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Items: 1 to 50 of 243

1.

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance.

Kale J, Kutuk O, Brito GC, Andrews TS, Leber B, Letai A, Andrews DW.

EMBO Rep. 2018 Jul 9. pii: e45235. doi: 10.15252/embr.201745235. [Epub ahead of print]

2.

miRNA-106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation.

Hoey C, Ray J, Jeon J, Huang X, Taeb S, Ylanko J, Andrews DW, Boutros PC, Liu SK.

Mol Oncol. 2018 May 30. doi: 10.1002/1878-0261.12328. [Epub ahead of print]

3.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

4.

Correction to: Salvage fractionated stereotactic re-irradiation (FSRT) for patients with recurrent high grade gliomas progressed after bevacizumab treatment.

Shi W, Blomain ES, Siglin J, Palmer JD, Dan T, Wang Y, Werner-Wasik M, Glass J, Kim L, Bar Ad V, Bhamidipati D, Evans JJ, Judy K, Farrell CJ, Andrews DW.

J Neurooncol. 2018 Mar;137(1):179. doi: 10.1007/s11060-018-2744-5.

PMID:
29313182
5.

Salvage fractionated stereotactic re-irradiation (FSRT) for patients with recurrent high grade gliomas progressed after bevacizumab treatment.

Shi W, Blomain ES, Siglin J, Palmer JD, Dan T, Wang Y, Werner-Wasik M, Glass J, Kim L, Bar Ad V, Bhamidipati D, Evans JJ, Judy K, Farrell CJ, Andrews DW.

J Neurooncol. 2018 Mar;137(1):171-177. doi: 10.1007/s11060-017-2709-0. Epub 2017 Dec 12. Erratum in: J Neurooncol. 2018 Jan 8;:.

PMID:
29235052
6.

BCL-2 family proteins: changing partners in the dance towards death.

Kale J, Osterlund EJ, Andrews DW.

Cell Death Differ. 2018 Jan;25(1):65-80. doi: 10.1038/cdd.2017.186. Epub 2017 Nov 17. Review.

7.

Investigating the Effect of Reirradiation or Systemic Therapy in Patients With Glioblastoma After Tumor Progression: A Secondary Analysis of NRG Oncology/Radiation Therapy Oncology Group Trial 0525.

Shi W, Scannell Bryan M, Gilbert MR, Mehta MP, Blumenthal DT, Brown PD, Valeinis E, Hopkins K, Souhami L, Andrews DW, Tzuk-Shina T, Howard SP, Youssef EF, Lessard N, Dignam JJ, Werner-Wasik M.

Int J Radiat Oncol Biol Phys. 2018 Jan 1;100(1):38-44. doi: 10.1016/j.ijrobp.2017.08.038. Epub 2017 Sep 4.

PMID:
29102648
8.

Phase 1 Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma Patients With Brain Metastases.

Williams NL, Wuthrick EJ, Kim H, Palmer JD, Garg S, Eldredge-Hindy H, Daskalakis C, Feeney KJ, Mastrangelo MJ, Kim LJ, Sato T, Kendra KL, Olencki T, Liebner DA, Farrell CJ, Evans JJ, Judy KD, Andrews DW, Dicker AP, Werner-Wasik M, Shi W.

Int J Radiat Oncol Biol Phys. 2017 Sep 1;99(1):22-30. doi: 10.1016/j.ijrobp.2017.05.028. Epub 2017 May 26.

PMID:
28816150
9.

A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.

Niu X, Brahmbhatt H, Mergenthaler P, Zhang Z, Sang J, Daude M, Ehlert FGR, Diederich WE, Wong E, Zhu W, Pogmore J, Nandy JP, Satyanarayana M, Jimmidi RK, Arya P, Leber B, Lin J, Culmsee C, Yi J, Andrews DW.

Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5. doi: 10.1016/j.chembiol.2017.03.011. Epub 2017 Apr 6.

10.

Spheno-Orbital Meningiomas: An Analysis Based on World Health Organization Classification and Ki-67 Proliferative Index.

Belinsky I, Murchison AP, Evans JJ, Andrews DW, Farrell CJ, Casey JP, Curtis MT, Nowak Choi KA, Werner-Wasik M, Bilyk JR.

Ophthalmic Plast Reconstr Surg. 2018 Mar/Apr;34(2):143-150. doi: 10.1097/IOP.0000000000000904.

PMID:
28350689
11.

Conformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation.

Liao C, Zhang Z, Kale J, Andrews DW, Lin J, Li J.

Sci Rep. 2016 Jul 6;6:29502. doi: 10.1038/srep29502.

12.

High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells.

Oppermann S, Ylanko J, Shi Y, Hariharan S, Oakes CC, Brauer PM, Zúñiga-Pflücker JC, Leber B, Spaner DE, Andrews DW.

Blood. 2016 Aug 18;128(7):934-47. doi: 10.1182/blood-2015-12-687814. Epub 2016 Jun 13.

13.

Using Förster-Resonance Energy Transfer to Measure Protein Interactions Between Bcl-2 Family Proteins on Mitochondrial Membranes.

Pogmore JP, Pemberton JM, Chi X, Andrews DW.

Methods Mol Biol. 2016;1419:197-212. doi: 10.1007/978-1-4939-3581-9_15.

PMID:
27108441
14.

Fractionated Stereotactic Radiotherapy for Facial Nerve Schwannomas.

Shi W, Jain V, Kim H, Champ C, Jain G, Farrell C, Andrews DW, Judy K, Liu H, Artz G, Werner-Wasik M, Evans JJ.

J Neurol Surg B Skull Base. 2016 Feb;77(1):75-80. doi: 10.1055/s-0035-1564056. Epub 2015 Sep 14.

15.

Plan Quality and Treatment Efficiency for Radiosurgery to Multiple Brain Metastases: Non-Coplanar RapidArc vs. Gamma Knife.

Liu H, Andrews DW, Evans JJ, Werner-Wasik M, Yu Y, Dicker AP, Shi W.

Front Oncol. 2016 Feb 11;6:26. doi: 10.3389/fonc.2016.00026. eCollection 2016.

16.

Lipid Droplet-Associated Proteins (LDAPs) Are Required for the Dynamic Regulation of Neutral Lipid Compartmentation in Plant Cells.

Gidda SK, Park S, Pyc M, Yurchenko O, Cai Y, Wu P, Andrews DW, Chapman KD, Dyer JM, Mullen RT.

Plant Physiol. 2016 Apr;170(4):2052-71. doi: 10.1104/pp.15.01977. Epub 2016 Feb 19.

17.

Phase I trial of panobinostat and fractionated stereotactic re-irradiation therapy for recurrent high grade gliomas.

Shi W, Palmer JD, Werner-Wasik M, Andrews DW, Evans JJ, Glass J, Kim L, Bar-Ad V, Judy K, Farrell C, Simone N, Liu H, Dicker AP, Lawrence YR.

J Neurooncol. 2016 May;127(3):535-9. doi: 10.1007/s11060-016-2059-3. Epub 2016 Jan 29.

PMID:
26821711
18.

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.

Thébault S, Agez M, Chi X, Stojko J, Cura V, Telerman SB, Maillet L, Gautier F, Billas-Massobrio I, Birck C, Troffer-Charlier N, Karafin T, Honoré J, Senff-Ribeiro A, Montessuit S, Johnson CM, Juin P, Cianférani S, Martinou JC, Andrews DW, Amson R, Telerman A, Cavarelli J.

Sci Rep. 2016 Jan 27;6:19725. doi: 10.1038/srep19725.

19.

BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes.

Zhang Z, Subramaniam S, Kale J, Liao C, Huang B, Brahmbhatt H, Condon SG, Lapolla SM, Hays FA, Ding J, He F, Zhang XC, Li J, Senes A, Andrews DW, Lin J.

EMBO J. 2016 Jan 18;35(2):208-36. doi: 10.15252/embj.201591552. Epub 2015 Dec 23.

20.

High-speed multifocal array scanning using refractive window tilting.

Tsikouras A, Berman R, Andrews DW, Fang Q.

Biomed Opt Express. 2015 Sep 2;6(10):3737-47. doi: 10.1364/BOE.6.003737. eCollection 2015 Oct 1.

21.

A Versatile Cell Death Screening Assay Using Dye-Stained Cells and Multivariate Image Analysis.

Collins TJ, Ylanko J, Geng F, Andrews DW.

Assay Drug Dev Technol. 2015 Nov;13(9):547-57. doi: 10.1089/adt.2015.661. Epub 2015 Sep 30.

22.

Serum exosomes and cytokines promote a T-helper cell type 2 environment in the peripheral blood of glioblastoma patients.

Harshyne LA, Nasca BJ, Kenyon LC, Andrews DW, Hooper DC.

Neuro Oncol. 2016 Feb;18(2):206-15. doi: 10.1093/neuonc/nov107. Epub 2015 Jul 14.

23.

Re-resection for recurrent high-grade glioma in the setting of re-irradiation: more is not always better.

Palmer JD, Siglin J, Yamoah K, Dan T, Champ CE, Bar-Ad V, Werner-Wasik M, Evans JJ, Kim L, Glass J, Farrell C, Andrews DW, Shi W.

J Neurooncol. 2015 Sep;124(2):215-21. doi: 10.1007/s11060-015-1825-y. Epub 2015 May 30.

PMID:
26024653
24.

Tumor volume threshold for achieving improved conformity in VMAT and Gamma Knife stereotactic radiosurgery for vestibular schwannoma.

Kim H, Potrebko P, Rivera A, Liu H, Eldredge-Hindy HB, Gunn V, Werner-Wasik M, Andrews DW, Evans JJ, Farrell CJ, Judy K, Shi W.

Radiother Oncol. 2015 May;115(2):229-34. doi: 10.1016/j.radonc.2015.03.031. Epub 2015 May 18.

PMID:
25998805
25.

Tunable hydrogel thin films from reactive synthetic polymers as potential two-dimensional cell scaffolds.

Goujon LJ, Hariharan S, Sayyar B, Burke NA, Cranston ED, Andrews DW, Stöver HD.

Langmuir. 2015 May 26;31(20):5623-32. doi: 10.1021/acs.langmuir.5b00376. Epub 2015 May 12.

PMID:
25907892
26.

Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells--Mitochondrial Outer Membrane Permeabilization and Beyond.

Brahmbhatt H, Oppermann S, Osterlund EJ, Leber B, Andrews DW.

Clin Cancer Res. 2015 Jun 15;21(12):2671-6. doi: 10.1158/1078-0432.CCR-14-0959. Epub 2015 Apr 2. Review.

27.

5-Aminolevulinic acid induced protoporphyrin IX as a fluorescence marker for quantitative image analysis of high-grade dysplasia in Barrett's esophagus cellular models.

Yeh SC, Sahli S, Andrews DW, Patterson MS, Armstrong D, Provias J, Fang Q.

J Biomed Opt. 2015 Mar;20(3):036010. doi: 10.1117/1.JBO.20.3.036010.

PMID:
25790343
28.

Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax.

Shamas-Din A, Bindner S, Chi X, Leber B, Andrews DW, Fradin C.

Biochem J. 2015 May 1;467(3):495-505. doi: 10.1042/BJ20141291.

PMID:
25714678
29.

5-aminolevulinic acid for quantitative seek-and-treat of high-grade dysplasia in Barrett's esophagus cellular models.

Yeh SC, Ling CS, Andrews DW, Patterson MS, Diamond KR, Hayward JE, Armstrong D, Fang Q.

J Biomed Opt. 2015 Feb;20(2):28002. doi: 10.1117/1.JBO.20.2.028002.

PMID:
25671673
30.

The use of FLIM-FRET for the detection of mitochondria-associated protein interactions.

Osterlund EJ, Liu Q, Andrews DW.

Methods Mol Biol. 2015;1264:395-419. doi: 10.1007/978-1-4939-2257-4_34.

PMID:
25631031
31.

Enhancement of glioma-specific immunity in mice by "NOBEL", an insulin-like growth factor 1 receptor antisense oligodeoxynucleotide.

Morin-Brureau M, Hooper KM, Prosniak M, Sauma S, Harshyne LA, Andrews DW, Hooper DC.

Cancer Immunol Immunother. 2015 Apr;64(4):447-57. doi: 10.1007/s00262-015-1654-z. Epub 2015 Jan 13.

PMID:
25579379
32.

The relative biological effectiveness of low-dose mammography quality X rays in the human breast MCF-10A cell line.

Mills CE, Thome C, Koff D, Andrews DW, Boreham DR.

Radiat Res. 2015 Jan;183(1):42-51. doi: 10.1667/RR13821.1. Epub 2014 Dec 23.

PMID:
25536231
33.

Pores of no return.

Andrews DW.

Mol Cell. 2014 Nov 20;56(4):465-6. doi: 10.1016/j.molcel.2014.11.005. Epub 2014 Nov 20.

34.

Glioblastoma exosomes and IGF-1R/AS-ODN are immunogenic stimuli in a translational research immunotherapy paradigm.

Harshyne LA, Hooper KM, Andrews EG, Nasca BJ, Kenyon LC, Andrews DW, Hooper DC.

Cancer Immunol Immunother. 2015 Mar;64(3):299-309. doi: 10.1007/s00262-014-1622-z. Epub 2014 Nov 14.

PMID:
25391690
35.

New insights into the targeting of a subset of tail-anchored proteins to the outer mitochondrial membrane.

Marty NJ, Teresinski HJ, Hwang YT, Clendening EA, Gidda SK, Sliwinska E, Zhang D, Miernyk JA, Brito GC, Andrews DW, Dyer JM, Mullen RT.

Front Plant Sci. 2014 Sep 4;5:426. doi: 10.3389/fpls.2014.00426. eCollection 2014.

36.

A pilot study of hypofractionated stereotactic radiation therapy and sunitinib in previously irradiated patients with recurrent high-grade glioma.

Wuthrick EJ, Curran WJ Jr, Camphausen K, Lin A, Glass J, Evans J, Andrews DW, Axelrod R, Shi W, Werner-Wasik M, Haacke EM, Hillman GG, Dicker AP.

Int J Radiat Oncol Biol Phys. 2014 Oct 1;90(2):369-75. doi: 10.1016/j.ijrobp.2014.05.034. Epub 2014 Aug 4.

PMID:
25104067
37.

Regulating cell death at, on, and in membranes.

Chi X, Kale J, Leber B, Andrews DW.

Biochim Biophys Acta. 2014 Sep;1843(9):2100-13. doi: 10.1016/j.bbamcr.2014.06.002. Epub 2014 Jun 11. Review.

38.

Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid.

Shamas-Din A, Satsoura D, Khan O, Zhu W, Leber B, Fradin C, Andrews DW.

Cell Death Dis. 2014 Jun 5;5:e1277. doi: 10.1038/cddis.2014.234.

39.

The proapoptotic protein tBid forms both superficially bound and membrane-inserted oligomers.

Shivakumar S, Kurylowicz M, Hirmiz N, Manan Y, Friaa O, Shamas-Din A, Masoudian P, Leber B, Andrews DW, Fradin C.

Biophys J. 2014 May 20;106(10):2085-95. doi: 10.1016/j.bpj.2014.03.049.

40.

Vorinostat as a radiosensitizer for brain metastasis: a phase I clinical trial.

Shi W, Lawrence YR, Choy H, Werner-Wasik M, Andrews DW, Evans JJ, Judy KD, Farrell CJ, Moshel Y, Berger AC, Bar-Ad V, Dicker AP.

J Neurooncol. 2014 Jun;118(2):313-319. doi: 10.1007/s11060-014-1433-2. Epub 2014 Apr 13.

PMID:
24728831
41.

After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.

Ding J, Mooers BH, Zhang Z, Kale J, Falcone D, McNichol J, Huang B, Zhang XC, Xing C, Andrews DW, Lin J.

J Biol Chem. 2014 Apr 25;289(17):11873-96. doi: 10.1074/jbc.M114.552562. Epub 2014 Mar 10.

42.

Spine Stereotactic Body Radiation Therapy Residual Setup Errors and Intra-Fraction Motion Using the Stereotactic X-Ray Image Guidance Verification System.

Yamoah K, Zaorsky NG, Siglin J, Shi W, Werner-Wasik M, Andrews DW, Dicker AP, Bar-Ad V, Liu H.

Int J Med Phys Clin Eng Radiat Oncol. 2014 Feb;3(1):1-8. doi: 10.4236/ijmpcero.2014.31001.

43.

Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme.

Champ CE, Palmer JD, Volek JS, Werner-Wasik M, Andrews DW, Evans JJ, Glass J, Kim L, Shi W.

J Neurooncol. 2014 Mar;117(1):125-31. doi: 10.1007/s11060-014-1362-0. Epub 2014 Jan 19.

PMID:
24442482
44.

The apoptotic pore on mitochondria: are we breaking through or still stuck?

Borner C, Andrews DW.

Cell Death Differ. 2014 Feb;21(2):187-91. doi: 10.1038/cdd.2013.169. No abstract available.

45.

The somatic genomic landscape of glioblastoma.

Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O'Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L; TCGA Research Network.

Cell. 2013 Oct 10;155(2):462-77. doi: 10.1016/j.cell.2013.09.034. Erratum in: Cell. 2014 Apr 24;157(3):753.

46.

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response.

Sarosiek KA, Chi X, Bachman JA, Sims JJ, Montero J, Patel L, Flanagan A, Andrews DW, Sorger P, Letai A.

Mol Cell. 2013 Sep 26;51(6):751-65. doi: 10.1016/j.molcel.2013.08.048.

47.

Chemical and biosynthetic evolution of the antimycin-type depsipeptides.

Vanner SA, Li X, Zvanych R, Torchia J, Sang J, Andrews DW, Magarvey NA.

Mol Biosyst. 2013 Nov;9(11):2712-9. doi: 10.1039/c3mb70219g.

PMID:
23989727
48.

Optimizing the acquisition and analysis of confocal images for quantitative single-mobile-particle detection.

Friaa O, Furukawa M, Shamas-Din A, Leber B, Andrews DW, Fradin C.

Chemphyschem. 2013 Aug 5;14(11):2476-90. doi: 10.1002/cphc.201201047. Epub 2013 Jul 3.

PMID:
23824691
49.

Reduced-dose fractionated stereotactic radiotherapy for acoustic neuromas: maintenance of tumor control with improved hearing preservation.

Champ CE, Shen X, Shi W, Mayekar SU, Chapman K, Werner-Wasik M, Farrell CJ, Gunn V, Downes MB, Liu H, Evans JJ, Andrews DW.

Neurosurgery. 2013 Sep;73(3):489-96. doi: 10.1227/NEU.0000000000000019.

PMID:
23756743
50.

tBid undergoes multiple conformational changes at the membrane required for Bax activation.

Shamas-Din A, Bindner S, Zhu W, Zaltsman Y, Campbell C, Gross A, Leber B, Andrews DW, Fradin C.

J Biol Chem. 2013 Jul 26;288(30):22111-27. doi: 10.1074/jbc.M113.482109. Epub 2013 Jun 6.

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