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Items: 40


SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells.

Hossain MI, Marcus JM, Lee JH, Garcia PL, Gagné JP, Poirier GG, Falany CN, Andrabi SA.

Drug Metab Dispos. 2019 Sep;47(9):949-953. doi: 10.1124/dmd.119.088047. Epub 2019 Jul 2.


SIRT3 Regulation Under Cellular Stress: Making Sense of the Ups and Downs.

Marcus JM, Andrabi SA.

Front Neurosci. 2018 Nov 2;12:799. doi: 10.3389/fnins.2018.00799. eCollection 2018.


Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.

Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL.

Science. 2018 Nov 2;362(6414). pii: eaat8407. doi: 10.1126/science.aat8407.


The AAA + ATPase Thorase is neuroprotective against ischemic injury.

Zhang J, Yang J, Wang H, Sherbini O, Keuss MJ, Umanah GK, Pai EL, Chi Z, Paldanius KM, He W, Wang H, Andrabi SA, Dawson TM, Dawson VL.

J Cereb Blood Flow Metab. 2018 Apr 16:271678X18769770. doi: 10.1177/0271678X18769770. [Epub ahead of print]


Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel.

Umanah GKE, Pignatelli M, Yin X, Chen R, Crawford J, Neifert S, Scarffe L, Behensky AA, Guiberson N, Chang M, Ma E, Kim JW, Castro CC, Mao X, Chen L, Andrabi SA, Pletnikov MV, Pulver AE, Avramopoulos D, Bonci A, Valle D, Dawson TM, Dawson VL.

Sci Transl Med. 2017 Dec 13;9(420). pii: eaah4985. doi: 10.1126/scitranslmed.aah4985.


Generation and Characterization of SULT4A1 Mutant Mouse Models.

Garcia PL, Hossain MI, Andrabi SA, Falany CN.

Drug Metab Dispos. 2018 Jan;46(1):41-45. doi: 10.1124/dmd.117.077560. Epub 2017 Nov 6.


A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.

Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim B, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam TI, Jeong JS, Xie Z, Neifert S, Qian J, Andrabi SA, Blackshaw S, Zhu H, Song H, Ming GL, Dawson VL, Dawson TM.

Science. 2016 Oct 7;354(6308). pii: aad6872.


High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death.

Zhang J, Wang H, Sherbini O, Ling-Lin Pai E, Kang SU, Kwon JS, Yang J, He W, Wang H, Eacker SM, Chi Z, Mao X, Xu J, Jiang H, Andrabi SA, Dawson TM, Dawson VL.

eNeuro. 2016 Oct 24;3(5). pii: ENEURO.0185-16.2016. eCollection 2016 Sep-Oct.


Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.

Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM.

Science. 2016 Sep 30;353(6307). pii: aah3374.


Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons.

Jiang H, Kang SU, Zhang S, Karuppagounder S, Xu J, Lee YK, Kang BG, Lee Y, Zhang J, Pletnikova O, Troncoso JC, Pirooznia S, Andrabi SA, Dawson VL, Dawson TM.

eNeuro. 2016 Sep 2;3(4). pii: ENEURO.0183-16.2016. doi: 10.1523/ENEURO.0183-16.2016. eCollection 2016 Jul-Aug.


Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis.

Zhang J, Li X, Kwansa H, Kim YT, Yi L, Hong G, Andrabi SA, Dawson VL, Dawson TM, Koehler RC, Yang ZJ.

J Cereb Blood Flow Metab. 2017 Jun;37(6):1982-1993. doi: 10.1177/0271678X16658491. Epub 2016 Jan 1.


PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.

Samanta D, Park Y, Andrabi SA, Shelton LM, Gilkes DM, Semenza GL.

Cancer Res. 2016 Aug 1;76(15):4430-42. doi: 10.1158/0008-5472.CAN-16-0530. Epub 2016 Jun 8.


LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity.

Karuppagounder SS, Xiong Y, Lee Y, Lawless MC, Kim D, Nordquist E, Martin I, Ge P, Brahmachari S, Jhaldiyal A, Kumar M, Andrabi SA, Dawson TM, Dawson VL.

J Chem Neuroanat. 2016 Oct;76(Pt B):90-97. doi: 10.1016/j.jchemneu.2016.01.007. Epub 2016 Jan 22.


Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.

Stevens DA, Lee Y, Kang HC, Lee BD, Lee YI, Bower A, Jiang H, Kang SU, Andrabi SA, Dawson VL, Shin JH, Dawson TM.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11696-701. doi: 10.1073/pnas.1500624112. Epub 2015 Aug 31.


Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.

Kageyama Y, Hoshijima M, Seo K, Bedja D, Sysa-Shah P, Andrabi SA, Chen W, Höke A, Dawson VL, Dawson TM, Gabrielson K, Kass DA, Iijima M, Sesaki H.

EMBO J. 2014 Dec 1;33(23):2798-813. doi: 10.15252/embj.201488658. Epub 2014 Oct 27.


Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis.

Andrabi SA, Umanah GK, Chang C, Stevens DA, Karuppagounder SS, Gagné JP, Poirier GG, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10209-14. doi: 10.1073/pnas.1405158111. Epub 2014 Jul 1.


Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins.

Chen YC, Umanah GK, Dephoure N, Andrabi SA, Gygi SP, Dawson TM, Dawson VL, Rutter J.

EMBO J. 2014 Jul 17;33(14):1548-64. doi: 10.15252/embj.201487943. Epub 2014 May 19.


Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.

Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, Stankowski J, Kim MS, Zhong J, Kumar M, Andrabi SA, Xiong Y, Dickson DW, Wszolek ZK, Pandey A, Dawson TM, Dawson VL.

Cell. 2014 Apr 10;157(2):472-485. doi: 10.1016/j.cell.2014.01.064.


Advancement of scientific research on Helicobacter pylori in humans: where do we stand?

Andrabi SA, Shamila H, Masooda S.

East Afr J Public Health. 2012 Sep;9(3):118-22. Review.


Brucellosis masquerading as spondylodiscitis with multiple intervertebral disc prolapse.

Andrabi SA, Hamid S, Aijaz S.

J Glob Infect Dis. 2012 Jul;4(3):184-5. doi: 10.4103/0974-777X.100585. No abstract available.


Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.

Kang HC, Lee YI, Shin JH, Andrabi SA, Chi Z, Gagné JP, Lee Y, Ko HS, Lee BD, Poirier GG, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14103-8. doi: 10.1073/pnas.1108799108. Epub 2011 Aug 8.


Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death.

Andrabi SA, Kang HC, Haince JF, Lee YI, Zhang J, Chi Z, West AB, Koehler RC, Poirier GG, Dawson TM, Dawson VL.

Nat Med. 2011 Jun;17(6):692-9. doi: 10.1038/nm.2387. Epub 2011 May 22.


Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos).

Wang Y, Kim NS, Haince JF, Kang HC, David KK, Andrabi SA, Poirier GG, Dawson VL, Dawson TM.

Sci Signal. 2011 Apr 5;4(167):ra20. doi: 10.1126/scisignal.2000902.


The bubbling spleen - a cause of pneumoperitoneum.

Green WJ, Andrabi SA, De Nunzio MC, Lingam K.

Surgeon. 2011 Apr;9(2):112-4. doi: 10.1016/j.surge.2010.10.007. Epub 2010 Dec 9. No abstract available.


Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.

Thomas B, Mandir AS, West N, Liu Y, Andrabi SA, Stirling W, Dawson VL, Dawson TM, Lee MK.

PLoS One. 2011 Jan 31;6(1):e16706. doi: 10.1371/journal.pone.0016706. Erratum in: PLoS One. 2012;7(3). doi: 10.1371/annotation/f743434e-a6bf-4c6c-a836-ae5af66035a4.


Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia.

Li X, Klaus JA, Zhang J, Xu Z, Kibler KK, Andrabi SA, Rao K, Yang ZJ, Dawson TM, Dawson VL, Koehler RC.

J Neurochem. 2010 May;113(4):1012-22. doi: 10.1111/j.1471-4159.2010.06667.x. Epub 2010 Mar 4.


Parthanatos, a messenger of death.

David KK, Andrabi SA, Dawson TM, Dawson VL.

Front Biosci (Landmark Ed). 2009 Jan 1;14:1116-28. Review.


Mitochondrial and nuclear cross talk in cell death: parthanatos.

Andrabi SA, Dawson TM, Dawson VL.

Ann N Y Acad Sci. 2008 Dec;1147:233-41. doi: 10.1196/annals.1427.014. Review.


An iatrogenic complication of closed tube thoracostomy for penetrating chest trauma.

Andrabi SA, Andrabi SI, Mansha M, Ahmed M.

N Z Med J. 2007 Oct 26;120(1264):U2784.


Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain.

Poitras MF, Koh DW, Yu SW, Andrabi SA, Mandir AS, Poirier GG, Dawson VL, Dawson TM.

Neuroscience. 2007 Aug 10;148(1):198-211. Epub 2007 Jul 19.


Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.

West AB, Moore DJ, Choi C, Andrabi SA, Li X, Dikeman D, Biskup S, Zhang Z, Lim KL, Dawson VL, Dawson TM.

Hum Mol Genet. 2007 Jan 15;16(2):223-32. Epub 2007 Jan 2.


Localization of LRRK2 to membranous and vesicular structures in mammalian brain.

Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, Dawson VL.

Ann Neurol. 2006 Nov;60(5):557-69.


Poly(ADP-ribose) (PAR) polymer is a death signal.

Andrabi SA, Kim NS, Yu SW, Wang H, Koh DW, Sasaki M, Klaus JA, Otsuka T, Zhang Z, Koehler RC, Hurn PD, Poirier GG, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18308-13. Epub 2006 Nov 20.


Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death.

Yu SW, Andrabi SA, Wang H, Kim NS, Poirier GG, Dawson TM, Dawson VL.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18314-9. Epub 2006 Nov 20.


Influence of duration of focal cerebral ischemia and neuronal nitric oxide synthase on translocation of apoptosis-inducing factor to the nucleus.

Li X, Nemoto M, Xu Z, Yu SW, Shimoji M, Andrabi SA, Haince JF, Poirier GG, Dawson TM, Dawson VL, Koehler RC.

Neuroscience. 2007 Jan 5;144(1):56-65. Epub 2006 Oct 13.


Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.

von Coelln R, Thomas B, Andrabi SA, Lim KL, Savitt JM, Saffary R, Stirling W, Bruno K, Hess EJ, Lee MK, Dawson VL, Dawson TM.

J Neurosci. 2006 Apr 5;26(14):3685-96.


Blood-brain barrier permeability to the neuroprotectant oxyresveratrol.

Breuer C, Wolf G, Andrabi SA, Lorenz P, Horn TF.

Neurosci Lett. 2006 Jan 30;393(2-3):113-8. Epub 2005 Oct 26.


Nitric oxide applications prior and simultaneous to potentially excitotoxic NMDA-evoked calcium transients: cell death or survival.

Schröter A, Andrabi SA, Wolf G, Horn TF.

Brain Res. 2005 Oct 26;1060(1-2):1-15. Epub 2005 Sep 30.


Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia.

Andrabi SA, Spina MG, Lorenz P, Ebmeyer U, Wolf G, Horn TF.

Brain Res. 2004 Aug 13;1017(1-2):98-107.


Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin.

Andrabi SA, Sayeed I, Siemen D, Wolf G, Horn TF.

FASEB J. 2004 May;18(7):869-71. Epub 2004 Mar 19.


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