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Editorial overview: Host-microbe interactions: parasites 2019 - publisher's note.

Andrews NW, Zamboni DS.

Curr Opin Microbiol. 2019 Dec;52:vii. doi: 10.1016/j.mib.2019.11.006. No abstract available.


Ascorbate-Dependent Peroxidase (APX) from Leishmania amazonensis Is a Reactive Oxygen Species-Induced Essential Enzyme That Regulates Virulence.

Xiang L, Laranjeira-Silva MF, Maeda FY, Hauzel J, Andrews NW, Mittra B.

Infect Immun. 2019 Nov 18;87(12). pii: e00193-19. doi: 10.1128/IAI.00193-19. Print 2019 Dec.


Leishmania amazonensis ferric iron reductase (LFR1) is a bifunctional enzyme: Unveiling a NADPH oxidase activity.

Rocco-Machado N, Cosentino-Gomes D, Nascimento MT, Paes-Vieira L, Khan YA, Mittra B, Andrews NW, Meyer-Fernandes JR.

Free Radic Biol Med. 2019 Nov 1;143:341-353. doi: 10.1016/j.freeradbiomed.2019.08.026. Epub 2019 Aug 22.


Solving the secretory acid sphingomyelinase puzzle: Insights from lysosome-mediated parasite invasion and plasma membrane repair.

Andrews NW.

Cell Microbiol. 2019 Nov;21(11):e13065. doi: 10.1111/cmi.13065. Epub 2019 Jun 10.


Intracellular iron availability modulates the requirement for Leishmania Iron Regulator 1 (LIR1) during macrophage infections.

Sarkar A, Andrews NW, Laranjeira-Silva MF.

Int J Parasitol. 2019 May;49(6):423-427. doi: 10.1016/j.ijpara.2019.02.002. Epub 2019 Mar 22.


Defects in sarcolemma repair and skeletal muscle function after injury in a mouse model of Niemann-Pick type A/B disease.

Michailowsky V, Li H, Mittra B, Iyer SR, Mazála DAG, Corrotte M, Wang Y, Chin ER, Lovering RM, Andrews NW.

Skelet Muscle. 2019 Jan 5;9(1):1. doi: 10.1186/s13395-018-0187-5.


A MFS-like plasma membrane transporter required for Leishmania virulence protects the parasites from iron toxicity.

Laranjeira-Silva MF, Wang W, Samuel TK, Maeda FY, Michailowsky V, Hamza I, Liu Z, Andrews NW.

PLoS Pathog. 2018 Jun 15;14(6):e1007140. doi: 10.1371/journal.ppat.1007140. eCollection 2018 Jun.


Plasma membrane repair.

Andrews NW, Corrotte M.

Curr Biol. 2018 Apr 23;28(8):R392-R397. doi: 10.1016/j.cub.2017.12.034. Review.


Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites.

Sarkar A, Khan YA, Laranjeira-Silva MF, Andrews NW, Mittra B.

J Vis Exp. 2018 Mar 16;(133). doi: 10.3791/57486.


Gaucher disease iPSC-derived osteoblasts have developmental and lysosomal defects that impair bone matrix deposition.

Panicker LM, Srikanth MP, Castro-Gomes T, Miller D, Andrews NW, Feldman RA.

Hum Mol Genet. 2018 Mar 1;27(5):811-822. doi: 10.1093/hmg/ddx442.


ROS regulate differentiation of visceralizing Leishmania species into the virulent amastigote form.

Khan YA, Andrews NW, Mittra B.

Parasitol Open. 2018;4. pii: e19. doi: 10.1017/pao.2018.15. Epub 2018 Nov 6.


The iron-dependent mitochondrial superoxide dismutase SODA promotes Leishmania virulence.

Mittra B, Laranjeira-Silva MF, Miguel DC, Perrone Bezerra de Menezes J, Andrews NW.

J Biol Chem. 2017 Jul 21;292(29):12324-12338. doi: 10.1074/jbc.M116.772624. Epub 2017 May 26.


Detection of Lysosomal Exocytosis by Surface Exposure of Lamp1 Luminal Epitopes.

Andrews NW.

Methods Mol Biol. 2017;1594:205-211. doi: 10.1007/978-1-4939-6934-0_13.


PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.

Fujiwara T, Ye S, Castro-Gomes T, Winchell CG, Andrews NW, Voth DE, Varughese KI, Mackintosh SG, Feng Y, Pavlos N, Nakamura T, Manolagas SC, Zhao H.

JCI Insight. 2016 Oct 20;1(17):e86330. doi: 10.1172/jci.insight.86330.


Leishmania infection inhibits macrophage motility by altering F-actin dynamics and the expression of adhesion complex proteins.

de Menezes JP, Koushik A, Das S, Guven C, Siegel A, Laranjeira-Silva MF, Losert W, Andrews NW.

Cell Microbiol. 2017 Mar;19(3). doi: 10.1111/cmi.12668. Epub 2016 Oct 11.


Plasma Membrane Repair Is Regulated Extracellularly by Proteases Released from Lysosomes.

Castro-Gomes T, Corrotte M, Tam C, Andrews NW.

PLoS One. 2016 Mar 30;11(3):e0152583. doi: 10.1371/journal.pone.0152583. eCollection 2016.


A Trypanosomatid Iron Transporter that Regulates Mitochondrial Function Is Required for Leishmania amazonensis Virulence.

Mittra B, Laranjeira-Silva MF, Perrone Bezerra de Menezes J, Jensen J, Michailowsky V, Andrews NW.

PLoS Pathog. 2016 Jan 7;12(1):e1005340. doi: 10.1371/journal.ppat.1005340. eCollection 2016 Jan.


Lipid raft-dependent plasma membrane repair interferes with the activation of B lymphocytes.

Miller H, Castro-Gomes T, Corrotte M, Tam C, Maugel TK, Andrews NW, Song W.

J Cell Biol. 2015 Dec 21;211(6):1193-205. doi: 10.1083/jcb.201505030.


The plasma membrane repair shop: Fixing the damage.

Andrews NW, Perez F.

Semin Cell Dev Biol. 2015 Sep;45:1. doi: 10.1016/j.semcdb.2015.11.008. No abstract available.


Above the fray: Surface remodeling by secreted lysosomal enzymes leads to endocytosis-mediated plasma membrane repair.

Andrews NW, Corrotte M, Castro-Gomes T.

Semin Cell Dev Biol. 2015 Sep;45:10-7. doi: 10.1016/j.semcdb.2015.09.022. Epub 2015 Oct 1. Review.


The Heme Transport Capacity of LHR1 Determines the Extent of Virulence in Leishmania amazonensis.

Renberg RL, Yuan X, Samuel TK, Miguel DC, Hamza I, Andrews NW, Flannery AR.

PLoS Negl Trop Dis. 2015 May 22;9(5):e0003804. doi: 10.1371/journal.pntd.0003804. eCollection 2015 May.


Approaches for plasma membrane wounding and assessment of lysosome-mediated repair responses.

Corrotte M, Castro-Gomes T, Koushik AB, Andrews NW.

Methods Cell Biol. 2015;126:139-58. doi: 10.1016/bs.mcb.2014.11.009. Epub 2015 Jan 14.


The exocyst is required for trypanosome invasion and the repair of mechanical plasma membrane wounds.

Fernandes MC, Corrotte M, Miguel DC, Tam C, Andrews NW.

J Cell Sci. 2015 Jan 1;128(1):27-32. doi: 10.1242/jcs.150573. Epub 2014 Nov 6.


Damage control: cellular mechanisms of plasma membrane repair.

Andrews NW, Almeida PE, Corrotte M.

Trends Cell Biol. 2014 Dec;24(12):734-42. doi: 10.1016/j.tcb.2014.07.008. Epub 2014 Aug 20. Review.


ESCRT: nipping the wound in the bud?

Castro-Gomes T, Koushik AB, Andrews NW.

Trends Biochem Sci. 2014 Jul;39(7):307-9. doi: 10.1016/j.tibs.2014.06.001. Epub 2014 Jun 20.


Leishmania-mediated inhibition of iron export promotes parasite replication in macrophages.

Ben-Othman R, Flannery AR, Miguel DC, Ward DM, Kaplan J, Andrews NW.

PLoS Pathog. 2014 Jan 30;10(1):e1003901. doi: 10.1371/journal.ppat.1003901. eCollection 2014 Jan.


Membrane cholesterol removal changes mechanical properties of cells and induces secretion of a specific pool of lysosomes.

Hissa B, Pontes B, Roma PM, Alves AP, Rocha CD, Valverde TM, Aguiar PH, Almeida FP, Guimarães AJ, Guatimosim C, Silva AM, Fernandes MC, Andrews NW, Viana NB, Mesquita ON, Agero U, Andrade LO.

PLoS One. 2013 Dec 20;8(12):e82988. doi: 10.1371/journal.pone.0082988. eCollection 2013.


Caveolae internalization repairs wounded cells and muscle fibers.

Corrotte M, Almeida PE, Tam C, Castro-Gomes T, Fernandes MC, Millis BA, Cortez M, Miller H, Song W, Maugel TK, Andrews NW.

Elife. 2013 Sep 17;2:e00926. doi: 10.7554/eLife.00926.


Pathways of iron acquisition and utilization in Leishmania.

Flannery AR, Renberg RL, Andrews NW.

Curr Opin Microbiol. 2013 Dec;16(6):716-21. doi: 10.1016/j.mib.2013.07.018. Epub 2013 Aug 17. Review.


IRONy OF FATE: role of iron-mediated ROS in Leishmania differentiation.

Mittra B, Andrews NW.

Trends Parasitol. 2013 Oct;29(10):489-96. doi: 10.1016/ Epub 2013 Aug 12. Review.


Heme uptake mediated by LHR1 is essential for Leishmania amazonensis virulence.

Miguel DC, Flannery AR, Mittra B, Andrews NW.

Infect Immun. 2013 Oct;81(10):3620-6. doi: 10.1128/IAI.00687-13. Epub 2013 Jul 22.


Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels.

Mittra B, Cortez M, Haydock A, Ramasamy G, Myler PJ, Andrews NW.

J Exp Med. 2013 Feb 11;210(2):401-16. doi: 10.1084/jem.20121368. Epub 2013 Feb 4.


Heme uptake by Leishmania amazonensis is mediated by the transmembrane protein LHR1.

Huynh C, Yuan X, Miguel DC, Renberg RL, Protchenko O, Philpott CC, Hamza I, Andrews NW.

PLoS Pathog. 2012;8(7):e1002795. doi: 10.1371/journal.ppat.1002795. Epub 2012 Jul 12.


Oxidative stress and intracellular infections: more iron to the fire.

Andrews NW.

J Clin Invest. 2012 Jul;122(7):2352-4. doi: 10.1172/JCI64239. Epub 2012 Jun 25.


Host cell invasion by Trypanosoma cruzi: a unique strategy that promotes persistence.

Fernandes MC, Andrews NW.

FEMS Microbiol Rev. 2012 May;36(3):734-47. doi: 10.1111/j.1574-6976.2012.00333.x. Epub 2012 Mar 13. Review.


Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during HeLa cell invasion.

Fernandes MC, Andrade LR, Andrews NW, Mortara RA.

Mem Inst Oswaldo Cruz. 2011 Dec;106(8):1014-6. Erratum in: Mem Inst Oswaldo Cruz. 2012 Feb;107(1). doi: 10.1590/S0074-02762012000100022.


Toxin pores endocytosed during plasma membrane repair traffic into the lumen of MVBs for degradation.

Corrotte M, Fernandes MC, Tam C, Andrews NW.

Traffic. 2012 Mar;13(3):483-94. doi: 10.1111/j.1600-0854.2011.01323.x. Epub 2012 Jan 24.


Leishmania promotes its own virulence by inducing expression of the host immune inhibitory ligand CD200.

Cortez M, Huynh C, Fernandes MC, Kennedy KA, Aderem A, Andrews NW.

Cell Host Microbe. 2011 Jun 16;9(6):463-71. doi: 10.1016/j.chom.2011.04.014.


LFR1 ferric iron reductase of Leishmania amazonensis is essential for the generation of infective parasite forms.

Flannery AR, Huynh C, Mittra B, Mortara RA, Andrews NW.

J Biol Chem. 2011 Jul 1;286(26):23266-79. doi: 10.1074/jbc.M111.229674. Epub 2011 May 10.


Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion.

Fernandes MC, Cortez M, Flannery AR, Tam C, Mortara RA, Andrews NW.

J Exp Med. 2011 May 9;208(5):909-21. doi: 10.1084/jem.20102518. Epub 2011 May 2.


Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes.

Flannery AR, Czibener C, Andrews NW.

J Cell Biol. 2010 Nov 1;191(3):599-613. doi: 10.1083/jcb.201003021.


Role of host lysosomal associated membrane protein (LAMP) in Trypanosoma cruzi invasion and intracellular development.

Albertti LA, Macedo AM, Chiari E, Andrews NW, Andrade LO.

Microbes Infect. 2010 Sep;12(10):784-9. doi: 10.1016/j.micinf.2010.05.015. Epub 2010 Jun 16.


Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair.

Tam C, Idone V, Devlin C, Fernandes MC, Flannery A, He X, Schuchman E, Tabas I, Andrews NW.

J Cell Biol. 2010 Jun 14;189(6):1027-38. doi: 10.1083/jcb.201003053. Epub 2010 Jun 7.


Synaptotagmin-mediated vesicle fusion regulates cell migration.

Colvin RA, Means TK, Diefenbach TJ, Moita LF, Friday RP, Sever S, Campanella GS, Abrazinski T, Manice LA, Moita C, Andrews NW, Wu D, Hacohen N, Luster AD.

Nat Immunol. 2010 Jun;11(6):495-502. doi: 10.1038/ni.1878. Epub 2010 May 16.


Functional characterization of LIT1, the Leishmania amazonensis ferrous iron transporter.

Jacques I, Andrews NW, Huynh C.

Mol Biochem Parasitol. 2010 Mar;170(1):28-36. doi: 10.1016/j.molbiopara.2009.12.003. Epub 2009 Dec 16.


Characterization of a 21kDa protein from Trypanosoma cruzi associated with mammalian cell invasion.

da Silva CV, Kawashita SY, Probst CM, Dallagiovanna B, Cruz MC, da Silva EA, Souto-Padrón TC, Krieger MA, Goldenberg S, Briones MR, Andrews NW, Mortara RA.

Microbes Infect. 2009 Apr;11(5):563-70. doi: 10.1016/j.micinf.2009.03.007. Epub 2009 Apr 1.


Differential role of the Ca(2+) sensor synaptotagmin VII in macrophages and dendritic cells.

Becker SM, Delamarre L, Mellman I, Andrews NW.

Immunobiology. 2009;214(7):495-505. doi: 10.1016/j.imbio.2008.11.006. Epub 2009 Jan 20.


Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis.

Wilson J, Huynh C, Kennedy KA, Ward DM, Kaplan J, Aderem A, Andrews NW.

PLoS Pathog. 2008 Oct;4(10):e1000179. doi: 10.1371/journal.ppat.1000179. Epub 2008 Oct 17.


Two-way traffic on the road to plasma membrane repair.

Idone V, Tam C, Andrews NW.

Trends Cell Biol. 2008 Nov;18(11):552-9. doi: 10.1016/j.tcb.2008.09.001. Epub 2008 Oct 9. Review.


Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion.

Zhao H, Ito Y, Chappel J, Andrews NW, Teitelbaum SL, Ross FP.

Dev Cell. 2008 Jun;14(6):914-25. doi: 10.1016/j.devcel.2008.03.022.

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