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Items: 25


Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.

Wagner T, André-Leroux G, Hindie V, Barilone N, Lisa MN, Hoos S, Raynal B, Vulliez-Le Normand B, O'Hare HM, Bellinzoni M, Alzari PM.

Sci Signal. 2019 May 7;12(580). pii: eaav9504. doi: 10.1126/scisignal.aav9504.


Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor.

Lisa MN, Cvirkaite-Krupovic V, Richet E, André-Leroux G, Alzari PM, Haouz A, Danot O.

Nucleic Acids Res. 2019 Apr 23;47(7):3795-3810. doi: 10.1093/nar/gkz112.


Altered spinogenesis in iPSC-derived cortical neurons from patients with autism carrying de novo SHANK3 mutations.

Gouder L, Vitrac A, Goubran-Botros H, Danckaert A, Tinevez JY, André-Leroux G, Atanasova E, Lemière N, Biton A, Leblond CS, Poulet A, Boland A, Deleuze JF, Benchoua A, Delorme R, Bourgeron T, Cloëz-Tayarani I.

Sci Rep. 2019 Jan 14;9(1):94. doi: 10.1038/s41598-018-36993-x.


OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity.

Segovia D, Haouz A, Porley D, Olivero N, Martínez M, Mariadassou M, Berois M, André-Leroux G, Villarino A.

J Mol Biol. 2017 Sep 1;429(18):2816-2824. doi: 10.1016/j.jmb.2017.07.017. Epub 2017 Jul 25.


Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis.

Le NH, Molle V, Eynard N, Miras M, Stella A, Bardou F, Galandrin S, Guillet V, André-Leroux G, Bellinzoni M, Alzari P, Mourey L, Burlet-Schiltz O, Daffé M, Marrakchi H.

J Biol Chem. 2016 Oct 21;291(43):22793-22805. Epub 2016 Sep 2.


CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders.

Mercati O, Huguet G, Danckaert A, André-Leroux G, Maruani A, Bellinzoni M, Rolland T, Gouder L, Mathieu A, Buratti J, Amsellem F, Benabou M, Van-Gils J, Beggiato A, Konyukh M, Bourgeois JP, Gazzellone MJ, Yuen RK, Walker S, Delépine M, Boland A, Régnault B, Francois M, Van Den Abbeele T, Mosca-Boidron AL, Faivre L, Shimoda Y, Watanabe K, Bonneau D, Rastam M, Leboyer M, Scherer SW, Gillberg C, Delorme R, Cloëz-Tayarani I, Bourgeron T.

Mol Psychiatry. 2017 Apr;22(4):625-633. doi: 10.1038/mp.2016.61. Epub 2016 May 10.


Characterization of a double-CRD-mutated Gal-8 recombinant protein that retains co-stimulatory activity on antigen-specific T-cell response.

Schroeder MN, Tribulatti MV, Carabelli J, André-Leroux G, Caramelo JJ, Cattaneo V, Campetella O.

Biochem J. 2016 Apr 1;473(7):887-98. doi: 10.1042/BJ20150409. Epub 2016 Jan 21.


The pro-inflammatory cytokine 14-3-3ε is a ligand of CD13 in cartilage.

Nefla M, Sudre L, Denat G, Priam S, Andre-Leroux G, Berenbaum F, Jacques C.

J Cell Sci. 2015 Sep 1;128(17):3250-62. doi: 10.1242/jcs.169573. Epub 2015 Jul 24.


Heme interplay between IlsA and IsdC: Two structurally different surface proteins from Bacillus cereus.

Abi-Khalil E, Segond D, Terpstra T, André-Leroux G, Kallassy M, Lereclus D, Bou-Abdallah F, Nielsen-Leroux C.

Biochim Biophys Acta. 2015 Sep;1850(9):1930-41. doi: 10.1016/j.bbagen.2015.06.006. Epub 2015 Jun 18.


Investigating the in Vitro Thermal Stability and Conformational Flexibility of Estrogen Receptors as Potential Key Factors of Their in Vivo Activity.

Le Grand A, André-Leroux G, Marteil G, Duval H, Sire O, Le Tilly V.

Biochemistry. 2015 Jun 30;54(25):3890-900. doi: 10.1021/acs.biochem.5b00026. Epub 2015 Jun 18.


Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis.

Lisa MN, Gil M, André-Leroux G, Barilone N, Durán R, Biondi RM, Alzari PM.

Structure. 2015 Jun 2;23(6):1039-48. doi: 10.1016/j.str.2015.04.001. Epub 2015 May 7.


Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.

Bellinzoni M, Haouz A, Miras I, Magnet S, André-Leroux G, Mukherjee R, Shepard W, Cole ST, Alzari PM.

J Struct Biol. 2014 Nov;188(2):156-64. doi: 10.1016/j.jsb.2014.09.003. Epub 2014 Sep 24.


Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity.

Lucas-Hourani M, Dauzonne D, Jorda P, Cousin G, Lupan A, Helynck O, Caignard G, Janvier G, André-Leroux G, Khiar S, Escriou N, Desprès P, Jacob Y, Munier-Lehmann H, Tangy F, Vidalain PO.

PLoS Pathog. 2013;9(10):e1003678. doi: 10.1371/journal.ppat.1003678. Epub 2013 Oct 3.


Contactin 4, -5 and -6 differentially regulate neuritogenesis while they display identical PTPRG binding sites.

Mercati O, Danckaert A, André-Leroux G, Bellinzoni M, Gouder L, Watanabe K, Shimoda Y, Grailhe R, De Chaumont F, Bourgeron T, Cloëz-Tayarani I.

Biol Open. 2013 Mar 15;2(3):324-34. doi: 10.1242/bio.20133343. Epub 2013 Jan 10.


PlcRa, a new quorum-sensing regulator from Bacillus cereus, plays a role in oxidative stress responses and cysteine metabolism in stationary phase.

Huillet E, Tempelaars MH, André-Leroux G, Wanapaisan P, Bridoux L, Makhzami S, Panbangred W, Martin-Verstraete I, Abee T, Lereclus D.

PLoS One. 2012;7(12):e51047. doi: 10.1371/journal.pone.0051047. Epub 2012 Dec 11.


Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.

Piton J, Petrella S, Delarue M, André-Leroux G, Jarlier V, Aubry A, Mayer C.

PLoS One. 2010 Aug 18;5(8):e12245. doi: 10.1371/journal.pone.0012245.


Molecular determinants of substrate and inhibitor specificities of the Penicillium griseofulvum family 11 xylanases.

Cervera Tison M, André-Leroux G, Lafond M, Georis J, Juge N, Berrin JG.

Biochim Biophys Acta. 2009 Mar;1794(3):438-45. doi: 10.1016/j.bbapap.2008.11.024. Epub 2008 Dec 13.


The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling.

England P, Wehenkel A, Martins S, Hoos S, André-Leroux G, Villarino A, Alzari PM.

FEBS Lett. 2009 Jan 22;583(2):301-7. doi: 10.1016/j.febslet.2008.12.036. Epub 2008 Dec 27.


Endopolygalacturonases reveal molecular features for processivity pattern and tolerance towards acetylated pectin.

André-Leroux G, Tessier D, Bonnin E.

Biochim Biophys Acta. 2009 Jan;1794(1):5-13. doi: 10.1016/j.bbapap.2008.09.004. Epub 2008 Sep 25.


Structure-based mutagenesis of Penicillium griseofulvum xylanase using computational design.

André-Leroux G, Berrin JG, Georis J, Arnaut F, Juge N.

Proteins. 2008 Sep;72(4):1298-307. doi: 10.1002/prot.22029.


Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1.

Ahmed F, André-Leroux G, Haouz A, Boutonnier A, Delepierre M, Qadri F, Nato F, Fournier JM, Alzari PM.

Proteins. 2008 Jan 1;70(1):284-8. No abstract available.


Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential.

Wehenkel A, Bellinzoni M, Graña M, Duran R, Villarino A, Fernandez P, Andre-Leroux G, England P, Takiff H, Cerveñansky C, Cole ST, Alzari PM.

Biochim Biophys Acta. 2008 Jan;1784(1):193-202. Epub 2007 Aug 14. Review.


Towards the molecular understanding of glycogen elongation by amylosucrase.

Albenne C, Skov LK, Tran V, Gajhede M, Monsan P, Remaud-Siméon M, André-Leroux G.

Proteins. 2007 Jan 1;66(1):118-26.


Sugar beet (Beta vulgaris) pectins are covalently cross-linked through diferulic bridges in the cell wall.

Ralet MC, André-Leroux G, Quéméner B, Thibault JF.

Phytochemistry. 2005 Dec;66(24):2800-14. Epub 2005 Nov 17.


Action pattern of Fusarium moniliforme endopolygalacturonase towards pectin fragments: Comprehension and prediction.

André-Leroux G, Tessier D, Bonnin E.

Biochim Biophys Acta. 2005 May 20;1749(1):53-64.


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