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Characterization of an Uncinocarpus reesii-expressed recombinant tube precipitin antigen of Coccidioides posadasii for serodiagnosis.

Yu JJ, Holbrook E, Liao YR, Zarnowski R, Andes DR, Wheat LJ, Malo J, Hung CY.

PLoS One. 2019 Aug 14;14(8):e0221228. doi: 10.1371/journal.pone.0221228. eCollection 2019.


The Candida albicans biofilm gene circuit modulated at the chromatin level by a recent molecular histone innovation.

Rai LS, Singha R, Sanchez H, Chakraborty T, Chand B, Bachellier-Bassi S, Chowdhury S, d'Enfert C, Andes DR, Sanyal K.

PLoS Biol. 2019 Aug 9;17(8):e3000422. doi: 10.1371/journal.pbio.3000422. eCollection 2019 Aug.


In vivo Pharmacodynamic Target Determination for Delafloxacin against Klebsiella pneumoniae and Pseudomonas aeruginosa in the Neutropenic Murine Pneumonia Model.

Zhao M, Lepak AJ, Marchillo K, Andes DR.

Antimicrob Agents Chemother. 2019 Jul 22. pii: AAC.01131-19. doi: 10.1128/AAC.01131-19. [Epub ahead of print]


Impact of triazole therapeutic drug monitoring availability and timing.

McCreary EK, Bayless M, Van AP, Lepak AJ, Wiebe DA, Schulz LT, Andes DR.

Antimicrob Agents Chemother. 2019 Jul 22. pii: AAC.01245-19. doi: 10.1128/AAC.01245-19. [Epub ahead of print]


Small-molecule morphogenesis modulators enhance the ability of 14-helical β-peptides to prevent Candida albicans biofilm formation.

Rodríguez López AL, Lee MR, Wang NB, Dunn KK, Sanchez H, Raman N, Andes DR, Lynn DM, Palecek SP.

Antimicrob Agents Chemother. 2019 Jun 17. pii: AAC.02653-18. doi: 10.1128/AAC.02653-18. [Epub ahead of print]


Pharmacokinetic/Pharmacodynamic Evaluation of Solithromycin against Streptococcus pneumoniae Using Data from a Neutropenic Murine Lung Infection Model.

Okusanya OO, Forrest A, Bhavnani SM, Fernandes P, Ambrose PG, Andes DR.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e02606-18. doi: 10.1128/AAC.02606-18. Print 2019 Aug.


In Vivo Pharmacodynamics of Omadacycline against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model.

Lepak AJ, Zhao M, Marchillo K, VanHecker J, Andes DR.

Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e00624-19. doi: 10.1128/AAC.00624-19. Print 2019 Jul.


Bacterial Infections in the Stem Cell Transplant Recipient and Hematologic Malignancy Patient.

Misch EA, Andes DR.

Infect Dis Clin North Am. 2019 Jun;33(2):399-445. doi: 10.1016/j.idc.2019.02.011. Review.


The antimicrobial potential of Streptomyces from insect microbiomes.

Chevrette MG, Carlson CM, Ortega HE, Thomas C, Ananiev GE, Barns KJ, Book AJ, Cagnazzo J, Carlos C, Flanigan W, Grubbs KJ, Horn HA, Hoffmann FM, Klassen JL, Knack JJ, Lewin GR, McDonald BR, Muller L, Melo WGP, Pinto-Tomás AA, Schmitz A, Wendt-Pienkowski E, Wildman S, Zhao M, Zhang F, Bugni TS, Andes DR, Pupo MT, Currie CR.

Nat Commun. 2019 Jan 31;10(1):516. doi: 10.1038/s41467-019-08438-0.


APX001 Pharmacokinetic/Pharmacodynamic Target Determination against Aspergillus fumigatus in an In Vivo Model of Invasive Pulmonary Aspergillosis.

Zhao M, Lepak AJ, Marchillo K, Vanhecker J, Sanchez H, Ambrose PG, Andes DR.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02372-18. doi: 10.1128/AAC.02372-18. Print 2019 Apr.


Conserved Role for Biofilm Matrix Polysaccharides in Candida auris Drug Resistance.

Dominguez EG, Zarnowski R, Choy HL, Zhao M, Sanchez H, Nett JE, Andes DR.

mSphere. 2019 Jan 2;4(1). pii: e00680-18. doi: 10.1128/mSphereDirect.00680-18.


Exploiting the vulnerable active site of a copper-only superoxide dismutase to disrupt fungal pathogenesis.

Robinett NG, Culbertson EM, Peterson RL, Sanchez H, Andes DR, Nett JE, Culotta VC.

J Biol Chem. 2019 Feb 22;294(8):2700-2713. doi: 10.1074/jbc.RA118.007095. Epub 2018 Dec 28.


Time for Precision: A World Without Susceptibility Breakpoints.

Bader JC, Lakota EA, Andes DR, Rubino CM, Ambrose PG, Bhavnani SM.

Open Forum Infect Dis. 2018 Oct 31;5(12):ofy282. doi: 10.1093/ofid/ofy282. eCollection 2018 Dec.


Pharmacokinetic/Pharmacodynamic Evaluation of a Novel Aminomethylcycline Antibiotic, KBP-7072, in the Neutropenic Murine Pneumonia Model against Staphylococcus aureus and Streptococcus pneumoniae.

Lepak AJ, Zhao M, Liu Q, Wang P, Wang Y, Bader JC, Ambrose PG, Andes DR.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e02404-18. doi: 10.1128/AAC.02404-18. Print 2019 Mar.


Candida-streptococcal interactions in biofilm-associated oral diseases.

Koo H, Andes DR, Krysan DJ.

PLoS Pathog. 2018 Dec 13;14(12):e1007342. doi: 10.1371/journal.ppat.1007342. eCollection 2018 Dec. Review. No abstract available.


Outcomes by MIC Values for Patients Treated with Isavuconazole or Voriconazole for Invasive Aspergillosis in the Phase 3 SECURE and VITAL Trials.

Andes DR, Ghannoum MA, Mukherjee PK, Kovanda LL, Lu Q, Jones ME, Santerre Henriksen A, Lademacher C, Hope WW.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01634-18. doi: 10.1128/AAC.01634-18. Print 2019 Jan.


How Clean Is the Linen at My Hospital? The Mucorales on Unclean Linen Discovery Study of Large United States Transplant and Cancer Centers.

Sundermann AJ, Clancy CJ, Pasculle AW, Liu G, Cumbie RB, Driscoll E, Ayres A, Donahue L, Pergam SA, Abbo L, Andes DR, Chandrasekar P, Galdys AL, Hanson KE, Marr KA, Mayer J, Mehta S, Morris MI, Perfect J, Revankar SG, Smith B, Swaminathan S, Thompson GR, Varghese M, Vazquez J, Whimbey E, Wingard JR, Nguyen MH.

Clin Infect Dis. 2019 Feb 15;68(5):850-853. doi: 10.1093/cid/ciy669.


Candida albicans biofilm-induced vesicles confer drug resistance through matrix biogenesis.

Zarnowski R, Sanchez H, Covelli AS, Dominguez E, Jaromin A, Bernhardt J, Mitchell KF, Heiss C, Azadi P, Mitchell A, Andes DR.

PLoS Biol. 2018 Oct 8;16(10):e2006872. doi: 10.1371/journal.pbio.2006872. eCollection 2018 Oct.


Pharmacodynamic Evaluation of Rezafungin (CD101) against Candida auris in the Neutropenic Mouse Invasive Candidiasis Model.

Lepak AJ, Zhao M, Andes DR.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01572-18. doi: 10.1128/AAC.01572-18. Print 2018 Nov.


Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

Van Dijck P, Sjollema J, Cammue BP, Lagrou K, Berman J, d'Enfert C, Andes DR, Arendrup MC, Brakhage AA, Calderone R, Cantón E, Coenye T, Cos P, Cowen LE, Edgerton M, Espinel-Ingroff A, Filler SG, Ghannoum M, Gow NAR, Haas H, Jabra-Rizk MA, Johnson EM, Lockhart SR, Lopez-Ribot JL, Maertens J, Munro CA, Nett JE, Nobile CJ, Pfaller MA, Ramage G, Sanglard D, Sanguinetti M, Spriet I, Verweij PE, Warris A, Wauters J, Yeaman MR, Zaat SAJ, Thevissen K.

Microb Cell. 2018 Jun 14;5(7):300-326. doi: 10.15698/mic2018.07.638. Review.


In Vivo Pharmacodynamic Characterization of a Novel Odilorhabdin Antibiotic, NOSO-502, against Escherichia coli and Klebsiella pneumoniae in a Murine Thigh Infection Model.

Zhao M, Lepak AJ, Marchillo K, VanHecker J, Andes DR.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e01067-18. doi: 10.1128/AAC.01067-18. Print 2018 Sep.


Topical delivery of ebselen encapsulated in biopolymeric nanocapsules: drug repurposing enhanced antifungal activity.

Jaromin A, Zarnowski R, Piętka-Ottlik M, Andes DR, Gubernator J.

Nanomedicine (Lond). 2018 May;13(10):1139-1155. doi: 10.2217/nnm-2017-0337. Epub 2018 Jun 6.


Pharmacokinetics-pharmacodynamics, computer decision support technologies, and antimicrobial stewardship: the compass and rudder.

Owens RC Jr, Bulik CC, Andes DR.

Diagn Microbiol Infect Dis. 2018 Aug;91(4):371-382. doi: 10.1016/j.diagmicrobio.2018.03.015. Epub 2018 Apr 13. Review.


A Mycoses Study Group International Prospective Study of Phaeohyphomycosis: An Analysis of 99 Proven/Probable Cases.

Revankar SG, Baddley JW, Chen SC, Kauffman CA, Slavin M, Vazquez JA, Seas C, Morris MI, Nguyen MH, Shoham S, Thompson GR 3rd, Alexander BD, Simkins J, Ostrosky-Zeichner L, Mullane K, Alangaden G, Andes DR, Cornely OA, Wahlers K, Lockhart SR, Pappas PG.

Open Forum Infect Dis. 2017 Sep 26;4(4):ofx200. doi: 10.1093/ofid/ofx200. eCollection 2017 Fall.


Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm.

Kim D, Liu Y, Benhamou RI, Sanchez H, Simón-Soro Á, Li Y, Hwang G, Fridman M, Andes DR, Koo H.

ISME J. 2018 Jun;12(6):1427-1442. doi: 10.1038/s41396-018-0113-1. Epub 2018 Apr 18.


Conservation and Divergence in the Candida Species Biofilm Matrix Mannan-Glucan Complex Structure, Function, and Genetic Control.

Dominguez E, Zarnowski R, Sanchez H, Covelli AS, Westler WM, Azadi P, Nett J, Mitchell AP, Andes DR.

MBio. 2018 Apr 3;9(2). pii: e00451-18. doi: 10.1128/mBio.00451-18.


Identification of the In Vivo Pharmacokinetics and Pharmacodynamic Driver of Iclaprim.

Park JH, Craig W, Marchillo K, Huang DB, Andes DR.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02550-17. doi: 10.1128/AAC.02550-17. Print 2018 Apr.


In Vivo Pharmacokinetics and Pharmacodynamics of APX001 against Candida spp. in a Neutropenic Disseminated Candidiasis Mouse Model.

Zhao M, Lepak AJ, VanScoy B, Bader JC, Marchillo K, Vanhecker J, Ambrose PG, Andes DR.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02542-17. doi: 10.1128/AAC.02542-17. Print 2018 Apr.


We can do better: a fresh look at echinocandin dosing.

Bader JC, Bhavnani SM, Andes DR, Ambrose PG.

J Antimicrob Chemother. 2018 Mar 1;73(3):831. doi: 10.1093/jac/dky013. No abstract available.


We can do better: a fresh look at echinocandin dosing.

Bader JC, Bhavnani SM, Andes DR, Ambrose PG.

J Antimicrob Chemother. 2018 Jan 1;73(suppl_1):i44-i50. doi: 10.1093/jac/dkx448. Review. Erratum in: J Antimicrob Chemother. 2018 Mar 1;73(3):831.


Pharmacodynamics of a Long-Acting Echinocandin, CD101, in a Neutropenic Invasive-Candidiasis Murine Model Using an Extended-Interval Dosing Design.

Lepak AJ, Zhao M, VanScoy B, Ambrose PG, Andes DR.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02154-17. doi: 10.1128/AAC.02154-17. Print 2018 Feb.


Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis.

Rossi DCP, Gleason JE, Sanchez H, Schatzman SS, Culbertson EM, Johnson CJ, McNees CA, Coelho C, Nett JE, Andes DR, Cormack BP, Culotta VC.

PLoS Pathog. 2017 Dec 1;13(12):e1006763. doi: 10.1371/journal.ppat.1006763. eCollection 2017 Dec.


In vivo infection models in the pre-clinical pharmacokinetic/pharmacodynamic evaluation of antimicrobial agents.

Andes DR, Lepak AJ.

Curr Opin Pharmacol. 2017 Oct;36:94-99. doi: 10.1016/j.coph.2017.09.004. Epub 2017 Sep 29. Review.


Pharmacological Basis of CD101 Efficacy: Exposure Shape Matters.

Lakota EA, Bader JC, Ong V, Bartizal K, Miesel L, Andes DR, Bhavnani SM, Rubino CM, Ambrose PG, Lepak AJ.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e00758-17. doi: 10.1128/AAC.00758-17. Print 2017 Nov.


Thalassosamide, a Siderophore Discovered from the Marine-Derived Bacterium Thalassospira profundimaris.

Zhang F, Barns K, Hoffmann FM, Braun DR, Andes DR, Bugni TS.

J Nat Prod. 2017 Sep 22;80(9):2551-2555. doi: 10.1021/acs.jnatprod.7b00328. Epub 2017 Aug 25.


Distinct roles of the 7-transmembrane receptor protein Rta3 in regulating the asymmetric distribution of phosphatidylcholine across the plasma membrane and biofilm formation in Candida albicans.

Srivastava A, Sircaik S, Husain F, Thomas E, Ror S, Rastogi S, Alim D, Bapat P, Andes DR, Nobile CJ, Panwar SL.

Cell Microbiol. 2017 Dec;19(12). doi: 10.1111/cmi.12767. Epub 2017 Oct 4.


Pharmacodynamic Optimization for Treatment of Invasive Candida auris Infection.

Lepak AJ, Zhao M, Berkow EL, Lockhart SR, Andes DR.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00791-17. doi: 10.1128/AAC.00791-17. Print 2017 Aug.


In Vivo Pharmacodynamic Target Assessment of Eravacycline against Escherichia coli in a Murine Thigh Infection Model.

Zhao M, Lepak AJ, Marchillo K, VanHecker J, Andes DR.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00250-17. doi: 10.1128/AAC.00250-17. Print 2017 Jul.


Comparative Pharmacodynamics of Telavancin and Vancomycin in the Neutropenic Murine Thigh and Lung Infection Models against Staphylococcus aureus.

Lepak AJ, Zhao M, Andes DR.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00281-17. doi: 10.1128/AAC.00281-17. Print 2017 Jul.


In Vivo Pharmacokinetics and Pharmacodynamics of ZTI-01 (Fosfomycin for Injection) in the Neutropenic Murine Thigh Infection Model against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

Lepak AJ, Zhao M, VanScoy B, Taylor DS, Ellis-Grosse E, Ambrose PG, Andes DR.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00476-17. doi: 10.1128/AAC.00476-17. Print 2017 Jun.


Antifungal Efficacy of an Intravenous Formulation Containing Monomeric Amphotericin B, 5-Fluorocytosine, and Saline for Sodium Supplementation.

Alvarez C, Andes DR, Kang JY, Krug C, Kwon GS.

Pharm Res. 2017 May;34(5):1115-1124. doi: 10.1007/s11095-017-2121-7. Epub 2017 Feb 15.


In Vivo Pharmacodynamic Evaluation of Omadacycline (PTK 0796) against Streptococcus pneumoniae in the Murine Pneumonia Model.

Lepak AJ, Zhao M, Marchillo K, VanHecker J, Andes DR.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02368-16. doi: 10.1128/AAC.02368-16. Print 2017 May.


Bypass of Candida albicans Filamentation/Biofilm Regulators through Diminished Expression of Protein Kinase Cak1.

Woolford CA, Lagree K, Xu W, Aleynikov T, Adhikari H, Sanchez H, Cullen PJ, Lanni F, Andes DR, Mitchell AP.

PLoS Genet. 2016 Dec 9;12(12):e1006487. doi: 10.1371/journal.pgen.1006487. eCollection 2016 Dec.


Animal models in the pharmacokinetic/pharmacodynamic evaluation of antimicrobial agents.

Zhao M, Lepak AJ, Andes DR.

Bioorg Med Chem. 2016 Dec 15;24(24):6390-6400. doi: 10.1016/j.bmc.2016.11.008. Epub 2016 Nov 9. Review.


Pharmacokinetic-Pharmacodynamic Evaluation of Gepotidacin against Gram-Positive Organisms Using Data from Murine Infection Models.

Bulik CC, Okusanya ÓO, Lakota EA, Forrest A, Bhavnani SM, Hoover JL, Andes DR, Ambrose PG.

Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e00115-16. doi: 10.1128/AAC.00115-16. Print 2017 Feb.


Large-scale production and isolation of Candida biofilm extracellular matrix.

Zarnowski R, Sanchez H, Andes DR.

Nat Protoc. 2016 Dec;11(12):2320-2327. doi: 10.1038/nprot.2016.132. Epub 2016 Oct 27.


Transcriptional rewiring over evolutionary timescales changes quantitative and qualitative properties of gene expression.

Dalal CK, Zuleta IA, Mitchell KF, Andes DR, El-Samad H, Johnson AD.

Elife. 2016 Sep 10;5. pii: e18981. doi: 10.7554/eLife.18981.


Fungal Super Glue: The Biofilm Matrix and Its Composition, Assembly, and Functions.

Mitchell KF, Zarnowski R, Andes DR.

PLoS Pathog. 2016 Sep 29;12(9):e1005828. doi: 10.1371/journal.ppat.1005828. eCollection 2016 Sep. No abstract available.


The epidemiology and outcomes of invasive Candida infections among organ transplant recipients in the United States: results of the Transplant-Associated Infection Surveillance Network (TRANSNET).

Andes DR, Safdar N, Baddley JW, Alexander B, Brumble L, Freifeld A, Hadley S, Herwaldt L, Kauffman C, Lyon GM, Morrison V, Patterson T, Perl T, Walker R, Hess T, Chiller T, Pappas PG; TRANSNET Investigators.

Transpl Infect Dis. 2016 Dec;18(6):921-931. doi: 10.1111/tid.12613. Epub 2016 Nov 14.


Global Identification of Biofilm-Specific Proteolysis in Candida albicans.

Winter MB, Salcedo EC, Lohse MB, Hartooni N, Gulati M, Sanchez H, Takagi J, Hube B, Andes DR, Johnson AD, Craik CS, Nobile CJ.

MBio. 2016 Sep 13;7(5). pii: e01514-16. doi: 10.1128/mBio.01514-16.

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