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Improved workflow for mass spectrometry-based metabolomics analysis of the heart.

Andres DA, Young LEA, Veeranki S, Hawkinson TR, Levitan BM, He D, Wang C, Satin J, Sun RC.

J Biol Chem. 2020 Jan 24. pii: jbc.RA119.011081. doi: 10.1074/jbc.RA119.011081. [Epub ahead of print]


Myocardial-restricted ablation of the GTPase RAD results in a pro-adaptive heart response in mice.

Ahern BM, Levitan BM, Veeranki S, Shah M, Ali N, Sebastian A, Su W, Gong MC, Li J, Stelzer JE, Andres DA, Satin J.

J Biol Chem. 2019 Jul 12;294(28):10913-10927. doi: 10.1074/jbc.RA119.008782. Epub 2019 May 30.


Small GTPase RIT1 in Mouse Retina; Cellular and Functional Analysis.

Mir S, Andres DA.

Curr Eye Res. 2018 Sep;43(9):1160-1168. doi: 10.1080/02713683.2018.1482557. Epub 2018 Jun 25.


Rad GTPase deletion attenuates post-ischemic cardiac dysfunction and remodeling.

Manning JR, Chelvarajan L, Levitan BM, Withers CN, Nagareddy PR, Haggerty CM, Fornwalt BK, Gao E, Tripathi H, Abdel-Latif A, Andres DA, Satin J.

JACC Basic Transl Sci. 2018 Feb;3(1):83-96. doi: 10.1016/j.jacbts.2017.09.004.


Rad GTPase is essential for the regulation of bone density and bone marrow adipose tissue in mice.

Withers CN, Brown DM, Byiringiro I, Allen MR, Condon KW, Satin J, Andres DA.

Bone. 2017 Oct;103:270-280. doi: 10.1016/j.bone.2017.07.018. Epub 2017 Jul 18.


IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade.

Mir S, Cai W, Carlson SW, Saatman KE, Andres DA.

Sci Rep. 2017 Jun 12;7(1):3283. doi: 10.1038/s41598-017-03641-9.


RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis.

Mir S, Cai W, Andres DA.

J Biol Chem. 2017 Feb 10;292(6):2054-2064. doi: 10.1074/jbc.M116.749770. Epub 2016 Dec 22.


Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart.

Levitan BM, Manning JR, Withers CN, Smith JD, Shaw RM, Andres DA, Sorrell VL, Satin J.

J Cardiovasc Transl Res. 2016 Dec;9(5-6):432-444. Epub 2016 Oct 31.


Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging.

Manning JR, Withers CN, Levitan B, Smith JD, Andres DA, Satin J.

Am J Physiol Heart Circ Physiol. 2015 Oct;309(8):H1336-45. doi: 10.1152/ajpheart.00389.2015. Epub 2015 Sep 14.


Mutations in RIT1 cause Noonan syndrome - additional functional evidence and expanding the clinical phenotype.

Koenighofer M, Hung CY, McCauley JL, Dallman J, Back EJ, Mihalek I, Gripp KW, Sol-Church K, Rusconi P, Zhang Z, Shi GX, Andres DA, Bodamer OA.

Clin Genet. 2016 Mar;89(3):359-66. doi: 10.1111/cge.12608. Epub 2015 Jun 4.


Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase.

Rising KA, Crenshaw CM, Koo HJ, Subramanian T, Chehade KA, Starks C, Allen KD, Andres DA, Spielmann HP, Noel JP, Chappell J.

ACS Chem Biol. 2015 Jul 17;10(7):1729-36. doi: 10.1021/acschembio.5b00145. Epub 2015 May 4.


Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors.

Holland AJ, Reis RM, Niessen S, Pereira C, Andres DA, Spielmann HP, Cleveland DW, Desai A, Gassmann R.

Mol Biol Cell. 2015 May 15;26(10):1845-56. doi: 10.1091/mbc.E14-11-1560. Epub 2015 Mar 25.


mTORC2 is required for rit-mediated oxidative stress resistance.

Cai W, Andres DA.

PLoS One. 2014 Dec 22;9(12):e115602. doi: 10.1371/journal.pone.0115602. eCollection 2014.


Oncogenic RIT1 mutations in lung adenocarcinoma.

Berger AH, Imielinski M, Duke F, Wala J, Kaplan N, Shi GX, Andres DA, Meyerson M.

Oncogene. 2014 Aug 28;33(35):4418-23. doi: 10.1038/onc.2013.581. Epub 2014 Jan 27.


Valproic acid causes proteasomal degradation of DICER and influences miRNA expression.

Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S.

PLoS One. 2013 Dec 17;8(12):e82895. doi: 10.1371/journal.pone.0082895. eCollection 2013.


Rad GTPase deletion increases L-type calcium channel current leading to increased cardiac contraction.

Manning JR, Yin G, Kaminski CN, Magyar J, Feng HZ, Penn J, Sievert G, Thompson K, Jin JP, Andres DA, Satin J.

J Am Heart Assoc. 2013 Dec 12;2(6):e000459. doi: 10.1161/JAHA.113.000459.


Putting the Rit in cellular resistance: Rit, p38 MAPK and oxidative stress.

Cai W, Shi GX, Andres DA.

Commun Integr Biol. 2013 Jan 1;6(1):e22297. doi: 10.4161/cib.22297.


Rit subfamily small GTPases: regulators in neuronal differentiation and survival.

Shi GX, Cai W, Andres DA.

Cell Signal. 2013 Oct;25(10):2060-8. doi: 10.1016/j.cellsig.2013.06.002. Epub 2013 Jun 11. Review.


The cardiac L-type calcium channel distal carboxy terminus autoinhibition is regulated by calcium.

Crump SM, Andres DA, Sievert G, Satin J.

Am J Physiol Heart Circ Physiol. 2013 Feb 1;304(3):H455-64. doi: 10.1152/ajpheart.00396.2012. Epub 2012 Nov 30.


Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway.

Cai W, Rudolph JL, Sengoku T, Andres DA.

Neurosci Lett. 2012 Dec 7;531(2):125-30. doi: 10.1016/j.neulet.2012.10.036. Epub 2012 Nov 2.


Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase.

Subramanian T, Pais JE, Liu S, Troutman JM, Suzuki Y, Leela Subramanian K, Fierke CA, Andres DA, Spielmann HP.

Biochemistry. 2012 Oct 16;51(41):8307-19. doi: 10.1021/bi3011362. Epub 2012 Oct 2.


Rem-GTPase regulates cardiac myocyte L-type calcium current.

Magyar J, Kiper CE, Sievert G, Cai W, Shi GX, Crump SM, Li L, Niederer S, Smith N, Andres DA, Satin J.

Channels (Austin). 2012 May-Jun;6(3):166-73. doi: 10.4161/chan.20192.


Rit GTPase signaling promotes immature hippocampal neuronal survival.

Cai W, Carlson SW, Brelsfoard JM, Mannon CE, Moncman CL, Saatman KE, Andres DA.

J Neurosci. 2012 Jul 18;32(29):9887-97. doi: 10.1523/JNEUROSCI.0375-12.2012.


Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling.

Gunton JE, Sisavanh M, Stokes RA, Satin J, Satin LS, Zhang M, Liu SM, Cai W, Cheng K, Cooney GJ, Laybutt DR, So T, Molero JC, Grey ST, Andres DA, Rolph MS, Mackay CR.

PLoS One. 2012;7(6):e39462. doi: 10.1371/journal.pone.0039462. Epub 2012 Jun 28.


Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24.

Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann HP, Hrycyna CA, Young SG, Fong LG.

J Lipid Res. 2012 Jun;53(6):1176-82. doi: 10.1194/jlr.M026161. Epub 2012 Mar 23.


An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance.

Cai W, Rudolph JL, Harrison SM, Jin L, Frantz AL, Harrison DA, Andres DA.

Mol Biol Cell. 2011 Sep;22(17):3231-41. doi: 10.1091/mbc.E11-05-0400. Epub 2011 Jul 7.


Ras family small GTPase-mediated neuroprotective signaling in stroke.

Shi GX, Andres DA, Cai W.

Cent Nerv Syst Agents Med Chem. 2011 Jun 1;11(2):114-37. Review.


A rit GTPase-p38 mitogen-activated protein kinase survival pathway confers resistance to cellular stress.

Shi GX, Jin L, Andres DA.

Mol Cell Biol. 2011 May;31(10):1938-48. doi: 10.1128/MCB.01380-10. Epub 2011 Mar 28.


Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.

Yang SH, Chang SY, Ren S, Wang Y, Andres DA, Spielmann HP, Fong LG, Young SG.

Hum Mol Genet. 2011 Feb 1;20(3):436-44. doi: 10.1093/hmg/ddq490. Epub 2010 Nov 18.


Method for Shipping Live Cultures of Dissociated Rat Hippocampal Neurons.

Yang D, Bruun D, Andres DA, Lein PJ.

Curr Neurobiol. 2010 Oct;1(2):95-98.


Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivation.

Pang C, Crump SM, Jin L, Correll RN, Finlin BS, Satin J, Andres DA.

Channels (Austin). 2010 May-Jun;4(3):192-202. Epub 2010 May 1.


An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria.

Davies BS, Barnes RH 2nd, Tu Y, Ren S, Andres DA, Spielmann HP, Lammerding J, Wang Y, Young SG, Fong LG.

Hum Mol Genet. 2010 Jul 1;19(13):2682-94. doi: 10.1093/hmg/ddq158. Epub 2010 Apr 26.


Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation.

Shi GX, Jin L, Andres DA.

Mol Biol Cell. 2010 May 1;21(9):1597-608. doi: 10.1091/mbc.E09-12-1033. Epub 2010 Mar 10.


A tagging-via-substrate approach to detect the farnesylated proteome using two-dimensional electrophoresis coupled with Western blotting.

Onono FO, Morgan MA, Spielmann HP, Andres DA, Subramanian T, Ganser A, Reuter CW.

Mol Cell Proteomics. 2010 Apr;9(4):742-51. doi: 10.1074/mcp.M900597-MCP200. Epub 2010 Jan 26.


Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F.

Gurden MD, Holland AJ, van Zon W, Tighe A, Vergnolle MA, Andres DA, Spielmann HP, Malumbres M, Wolthuis RM, Cleveland DW, Taylor SS.

J Cell Sci. 2010 Feb 1;123(Pt 3):321-30. doi: 10.1242/jcs.062075. Epub 2010 Jan 5.


Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria.

Yang SH, Chang SY, Andres DA, Spielmann HP, Young SG, Fong LG.

J Lipid Res. 2010 Feb;51(2):400-5. doi: 10.1194/jlr.M002808. Epub 2009 Oct 26.


Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides.

Fong LG, Vickers TA, Farber EA, Choi C, Yun UJ, Hu Y, Yang SH, Coffinier C, Lee R, Yin L, Davies BS, Andres DA, Spielmann HP, Bennett CF, Young SG.

Hum Mol Genet. 2009 Jul 1;18(13):2462-71. doi: 10.1093/hmg/ddp184. Epub 2009 Apr 17.


Steady-state coupling of plasma membrane calcium entry to extrusion revealed by novel L-type calcium channel block.

Lester WC, Schroder EA, Burgess DE, Yozwiak D, Andres DA, Satin J.

Cell Calcium. 2008 Oct;44(4):353-62.


Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity.

Subramanian T, Liu S, Troutman JM, Andres DA, Spielmann HP.

Chembiochem. 2008 Nov 24;9(17):2872-82. doi: 10.1002/cbic.200800248.


Rit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation.

Andres DA, Shi GX, Bruun D, Barnhart C, Lein PJ.

J Neurochem. 2008 Dec;107(5):1436-47. doi: 10.1111/j.1471-4159.2008.05708.x. Epub 2008 Oct 24.


Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.

Yang SH, Andres DA, Spielmann HP, Young SG, Fong LG.

J Clin Invest. 2008 Oct;118(10):3291-300. doi: 10.1172/JCI35876.


Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome.

Davies BS, Yang SH, Farber E, Lee R, Buck SB, Andres DA, Spielmann HP, Agnew BJ, Tamanoi F, Fong LG, Young SG.

J Lipid Res. 2009 Jan;50(1):126-34. doi: 10.1194/jlr.M800424-JLR200. Epub 2008 Aug 29.


A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells.

Coffinier C, Hudon SE, Lee R, Farber EA, Nobumori C, Miner JH, Andres DA, Spielmann HP, Hrycyna CA, Fong LG, Young SG.

J Biol Chem. 2008 Apr 11;283(15):9797-804. doi: 10.1074/jbc.M709629200. Epub 2008 Jan 28.


Calmodulin binding is dispensable for Rem-mediated Ca2+ channel inhibition.

Correll RN, Pang C, Niedowicz DM, Satin J, Andres DA.

Mol Cell Biochem. 2008 Mar;310(1-2):103-10. Epub 2007 Dec 4.


The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling.

Correll RN, Pang C, Niedowicz DM, Finlin BS, Andres DA.

Cell Signal. 2008 Feb;20(2):292-300. Epub 2007 Nov 6. Review.


Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction.

Rudolph JL, Shi GX, Erdogan E, Fields AP, Andres DA.

Biochim Biophys Acta. 2007 Dec;1773(12):1793-800. Epub 2007 Oct 9.


Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release.

Troutman JM, Andres DA, Spielmann HP.

Biochemistry. 2007 Oct 9;46(40):11299-309. Epub 2007 Sep 18.


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