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Items: 37

1.

Different phenotypes and factors associated with atopic dermatitis in the young adult Singaporean Chinese population: A cross-sectional study.

Matta SA, Blanchet-Rethore S, Sio YY, Suri BK, Andiappan AK, Anantharaman R, Piketty C, Bourdes V, Chew FT.

World Allergy Organ J. 2019 Jan 26;12(1):100008. doi: 10.1016/j.waojou.2018.11.006. eCollection 2019.

2.

Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances.

Timmers PR, Mounier N, Lall K, Fischer K, Ning Z, Feng X, Bretherick AD, Clark DW; eQTLGen Consortium, Agbessi M, Ahsan H, Alves I, Andiappan A, Awadalla P, Battle A, Bonder MJ, Boomsma D, Christiansen M, Claringbould A, Deelen P, van Dongen J, Esko T, Favé M, Franke L, Frayling T, Gharib SA, Gibson G, Hemani G, Jansen R, Kalnapenkis A, Kasela S, Kettunen J, Kim Y, Kirsten H, Kovacs P, Krohn K, Kronberg-Guzman J, Kukushkina V, Kutalik Z, Kähönen M, Lee B, Lehtimäki T, Loeffler M, Marigorta U, Metspalu A, van Meurs J, Milani L, Müller-Nurasyid M, Nauck M, Nivard M, Penninx B, Perola M, Pervjakova N, Pierce B, Powell J, Prokisch H, Psaty BM, Raitakari O, Ring S, Ripatti S, Rotzschke O, Ruëger S, Saha A, Scholz M, Schramm K, Seppälä I, Stumvoll M, Sullivan P, Teumer A, Thiery J, Tong L, Tönjes A, Verlouw J, Visscher PM, Võsa U, Völker U, Yaghootkar H, Yang J, Zeng B, Zhang F, Agbessi M, Ahsan H, Alves I, Andiappan A, Awadalla P, Battle A, Bonder MJ, Boomsma D, Christiansen M, Claringbould A, Deelen P, van Dongen J, Esko T, Favé M, Franke L, Frayling T, Gharib SA, Gibson G, Hemani G, Jansen R, Kalnapenkis A, Kasela S, Kettunen J, Kim Y, Kirsten H, Kovacs P, Krohn K, Kronberg-Guzman J, Kukushkina V, Kutalik Z, Kähönen M, Lee B, Lehtimäki T, Loeffler M, Marigorta U, Metspalu A, van Meurs J, Milani L, Müller-Nurasyid M, Nauck M, Nivard M, Penninx B, Perola M, Pervjakova N, Pierce B, Powell J, Prokisch H, Psaty BM, Raitakari O, Ring S, Ripatti S, Rotzschke O, Ruëger S, Saha A, Scholz M, Schramm K, Seppälä I, Stumvoll M, Sullivan P, Teumer A, Thiery J, Tong L, Tönjes A, Verlouw J, Visscher PM, Võsa U, Völker U, Yaghootkar H, Yang J, Zeng B, Zhang F, Shen X, Esko T, Kutalik Z, Wilson JF, Joshi PK.

Elife. 2019 Jan 15;8. pii: e39856. doi: 10.7554/eLife.39856.

3.

Biomarker Signatures Predicting 10-Year All-Cause and Disease-Specific Mortality.

Lu Y, Monaco G, Camous X, Andiappan AK, Rotzschke O, Ng TP, Larbi A.

J Gerontol A Biol Sci Med Sci. 2019 Mar 14;74(4):469-479. doi: 10.1093/gerona/gly138.

PMID:
30084875
4.

Role of IL-13Rα2 in modulating IL-13-induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa.

Liu J, Li YY, Andiappan AK, Yan Y, Tan KS, Ong HH, Thong KT, Ong YK, Yu FG, Low HB, Zhang YL, Shi L, Wang DY.

Allergy. 2018 Aug;73(8):1673-1685. doi: 10.1111/all.13424. Epub 2018 Mar 27.

PMID:
29405354
5.

Genome-Wide Analysis of Protein-Coding Variants in Leprosy.

Liu H, Wang Z, Li Y, Yu G, Fu X, Wang C, Liu W, Yu Y, Bao F, Irwanto A, Liu J, Chu T, Andiappan AK, Maurer-Stroh S, Limviphuvadh V, Wang H, Mi Z, Sun Y, Sun L, Wang L, Wang C, You J, Li J, Foo JN, Liany H, Meah WY, Niu G, Yue Z, Zhao Q, Wang N, Yu M, Yu W, Cheng X, Khor CC, Sim KS, Aung T, Wang N, Wang D, Shi L, Ning Y, Zheng Z, Yang R, Li J, Yang J, Yan L, Shen J, Zhang G, Chen S, Liu J, Zhang F.

J Invest Dermatol. 2017 Dec;137(12):2544-2551. doi: 10.1016/j.jid.2017.08.004. Epub 2017 Aug 24.

6.

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.

Farzan N, Vijverberg SJ, Andiappan AK, Arianto L, Berce V, Blanca-López N, Bisgaard H, Bønnelykke K, Burchard EG, Campo P, Canino G, Carleton B, Celedón JC, Chew FT, Chiang WC, Cloutier MM, Daley D, Den Dekker HT, Dijk FN, Duijts L, Flores C, Forno E, Hawcutt DB, Hernandez-Pacheco N, de Jongste JC, Kabesch M, Koppelman GH, Manolopoulos VG, Melén E, Mukhopadhyay S, Nilsson S, Palmer CN, Pino-Yanes M, Pirmohamed M, Potočnik U, Raaijmakers JA, Repnik K, Schieck M, Sio YY, Smyth RL, Szalai C, Tantisira KG, Turner S, van der Schee MP, Verhamme KM, Maitland-van der Zee AH.

Pharmacogenomics. 2017 Jul;18(10):931-943. doi: 10.2217/pgs-2017-0035. Epub 2017 Jun 22.

7.

Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease.

Obeidat M, Nie Y, Chen V, Shannon CP, Andiappan AK, Lee B, Rotzschke O, Castaldi PJ, Hersh CP, Fishbane N, Ng RT, McManus B, Miller BE, Rennard S, Paré PD, Sin DD.

Respir Res. 2017 Apr 24;18(1):72. doi: 10.1186/s12931-017-0558-1.

8.

A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus.

Kumar D, Puan KJ, Andiappan AK, Lee B, Westerlaken GH, Haase D, Melchiotti R, Li Z, Yusof N, Lum J, Koh G, Foo S, Yeong J, Alves AC, Pekkanen J, Sun LD, Irwanto A, Fairfax BP, Naranbhai V, Common JE, Tang M, Chuang CK, Jarvelin MR, Knight JC, Zhang X, Chew FT, Prabhakar S, Jianjun L, Wang Y, Zolezzi F, Poidinger M, Lane EB, Meyaard L, Rötzschke O.

Genome Med. 2017 Feb 20;9(1):18. doi: 10.1186/s13073-017-0404-6.

9.

Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice.

Lee WW, Teo TH, Lum FM, Andiappan AK, Amrun SN, Rénia L, Rötzschke O, Ng LF.

Sci Rep. 2016 Nov 25;6:37603. doi: 10.1038/srep37603.

10.

Fine-mapping analysis revealed complex pleiotropic effect and tissue-specific regulatory mechanism of TNFSF15 in primary biliary cholangitis, Crohn's disease and leprosy.

Sun Y, Irwanto A, Toyo-Oka L, Hong M, Liu H, Andiappan AK, Choi H, Hitomi Y, Yu G, Yu Y, Bao F, Wang C, Fu X, Yue Z, Wang H, Zhang H, Kawashima M, Kojima K, Nagasaki M, Nakamura M, Yang SK, Ye BD, Denise Y, Rotzschke O, Song K, Tokunaga K, Zhang F, Liu J.

Sci Rep. 2016 Aug 10;6:31429. doi: 10.1038/srep31429.

11.

Neuropeptide Y associated with asthma in young adults.

Lu Y, Andiappan AK, Lee B, Ho R, Lim TK, Kuan WS, Goh DY, Mahadevan M, Sim TB, Wang Y, Van Bever HP, Rotzschke O, Larbi A, Ng TP.

Neuropeptides. 2016 Oct;59:117-121. doi: 10.1016/j.npep.2016.07.003. Epub 2016 Jul 20.

PMID:
27469060
12.

Systematic characterization of basophil anergy.

Puan KJ, Andiappan AK, Lee B, Kumar D, Lai TS, Yeo G, Bercin D, Starke M, Haase D, Lum J, Chew FT, Connolly J, Wong SC, Zolezzi F, Poidinger M, Wang Y, Rötzschke O.

Allergy. 2017 Mar;72(3):373-384. doi: 10.1111/all.12952. Epub 2016 Aug 8.

PMID:
27271846
13.

Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis.

Andiappan AK, Sio YY, Lee B, Suri BK, Matta SA, Lum J, Foo S, Koh G, Liu J, Zolezzi F, Poidinger M, Wang de Y, Rotzschke O, Chew FT.

J Allergy Clin Immunol. 2016 Mar;137(3):758-66.e3. doi: 10.1016/j.jaci.2015.08.038. Epub 2015 Oct 23.

PMID:
26483175
14.

Genome-wide analysis of the genetic regulation of gene expression in human neutrophils.

Andiappan AK, Melchiotti R, Poh TY, Nah M, Puan KJ, Vigano E, Haase D, Yusof N, San Luis B, Lum J, Kumar D, Foo S, Zhuang L, Vasudev A, Irwanto A, Lee B, Nardin A, Liu H, Zhang F, Connolly J, Liu J, Mortellaro A, Wang Y, Poidinger M, Larbi A, Zolezzi F, Rotzschke O.

Nat Commun. 2015 Aug 10;6:7971. doi: 10.1038/ncomms8971.

15.

Health Promotion Board-Ministry of Health Clinical Practice Guidelines: Falls Prevention among Older Adults Living in the Community.

Shyamala T, Wong SF, Andiappan A, Au Eong KG, Bakshi AB, Boey D, Chong TW, Eng HP, Ismail NH, Lau TC, Lim WY, Lim HW, Seong L, Wong WC, Yap KZ, Yudah S.

Singapore Med J. 2015 May;56(5):298-300; quiz 301. doi: 10.11622/smedj.2015073.

16.

Identification of new susceptibility loci for IgA nephropathy in Han Chinese.

Li M, Foo JN, Wang JQ, Low HQ, Tang XQ, Toh KY, Yin PR, Khor CC, Goh YF, Irwan ID, Xu RC, Andiappan AK, Bei JX, Rotzschke O, Chen MH, Cheng CY, Sun LD, Jiang GR, Wong TY, Lin HL, Aung T, Liao YH, Saw SM, Ye K, Ebstein RP, Chen QK, Shi W, Chew SH, Chen J, Zhang FR, Li SP, Xu G, Shyong Tai E, Wang L, Chen N, Zhang XJ, Zeng YX, Zhang H, Liu ZH, Yu XQ, Liu JJ.

Nat Commun. 2015 Jun 1;6:7270. doi: 10.1038/ncomms8270.

17.

Cell Specific eQTL Analysis without Sorting Cells.

Westra HJ, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, Li Y, Fu J, Karjalainen J, Platteel M, Visschedijk M, Weersma RK, Kasela S, Milani L, Tserel L, Peterson P, Reinmaa E, Hofman A, Uitterlinden AG, Rivadeneira F, Homuth G, Petersmann A, Lorbeer R, Prokisch H, Meitinger T, Herder C, Roden M, Grallert H, Ripatti S, Perola M, Wood AR, Melzer D, Ferrucci L, Singleton AB, Hernandez DG, Knight JC, Melchiotti R, Lee B, Poidinger M, Zolezzi F, Larbi A, Wang de Y, van den Berg LH, Veldink JH, Rotzschke O, Makino S, Salomaa V, Strauch K, Völker U, van Meurs JB, Metspalu A, Wijmenga C, Jansen RC, Franke L.

PLoS Genet. 2015 May 8;11(5):e1005223. doi: 10.1371/journal.pgen.1005223. eCollection 2015 May.

18.

Evaluation of the applicability of the Immuno-solid-phase allergen chip (ISAC) assay in atopic patients in Singapore.

Santosa A, Andiappan AK, Rotzschke O, Wong HC, Chang A, Bigliardi-Qi M, Wang DY, Bigliardi PL.

Clin Transl Allergy. 2015 Feb 27;5:9. doi: 10.1186/s13601-015-0053-z. eCollection 2015.

19.

A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis.

Jin P, Andiappan AK, Quek JM, Lee B, Au B, Sio YY, Irwanto A, Schurmann C, Grabe HJ, Suri BK, Matta SA, Westra HJ, Franke L, Esko T, Sun L, Zhang X, Liu H, Zhang F, Larbi A, Xu X, Poidinger M, Liu J, Chew FT, Rotzschke O, Shi L, Wang de Y.

J Allergy Clin Immunol. 2015 Jun;135(6):1486-93.e8. doi: 10.1016/j.jaci.2014.12.1870. Epub 2015 Jan 30.

PMID:
25649076
20.

Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.

Liu H, Irwanto A, Fu X, Yu G, Yu Y, Sun Y, Wang C, Wang Z, Okada Y, Low H, Li Y, Liany H, Chen M, Bao F, Li J, You J, Zhang Q, Liu J, Chu T, Andiappan AK, Wang N, Niu G, Liu D, Yu X, Zhang L, Tian H, Zhou G, Rotzschke O, Chen S, Zhang X, Liu J, Zhang F.

Nat Genet. 2015 Mar;47(3):267-71. doi: 10.1038/ng.3212. Epub 2015 Feb 2.

PMID:
25642632
21.

Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response.

Her Z, Teng TS, Tan JJ, Teo TH, Kam YW, Lum FM, Lee WW, Gabriel C, Melchiotti R, Andiappan AK, Lulla V, Lulla A, Win MK, Chow A, Biswas SK, Leo YS, Lecuit M, Merits A, Rénia L, Ng LF.

EMBO Mol Med. 2015 Jan;7(1):24-41. doi: 10.15252/emmm.201404459.

22.

Genetic variants of inducible costimulator are associated with allergic asthma susceptibility.

Andiappan AK, Narayanan S, Myers RA, Lee B, Nieuwenhuis MA, Nardin A, Park CS, Shin HD, Kim JH, Westra HJ, Franke L, Esko T, Metspalu A, Teo YY, Saw SM, Khor CC, Liu J, Koppelman GH, Postma DS, Poidinger M, Connolly JE, Wang de Y, Rotzschke O, Curotto de Lafaille MA, Chew FT.

J Allergy Clin Immunol. 2015 Feb;135(2):556-8. doi: 10.1016/j.jaci.2014.06.028. Epub 2014 Aug 7. No abstract available.

PMID:
25109803
23.

γ/δ T cell subsets in human aging using the classical α/β T cell model.

Vasudev A, Ying CT, Ayyadhury S, Puan KJ, Andiappan AK, Nyunt MS, Shadan NB, Mustafa S, Low I, Rotzschke O, Fulop T, Ng TP, Larbi A.

J Leukoc Biol. 2014 Oct;96(4):647-55. doi: 10.1189/jlb.5A1213-650RR. Epub 2014 Jul 7.

PMID:
25001861
24.

Genetic analysis of an allergic rhinitis cohort reveals an intercellular epistasis between FAM134B and CD39.

Melchiotti R, Puan KJ, Andiappan AK, Poh TY, Starke M, Zhuang L, Petsch K, Lai TS, Chew FT, Larbi A, Wang de Y, Poidinger M, Rotzschke O.

BMC Med Genet. 2014 Jun 27;15:73. doi: 10.1186/1471-2350-15-73.

25.

A comprehensive association analysis confirms ZMIZ1 to be a susceptibility gene for vitiligo in Chinese population.

Sun Y, Zuo X, Zheng X, Zhou F, Liang B, Liu H, Chang R, Gao J, Sheng Y, Cui H, Wang W, Andiappan AK, Rotzschke O, Yang S, Sun L, Zhang F, Zhang X, Ren Y, Liu J.

J Med Genet. 2014 May;51(5):345-53. doi: 10.1136/jmedgenet-2013-102233. Epub 2014 Mar 25.

PMID:
24667117
26.

Allergic airway diseases in a tropical urban environment are driven by dominant mono-specific sensitization against house dust mites.

Andiappan AK, Puan KJ, Lee B, Nardin A, Poidinger M, Connolly J, Chew FT, Wang DY, Rotzschke O.

Allergy. 2014 Apr;69(4):501-9. doi: 10.1111/all.12364. Epub 2014 Jan 24.

27.

Association of interleukin-13 SNP rs20541 (Arg>Gln) to allergic rhinitis in an Asian population of ethnic Chinese in Singapore.

Andiappan AK, Rotzschke O, Wang de Y, Chew FT.

Gene. 2013 Oct 25;529(2):357-8. doi: 10.1016/j.gene.2013.08.014. Epub 2013 Aug 15.

PMID:
23954258
28.

Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.

Andiappan AK, Nilsson D, Halldén C, Yun WD, Säll T, Cardell LO, Tim CF.

BMC Med Genet. 2013 May 10;14:51. doi: 10.1186/1471-2350-14-51.

29.

Poor reproducibility of allergic rhinitis SNP associations.

Nilsson D, Andiappan AK, Halldén C, Tim CF, Säll T, Wang de Y, Cardell LO.

PLoS One. 2013;8(1):e53975. doi: 10.1371/journal.pone.0053975. Epub 2013 Jan 30.

30.

Replication of genome-wide association study loci for allergic rhinitis and house dust mite sensitization in an Asian population of ethnic Chinese in Singapore.

Andiappan AK, Wang de Y, Anantharaman R, Suri BK, Lee BT, Rotzschke O, Liu J, Chew FT.

J Allergy Clin Immunol. 2013 May;131(5):1431-3.e8. doi: 10.1016/j.jaci.2012.11.001. Epub 2012 Dec 8. No abstract available.

PMID:
23228246
31.

Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study.

Nilsson D, Andiappan AK, Halldén C, De Yun W, Säll T, Tim CF, Cardell LO.

BMC Med Genet. 2012 Aug 2;13:66.

32.

Validation of GWAS loci for atopic dermatitis in a Singapore Chinese population.

Andiappan AK, Foo JN, Choy MW, Chen H, Common JE, Tang MB, van Bever HP, Giam YC, Suri BK, Ramani A, Nilkanth PP, Lane EB, Wang de Y, Chew FT, Liu J.

J Invest Dermatol. 2012 May;132(5):1505-7. doi: 10.1038/jid.2011.471. Epub 2012 Feb 9. No abstract available.

33.

Genome-wide association study identifies PERLD1 as asthma candidate gene.

Anantharaman R, Andiappan AK, Nilkanth PP, Suri BK, Wang de Y, Chew FT.

BMC Med Genet. 2011 Dec 21;12:170. doi: 10.1186/1471-2350-12-170.

34.

Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore.

Andiappan AK, Parate PN, Anantharaman R, Suri BK, Wang de Y, Chew FT.

Cytokine. 2011 Nov;56(2):218-23. doi: 10.1016/j.cyto.2011.05.008. Epub 2011 Jun 30.

PMID:
21723144
35.

Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population.

Andiappan AK, Wang de Y, Anantharaman R, Parate PN, Suri BK, Low HQ, Li Y, Zhao W, Castagnoli P, Liu J, Chew FT.

PLoS One. 2011;6(5):e19719. doi: 10.1371/journal.pone.0019719. Epub 2011 May 20.

36.

Variation in Uteroglobin-Related Protein 1 (UGRP1) gene is associated with allergic rhinitis in Singapore Chinese.

Andiappan AK, Yeo WS, Parate PN, Anantharaman R, Suri BK, Wang de Y, Chew FT.

BMC Med Genet. 2011 Mar 16;12:39. doi: 10.1186/1471-2350-12-39.

37.

Evaluating the transferability of Hapmap SNPs to a Singapore Chinese population.

Andiappan AK, Anantharaman R, Nilkanth PP, Wang de Y, Chew FT.

BMC Genet. 2010 May 7;11:36. doi: 10.1186/1471-2156-11-36.

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