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NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation.

Yu Y, Choi K, Wu J, Andreassen PR, Dexheimer PJ, Keddache M, Brems H, Spinner RJ, Cancelas JA, Martin LJ, Wallace MR, Legius E, Vogel KS, Ratner N.

Acta Neuropathol. 2019 Oct 29. doi: 10.1007/s00401-019-02086-w. [Epub ahead of print]


XRCC2 (X-ray repair cross complementing 2).

Andreassen PR, Hanenberg H.

Atlas Genet Cytogenet Oncol Haematol. 2019 Jan;23(1):1-7. doi: 10.4267/2042/69759.


CRISPR-Cas9 fusion to dominant-negative 53BP1 enhances HDR and inhibits NHEJ specifically at Cas9 target sites.

Jayavaradhan R, Pillis DM, Goodman M, Zhang F, Zhang Y, Andreassen PR, Malik P.

Nat Commun. 2019 Jun 28;10(1):2866. doi: 10.1038/s41467-019-10735-7.


Advance care planning and place of death, hospitalisation and actual place of death in lung, heart and cancer disease: a randomised controlled trial.

Skorstengaard MH, Jensen AB, Andreassen P, Brogaard T, Brendstrup E, Løkke A, Aagaard S, Wiggers H, Neergaard MA.

BMJ Support Palliat Care. 2019 Apr 11. pii: bmjspcare-2018-001677. doi: 10.1136/bmjspcare-2018-001677. [Epub ahead of print]


SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints.

Dong Y, Zhao X, Feng X, Zhou Y, Yan X, Zhang Y, Bu J, Zhan D, Hayashi Y, Zhang Y, Xu Z, Huang R, Wang J, Zhao T, Xiao Z, Ju Z, Andreassen PR, Wang QF, Chen W, Huang G.

Leukemia. 2019 Nov;33(11):2585-2598. doi: 10.1038/s41375-019-0456-2. Epub 2019 Apr 9.


Advance care planning for patients and their relatives.

Skorstengaard MH, Brogaard T, Jensen AB, Andreassen P, Bendstrup E, Løkke A, Aagaard S, Wiggers H, Johnsen AT, Neergaard MA.

Int J Palliat Nurs. 2019 Mar 2;25(3):112-127. doi: 10.12968/ijpn.2019.25.3.112.


Genetic Testing to Guide Risk-Stratified Screens for Breast Cancer.

Willoughby A, Andreassen PR, Toland AE.

J Pers Med. 2019 Mar 1;9(1). pii: E15. doi: 10.3390/jpm9010015. Review.


Site-Directed Mutagenesis for In Vitro and In Vivo Experiments Exemplified with RNA Interactions in Escherichia Coli.

Andreassen PR, Pettersen JS, Jørgensen M.

J Vis Exp. 2019 Feb 5;(144). doi: 10.3791/58996.


Deficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination.

Lewis TW, Barthelemy JR, Virts EL, Kennedy FM, Gadgil RY, Wiek C, Linka RM, Zhang F, Andreassen PR, Hanenberg H, Leffak M.

Nucleic Acids Res. 2019 Apr 23;47(7):3503-3520. doi: 10.1093/nar/gkz026.


The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development.

Ge C, Vilfranc CL, Che L, Pandita RK, Hambarde S, Andreassen PR, Niu L, Olowokure O, Shah S, Waltz SE, Zou L, Wang J, Pandita TK, Du C.

Hepatology. 2019 Jun;69(6):2608-2622. doi: 10.1002/hep.30529. Epub 2019 Mar 13.


A SWOT analysis of how the youngest doctors perceive the formal Danish educational advisory programme.

Sørensen A, Møller MK, Andreassen P, Malling B.

Dan Med J. 2018 Sep;65(9). pii: A5498.


sRNA-dependent control of curli biosynthesis in Escherichia coli: McaS directs endonucleolytic cleavage of csgD mRNA.

Andreassen PR, Pettersen JS, Szczerba M, Valentin-Hansen P, Møller-Jensen J, Jørgensen MG.

Nucleic Acids Res. 2018 Jul 27;46(13):6746-6760. doi: 10.1093/nar/gky479.


Science in the clinic: a qualitative study of the positioning of MD-PhDs in the everyday clinical setting.

Andreassen P, Christensen MK.

BMC Med Educ. 2018 May 25;18(1):115. doi: 10.1186/s12909-018-1222-2.


Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation.

Zhou Y, Yan X, Feng X, Bu J, Dong Y, Lin P, Hayashi Y, Huang R, Olsson A, Andreassen PR, Grimes HL, Wang QF, Cheng T, Xiao Z, Jin J, Huang G.

Haematologica. 2018 Jul;103(7):1110-1123. doi: 10.3324/haematol.2018.187708. Epub 2018 Apr 12.


"We're at a watershed": The positioning of PhD nurses in clinical practice.

Andreassen P, Christensen MK.

J Adv Nurs. 2018 Apr 6. doi: 10.1111/jan.13581. [Epub ahead of print]


PALB2 (partner and localizer of BRCA2).

Hanenberg H, Andreassen PR.

Atlas Genet Cytogenet Oncol Haematol. 2018 Apr;22(12):484-490. doi: 10.4267/2042/69016.


RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes.

Adams SR, Maezawa S, Alavattam KG, Abe H, Sakashita A, Shroder M, Broering TJ, Sroga Rios J, Thomas MA, Lin X, Price CM, Barski A, Andreassen PR, Namekawa SH.

PLoS Genet. 2018 Feb 20;14(2):e1007233. doi: 10.1371/journal.pgen.1007233. eCollection 2018 Feb.


CHEK1 coordinates DNA damage signaling and meiotic progression in the male germline of mice.

Abe H, Alavattam KG, Kato Y, Castrillon DH, Pang Q, Andreassen PR, Namekawa SH.

Hum Mol Genet. 2018 Apr 1;27(7):1136-1149. doi: 10.1093/hmg/ddy022.


Polycomb directs timely activation of germline genes in spermatogenesis.

Maezawa S, Hasegawa K, Yukawa M, Sakashita A, Alavattam KG, Andreassen PR, Vidal M, Koseki H, Barski A, Namekawa SH.

Genes Dev. 2017 Aug 15;31(16):1693-1703. doi: 10.1101/gad.302000.117. Epub 2017 Sep 18.


DNA repair-related functional assays for the classification of BRCA1 and BRCA2 variants: a critical review and needs assessment.

Toland AE, Andreassen PR.

J Med Genet. 2017 Nov;54(11):721-731. doi: 10.1136/jmedgenet-2017-104707. Epub 2017 Sep 2. Review.


Preferred Place of Care and Death in Terminally Ill Patients with Lung and Heart Disease Compared to Cancer Patients.

Skorstengaard MH, Neergaard MA, Andreassen P, Brogaard T, Bendstrup E, Løkke A, Aagaard S, Wiggers H, Bech P, Jensen AB.

J Palliat Med. 2017 Nov;20(11):1217-1224. doi: 10.1089/jpm.2017.0082. Epub 2017 Jun 2.


Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases.

McNally JP, Millen SH, Chaturvedi V, Lakes N, Terrell CE, Elfers EE, Carroll KR, Hogan SP, Andreassen PR, Kanter J, Allen CE, Henry MM, Greenberg JN, Ladisch S, Hermiston ML, Joyce M, Hildeman DA, Katz JD, Jordan MB.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4782-E4791. doi: 10.1073/pnas.1703683114. Epub 2017 May 22.


[Care and treatment can be planned in advance with advance care planning].

Skorstengaard MH, Grønvold M, Jensen AB, Johnsen AT, Brogaard T, Christensen CA, Andreassen P, Marsaa K, Neergaard MA.

Ugeskr Laeger. 2017 Feb 13;179(7). pii: V10160760. Review. Danish.


Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.

Zhang T, Du W, Wilson AF, Namekawa SH, Andreassen PR, Meetei AR, Pang Q.

Sci Rep. 2017 Apr 5;7:45626. doi: 10.1038/srep45626.


DEK is required for homologous recombination repair of DNA breaks.

Smith EA, Gole B, Willis NA, Soria R, Starnes LM, Krumpelbeck EF, Jegga AG, Ali AM, Guo H, Meetei AR, Andreassen PR, Kappes F, Vinnedge LM, Daniel JA, Scully R, Wiesmüller L, Wells SI.

Sci Rep. 2017 Mar 20;7:44662. doi: 10.1038/srep44662.


A Comparative Study of Sleep and Mood Between Young Elite Athletes and Age-Matched Controls.

Harris A, Gundersen H, Andreassen PM, Thun E, Bjorvatn B, Pallesen S.

J Phys Act Health. 2017 Jun;14(6):465-473. doi: 10.1123/jpah.2016-0513. Epub 2017 Mar 2.


The employers' perspective on how PhD training affects physicians' performance in the clinic.

Andreassen P, Wogensen L, Christensen MK.

Dan Med J. 2017 Feb;64(2). pii: A5332.


Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.

Alavattam KG, Kato Y, Sin HS, Maezawa S, Kowalski IJ, Zhang F, Pang Q, Andreassen PR, Namekawa SH.

Cell Rep. 2016 Oct 18;17(4):1141-1157. doi: 10.1016/j.celrep.2016.09.073.


Coordination of the recruitment of the FANCD2 and PALB2 Fanconi anemia proteins by an ubiquitin signaling network.

Bick G, Zhang F, Meetei AR, Andreassen PR.

Chromosoma. 2017 Jun;126(3):417-430. doi: 10.1007/s00412-016-0602-9. Epub 2016 Jun 8.


Complementation of hypersensitivity to DNA interstrand crosslinking agents demonstrates that XRCC2 is a Fanconi anaemia gene.

Park JY, Virts EL, Jankowska A, Wiek C, Othman M, Chakraborty SC, Vance GH, Alkuraya FS, Hanenberg H, Andreassen PR.

J Med Genet. 2016 Oct;53(10):672-680. doi: 10.1136/jmedgenet-2016-103847. Epub 2016 May 20.


Fancb deficiency impairs hematopoietic stem cell function.

Du W, Amarachintha S, Erden O, Wilson A, Meetei AR, Andreassen PR, Namekawa SH, Pang Q.

Sci Rep. 2015 Dec 11;5:18127. doi: 10.1038/srep18127.


The diverse impact of advance care planning: a long-term follow-up study on patients' and relatives' experiences.

Andreassen P, Neergaard MA, Brogaard T, Skorstengaard MH, Jensen AB.

BMJ Support Palliat Care. 2017 Sep;7(3):335-340. doi: 10.1136/bmjspcare-2015-000886. Epub 2015 Sep 30.


Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation.

Konstantinidis DG, Giger KM, Risinger M, Pushkaran S, Zhou P, Dexheimer P, Yerneni S, Andreassen P, Klingmüller U, Palis J, Zheng Y, Kalfa TA.

Blood. 2015 Sep 17;126(12):1473-82. doi: 10.1182/blood-2014-12-616169. Epub 2015 Jul 30.


FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.

Kato Y, Alavattam KG, Sin HS, Meetei AR, Pang Q, Andreassen PR, Namekawa SH.

Hum Mol Genet. 2015 Sep 15;24(18):5234-49. doi: 10.1093/hmg/ddv244. Epub 2015 Jun 29.


Talking about sensitive topics during the advance care planning discussion: A peek into the black box.

Andreassen P, Neergaard MA, Brogaard T, Skorstengaard MH, Jensen AB.

Palliat Support Care. 2015 Dec;13(6):1669-76. doi: 10.1017/S1478951515000577. Epub 2015 Jun 2.


Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress.

Zhang T, Wilson AF, Mahmood Ali A, Namekawa SH, Andreassen PR, Ruhikanta Meetei A, Pang Q.

Stem Cells. 2015 Jul;33(7):2320-30. doi: 10.1002/stem.2048. Epub 2015 May 25.


SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination.

Hasegawa K, Sin HS, Maezawa S, Broering TJ, Kartashov AV, Alavattam KG, Ichijima Y, Zhang F, Bacon WC, Greis KD, Andreassen PR, Barski A, Namekawa SH.

Dev Cell. 2015 Mar 9;32(5):574-88. doi: 10.1016/j.devcel.2015.01.014. Epub 2015 Feb 19.


Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers.

Lombardi AJ, Hoskins EE, Foglesong GD, Wikenheiser-Brokamp KA, Wiesmüller L, Hanenberg H, Andreassen PR, Jacobs AJ, Olson SB, Keeble WW, Hays LE, Wells SI.

Clin Cancer Res. 2015 Apr 15;21(8):1962-72. doi: 10.1158/1078-0432.CCR-14-2616. Epub 2015 Jan 21.


Natural LacI from E. coli yields faster response and higher level of expression than the LVA-tagged LacI.

Andreassen PR, Fredberg S, Horan M, Knudsen MH, Jacobsen K, Kjær A, Krogh TJ, Kronborg T, Mattsson NC, Schmidt SI, Wille H, Andersen A.

ACS Synth Biol. 2014 Dec 19;3(12):949-52. doi: 10.1021/sb500031h.


PALB2: the hub of a network of tumor suppressors involved in DNA damage responses.

Park JY, Zhang F, Andreassen PR.

Biochim Biophys Acta. 2014 Aug;1846(1):263-75. doi: 10.1016/j.bbcan.2014.06.003. Epub 2014 Jul 3. Review.


BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.

Broering TJ, Alavattam KG, Sadreyev RI, Ichijima Y, Kato Y, Hasegawa K, Camerini-Otero RD, Lee JT, Andreassen PR, Namekawa SH.

J Cell Biol. 2014 Jun 9;205(5):663-75. doi: 10.1083/jcb.201311050.


Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.

Park JY, Singh TR, Nassar N, Zhang F, Freund M, Hanenberg H, Meetei AR, Andreassen PR.

Oncogene. 2014 Oct 2;33(40):4803-12. doi: 10.1038/onc.2013.421. Epub 2013 Oct 21.


Hiding the plot: parents' moral dilemmas and strategies when helping their overweight children lose weight.

Andreassen P, Grøn L, Roessler KK.

Qual Health Res. 2013 Oct;23(10):1333-43. doi: 10.1177/1049732313505151. Epub 2013 Sep 9.


RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids.

Sin HS, Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH.

Genes Dev. 2012 Dec 15;26(24):2737-48. doi: 10.1101/gad.202713.112. Erratum in: Genes Dev. 2013 Jan 1;27(1):116.


Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents.

Duan W, Gao L, Zhao W, Leon M, Sadee W, Webb A, Resnick K, Wu X, Ramaswamy B, Cohn DE, Shapiro C, Andreassen PR, Otterson GA, Villalona-Calero MA.

Transl Res. 2013 Mar;161(3):156-64. doi: 10.1016/j.trsl.2012.09.003. Epub 2012 Oct 11.


MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination.

Zhang F, Bick G, Park JY, Andreassen PR.

J Cell Sci. 2012 Dec 15;125(Pt 24):6049-57. doi: 10.1242/jcs.111872. Epub 2012 Oct 4.


The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters.

Du W, Rani R, Sipple J, Schick J, Myers KC, Mehta P, Andreassen PR, Davies SM, Pang Q.

Blood. 2012 May 3;119(18):4142-51. doi: 10.1182/blood-2011-09-381970. Epub 2012 Mar 9.


Barrier-to-Autointegration Factor influences specific histone modifications.

Montes de Oca R, Andreassen PR, Wilson KL.

Nucleus. 2011 Nov-Dec;2(6):580-90. doi: 10.4161/nucl.2.6.17960. Epub 2011 Nov 1.


The human DEK oncogene regulates DNA damage response signaling and repair.

Kavanaugh GM, Wise-Draper TM, Morreale RJ, Morrison MA, Gole B, Schwemberger S, Tichy ED, Lu L, Babcock GF, Wells JM, Drissi R, Bissler JJ, Stambrook PJ, Andreassen PR, Wiesmüller L, Wells SI.

Nucleic Acids Res. 2011 Sep 1;39(17):7465-76. doi: 10.1093/nar/gkr454. Epub 2011 Jun 7.


MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells.

Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH.

Genes Dev. 2011 May 1;25(9):959-71. doi: 10.1101/gad.2030811.

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