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Items: 47

1.

Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression.

Hughes ZA, Neal SJ, Smith DL, Sukoff Rizzo SJ, Pulicicchio CM, Lotarski S, Lu S, Dwyer JM, Brennan J, Olsen M, Bender CN, Kouranova E, Andree TH, Harrison JE, Whiteside GT, Springer D, O'Neil SV, Leonard SK, Schechter LE, Dunlop J, Rosenzweig-Lipson S, Ring RH.

Neuropharmacology. 2013 Mar;66:202-14. doi: 10.1016/j.neuropharm.2012.04.007. Epub 2012 Apr 21.

PMID:
22551786
2.

The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists.

Childers WE Jr, Havran LM, Asselin M, Bicksler JJ, Chong DC, Grosu GT, Shen Z, Abou-Gharbia MA, Bach AC 3rd, Harrison BL, Kagan N, Kleintop T, Magolda R, Marathias V, Robichaud AJ, Sabb AL, Zhang MY, Andree TH, Aschmies SH, Beyer C, Comery TA, Day M, Grauer SM, Hughes ZA, Rosenzweig-Lipson S, Platt B, Pulicicchio C, Smith DE, Sukoff-Rizzo SJ, Sullivan KM, Adedoyin A, Huselton C, Hirst WD.

J Med Chem. 2010 May 27;53(10):4066-84. doi: 10.1021/jm1000908.

PMID:
20443629
3.

Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity.

Venkatesan AM, Dos Santos O, Ellingboe J, Evrard DA, Harrison BL, Smith DL, Scerni R, Hornby GA, Schechter LE, Andree TH.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):824-7. doi: 10.1016/j.bmcl.2009.12.093. Epub 2010 Jan 4.

PMID:
20064720
4.

Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT(1A) receptor and the serotonin transporter.

Shen Z, Siva Ramamoorthy P, Hatzenbuhler NT, Evrard DA, Childers W, Harrison BL, Chlenov M, Hornby G, Smith DL, Sullivan KM, Schechter LE, Andree TH.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):222-7. doi: 10.1016/j.bmcl.2009.10.134. Epub 2009 Oct 31.

PMID:
19932965
5.

The dopamine D(2) receptor partial agonist aplindore improves motor deficits in MPTP-treated common marmosets alone and combined with L-dopa.

Jackson MJ, Andree TH, Hansard M, Hoffman DC, Hurtt MR, Kehne JH, Pitler TA, Smith LA, Stack G, Jenner P.

J Neural Transm (Vienna). 2010 Jan;117(1):55-67. doi: 10.1007/s00702-009-0323-9. Epub 2009 Oct 7.

PMID:
19809864
6.

Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.

Zhou D, Stack GP, Lo J, Failli AA, Evrard DA, Harrison BL, Hatzenbuhler NT, Tran M, Croce S, Yi S, Golembieski J, Hornby GA, Lai M, Lin Q, Schechter LE, Smith DL, Shilling AD, Huselton C, Mitchell P, Beyer CE, Andree TH.

J Med Chem. 2009 Aug 13;52(15):4955-9. doi: 10.1021/jm900374r.

PMID:
19719241
7.

5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats.

Sukoff Rizzo SJ, Pulicicchio C, Malberg JE, Andree TH, Stack GP, Hughes ZA, Schechter LE, Rosenzweig-Lipson S.

Int J Neuropsychopharmacol. 2009 Sep;12(8):1045-53. doi: 10.1017/S1461145709000406. Epub 2009 May 13.

PMID:
19435548
8.

Preclinical characterization of WAY-211612: a dual 5-HT uptake inhibitor and 5-HT (1A) receptor antagonist and potential novel antidepressant.

Beyer CE, Lin Q, Platt B, Malberg J, Hornby G, Sullivan KM, Smith DL, Lock T, Mitchell PJ, Hatzenbuhler NT, Evrard DA, Harrison BL, Magolda R, Pangalos MN, Schechter LE, Rosenzweig-Lipson S, Andree TH.

Br J Pharmacol. 2009 May;157(2):307-19. doi: 10.1111/j.1476-5381.2009.00146.x. Epub 2009 Mar 26.

9.

The identification of neurotensin NTS1 receptor partial agonists through a ligand-based virtual screening approach.

Fan Y, Lai MH, Sullivan K, Popiolek M, Andree TH, Dollings P, Pausch MH.

Bioorg Med Chem Lett. 2008 Nov 1;18(21):5789-91. doi: 10.1016/j.bmcl.2008.09.075. Epub 2008 Sep 24.

PMID:
18849166
10.

Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2.

Hatzenbuhler NT, Baudy R, Evrard DA, Failli A, Harrison BL, Lenicek S, Mewshaw RE, Saab A, Shah U, Sze J, Zhang M, Zhou D, Chlenov M, Kagan M, Golembieski J, Hornby G, Lai M, Smith DL, Sullivan KM, Schechter LE, Andree TH.

J Med Chem. 2008 Nov 13;51(21):6980-7004. doi: 10.1021/jm8007097. Epub 2008 Oct 4.

PMID:
18834188
11.

D2 receptor partial agonists: treatment of CNS disorders of dopamine function.

Kehne JH, Andree TH, Heinrich JN.

Curr Top Med Chem. 2008;8(12):1068-88. Review.

PMID:
18691133
12.

Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.

Zhou D, Zhou P, Evrard DA, Meagher K, Webb M, Harrison BL, Huryn DM, Golembieski J, Hornby GA, Schechter LE, Smith DL, Andree TH, Mewshaw RE.

Bioorg Med Chem. 2008 Jul 15;16(14):6707-23. doi: 10.1016/j.bmc.2008.05.075. Epub 2008 Jun 5.

PMID:
18571421
13.

Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405).

Hirst WD, Andree TH, Aschmies S, Childers WE, Comery TA, Dawson LA, Day M, Feingold IB, Grauer SM, Harrison BL, Hughes ZA, Kao J, Kelly MG, van der Lee H, Rosenzweig-Lipson S, Saab AL, Smith DL, Sullivan K, Rizzo SJ, Tio C, Zhang MY, Schechter LE.

J Pharmacol Exp Ther. 2008 Apr;325(1):134-45. doi: 10.1124/jpet.107.133082. Epub 2008 Jan 8.

PMID:
18182558
14.

From menarche to menopause: exploring the underlying biology of depression in women experiencing hormonal changes.

Deecher D, Andree TH, Sloan D, Schechter LE.

Psychoneuroendocrinology. 2008 Jan;33(1):3-17. Epub 2007 Dec 3. Review.

PMID:
18063486
15.

Novel pyridyl-fused 3-amino chroman derivatives with dual action at serotonin transporter and 5-HT1A receptor.

Zhou D, Hatzenbuhler NT, Gross JL, Harrison BL, Evrard DA, Chlenov M, Golembieski J, Hornby G, Schechter LE, Smith DL, Andree TH, Stack GP.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3117-21. Epub 2007 Mar 19.

PMID:
17407811
16.

Differential and synergistic effects of selective norepinephrine and serotonin reuptake inhibitors in rodent models of pain.

Leventhal L, Smith V, Hornby G, Andree TH, Brandt MR, Rogers KE.

J Pharmacol Exp Ther. 2007 Mar;320(3):1178-85. Epub 2006 Dec 1.

PMID:
17142646
17.

Aplindore (DAB-452), a high affinity selective dopamine D2 receptor partial agonist.

Heinrich JN, Brennan J, Lai MH, Sullivan K, Hornby G, Popiolek M, Jiang LX, Pausch MH, Stack G, Marquis KL, Andree TH.

Eur J Pharmacol. 2006 Dec 15;552(1-3):36-45. Epub 2006 Sep 14.

PMID:
17056032
18.

Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity.

Hatzenbuhler NT, Evrard DA, Harrison BL, Huryn D, Inghrim J, Kraml C, Mattes JF, Mewshaw RE, Zhou D, Hornby G, Lin Q, Smith DL, Sullivan KM, Schechter LE, Beyer CE, Andree TH.

J Med Chem. 2006 Jul 27;49(15):4785-9.

PMID:
16854086
19.

Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor.

Deecher DC, Beyer CE, Johnston G, Bray J, Shah S, Abou-Gharbia M, Andree TH.

J Pharmacol Exp Ther. 2006 Aug;318(2):657-65. Epub 2006 May 4.

PMID:
16675639
20.

The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices.

Liu F, Zhang G, Hornby G, Vasylyev D, Bowlby M, Park K, Gilbert A, Marquis K, Andree TH.

Eur J Pharmacol. 2006 May 1;536(3):262-8. Epub 2006 Apr 5.

PMID:
16600209
21.

Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.

Zhou D, Harrison BL, Shah U, Andree TH, Hornby GA, Scerni R, Schechter LE, Smith DL, Sullivan KM, Mewshaw RE.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1338-41. Epub 2005 Dec 5.

PMID:
16332439
22.

The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides.

Liu F, Gong X, Zhang G, Marquis K, Reinhart P, Andree TH.

J Neurochem. 2005 Dec;95(5):1363-72. Epub 2005 Nov 8.

23.

Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan.

Childers WE Jr, Abou-Gharbia MA, Kelly MG, Andree TH, Harrison BL, Ho DM, Hornby G, Huryn DM, Potestio L, Rosenzweig-Lipson SJ, Schmid J, Smith DL, Sukoff SJ, Zhang G, Schechter LE.

J Med Chem. 2005 May 19;48(10):3467-70.

PMID:
15887953
24.

Studies towards the next generation of antidepressants. Part 4: derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor.

Evrard DA, Zhou P, Yi SY, Zhou D, Smith DL, Sullivan KM, Hornby GA, Schechter LE, Andree TH, Mewshaw RE.

Bioorg Med Chem Lett. 2005 Feb 15;15(4):911-4.

PMID:
15686885
25.

Novel aryloxy-8-azabicyclo[3.2.1]oct-3-enes with 5-HT transporter and 5-HT1A affinity.

Gilbert AM, Coleman T, Kodah J, Mewshaw RE, Scerni R, Schechter LE, Smith DL, Andree TH.

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5281-4.

PMID:
15454211
26.

Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.

Mewshaw RE, Zhou D, Zhou P, Shi X, Hornby G, Spangler T, Scerni R, Smith D, Schechter LE, Andree TH.

J Med Chem. 2004 Jul 15;47(15):3823-42.

PMID:
15239661
27.

Modulation of selective serotonin reuptake inhibitor and 5-HT1A antagonist activity in 8-aza-bicyclo[3.2.1]octane derivatives of 2,3-dihydro-1,4-benzodioxane.

Gilbert AM, Stack GP, Nilakantan R, Kodah J, Tran M, Scerni R, Shi X, Smith DL, Andree TH.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):515-8.

PMID:
14698193
28.

Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.

Mewshaw RE, Meagher KL, Zhou P, Zhou D, Shi X, Scerni R, Smith D, Schechter LE, Andree TH.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):307-10.

PMID:
11814784
29.

New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template.

Mewshaw RE, Zhao R, Shi X, Marquis K, Brennan JA, Mazandarani H, Coupet J, Andree TH.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):271-4.

PMID:
11814775
30.

Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.

Meagher KL, Mewshaw RE, Evrard DA, Zhou P, Smith DL, Scerni R, Spangler T, Abulhawa S, Shi X, Schechter LE, Andree TH.

Bioorg Med Chem Lett. 2001 Jul 23;11(14):1885-8.

PMID:
11459653
31.

1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors.

Sabb AL, Vogel RL, Kelly MG, Palmer Y, Smith DL, Andree TH, Schechter LE.

Bioorg Med Chem Lett. 2001 Apr 23;11(8):1069-71.

PMID:
11327592
32.

New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template.

Mewshaw RE, Nelson JA, Shah US, Shi X, Mazandarani H, Coupet J, Marquis K, Brennan JA, Andree TH.

Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8.

PMID:
10498215
33.
34.

New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template.

Mewshaw RE, Verwijs A, Shi X, McGaughey GB, Nelson JA, Mazandarani H, Brennan JA, Marquis KL, Coupet J, Andree TH.

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80.

PMID:
9873601
35.

New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.

Mewshaw RE, Husbands M, Gildersleeve ES, Webb MB, Shi X, Mazandarani H, Cockett MI, Ochalski R, Brennan JA, Abou-Gharbia M, Marquis K, McGaughey GB, Coupet J, Andree TH.

Bioorg Med Chem Lett. 1998 Feb 3;8(3):295-300.

PMID:
9871673
36.

New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.

Mewshaw RE, Kavanagh J, Stack G, Marquis KL, Shi X, Kagan MZ, Webb MB, Katz AH, Park A, Kang YH, Abou-Gharbia M, Scerni R, Wasik T, Cortes-Burgos L, Spangler T, Brennan JA, Piesla M, Mazandarani H, Cockett MI, Ochalski R, Coupet J, Andree TH.

J Med Chem. 1997 Dec 19;40(26):4235-56.

PMID:
9435894
37.
38.

Antipsychotic activity of substituted gamma-carbolines.

Abou-Gharbia M, Patel UR, Webb MB, Moyer JA, Andree TH, Muth EA.

J Med Chem. 1987 Oct;30(10):1818-23.

PMID:
2888898
39.

Biochemical and electrophysiological studies of the psychotropic compound, amperozide.

Haskins JT, Muth EA, Andree TH.

Brain Res Bull. 1987 Oct;19(4):465-71.

PMID:
2825928
40.

Differential effect of subchronic treatment with various neuroleptic agents on serotonin2 receptors in rat cerebral cortex.

Andree TH, Mikuni M, Tong CY, Koenig JI, Meltzer HY.

J Neurochem. 1986 Jan;46(1):191-7.

PMID:
2866233
41.

Phosphorus analogues of gamma-aminobutyric acid, a new class of anticonvulsants.

Cates LA, Li VS, Yakshe CC, Fadeyi MO, Andree TH, Karbon EW, Enna SJ.

J Med Chem. 1984 May;27(5):654-9.

PMID:
6325692
42.

Effect of subchronic treatment with neuroleptic, imipramine, and the combination on serotonin receptor binding in rat cerebral cortex.

Andree TH, Mikuni M, Meltzer HY.

Psychopharmacol Bull. 1984 Summer;20(3):349-53. No abstract available.

PMID:
6147873
43.

Evidence for cholinergic muscarinic receptors on mediodorsal thalamic projections to the anterior cingulate cortex.

Andree TH, Gottesfeld Z, DeFrance JF, Sikes RW, Enna SJ.

Neurosci Lett. 1983 Sep 30;40(2):99-103.

PMID:
6633977
44.

Characteristics of rat skull benzylamine oxidase.

Andree TH, Clarke DE.

Proc Soc Exp Biol Med. 1982 Dec;171(3):298-305. No abstract available.

PMID:
7178133
45.
46.

Neurochemical effects of kojic amine, a GABAmimetic and its interaction with benzylamine oxidase.

Ferkany JW, Andree TH, Clarke DE, Enna SJ.

Neuropharmacology. 1981 Dec;20(12A):1177-82. No abstract available.

PMID:
7322292
47.

The isolated perfused rat brain preparation in the study of monoamine oxidase and benzylamine oxidase. Lack of selective brain perfusion.

Andree TH, Clarke DE.

Biochem Pharmacol. 1981 May 1;30(9):959-65. No abstract available.

PMID:
7236317

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