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The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell-specific adapter protein.

Andersen TCB, Kristiansen PE, Huszenicza Z, Johansson MU, Gopalakrishnan RP, Kjelstrup H, Boyken S, Sundvold-Gjerstad V, Granum S, Sørlie M, Backe PH, Fulton DB, Karlsson BG, Andreotti AH, Spurkland A.

J Biol Chem. 2019 Sep 4. pii: jbc.RA119.008318. doi: 10.1074/jbc.RA119.008318. [Epub ahead of print]


Dynamic regulatory features of the protein tyrosine kinases.

Amatya N, Lin DY, Andreotti AH.

Biochem Soc Trans. 2019 Aug 30;47(4):1101-1116. doi: 10.1042/BST20180590. Epub 2019 Aug 8. Review.


Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response.

Andreotti AH, Joseph RE, Conley JM, Iwasa J, Berg LJ.

Annu Rev Immunol. 2018 Apr 26;36:549-578. doi: 10.1146/annurev-immunol-042617-053344.


Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts.

Joseph RE, Wales TE, Fulton DB, Engen JR, Andreotti AH.

Structure. 2017 Oct 3;25(10):1481-1494.e4. doi: 10.1016/j.str.2017.07.014. Epub 2017 Aug 31.


An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition.

Devkota S, Joseph RE, Boyken SE, Fulton DB, Andreotti AH.

Biochemistry. 2017 Jun 13;56(23):2938-2949. doi: 10.1021/acs.biochem.6b01182. Epub 2017 May 25.


Role of Reversible Histidine Coordination in Hydroxylamine Reduction by Plant Hemoglobins (Phytoglobins).

Athwal NS, Alagurajan J, Andreotti AH, Hargrove MS.

Biochemistry. 2016 Oct 18;55(41):5809-5817. doi: 10.1021/acs.biochem.6b00775. Epub 2016 Oct 5.


Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.

Chopra N, Wales TE, Joseph RE, Boyken SE, Engen JR, Jernigan RL, Andreotti AH.

PLoS Comput Biol. 2016 Mar 24;12(3):e1004826. doi: 10.1371/journal.pcbi.1004826. eCollection 2016 Mar.


Dynamics of the Tec-family tyrosine kinase SH3 domains.

Roberts JM, Tarafdar S, Joseph RE, Andreotti AH, Smithgall TE, Engen JR, Wales TE.

Protein Sci. 2016 Apr;25(4):852-64. doi: 10.1002/pro.2887. Epub 2016 Mar 18.


Electron self-exchange in hemoglobins revealed by deutero-hemin substitution.

Athwal NS, Alagurajan J, Sturms R, Fulton DB, Andreotti AH, Hargrove MS.

J Inorg Biochem. 2015 Sep;150:139-47. doi: 10.1016/j.jinorgbio.2015.06.014. Epub 2015 Jun 18.


Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation.

Devkota S, Joseph RE, Min L, Bruce Fulton D, Andreotti AH.

J Mol Biol. 2015 Aug 28;427(17):2734-47. doi: 10.1016/j.jmb.2015.04.012. Epub 2015 Apr 25.


Defining a two-pronged structural model for PB1 (Phox/Bem1p) domain interaction in plant auxin responses.

Korasick DA, Chatterjee S, Tonelli M, Dashti H, Lee SG, Westfall CS, Fulton DB, Andreotti AH, Amarasinghe GK, Strader LC, Jez JM.

J Biol Chem. 2015 May 15;290(20):12868-78. doi: 10.1074/jbc.M115.648253. Epub 2015 Apr 3.


A selective NMR probe to monitor the conformational transition from inactive to active kinase.

Xie Q, Fulton DB, Andreotti AH.

ACS Chem Biol. 2015 Jan 16;10(1):262-8. doi: 10.1021/cb5004702. Epub 2014 Sep 26.


A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.

Boyken SE, Chopra N, Xie Q, Joseph RE, Wales TE, Fulton DB, Engen JR, Jernigan RL, Andreotti AH.

J Mol Biol. 2014 Oct 23;426(21):3656-69. doi: 10.1016/j.jmb.2014.08.018. Epub 2014 Sep 2.


Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.

Wang X, Boyken SE, Hu J, Xu X, Rimer RP, Shea MA, Shaw AS, Andreotti AH, Huang YH.

Sci Signal. 2014 Aug 5;7(337):ra74. doi: 10.1126/scisignal.2005147.


Solubility of recombinant Src homology 2 domains expressed in E. coli can be predicted by TANGO.

Andersen TC, Lindsjø K, Hem CD, Koll L, Kristiansen PE, Skjeldal L, Andreotti AH, Spurkland A.

BMC Biotechnol. 2014 Jan 14;14:3. doi: 10.1186/1472-6750-14-3.


Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.

Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH.

Sci Signal. 2013 Aug 27;6(290):ra76. doi: 10.1126/scisignal.2004298.


Substrate recognition of PLCγ1 via a specific docking surface on Itk.

Xie Q, Joseph RE, Fulton DB, Andreotti AH.

J Mol Biol. 2013 Feb 22;425(4):683-96. doi: 10.1016/j.jmb.2012.10.023. Epub 2012 Dec 3.


Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec.

Boyken SE, Fulton DB, Andreotti AH.

Protein Sci. 2012 Sep;21(9):1288-97. doi: 10.1002/pro.2114. Epub 2012 Jul 16.


In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell Kinase.

Levytskyy RM, Hirve N, Guimond DM, Min L, Andreotti AH, Tsoukas CD.

J Signal Transduct. 2012;2012:694386. doi: 10.1155/2012/694386. Epub 2012 May 9.


Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures.

Joseph RE, Ginder ND, Hoy JA, Nix JC, Fulton DB, Honzatko RB, Andreotti AH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Feb 1;68(Pt 2):145-53. doi: 10.1107/S1744309111049761. Epub 2012 Jan 25.


Purification, crystallization and preliminary crystallographic analysis of the SH2 domain of IL-2-inducible T-cell kinase.

Joseph RE, Ginder ND, Hoy JA, Nix JC, Honzatko RB, Andreotti AH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 1;67(Pt 2):269-73. doi: 10.1107/S1744309110052346. Epub 2011 Jan 27.


Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue.

Joseph RE, Andreotti AH.

Biochemistry. 2011 Jan 18;50(2):221-9. Epub 2010 Dec 16.


Identification of an allosteric signaling network within Tec family kinases.

Joseph RE, Xie Q, Andreotti AH.

J Mol Biol. 2010 Oct 22;403(2):231-42. doi: 10.1016/j.jmb.2010.08.035. Epub 2010 Sep 6.


T-cell signaling regulated by the Tec family kinase, Itk.

Andreotti AH, Schwartzberg PL, Joseph RE, Berg LJ.

Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a002287. doi: 10.1101/cshperspect.a002287. Epub 2010 Jun 2. Review.


T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.

Berge T, Sundvold-Gjerstad V, Granum S, Andersen TC, Holthe GB, Claesson-Welsh L, Andreotti AH, Inngjerdingen M, Spurkland A.

PLoS One. 2010 Mar 18;5(3):e9761. doi: 10.1371/journal.pone.0009761.


Disrupting the intermolecular self-association of Itk enhances T cell signaling.

Min L, Wu W, Joseph RE, Fulton DB, Berg L, Andreotti AH.

J Immunol. 2010 Apr 15;184(8):4228-35. doi: 10.4049/jimmunol.0901908. Epub 2010 Mar 17.


Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.

Min L, Joseph RE, Fulton DB, Andreotti AH.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21143-8. doi: 10.1073/pnas.0911309106. Epub 2009 Dec 1.


SH2-dependent autophosphorylation within the Tec family kinase Itk.

Joseph RE, Severin A, Min L, Fulton DB, Andreotti AH.

J Mol Biol. 2009 Aug 7;391(1):164-77. doi: 10.1016/j.jmb.2009.06.023. Epub 2009 Jun 11.


Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.

Severin A, Joseph RE, Boyken S, Fulton DB, Andreotti AH.

J Mol Biol. 2009 Apr 3;387(3):726-43. doi: 10.1016/j.jmb.2009.02.012. Epub 2009 Feb 12.


Conformational snapshots of Tec kinases during signaling.

Joseph RE, Andreotti AH.

Immunol Rev. 2009 Mar;228(1):74-92. doi: 10.1111/j.1600-065X.2008.00740.x.


Bacterial expression and purification of interleukin-2 tyrosine kinase: single step separation of the chaperonin impurity.

Joseph RE, Andreotti AH.

Protein Expr Purif. 2008 Aug;60(2):194-7. doi: 10.1016/j.pep.2008.04.001. Epub 2008 Apr 11.


Murine Itk SH3 domain.

Severin A, Fulton DB, Andreotti AH.

J Biomol NMR. 2008 Apr;40(4):285-90. doi: 10.1007/s10858-008-9231-9. Epub 2008 Mar 5. No abstract available.


Mechanism and functional significance of Itk autophosphorylation.

Joseph RE, Fulton DB, Andreotti AH.

J Mol Biol. 2007 Nov 9;373(5):1281-92. Epub 2007 Aug 31.


A remote substrate docking mechanism for the tec family tyrosine kinases.

Joseph RE, Min L, Xu R, Musselman ED, Andreotti AH.

Biochemistry. 2007 May 8;46(18):5595-603. Epub 2007 Apr 17.


The linker between SH2 and kinase domains positively regulates catalysis of the Tec family kinases.

Joseph RE, Min L, Andreotti AH.

Biochemistry. 2007 May 8;46(18):5455-62. Epub 2007 Apr 11.


Positive regulation of Itk PH domain function by soluble IP4.

Huang YH, Grasis JA, Miller AT, Xu R, Soonthornvacharin S, Andreotti AH, Tsoukas CD, Cooke MP, Sauer K.

Science. 2007 May 11;316(5826):886-9. Epub 2007 Apr 5.


Mapping the Ca2+ -dependent binding of an invertebrate homolog of protein phosphatase 4 regulatory subunit 2 to the small EF-hand protein, calsensin.

Venkitaramani DV, Fulton DB, Andreotti AH, Johansen KM, Johansen J.

Biochim Biophys Acta. 2006 Mar;1763(3):322-9. Epub 2006 Mar 24.


Molecular details of Itk activation by prolyl isomerization and phospholigand binding: the NMR structure of the Itk SH2 domain bound to a phosphopeptide.

Pletneva EV, Sundd M, Fulton DB, Andreotti AH.

J Mol Biol. 2006 Mar 24;357(2):550-61. Epub 2006 Jan 18.


Opening the pore hinges on proline.

Andreotti AH.

Nat Chem Biol. 2006 Jan;2(1):13-4. No abstract available.


Solution structure and backbone dynamics of Calsensin, an invertebrate neuronal calcium-binding protein.

Venkitaramani DV, Fulton DB, Andreotti AH, Johansen KM, Johansen J.

Protein Sci. 2005 Jul;14(7):1894-901. Epub 2005 Jun 3.


A case study of proline isomerization in cell signaling.

Min L, Fulton DB, Andreotti AH.

Front Biosci. 2005 Jan 1;10:385-97. Print 2005 Jan 1. Review.


Ligand specificity modulated by prolyl imide bond Cis/Trans isomerization in the Itk SH2 domain: a quantitative NMR study.

Breheny PJ, Laederach A, Fulton DB, Andreotti AH.

J Am Chem Soc. 2003 Dec 24;125(51):15706-7.


Native state proline isomerization: an intrinsic molecular switch.

Andreotti AH.

Biochemistry. 2003 Aug 19;42(32):9515-24. Review. No abstract available.


Does solvent influence the ground-state tautomeric population of hypericin?

Wen J, Chowdhury P, Fulton DB, Datta A, Das K, Andreotti AH, Petrich JW.

Photochem Photobiol. 2003 Jan;77(1):5-9.


Determinants of intra versus intermolecular self-association within the regulatory domains of Rlk and Itk.

Laederach A, Cradic KW, Fulton DB, Andreotti AH.

J Mol Biol. 2003 Jun 20;329(5):1011-20.


Structural characterization of a proline-driven conformational switch within the Itk SH2 domain.

Mallis RJ, Brazin KN, Fulton DB, Andreotti AH.

Nat Struct Biol. 2002 Dec;9(12):900-5.


Solution and micelle-bound structures of tachyplesin I and its active aromatic linear derivatives.

Laederach A, Andreotti AH, Fulton DB.

Biochemistry. 2002 Oct 15;41(41):12359-68.


Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A.

Brazin KN, Mallis RJ, Fulton DB, Andreotti AH.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1899-904. Epub 2002 Feb 5.


Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization.

Laederach A, Cradic KW, Brazin KN, Zamoon J, Fulton DB, Huang XY, Andreotti AH.

Protein Sci. 2002 Jan;11(1):36-45.


Conformational changes in pediocin AcH upon vesicle binding and approximation of the membrane-bound structure in detergent micelles.

Watson RM, Woody RW, Lewis RV, Bohle DS, Andreotti AH, Ray B, Miller KW.

Biochemistry. 2001 Nov 20;40(46):14037-46.


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