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Formation of pre-pore complexes of pneumolysin is accompanied by a decrease in short-range order of lipid molecules throughout vesicle bilayers.

Faraj BHA, Collard L, Cliffe R, Blount LA, Lonnen R, Wallis R, Andrew PW, Hudson AJ.

Sci Rep. 2020 Mar 12;10(1):4585. doi: 10.1038/s41598-020-60348-0.


Phase variation in pneumococcal populations during carriage in the human nasopharynx.

De Ste Croix M, Mitsi E, Morozov A, Glenn S, Andrew PW, Ferreira DM, Oggioni MR.

Sci Rep. 2020 Feb 4;10(1):1803. doi: 10.1038/s41598-020-58684-2.


TprA/PhrA Quorum Sensing System Has a Major Effect on Pneumococcal Survival in Respiratory Tract and Blood, and Its Activity Is Controlled by CcpA and GlnR.

Motib AS, Al-Bayati FAY, Manzoor I, Shafeeq S, Kadam A, Kuipers OP, Hiller NL, Andrew PW, Yesilkaya H.

Front Cell Infect Microbiol. 2019 Sep 13;9:326. doi: 10.3389/fcimb.2019.00326. eCollection 2019.


The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface.

Haleem KS, Ali YM, Yesilkaya H, Kohler T, Hammerschmidt S, Andrew PW, Schwaeble WJ, Lynch NJ.

Infect Immun. 2018 Dec 19;87(1). pii: e00742-18. doi: 10.1128/IAI.00742-18. Print 2019 Jan.


Rgg-Shp regulators are important for pneumococcal colonization and invasion through their effect on mannose utilization and capsule synthesis.

Zhi X, Abdullah IT, Gazioglu O, Manzoor I, Shafeeq S, Kuipers OP, Hiller NL, Andrew PW, Yesilkaya H.

Sci Rep. 2018 Apr 23;8(1):6369. doi: 10.1038/s41598-018-24910-1.


Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia.

Ercoli G, Fernandes VE, Chung WY, Wanford JJ, Thomson S, Bayliss CD, Straatman K, Crocker PR, Dennison A, Martinez-Pomares L, Andrew PW, Moxon ER, Oggioni MR.

Nat Microbiol. 2018 May;3(5):600-610. doi: 10.1038/s41564-018-0147-1. Epub 2018 Apr 16.


A horizontally gene transferred copper resistance locus confers hyper-resistance to antibacterial copper toxicity and enables survival of community acquired methicillin resistant Staphylococcus aureus USA300 in macrophages.

Purves J, Thomas J, Riboldi GP, Zapotoczna M, Tarrant E, Andrew PW, Londoño A, Planet PJ, Geoghegan JA, Waldron KJ, Morrissey JA.

Environ Microbiol. 2018 Apr;20(4):1576-1589. doi: 10.1111/1462-2920.14088. Epub 2018 Mar 26.


Modulation of Quorum Sensing in a Gram-Positive Pathogen by Linear Molecularly Imprinted Polymers with Anti-infective Properties.

Motib A, Guerreiro A, Al-Bayati F, Piletska E, Manzoor I, Shafeeq S, Kadam A, Kuipers O, Hiller L, Cowen T, Piletsky S, Andrew PW, Yesilkaya H.

Angew Chem Int Ed Engl. 2017 Dec 22;56(52):16555-16558. doi: 10.1002/anie.201709313. Epub 2017 Dec 1.


Light Scattering By Optically-Trapped Vesicles Affords Unprecedented Temporal Resolution Of Lipid-Raft Dynamics.

Collard L, Perez-Guaita D, Faraj BHA, Wood BR, Wallis R, Andrew PW, Hudson AJ.

Sci Rep. 2017 Aug 17;7(1):8589. doi: 10.1038/s41598-017-08980-1.


Listeria monocytogenes Has Both Cytochrome bd-Type and Cytochrome aa 3-Type Terminal Oxidases, Which Allow Growth at Different Oxygen Levels, and Both Are Important in Infection.

Corbett D, Goldrick M, Fernandes VE, Davidge K, Poole RK, Andrew PW, Cavet J, Roberts IS.

Infect Immun. 2017 Oct 18;85(11). pii: e00354-17. doi: 10.1128/IAI.00354-17. Print 2017 Nov.


Severe asthma: Differential chemokine response of airway epithelial cells.

Thomas B, Hirst RA, Brett-Pitt MH, Williams G, Andrew PW, Sousa AR, Marshall RP, Brightling C, O'Callaghan C.

J Allergy Clin Immunol. 2017 Oct;140(4):1149-1152.e10. doi: 10.1016/j.jaci.2017.02.040. Epub 2017 Apr 12. No abstract available.


The intestinal proteome of diabetic and control children is enriched with different microbial and host proteins.

Pinto E, Anselmo M, Calha M, Bottrill A, Duarte I, Andrew PW, Faleiro ML.

Microbiology. 2017 Feb;163(2):161-174. doi: 10.1099/mic.0.000412.


Deacetylation of sialic acid by esterases potentiates pneumococcal neuraminidase activity for mucin utilization, colonization and virulence.

Kahya HF, Andrew PW, Yesilkaya H.

PLoS Pathog. 2017 Mar 3;13(3):e1006263. doi: 10.1371/journal.ppat.1006263. eCollection 2017 Mar.


Pneumococcal galactose catabolism is controlled by multiple regulators acting on pyruvate formate lyase.

Al-Bayati FA, Kahya HF, Damianou A, Shafeeq S, Kuipers OP, Andrew PW, Yesilkaya H.

Sci Rep. 2017 Feb 27;7:43587. doi: 10.1038/srep43587.


Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance and colonisation.

Hussey SJK, Purves J, Allcock N, Fernandes VE, Monks PS, Ketley JM, Andrew PW, Morrissey JA.

Environ Microbiol. 2017 May;19(5):1868-1880. doi: 10.1111/1462-2920.13686. Epub 2017 Feb 28.


Inactivation of Acanthamoeba spp. and Other Ocular Pathogens by Application of Cold Atmospheric Gas Plasma.

Heaselgrave W, Shama G, Andrew PW, Kong MG.

Appl Environ Microbiol. 2016 May 2;82(10):3143-3148. doi: 10.1128/AEM.03863-15. Print 2016 May 15.


NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma.

Wan WY, Hollins F, Haste L, Woodman L, Hirst RA, Bolton S, Gomez E, Sutcliffe A, Desai D, Chachi L, Mistry V, Szyndralewiez C, Wardlaw A, Saunders R, O'Callaghan C, Andrew PW, Brightling CE.

Chest. 2016 Jun;149(6):1445-59. doi: 10.1016/j.chest.2016.01.024. Epub 2016 Feb 2.


Variation in Inflammatory Response during Pneumococcal Infection Is Influenced by Host-Pathogen Interactions but Associated with Animal Survival.

Jonczyk MS, Escudero L, Sylvius N, Norman M, Henriques-Normark B, Andrew PW.

Infect Immun. 2016 Mar 24;84(4):894-905. doi: 10.1128/IAI.01057-15. Print 2016 Apr.


Pneumococcal 6-Phospho-β-Glucosidase (BglA3) Is Involved in Virulence and Nutrient Metabolism.

Terra VS, Zhi X, Kahya HF, Andrew PW, Yesilkaya H.

Infect Immun. 2015 Nov 2;84(1):286-92. doi: 10.1128/IAI.01108-15. Print 2016 Jan.


The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex.

Marshall JE, Faraj BH, Gingras AR, Lonnen R, Sheikh MA, El-Mezgueldi M, Moody PC, Andrew PW, Wallis R.

Sci Rep. 2015 Sep 3;5:13293. doi: 10.1038/srep13293.


Host glycan sugar-specific pathways in Streptococcus pneumoniae: galactose as a key sugar in colonisation and infection [corrected].

Paixão L, Oliveira J, Veríssimo A, Vinga S, Lourenço EC, Ventura MR, Kjos M, Veening JW, Fernandes VE, Andrew PW, Yesilkaya H, Neves AR.

PLoS One. 2015 Mar 31;10(3):e0121042. doi: 10.1371/journal.pone.0121042. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0127483.


Bright fluorescent Streptococcus pneumoniae for live-cell imaging of host-pathogen interactions.

Kjos M, Aprianto R, Fernandes VE, Andrew PW, van Strijp JA, Nijland R, Veening JW.

J Bacteriol. 2015 Mar;197(5):807-18. doi: 10.1128/JB.02221-14. Epub 2014 Dec 15.


The in vivo environment accelerates generation of resuscitation-promoting factor-dependent mycobacteria.

Turapov O, Glenn S, Kana B, Makarov V, Andrew PW, Mukamolova GV.

Am J Respir Crit Care Med. 2014 Dec 15;190(12):1455-7. doi: 10.1164/rccm.201407-1289LE. No abstract available.


Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin.

Leung C, Dudkina NV, Lukoyanova N, Hodel AW, Farabella I, Pandurangan AP, Jahan N, Pires Damaso M, Osmanović D, Reboul CF, Dunstone MA, Andrew PW, Lonnen R, Topf M, Saibil HR, Hoogenboom BW.

Elife. 2014 Dec 2;3:e04247. doi: 10.7554/eLife.04247. Erratum in: Elife. 2014;4:e06740.


Perfluorocarbon emulsion therapy attenuates pneumococcal infection in sickle cell mice.

Helmi N, Andrew PW, Pandya HC.

J Infect Dis. 2015 May 15;211(10):1677-85. doi: 10.1093/infdis/jiu653. Epub 2014 Nov 26.


Lactate dehydrogenase is the key enzyme for pneumococcal pyruvate metabolism and pneumococcal survival in blood.

Gaspar P, Al-Bayati FA, Andrew PW, Neves AR, Yesilkaya H.

Infect Immun. 2014 Dec;82(12):5099-109. doi: 10.1128/IAI.02005-14. Epub 2014 Sep 22.


Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria.

Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV.

J Biol Chem. 2014 Sep 5;289(36):25241-9. doi: 10.1074/jbc.M114.577338. Epub 2014 Jul 10.


Respiratory syncytial virus increases the virulence of Streptococcus pneumoniae by binding to penicillin binding protein 1a. A new paradigm in respiratory infection.

Smith CM, Sandrini S, Datta S, Freestone P, Shafeeq S, Radhakrishnan P, Williams G, Glenn SM, Kuipers OP, Hirst RA, Easton AJ, Andrew PW, O'Callaghan C.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):196-207. doi: 10.1164/rccm.201311-2110OC.


Development and characterization of a long-term murine model of Streptococcus pneumoniae infection of the lower airways.

Haste L, Hulland K, Bolton S, Yesilkaya H, McKechnie K, Andrew PW.

Infect Immun. 2014 Aug;82(8):3289-98. doi: 10.1128/IAI.01623-14. Epub 2014 May 27.


Septicaemia models using Streptococcus pneumoniae and Listeria monocytogenes: understanding the role of complement properdin.

Dupont A, Mohamed F, Salehen N, Glenn S, Francescut L, Adib R, Byrne S, Brewin H, Elliott I, Richards L, Dimitrova P, Schwaeble W, Ivanovska N, Kadioglu A, Machado LR, Andrew PW, Stover C.

Med Microbiol Immunol. 2014 Aug;203(4):257-71. doi: 10.1007/s00430-013-0324-z. Epub 2014 Apr 12.


Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection.

Ali YM, Hayat A, Saeed BM, Haleem KS, Alshamrani S, Kenawy HI, Ferreira VP, Saggu G, Buchberger A, Lachmann PJ, Sim RB, Goundis D, Andrew PW, Lynch NJ, Schwaeble WJ.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5301-6. doi: 10.1073/pnas.1401011111. Epub 2014 Mar 24.


The role of host and microbial factors in the pathogenesis of pneumococcal bacteraemia arising from a single bacterial cell bottleneck.

Gerlini A, Colomba L, Furi L, Braccini T, Manso AS, Pammolli A, Wang B, Vivi A, Tassini M, van Rooijen N, Pozzi G, Ricci S, Andrew PW, Koedel U, Moxon ER, Oggioni MR.

PLoS Pathog. 2014 Mar 20;10(3):e1004026. doi: 10.1371/journal.ppat.1004026. eCollection 2014 Mar.


Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection.

Jonczyk MS, Simon M, Kumar S, Fernandes VE, Sylvius N, Mallon AM, Denny P, Andrew PW.

PLoS One. 2014 Mar 3;9(3):e89831. doi: 10.1371/journal.pone.0089831. eCollection 2014.


Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions.

Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV.

Antimicrob Agents Chemother. 2014 May;58(5):2798-806. doi: 10.1128/AAC.02774-13. Epub 2014 Mar 3.


Recombinant plants provide a new approach to the production of bacterial polysaccharide for vaccines.

Smith CM, Fry SC, Gough KC, Patel AJ, Glenn S, Goldrick M, Roberts IS, Whitelam GC, Andrew PW.

PLoS One. 2014 Feb 3;9(2):e88144. doi: 10.1371/journal.pone.0088144. eCollection 2014.


Human L-ficolin, a recognition molecule of the lectin activation pathway of complement, activates complement by binding to pneumolysin, the major toxin of Streptococcus pneumoniae.

Ali YM, Kenawy HI, Muhammad A, Sim RB, Andrew PW, Schwaeble WJ.

PLoS One. 2013 Dec 12;8(12):e82583. doi: 10.1371/journal.pone.0082583. eCollection 2013.


Ciliated cultures from patients with primary ciliary dyskinesia do not produce nitric oxide or inducible nitric oxide synthase during early infection.

Smith CM, Fadaee-Shohada MJ, Sawhney R, Baker N, Williams G, Hirst RA, Andrew PW, O'Callaghan C.

Chest. 2013 Nov;144(5):1671-1676. doi: 10.1378/chest.13-0159.


The in vitro efficacy of antimicrobial agents against the pathogenic free-living amoeba Balamuthia mandrillaris.

Ahmad AF, Heaselgrave W, Andrew PW, Kilvington S.

J Eukaryot Microbiol. 2013 Sep-Oct;60(5):539-43. doi: 10.1111/jeu.12062. Epub 2013 Jul 19.


Spir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice.

Wisby L, Fernandes VE, Neill DR, Kadioglu A, Andrew PW, Denny P.

BMC Genomics. 2013 Apr 11;14:242. doi: 10.1186/1471-2164-14-242.


Listeria monocytogenes dairy isolates show a different proteome response to sequential exposure to gastric and intestinal fluids.

Melo J, Schrama D, Hussey S, Andrew PW, Faleiro ML.

Int J Food Microbiol. 2013 May 15;163(2-3):51-63. doi: 10.1016/j.ijfoodmicro.2013.03.001. Epub 2013 Mar 14.


Ciliary dyskinesia is an early feature of respiratory syncytial virus infection.

Smith CM, Kulkarni H, Radhakrishnan P, Rutman A, Bankart MJ, Williams G, Hirst RA, Easton AJ, Andrew PW, O'Callaghan C.

Eur Respir J. 2014 Feb;43(2):485-96. doi: 10.1183/09031936.00205312. Epub 2013 Mar 21.


Different assembly of acid and salt tolerance response in two dairy Listeria monocytogenes wild strains.

Melo J, Andrew PW, Faleiro ML.

Arch Microbiol. 2013 May;195(5):339-48. doi: 10.1007/s00203-013-0878-6. Epub 2013 Mar 2.


Proteomic analysis shows that individual Listeria monocytogenes strains use different strategies in response to gastric stress.

Melo J, Schrama D, Andrew PW, Faleiro ML.

Foodborne Pathog Dis. 2013 Feb;10(2):107-19. doi: 10.1089/fpd.2012.1297.


Streptococcus pneumoniae and reactive oxygen species: an unusual approach to living with radicals.

Yesilkaya H, Andisi VF, Andrew PW, Bijlsma JJ.

Trends Microbiol. 2013 Apr;21(4):187-95. doi: 10.1016/j.tim.2013.01.004. Epub 2013 Feb 13. Review.


ciliaFA: a research tool for automated, high-throughput measurement of ciliary beat frequency using freely available software.

Smith CM, Djakow J, Free RC, Djakow P, Lonnen R, Williams G, Pohunek P, Hirst RA, Easton AJ, Andrew PW, O'Callaghan C.

Cilia. 2012 Aug 1;1:14. doi: 10.1186/2046-2530-1-14. eCollection 2012.


Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases.

Hayre JK, Xu G, Borgianni L, Taylor GL, Andrew PW, Docquier JD, Oggioni MR.

BMC Biochem. 2012 Oct 2;13:19. doi: 10.1186/1471-2091-13-19.


Thiol peroxidase is an important component of Streptococcus pneumoniae in oxygenated environments.

Hajaj B, Yesilkaya H, Benisty R, David M, Andrew PW, Porat N.

Infect Immun. 2012 Dec;80(12):4333-43. doi: 10.1128/IAI.00126-12. Epub 2012 Oct 1.


The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.

Ali YM, Lynch NJ, Haleem KS, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Girija UV, Wallis R, Kadioglu A, Stover CM, Andrew PW, Schwaeble WJ.

PLoS Pathog. 2012;8(7):e1002793. doi: 10.1371/journal.ppat.1002793. Epub 2012 Jul 5.


T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice.

Neill DR, Fernandes VE, Wisby L, Haynes AR, Ferreira DM, Laher A, Strickland N, Gordon SB, Denny P, Kadioglu A, Andrew PW.

PLoS Pathog. 2012;8(4):e1002660. doi: 10.1371/journal.ppat.1002660. Epub 2012 Apr 19.


Two zinc uptake systems contribute to the full virulence of Listeria monocytogenes during growth in vitro and in vivo.

Corbett D, Wang J, Schuler S, Lopez-Castejon G, Glenn S, Brough D, Andrew PW, Cavet JS, Roberts IS.

Infect Immun. 2012 Jan;80(1):14-21. doi: 10.1128/IAI.05904-11. Epub 2011 Oct 24.

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