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Interaction between alpha-COP and SMN ameliorates disease phenotype in a mouse model of spinal muscular atrophy.

Custer SK, Astroski JW, Li HX, Androphy EJ.

Biochem Biophys Res Commun. 2019 Jun 25;514(2):530-537. doi: 10.1016/j.bbrc.2019.04.176. Epub 2019 May 3.


Phosphorylation of a Conserved Tyrosine in the Papillomavirus E2 Protein Regulates Brd4 Binding and Viral Replication.

DeSmet M, Jose L, Isaq N, Androphy EJ.

J Virol. 2019 May 1;93(10). pii: e01801-18. doi: 10.1128/JVI.01801-18. Print 2019 May 15.


Intraperitoneal delivery of a novel drug-like compound improves disease severity in severe and intermediate mouse models of Spinal Muscular Atrophy.

Osman EY, Rietz A, Kline RA, Cherry JJ, Hodgetts KJ, Lorson CL, Androphy EJ.

Sci Rep. 2019 Feb 7;9(1):1633. doi: 10.1038/s41598-018-38208-9.


Acetylation of E2 by P300 Mediates Topoisomerase Entry at the Papillomavirus Replicon.

Thomas Y, Androphy EJ.

J Virol. 2019 Mar 21;93(7). pii: e02224-18. doi: 10.1128/JVI.02224-18. Print 2019 Apr 1.


Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency.

Pastrana DV, Peretti A, Welch NL, Borgogna C, Olivero C, Badolato R, Notarangelo LD, Gariglio M, FitzGerald PC, McIntosh CE, Reeves J, Starrett GJ, Bliskovsky V, Velez D, Brownell I, Yarchoan R, Wyvill KM, Uldrick TS, Maldarelli F, Lisco A, Sereti I, Gonzalez CM, Androphy EJ, McBride AA, Van Doorslaer K, Garcia F, Dvoretzky I, Liu JS, Han J, Murphy PM, McDermott DH, Buck CB.

mSphere. 2018 Dec 12;3(6). pii: e00645-18. doi: 10.1128/mSphereDirect.00645-18.


Abnormal Golgi morphology and decreased COPI function in cells with low levels of SMN.

Custer SK, Foster JN, Astroski JW, Androphy EJ.

Brain Res. 2019 Mar 1;1706:135-146. doi: 10.1016/j.brainres.2018.11.005. Epub 2018 Nov 5.


Papillomavirus E2 protein is regulated by specific fibroblast growth factor receptors.

DeSmet M, Kanginakudru S, Jose L, Xie F, Gilson T, Androphy EJ.

Virology. 2018 Aug;521:62-68. doi: 10.1016/j.virol.2018.05.013. Epub 2018 Jun 6.


Human Papillomavirus Replication Regulation by Acetylation of a Conserved Lysine in the E2 Protein.

Thomas Y, Androphy EJ.

J Virol. 2018 Jan 17;92(3). pii: e01912-17. doi: 10.1128/JVI.01912-17. Print 2018 Feb 1.


Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers.

Choi S, Calder AN, Miller EH, Anderson KP, Fiejtek DK, Rietz A, Li H, Cherry JJ, Quist KM, Xing X, Glicksman MA, Cuny GD, Lorson CL, Androphy EA, Hodgetts KJ.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5144-5148. doi: 10.1016/j.bmcl.2017.10.066. Epub 2017 Oct 26.


In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels.

Cherry JJ, DiDonato CJ, Androphy EJ, Calo A, Potter K, Custer SK, Du S, Foley TL, Gopalsamy A, Reedich EJ, Gordo SM, Gordon W, Hosea N, Jones LH, Krizay DK, LaRosa G, Li H, Mathur S, Menard CA, Patel P, Ramos-Zayas R, Rietz A, Rong H, Zhang B, Tones MA.

PLoS One. 2017 Sep 25;12(9):e0185079. doi: 10.1371/journal.pone.0185079. eCollection 2017.


Kinase Activity of Fibroblast Growth Factor Receptor 3 Regulates Activity of the Papillomavirus E2 Protein.

Xie F, DeSmet M, Kanginakudru S, Jose L, Culleton SP, Gilson T, Li C, Androphy EJ.

J Virol. 2017 Sep 27;91(20). pii: e01066-17. doi: 10.1128/JVI.01066-17. Print 2017 Oct 15.


How the discovery of ISS-N1 led to the first medical therapy for spinal muscular atrophy.

Singh NN, Howell MD, Androphy EJ, Singh RN.

Gene Ther. 2017 Sep;24(9):520-526. doi: 10.1038/gt.2017.34. Epub 2017 May 9. Review.


Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.

Rietz A, Li H, Quist KM, Cherry JJ, Lorson CL, Burnett BG, Kern NL, Calder AN, Fritsche M, Lusic H, Boaler PJ, Choi S, Xing X, Glicksman MA, Cuny GD, Androphy EJ, Hodgetts KJ.

J Med Chem. 2017 Jun 8;60(11):4594-4610. doi: 10.1021/acs.jmedchem.6b01885. Epub 2017 May 19.


SMN deficiency negatively impacts red pulp macrophages and spleen development in mouse models of spinal muscular atrophy.

Khairallah MT, Astroski J, Custer SK, Androphy EJ, Franklin CL, Lorson CL.

Hum Mol Genet. 2017 Mar 1;26(5):932-941. doi: 10.1093/hmg/ddx008.


Association of Human Papillomavirus 16 E2 with Rad50-Interacting Protein 1 Enhances Viral DNA Replication.

Campos-León K, Wijendra K, Siddiqa A, Pentland I, Feeney KM, Knapman A, Davies R, Androphy EJ, Parish JL.

J Virol. 2017 Feb 14;91(5). pii: e02305-16. doi: 10.1128/JVI.02305-16. Print 2017 Mar 1.


ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice.

Abera MB, Xiao J, Nofziger J, Titus S, Southall N, Zheng W, Moritz KE, Ferrer M, Cherry JJ, Androphy EJ, Wang A, Xu X, Austin C, Fischbeck KH, Marugan JJ, Burnett BG.

JCI Insight. 2016 Nov 17;1(19):e88427. doi: 10.1172/jci.insight.88427.


Phosphorylation of the Bovine Papillomavirus E2 Protein on Tyrosine Regulates Its Transcription and Replication Functions.

Culleton SP, Kanginakudru S, DeSmet M, Gilson T, Xie F, Wu SY, Chiang CM, Qi G, Wang M, Androphy EJ.

J Virol. 2017 Jan 3;91(2). pii: e01854-16. doi: 10.1128/JVI.01854-16. Print 2017 Jan 15.


Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells.

Custer SK, Gilson TD, Li H, Todd AG, Astroski JW, Lin H, Liu Y, Androphy EJ.

PLoS One. 2016 Oct 13;11(10):e0163954. doi: 10.1371/journal.pone.0163954. eCollection 2016.


The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2.

DeSmet M, Kanginakudru S, Rietz A, Wu WH, Roden R, Androphy EJ.

PLoS Pathog. 2016 Oct 4;12(10):e1005934. doi: 10.1371/journal.ppat.1005934. eCollection 2016 Oct.


Small Molecules in Development for the Treatment of Spinal Muscular Atrophy.

Calder AN, Androphy EJ, Hodgetts KJ.

J Med Chem. 2016 Nov 23;59(22):10067-10083. Epub 2016 Aug 16. Review.


Human papillomavirus oncogenic E6 protein regulates human β-defensin 3 (hBD3) expression via the tumor suppressor protein p53.

DasGupta T, Nweze EI, Yue H, Wang L, Jin J, Ghosh SK, Kawsar HI, Zender C, Androphy EJ, Weinberg A, McCormick TS, Jin G.

Oncotarget. 2016 May 10;7(19):27430-44. doi: 10.18632/oncotarget.8443.


Molecular Probing of the HPV-16 E6 Protein Alpha Helix Binding Groove with Small Molecule Inhibitors.

Rietz A, Petrov DP, Bartolowits M, DeSmet M, Davisson VJ, Androphy EJ.

PLoS One. 2016 Feb 25;11(2):e0149845. doi: 10.1371/journal.pone.0149845. eCollection 2016.


α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth.

Li H, Custer SK, Gilson T, Hao le T, Beattie CE, Androphy EJ.

Hum Mol Genet. 2015 Dec 20;24(25):7295-307. doi: 10.1093/hmg/ddv428. Epub 2015 Oct 13.


SMN Modulator ML372 Increases SMN Protein Abundance, Body Weight, Lifespan, and Rescues Motor Function in SMNΔ7 SMA Mice.

Burnett BG, Xiao J, Southall N, Zheng W, Ferrer M, Cherry JJ, Androphy EJ, Fischbeck K, Marugan JJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Dec 15 [updated 2015 Feb 11].


Levels of the E2 interacting protein TopBP1 modulate papillomavirus maintenance stage replication.

Kanginakudru S, DeSmet M, Thomas Y, Morgan IM, Androphy EJ.

Virology. 2015 Apr;478:129-35. doi: 10.1016/j.virol.2015.01.011. Epub 2015 Feb 7.


Autophagy dysregulation in cell culture and animals models of spinal muscular atrophy.

Custer SK, Androphy EJ.

Mol Cell Neurosci. 2014 Jul;61:133-40. doi: 10.1016/j.mcn.2014.06.006. Epub 2014 Jun 28.


Structure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 function.

Cherry JJ, Rietz A, Malinkevich A, Liu Y, Xie M, Bartolowits M, Davisson VJ, Baleja JD, Androphy EJ.

PLoS One. 2013 Dec 23;8(12):e84506. doi: 10.1371/journal.pone.0084506. eCollection 2013.


Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds.

Cherry JJ, Osman EY, Evans MC, Choi S, Xing X, Cuny GD, Glicksman MA, Lorson CL, Androphy EJ.

EMBO Mol Med. 2013 Jul;5(7):1103-18. doi: 10.1002/emmm.201202305. Epub 2013 Jun 5.


Dilysine motifs in exon 2b of SMN protein mediate binding to the COPI vesicle protein α-COP and neurite outgrowth in a cell culture model of spinal muscular atrophy.

Custer SK, Todd AG, Singh NN, Androphy EJ.

Hum Mol Genet. 2013 Oct 15;22(20):4043-52. doi: 10.1093/hmg/ddt254. Epub 2013 May 31.


Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation.

Lakhter AJ, Sahu RP, Sun Y, Kaufmann WK, Androphy EJ, Travers JB, Naidu SR.

J Invest Dermatol. 2013 Sep;133(9):2247-54. doi: 10.1038/jid.2013.56. Epub 2013 Jan 31.


Genomic instability: Ada3 and HPV E6-acetyltransferase connections?

Androphy EJ.

Cell Cycle. 2013 Jan 1;12(1):13. doi: 10.4161/cc.23172. Epub 2012 Dec 19. No abstract available.


Transcriptional repression of E-cadherin by human papillomavirus type 16 E6.

D'Costa ZJ, Jolly C, Androphy EJ, Mercer A, Matthews CM, Hibma MH.

PLoS One. 2012;7(11):e48954. doi: 10.1371/journal.pone.0048954. Epub 2012 Nov 26.


COPI transport complexes bind to specific RNAs in neuronal cells.

Todd AG, Lin H, Ebert AD, Liu Y, Androphy EJ.

Hum Mol Genet. 2013 Feb 15;22(4):729-36. doi: 10.1093/hmg/dds480. Epub 2012 Nov 21.


Acetylation of conserved lysines in bovine papillomavirus E2 by p300.

Quinlan EJ, Culleton SP, Wu SY, Chiang CM, Androphy EJ.

J Virol. 2013 Feb;87(3):1497-507. doi: 10.1128/JVI.02771-12. Epub 2012 Nov 14.


Therapeutic strategies for the treatment of spinal muscular atrophy.

Cherry JJ, Androphy EJ.

Future Med Chem. 2012 Sep;4(13):1733-50. doi: 10.4155/fmc.12.107. Review.


PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy.

Naidu SR, Lakhter AJ, Androphy EJ.

Cell Cycle. 2012 Jul 15;11(14):2717-28. doi: 10.4161/cc.21091. Epub 2012 Jul 15.


The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3.

Love IM, Sekaric P, Shi D, Grossman SR, Androphy EJ.

Cell Cycle. 2012 Jul 1;11(13):2458-66. doi: 10.4161/cc.20864. Epub 2012 Jul 1.


Identification of novel compounds that increase SMN protein levels using an improved SMN2 reporter cell assay.

Cherry JJ, Evans MC, Ni J, Cuny GD, Glicksman MA, Androphy EJ.

J Biomol Screen. 2012 Apr;17(4):481-95. doi: 10.1177/1087057111431605. Epub 2012 Jan 10.


Discovery, SAR and Biological Evaluation of Aryl-thiazol-piperidines as SMN Modulators.

Xiao J, Marugan JJ, Zheng W, Titus S, Southall N, Cherry JJ, Evans M, Androphy EJ, Austin CP.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Mar 19 [updated 2011 May 5].


Differential regulation of the SMN2 gene by individual HDAC proteins.

Evans MC, Cherry JJ, Androphy EJ.

Biochem Biophys Res Commun. 2011 Oct 14;414(1):25-30. doi: 10.1016/j.bbrc.2011.09.011. Epub 2011 Sep 6.


Discovery, synthesis, and biological evaluation of novel SMN protein modulators.

Xiao J, Marugan JJ, Zheng W, Titus S, Southall N, Cherry JJ, Evans M, Androphy EJ, Austin CP.

J Med Chem. 2011 Sep 22;54(18):6215-33. doi: 10.1021/jm200497t. Epub 2011 Aug 19.


High throughput screening for SMA.

Titus S, Marugan J, Southall N, Inglese J, Austin C, Zheng W, Androphy E.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 May 18 [updated 2010 Sep 2].


The COPI vesicle complex binds and moves with survival motor neuron within axons.

Peter CJ, Evans M, Thayanithy V, Taniguchi-Ishigaki N, Bach I, Kolpak A, Bassell GJ, Rossoll W, Lorson CL, Bao ZZ, Androphy EJ.

Hum Mol Genet. 2011 May 1;20(9):1701-11. doi: 10.1093/hmg/ddr046. Epub 2011 Feb 7.


Valproate and bone loss: iTRAQ proteomics show that valproate reduces collagens and osteonectin in SMA cells.

Fuller HR, Man NT, Lam le T, Shamanin VA, Androphy EJ, Morris GE.

J Proteome Res. 2010 Aug 6;9(8):4228-33. doi: 10.1021/pr1005263.


Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function.

Mallappa C, Nasipak BT, Etheridge L, Androphy EJ, Jones SN, Sagerström CG, Ohkawa Y, Imbalzano AN.

Mol Cell Biol. 2010 Jul;30(13):3176-86. doi: 10.1128/MCB.00214-10. Epub 2010 Apr 26.


Topography of bovine papillomavirus E2 protein on the viral genome during the cell cycle.

Melanson SM, Androphy EJ.

Virology. 2009 Oct 25;393(2):258-64. doi: 10.1016/j.virol.2009.07.037. Epub 2009 Aug 28.


The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells.

Naidu SR, Love IM, Imbalzano AN, Grossman SR, Androphy EJ.

Oncogene. 2009 Jul 9;28(27):2492-501. doi: 10.1038/onc.2009.121. Epub 2009 May 18.


Determinants of stability for the E6 protein of papillomavirus type 16.

Liu Y, Cherry JJ, Dineen JV, Androphy EJ, Baleja JD.

J Mol Biol. 2009 Mar 6;386(4):1123-37.


Tax1BP1 interacts with papillomavirus E2 and regulates E2-dependent transcription and stability.

Wang X, Naidu SR, Sverdrup F, Androphy EJ.

J Virol. 2009 Mar;83(5):2274-84. doi: 10.1128/JVI.01791-08. Epub 2008 Dec 24.


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