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Items: 1 to 50 of 72

1.

Bilayer Thickness and Curvature Influence Binding and Insertion of a pHLIP Peptide.

Karabadzhak AG, Weerakkody D, Deacon J, Andreev OA, Reshetnyak YK, Engelman DM.

Biophys J. 2018 May 8;114(9):2107-2115. doi: 10.1016/j.bpj.2018.03.036.

PMID:
29742404
2.

Membrane-Induced p Ka Shifts in wt-pHLIP and Its L16H Variant.

Vila-Viçosa D, Silva TFD, Slaybaugh G, Reshetnyak YK, Andreev OA, Machuqueiro M.

J Chem Theory Comput. 2018 Jun 12;14(6):3289-3297. doi: 10.1021/acs.jctc.8b00102. Epub 2018 May 17.

PMID:
29733633
3.

Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors.

Wyatt LC, Moshnikova A, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2811-E2818. doi: 10.1073/pnas.1715350115. Epub 2018 Mar 5.

4.

Applications of pHLIP Technology for Cancer Imaging and Therapy: (Trends in Biotechnology 35, 653-664, 2017).

Wyatt LC, Lewis JS, Andreev OA, Reshetnyak YK, Engelman DM.

Trends Biotechnol. 2017 Nov 30. pii: S0167-7799(17)30303-7. doi: 10.1016/j.tibtech.2017.11.005. [Epub ahead of print] No abstract available.

5.

Synthesis and characterization of pHLIP® coated gold nanoparticles.

Daniels JL, Crawford TM, Andreev OA, Reshetnyak YK.

Biochem Biophys Rep. 2017 Feb 28;10:62-69. doi: 10.1016/j.bbrep.2017.02.008. eCollection 2017 Jul.

6.

pH-sensitive pHLIP® coated niosomes.

Pereira MC, Pianella M, Wei D, Moshnikova A, Marianecci C, Carafa M, Andreev OA, Reshetnyak YK.

Mol Membr Biol. 2016 May - Aug;33(3-5):51-63. doi: 10.1080/09687688.2017.1342969. Epub 2017 Aug 9.

7.

Insertion into lipid bilayer of truncated pHLIP®peptide.

Weerakkody D, Andreev OA, Reshetnyak YK.

Biochem Biophys Rep. 2016 Dec;8:290-295. doi: 10.1016/j.bbrep.2016.10.001. Epub 2016 Oct 8.

8.

Applications of pHLIP Technology for Cancer Imaging and Therapy.

Wyatt LC, Lewis JS, Andreev OA, Reshetnyak YK, Engelman DM.

Trends Biotechnol. 2017 Jul;35(7):653-664. doi: 10.1016/j.tibtech.2017.03.014. Epub 2017 Apr 21. Review. Erratum in: Trends Biotechnol. 2017 Nov 30;:.

9.

Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo.

Golijanin J, Amin A, Moshnikova A, Brito JM, Tran TY, Adochite RC, Andreev GO, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK, Golijanin D.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11829-11834. Epub 2016 Sep 29.

10.

pHLIP Peptide Interaction with a Membrane Monitored by SAXS.

Narayanan T, Weerakkody D, Karabadzhak AG, Anderson M, Andreev OA, Reshetnyak YK.

J Phys Chem B. 2016 Nov 10;120(44):11484-11491. Epub 2016 Oct 27.

11.

Novel pH-Sensitive Cyclic Peptides.

Weerakkody D, Moshnikova A, El-Sayed NS, Adochite RC, Slaybaugh G, Golijanin J, Tiwari RK, Andreev OA, Parang K, Reshetnyak YK.

Sci Rep. 2016 Aug 12;6:31322. doi: 10.1038/srep31322.

12.

PET Imaging of Extracellular pH in Tumors with (64)Cu- and (18)F-Labeled pHLIP Peptides: A Structure-Activity Optimization Study.

Demoin DW, Wyatt LC, Edwards KJ, Abdel-Atti D, Sarparanta M, Pourat J, Longo VA, Carlin SD, Engelman DM, Andreev OA, Reshetnyak YK, Viola-Villegas N, Lewis JS.

Bioconjug Chem. 2016 Sep 21;27(9):2014-23. doi: 10.1021/acs.bioconjchem.6b00306. Epub 2016 Jul 21.

13.

Probe for the measurement of cell surface pH in vivo and ex vivo.

Anderson M, Moshnikova A, Engelman DM, Reshetnyak YK, Andreev OA.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8177-81. doi: 10.1073/pnas.1608247113. Epub 2016 Jul 5.

14.

Comparative Study of Tumor Targeting and Biodistribution of pH (Low) Insertion Peptides (pHLIP(®) Peptides) Conjugated with Different Fluorescent Dyes.

Adochite RC, Moshnikova A, Golijanin J, Andreev OA, Katenka NV, Reshetnyak YK.

Mol Imaging Biol. 2016 Oct;18(5):686-96. doi: 10.1007/s11307-016-0949-6.

PMID:
27074841
15.

Corrigendum to "Advanced targeted nanomedicine" [J. Biotechnol. 202 (2015) 88-97].

Arachchige MC, Reshetnyak YK, Andreev OA.

J Biotechnol. 2016 May 10;225:68. doi: 10.1016/j.jbiotec.2016.02.037. Epub 2016 Mar 15. No abstract available.

PMID:
27068325
16.

Gold Nanoparticles for Radiation Enhancement in Vivo.

Shrestha S, Cooper LN, Andreev OA, Reshetnyak YK, Antosh MP.

Jacobs J Radiat Oncol. 2016 Apr;3(1). pii: 026. Epub 2016 Apr 27.

17.

The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions.

Tapmeier TT, Moshnikova A, Beech J, Allen D, Kinchesh P, Smart S, Harris A, McIntyre A, Engelman DM, Andreev OA, Reshetnyak YK, Muschel RJ.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9710-5. doi: 10.1073/pnas.1509488112. Epub 2015 Jul 20.

18.

Enhancement of radiation effect on cancer cells by gold-pHLIP.

Antosh MP, Wijesinghe DD, Shrestha S, Lanou R, Huang YH, Hasselbacher T, Fox D, Neretti N, Sun S, Katenka N, Cooper LN, Andreev OA, Reshetnyak YK.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5372-6. doi: 10.1073/pnas.1501628112. Epub 2015 Apr 13.

19.

Advanced targeted nanomedicine.

Pereira MC, Reshetnyak YK, Andreev OA.

J Biotechnol. 2015 May 20;202:88-97. doi: 10.1016/j.jbiotec.2015.01.009. Epub 2015 Jan 20. Erratum in: J Biotechnol. 2016 May 10;225:68. Arachchige, Mohan C M [corrected to Pereira, Mohan C].

20.

pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo.

Karabadzhak AG, An M, Yao L, Langenbacher R, Moshnikova A, Adochite RC, Andreev OA, Reshetnyak YK, Engelman DM.

ACS Chem Biol. 2014 Nov 21;9(11):2545-53. doi: 10.1021/cb500388m. Epub 2014 Sep 10.

21.

Targeting breast tumors with pH (low) insertion peptides.

Adochite RC, Moshnikova A, Carlin SD, Guerrieri RA, Andreev OA, Lewis JS, Reshetnyak YK.

Mol Pharm. 2014 Aug 4;11(8):2896-905. doi: 10.1021/mp5002526. Epub 2014 Jul 8.

22.

Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer.

Viola-Villegas NT, Carlin SD, Ackerstaff E, Sevak KK, Divilov V, Serganova I, Kruchevsky N, Anderson M, Blasberg RG, Andreev OA, Engelman DM, Koutcher JA, Reshetnyak YK, Lewis JS.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7254-9. doi: 10.1073/pnas.1405240111. Epub 2014 May 1.

23.

Targeting diseased tissues by pHLIP insertion at low cell surface pH.

Andreev OA, Engelman DM, Reshetnyak YK.

Front Physiol. 2014 Mar 13;5:97. doi: 10.3389/fphys.2014.00097. eCollection 2014. Review.

24.

Targeting pancreatic ductal adenocarcinoma acidic microenvironment.

Cruz-Monserrate Z, Roland CL, Deng D, Arumugam T, Moshnikova A, Andreev OA, Reshetnyak YK, Logsdon CD.

Sci Rep. 2014 Mar 19;4:4410. doi: 10.1038/srep04410.

25.

pH dependent transfer of nano-pores into membrane of cancer cells to induce apoptosis.

Wijesinghe D, Arachchige MC, Lu A, Reshetnyak YK, Andreev OA.

Sci Rep. 2013 Dec 20;3:3560. doi: 10.1038/srep03560.

26.

Family of pH (low) insertion peptides for tumor targeting.

Weerakkody D, Moshnikova A, Thakur MS, Moshnikova V, Daniels J, Engelman DM, Andreev OA, Reshetnyak YK.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5834-9. doi: 10.1073/pnas.1303708110. Epub 2013 Mar 25.

27.

pHLIP®-mediated delivery of PEGylated liposomes to cancer cells.

Yao L, Daniels J, Wijesinghe D, Andreev OA, Reshetnyak YK.

J Control Release. 2013 May 10;167(3):228-37. doi: 10.1016/j.jconrel.2013.01.037. Epub 2013 Feb 15.

28.

Antiproliferative effect of pHLIP-amanitin.

Moshnikova A, Moshnikova V, Andreev OA, Reshetnyak YK.

Biochemistry. 2013 Feb 19;52(7):1171-8. doi: 10.1021/bi301647y. Epub 2013 Feb 8.

29.

pHLIP peptide targets nanogold particles to tumors.

Yao L, Daniels J, Moshnikova A, Kuznetsov S, Ahmed A, Engelman DM, Reshetnyak YK, Andreev OA.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):465-70. doi: 10.1073/pnas.1219665110. Epub 2012 Dec 24. Erratum in: Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3651. Danniels, Jennifer [corrected to Daniels, Jennifer].

30.

pH (low) insertion peptide (pHLIP) targets ischemic myocardium.

Sosunov EA, Anyukhovsky EP, Sosunov AA, Moshnikova A, Wijesinghe D, Engelman DM, Reshetnyak YK, Andreev OA.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):82-6. doi: 10.1073/pnas.1220038110. Epub 2012 Dec 17.

31.

Parking problem and negative cooperativity of binding of myosin subfragment 1 to F-actin.

Reshetnyak YK, Prudence CN, Segala J, Markin VS, Andreev OA.

Biochem Biophys Res Commun. 2012 Sep 7;425(4):746-9. doi: 10.1016/j.bbrc.2012.07.146. Epub 2012 Aug 4.

PMID:
22867639
32.

Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation.

Daumar P, Wanger-Baumann CA, Pillarsetty N, Fabrizio L, Carlin SD, Andreev OA, Reshetnyak YK, Lewis JS.

Bioconjug Chem. 2012 Aug 15;23(8):1557-66. doi: 10.1021/bc3000222. Epub 2012 Jul 30.

33.

Modulation of the pHLIP transmembrane helix insertion pathway.

Karabadzhak AG, Weerakkody D, Wijesinghe D, Thakur MS, Engelman DM, Andreev OA, Markin VS, Reshetnyak YK.

Biophys J. 2012 Apr 18;102(8):1846-55. doi: 10.1016/j.bpj.2012.03.021.

34.

In vivo pH imaging with (99m)Tc-pHLIP.

Macholl S, Morrison MS, Iveson P, Arbo BE, Andreev OA, Reshetnyak YK, Engelman DM, Johannesen E.

Mol Imaging Biol. 2012 Dec;14(6):725-34. doi: 10.1007/s11307-012-0549-z.

35.

Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide.

Wijesinghe D, Engelman DM, Andreev OA, Reshetnyak YK.

Biochemistry. 2011 Nov 29;50(47):10215-22. doi: 10.1021/bi2009773. Epub 2011 Nov 4.

36.

Roles of carboxyl groups in the transmembrane insertion of peptides.

Barrera FN, Weerakkody D, Anderson M, Andreev OA, Reshetnyak YK, Engelman DM.

J Mol Biol. 2011 Oct 21;413(2):359-71. doi: 10.1016/j.jmb.2011.08.010. Epub 2011 Aug 23.

37.

Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP.

Reshetnyak YK, Yao L, Zheng S, Kuznetsov S, Engelman DM, Andreev OA.

Mol Imaging Biol. 2011 Dec;13(6):1146-56. doi: 10.1007/s11307-010-0457-z.

38.

pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation.

An M, Wijesinghe D, Andreev OA, Reshetnyak YK, Engelman DM.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20246-50. doi: 10.1073/pnas.1014403107. Epub 2010 Nov 3.

39.

pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents.

Andreev OA, Engelman DM, Reshetnyak YK.

Mol Membr Biol. 2010 Oct;27(7):341-52. doi: 10.3109/09687688.2010.509285. Epub 2010 Oct 13. Review.

40.

pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path.

Andreev OA, Karabadzhak AG, Weerakkody D, Andreev GO, Engelman DM, Reshetnyak YK.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4081-6. doi: 10.1073/pnas.0914330107. Epub 2010 Feb 16.

41.

Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP).

Segala J, Engelman DM, Reshetnyak YK, Andreev OA.

Int J Mol Sci. 2009 Aug 4;10(8):3478-87. doi: 10.3390/ijms10083478.

42.
43.

Tuning the insertion properties of pHLIP.

Musial-Siwek M, Karabadzhak A, Andreev OA, Reshetnyak YK, Engelman DM.

Biochim Biophys Acta. 2010 Jun;1798(6):1041-6. doi: 10.1016/j.bbamem.2009.08.023. Epub 2009 Sep 18.

44.

Fabrication of semiconductor nanowires by conjugation of quantum dots to actin filaments.

Yao L, Andreev GO, Reshetnyak YK, Andreev OA.

Anal Bioanal Chem. 2009 Nov;395(5):1563-6. doi: 10.1007/s00216-009-3077-1.

PMID:
19730829
45.

A novel technology for the imaging of acidic prostate tumors by positron emission tomography.

Vāvere AL, Biddlecombe GB, Spees WM, Garbow JR, Wijesinghe D, Andreev OA, Engelman DM, Reshetnyak YK, Lewis JS.

Cancer Res. 2009 May 15;69(10):4510-6. doi: 10.1158/0008-5472.CAN-08-3781. Epub 2009 May 5.

46.

Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane.

Reshetnyak YK, Andreev OA, Segala M, Markin VS, Engelman DM.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15340-5. doi: 10.1073/pnas.0804746105. Epub 2008 Sep 30.

47.

A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers.

Reshetnyak YK, Segala M, Andreev OA, Engelman DM.

Biophys J. 2007 Oct 1;93(7):2363-72. Epub 2007 Jun 8.

48.

Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo.

Andreev OA, Dupuy AD, Segala M, Sandugu S, Serra DA, Chichester CO, Engelman DM, Reshetnyak YK.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7893-8. Epub 2007 May 1.

49.

Mechanism of formation of actomyosin interface.

Andreev OA, Reshetnyak YK.

J Mol Biol. 2007 Jan 19;365(3):551-4. Epub 2006 Oct 11.

PMID:
17081565
50.

Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix.

Reshetnyak YK, Andreev OA, Lehnert U, Engelman DM.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6460-5. Epub 2006 Apr 11.

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