin V, Donnart A, Charpentier E, David L, Anegon I, Guillonneau C.

JCI Insight. 2017 Feb 9;2(3):e90088. doi: 10.1172/jci.insight.90088.


Improved Analyses of CD8+ T Cell Specificities Using Multimers of Peptide MHC Complexes Coupled to DNA Barcodes.

Guillonneau C, David L, Anegon I.

Transplantation. 2017 Feb;101(2):219-221. doi: 10.1097/TP.0000000000001601. No abstract available.


Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminative human monoclonal antibodies.

Ouisse LH, Gautreau-Rolland L, Devilder MC, Osborn M, Moyon M, Visentin J, Halary F, Bruggemann M, Buelow R, Anegon I, Saulquin X.

BMC Biotechnol. 2017 Jan 9;17(1):3. doi: 10.1186/s12896-016-0322-5.


21st Nantes Actualités Transplantation: "When Stem Cells Meet Immunology".

Anegon I, Nguyen TH.

Transplantation. 2017 Jan;101(1):12-16. doi: 10.1097/TP.0000000000001476.


Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats.

Jung CJ, Ménoret S, Brusselle L, Tesson L, Usal C, Chenouard V, Remy S, Ouisse LH, Poirier N, Vanhove B, de Jong PJ, Anegon I.

Sci Rep. 2016 Aug 17;6:31455. doi: 10.1038/srep31455.


A Rapid and Cost-Effective Method for Genotyping Genome-Edited Animals: A Heteroduplex Mobility Assay Using Microfluidic Capillary Electrophoresis.

Chenouard V, Brusselle L, Heslan JM, Remy S, Ménoret S, Usal C, Ouisse LH, NGuyen TH, Anegon I, Tesson L.

J Genet Genomics. 2016 May 20;43(5):341-8. doi: 10.1016/j.jgg.2016.04.005. Epub 2016 May 4.


New insights and current tools for genetically engineered (GE) sheep and goats.

Menchaca A, Anegon I, Whitelaw CB, Baldassarre H, Crispo M.

Theriogenology. 2016 Jul 1;86(1):160-9. doi: 10.1016/j.theriogenology.2016.04.028. Epub 2016 Apr 21. Review.


Successful correction of hemophilia by CRISPR/Cas9 genome editing in vivo: delivery vector and immune responses are the key to success.

Nguyen TH, Anegon I.

EMBO Mol Med. 2016 May 2;8(5):439-41. doi: 10.15252/emmm.201606325. Print 2016 May. No abstract available.


Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases.

Renaud JB, Boix C, Charpentier M, De Cian A, Cochennec J, Duvernois-Berthet E, Perrouault L, Tesson L, Edouard J, Thinard R, Cherifi Y, Menoret S, Fontanière S, de Crozé N, Fraichard A, Sohm F, Anegon I, Concordet JP, Giovannangeli C.

Cell Rep. 2016 Mar 8;14(9):2263-2272. doi: 10.1016/j.celrep.2016.02.018. Epub 2016 Feb 25.


"My Life Needs Editing" (Mort Sahl) and Genome Editing Needs Ethics.

Anegon I, Nguyen TH.

Curr Gene Ther. 2016;16(1):1-2. No abstract available.


Genome Editing and Dialogic Responsibility: "What's in a Name?".

Blasimme A, Anegon I, Concordet JP, De Vos J, Dubart-Kupperschmitt A, Fellous M, Fouchet P, Frydman N, Giovannangeli C, Jouannet P, Serre JL, Steffann J, Rial-Sebbag E, Thomsen M, Cambon-Thomsen A.

Am J Bioeth. 2015;15(12):54-7. doi: 10.1080/15265161.2015.1103811. No abstract available.


Compensatory Regulatory Networks between CD8 T, B, and Myeloid Cells in Organ Transplantation Tolerance.

Bézie S, Picarda E, Ossart J, Martinet B, Anegon I, Guillonneau C.

J Immunol. 2015 Dec 15;195(12):5805-15. doi: 10.4049/jimmunol.1500473. Epub 2015 Nov 9.


Carbon monoxide impairs mitochondria-dependent endosomal maturation and antigen presentation in dendritic cells.

Riquelme SA, Pogu J, Anegon I, Bueno SM, Kalergis AM.

Eur J Immunol. 2015 Dec;45(12):3269-88. doi: 10.1002/eji.201545671. Epub 2015 Oct 23.


Genome Editing in Rats Using TALE Nucleases.

Tesson L, Remy S, Ménoret S, Usal C, Thinard R, Savignard C, De Cian A, Giovannangeli C, Concordet JP, Anegon I.

Methods Mol Biol. 2016;1338:245-59. doi: 10.1007/978-1-4939-2932-0_18.


Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins.

Ménoret S, De Cian A, Tesson L, Remy S, Usal C, Boulé JB, Boix C, Fontanière S, Crénéguy A, Nguyen TH, Brusselle L, Thinard R, Gauguier D, Concordet JP, Cherifi Y, Fraichard A, Giovannangeli C, Anegon I.

Sci Rep. 2015 Oct 7;5:14410. doi: 10.1038/srep14410.


Regulatory B Cells with a Partial Defect in CD40 Signaling and Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents.

Durand J, Huchet V, Merieau E, Usal C, Chesneau M, Remy S, Heslan M, Anegon I, Cuturi MC, Brouard S, Chiffoleau E.

J Immunol. 2015 Nov 15;195(10):5035-44. doi: 10.4049/jimmunol.1500429. Epub 2015 Oct 2.


IL-34 is a Treg-specific cytokine and mediates transplant tolerance.

Bézie S, Picarda E, Ossart J, Tesson L, Usal C, Renaudin K, Anegon I, Guillonneau C.

J Clin Invest. 2015 Oct 1;125(10):3952-64. doi: 10.1172/JCI81227. Epub 2015 Sep 21.


Transgenic animals and genetic engineering techniques. Nantes, France, 2-3 July, 2015.

Ménoret S, Tesson L, Remy S, Usal C, Ouisse LH, Brusselle L, Chenouard V, Nguyen TH, David L, Anegon I.

Transgenic Res. 2015 Dec;24(6):1079-85. doi: 10.1007/s11248-015-9904-6. Epub 2015 Sep 10. No abstract available.


IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis.

Martin JC, Bériou G, Heslan M, Bossard C, Jarry A, Abidi A, Hulin P, Ménoret S, Thinard R, Anegon I, Jacqueline C, Lardeux B, Halary F, Renauld JC, Bourreille A, Josien R.

Mucosal Immunol. 2016 Mar;9(2):539-49. doi: 10.1038/mi.2015.83. Epub 2015 Sep 2.


Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes.

Crispo M, Mulet AP, Tesson L, Barrera N, Cuadro F, dos Santos-Neto PC, Nguyen TH, Crénéguy A, Brusselle L, Anegón I, Menchaca A.

PLoS One. 2015 Aug 25;10(8):e0136690. doi: 10.1371/journal.pone.0136690. eCollection 2015.


CFTR inactivation by lentiviral vector-mediated RNA interference and CRISPR-Cas9 genome editing in human airway epithelial cells.

Bellec J, Bacchetta M, Losa D, Anegon I, Chanson M, Nguyen TH.

Curr Gene Ther. 2015;15(5):447-59.


Fibrinogen-like protein 2/fibroleukin induces long-term allograft survival in a rat model through regulatory B cells.

Bézie S, Picarda E, Tesson L, Renaudin K, Durand J, Ménoret S, Mérieau E, Chiffoleau E, Guillonneau C, Caron L, Anegon I.

PLoS One. 2015 Mar 12;10(3):e0119686. doi: 10.1371/journal.pone.0119686. eCollection 2015.


New humanized mouse model of bronchiolitis obliterans syndrome.

Anegon I.

Transplantation. 2015 Mar;99(3):468-9. doi: 10.1097/TP.0000000000000631.


Codon swapping of zinc finger nucleases confers expression in primary cells and in vivo from a single lentiviral vector.

Abarrategui-Pontes C, Créneguy A, Thinard R, Fine EJ, Thepenier V, Fournier le RL, Cradick TJ, Bao G, Tesson L, Podevin G, Anegon I, Nguyen TH.

Curr Gene Ther. 2014;14(5):365-76.


Preface. Genes don't care.

Anegon I, Nguyen TH.

Curr Gene Ther. 2015;15(1):1-2. No abstract available.


Endothelial-to-mesenchymal transition in pulmonary hypertension.

Ranchoux B, Antigny F, Rucker-Martin C, Hautefort A, Péchoux C, Bogaard HJ, Dorfmüller P, Remy S, Lecerf F, Planté S, Chat S, Fadel E, Houssaini A, Anegon I, Adnot S, Simonneau G, Humbert M, Cohen-Kaminsky S, Perros F.

Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.


Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy.

Larcher T, Lafoux A, Tesson L, Remy S, Thepenier V, François V, Le Guiner C, Goubin H, Dutilleul M, Guigand L, Toumaniantz G, De Cian A, Boix C, Renaud JB, Cherel Y, Giovannangeli C, Concordet JP, Anegon I, Huchet C.

PLoS One. 2014 Oct 13;9(10):e110371. doi: 10.1371/journal.pone.0110371. eCollection 2014.


Embryo development, fetal growth and postnatal phenotype of eGFP lambs generated by lentiviral transgenesis.

Crispo M, Vilariño M, dos Santos-Neto PC, Núñez-Olivera R, Cuadro F, Barrera N, Mulet AP, Nguyen TH, Anegón I, Menchaca A.

Transgenic Res. 2015 Feb;24(1):31-41. doi: 10.1007/s11248-014-9816-x. Epub 2014 Jul 22.


Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases.

Remy S, Tesson L, Menoret S, Usal C, De Cian A, Thepenier V, Thinard R, Baron D, Charpentier M, Renaud JB, Buelow R, Cost GJ, Giovannangeli C, Fraichard A, Concordet JP, Anegon I.

Genome Res. 2014 Aug;24(8):1371-83. doi: 10.1101/gr.171538.113. Epub 2014 Jul 2.


MHC-derived allopeptide activates TCR-biased CD8+ Tregs and suppresses organ rejection.

Picarda E, Bézie S, Venturi V, Echasserieau K, Mérieau E, Delhumeau A, Renaudin K, Brouard S, Bernardeau K, Anegon I, Guillonneau C.

J Clin Invest. 2014 Jun;124(6):2497-512. doi: 10.1172/JCI71533. Epub 2014 May 1.

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