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PD-1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state.

Mair I, Besusso D, Saul L, Patel SD, Ravindran R, McPherson RC, Leech MD, O'Connor RA, Anderton SM, Mellanby RJ.

Eur J Immunol. 2019 Jan;49(1):112-120. doi: 10.1002/eji.201847868. Epub 2018 Dec 7.


Purine metabolism controls innate lymphoid cell function and protects against intestinal injury.

Crittenden S, Cheyne A, Adams A, Forster T, Robb CT, Felton J, Ho GT, Ruckerl D, Rossi AG, Anderton SM, Ghazal P, Satsangi J, Howie SE, Yao C.

Immunol Cell Biol. 2018 Nov;96(10):1049-1059. doi: 10.1111/imcb.12167. Epub 2018 Jul 10.


Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLD.

Lyall MJ, Cartier J, Richards JA, Cobice D, Thomson JP, Meehan RR, Anderton SM, Drake AJ.

Wellcome Open Res. 2017 Aug 22;2:67. doi: 10.12688/wellcomeopenres.12199.1. eCollection 2017.


Facilitation of IL-22 production from innate lymphoid cells by prostaglandin E2 prevents experimental lung neutrophilic inflammation.

Felton JM, Duffin R, Robb CT, Crittenden S, Anderton SM, Howie SEM, Whyte MKB, Rossi AG, Yao C.

Thorax. 2018 Nov;73(11):1081-1084. doi: 10.1136/thoraxjnl-2017-211097. Epub 2018 Mar 24.


A Context-Dependent Role for αv Integrins in Regulatory T Cell Accumulation at Sites of Inflammation.

Mair I, Zandee SEJ, Toor IS, Saul L, McPherson RC, Leech MD, Smyth DJ, O'Connor RA, Henderson NC, Anderton SM.

Front Immunol. 2018 Feb 26;9:264. doi: 10.3389/fimmu.2018.00264. eCollection 2018.


The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury.

Campana L, Starkey Lewis PJ, Pellicoro A, Aucott RL, Man J, O'Duibhir E, Mok SE, Ferreira-Gonzalez S, Livingstone E, Greenhalgh SN, Hull KL, Kendall TJ, Vernimmen D, Henderson NC, Boulter L, Gregory CD, Feng Y, Anderton SM, Forbes SJ, Iredale JP.

J Immunol. 2018 Feb 1;200(3):1169-1187. doi: 10.4049/jimmunol.1701247. Epub 2017 Dec 20.


IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks.

Serrels B, McGivern N, Canel M, Byron A, Johnson SC, McSorley HJ, Quinn N, Taggart D, Von Kreigsheim A, Anderton SM, Serrels A, Frame MC.

Sci Signal. 2017 Dec 5;10(508). pii: eaan8355. doi: 10.1126/scisignal.aan8355.


A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.

Johnston CJC, Smyth DJ, Kodali RB, White MPJ, Harcus Y, Filbey KJ, Hewitson JP, Hinck CS, Ivens A, Kemter AM, Kildemoes AO, Le Bihan T, Soares DC, Anderton SM, Brenn T, Wigmore SJ, Woodcock HV, Chambers RC, Hinck AP, McSorley HJ, Maizels RM.

Nat Commun. 2017 Nov 23;8(1):1741. doi: 10.1038/s41467-017-01886-6.


NKT cells are important mediators of hepatic ischemia-reperfusion injury.

Richards JA, Wigmore SJ, Anderton SM, Howie SEM.

Transpl Immunol. 2017 Dec;45:15-21. doi: 10.1016/j.trim.2017.08.002. Epub 2017 Aug 7.


Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis.

Robb CT, McSorley HJ, Lee J, Aoki T, Yu C, Crittenden S, Astier A, Felton JM, Parkinson N, Ayele A, Breyer RM, Anderton SM, Narumiya S, Rossi AG, Howie SE, Guttman-Yassky E, Weller RB, Yao C.

J Allergy Clin Immunol. 2018 Jan;141(1):152-162. doi: 10.1016/j.jaci.2017.04.045. Epub 2017 Jun 3.


FAK-inhibition opens the door to checkpoint immunotherapy in Pancreatic Cancer.

Symeonides SN, Anderton SM, Serrels A.

J Immunother Cancer. 2017 Feb 21;5:17. doi: 10.1186/s40425-017-0217-6. eCollection 2017.


IL-10-producing, ST2-expressing Foxp3+ T cells in multiple sclerosis brain lesions.

Zandee SEJ, O'Connor RA, Mair I, Leech MD, Williams A, Anderton SM.

Immunol Cell Biol. 2017 May;95(5):484-490. doi: 10.1038/icb.2017.3. Epub 2017 Feb 7.


Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity.

Kieback E, Hilgenberg E, Stervbo U, Lampropoulou V, Shen P, Bunse M, Jaimes Y, Boudinot P, Radbruch A, Klemm U, Kühl AA, Liblau R, Hoevelmeyer N, Anderton SM, Uckert W, Fillatreau S.

Immunity. 2016 May 17;44(5):1114-26. doi: 10.1016/j.immuni.2016.04.018.


Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.

Duffin R, O'Connor RA, Crittenden S, Forster T, Yu C, Zheng X, Smyth D, Robb CT, Rossi F, Skouras C, Tang S, Richards J, Pellicoro A, Weller RB, Breyer RM, Mole DJ, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Ghazal P, Howie SE, Rossi AG, Yao C.

Science. 2016 Mar 18;351(6279):1333-8. doi: 10.1126/science.aad9903.


1,25-Dihydroxyvitamin D3-Conditioned CD11c+ Dendritic Cells are Effective Initiators of CNS Autoimmune Disease.

Besusso D, Saul L, Leech MD, O'Connor RA, MacDonald AS, Anderton SM, Mellanby RJ.

Front Immunol. 2015 Nov 18;6:575. doi: 10.3389/fimmu.2015.00575. eCollection 2015.


Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.

Colbeck EJ, Hindley JP, Smart K, Jones E, Bloom A, Bridgeman H, McPherson RC, Turner DG, Ladell K, Price DA, O'Connor RA, Anderton SM, Godkin AJ, Gallimore AM.

Oncotarget. 2015 Sep 22;6(28):24649-59. doi: 10.18632/oncotarget.5584.


Acute Liver Injury Is Independent of B Cells or Immunoglobulin M.

Richards JA, Bucsaiova M, Hesketh EE, Ventre C, Henderson NC, Simpson K, Bellamy CO, Howie SE, Anderton SM, Hughes J, Wigmore SJ.

PLoS One. 2015 Sep 25;10(9):e0138688. doi: 10.1371/journal.pone.0138688. eCollection 2015.


Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.

Serrels A, Lund T, Serrels B, Byron A, McPherson RC, von Kriegsheim A, Gómez-Cuadrado L, Canel M, Muir M, Ring JE, Maniati E, Sims AH, Pachter JA, Brunton VG, Gilbert N, Anderton SM, Nibbs RJ, Frame MC.

Cell. 2015 Sep 24;163(1):160-73. doi: 10.1016/j.cell.2015.09.001.


Inflammation-associated genes: risks and benefits to Foxp3+ regulatory T-cell function.

O'Connor RA, Anderton SM.

Immunology. 2015 Oct;146(2):194-205. doi: 10.1111/imm.12507. Epub 2015 Sep 9. Review.


Editorial overview: Immunomodulation: New insights for future treatments.

Anderton SM, Fillatreau S.

Curr Opin Pharmacol. 2015 Aug;23:vii-ix. doi: 10.1016/j.coph.2015.06.005. Epub 2015 Jul 2. No abstract available.


Peptide immunotherapy in experimental autoimmune encephalomyelitis.

Anderton SM.

Biomed J. 2015 May-Jun;38(3):206-14. doi: 10.4103/2319-4170.158510. Review.


Antigen-based immunotherapy (AIT) for autoimmune and allergic disease.

MacLeod MK, Anderton SM.

Curr Opin Pharmacol. 2015 Aug;23:11-6. doi: 10.1016/j.coph.2015.05.003. Epub 2015 May 22. Review.


Methods for Ex Vivo Analysis of Immune Cell Function from the Central Nervous System.

Turner DG, Leech MD, O'Connor RA, Anderton SM.

Methods Mol Biol. 2016;1304:81-90. doi: 10.1007/7651_2015_222.


T-bet Expression by Foxp3(+) T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune Disease or Colitis.

McPherson RC, Turner DG, Mair I, O'Connor RA, Anderton SM.

Front Immunol. 2015 Feb 18;6:69. doi: 10.3389/fimmu.2015.00069. eCollection 2015.


Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems.

Nestor CE, Ottaviano R, Reinhardt D, Cruickshanks HA, Mjoseng HK, McPherson RC, Lentini A, Thomson JP, Dunican DS, Pennings S, Anderton SM, Benson M, Meehan RR.

Genome Biol. 2015 Feb 4;16:11. doi: 10.1186/s13059-014-0576-y.


Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4(+) T cells tolerized by peptide immunotherapy.

McPherson RC, Konkel JE, Prendergast CT, Thomson JP, Ottaviano R, Leech MD, Kay O, Zandee SE, Sweenie CH, Wraith DC, Meehan RR, Drake AJ, Anderton SM.

Elife. 2014 Dec 29;3. doi: 10.7554/eLife.03416.


Exposure to inflammatory cytokines selectively limits GM-CSF production by induced T regulatory cells.

Reynolds BC, Turner DG, McPherson RC, Prendergast CT, Phelps RG, Turner NA, O'Connor RA, Anderton SM.

Eur J Immunol. 2014 Nov;44(11):3342-52. doi: 10.1002/eji.201444687. Epub 2014 Oct 1.


Induction of passive EAE using myelin-reactive CD4+ T cells.

McPherson RC, Cambrook HE, O'Connor RA, Anderton SM.

Methods Mol Biol. 2014;1193:187-98. doi: 10.1007/978-1-4939-1212-4_17.


IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.

Shen P, Roch T, Lampropoulou V, O'Connor RA, Stervbo U, Hilgenberg E, Ries S, Dang VD, Jaimes Y, Daridon C, Li R, Jouneau L, Boudinot P, Wilantri S, Sakwa I, Miyazaki Y, Leech MD, McPherson RC, Wirtz S, Neurath M, Hoehlig K, Meinl E, Grützkau A, Grün JR, Horn K, Kühl AA, Dörner T, Bar-Or A, Kaufmann SHE, Anderton SM, Fillatreau S.

Nature. 2014 Mar 20;507(7492):366-370. doi: 10.1038/nature12979. Epub 2014 Feb 23.


Effector and central memory T helper 2 cells respond differently to peptide immunotherapy.

Mackenzie KJ, Nowakowska DJ, Leech MD, McFarlane AJ, Wilson C, Fitch PM, O'Connor RA, Howie SE, Schwarze J, Anderton SM.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):E784-93. doi: 10.1073/pnas.1316178111. Epub 2014 Feb 10.


Viral respiratory tract infections and asthma in early life: cause and effect?

Mackenzie KJ, Anderton SM, Schwarze J.

Clin Exp Allergy. 2014 Jan;44(1):9-19. doi: 10.1111/cea.12246. Review.


T cells at the site of autoimmune inflammation show increased potential for trogocytosis.

Haastert B, Mellanby RJ, Anderton SM, O'Connor RA.

PLoS One. 2013 Dec 4;8(12):e81404. doi: 10.1371/journal.pone.0081404. eCollection 2013.


Helminths and immunological tolerance.

Johnston CJ, McSorley HJ, Anderton SM, Wigmore SJ, Maizels RM.

Transplantation. 2014 Jan 27;97(2):127-32. doi: 10.1097/TP.0b013e3182a53f59. Review. Erratum in: Transplantation. 2014 Sep 27;98(6):e67.


T-bet is essential for Th1-mediated, but not Th17-mediated, CNS autoimmune disease.

O'Connor RA, Cambrook H, Huettner K, Anderton SM.

Eur J Immunol. 2013 Nov;43(11):2818-23. doi: 10.1002/eji.201343689. Epub 2013 Aug 21.


Autoimmune memory T helper 17 cell function and expansion are dependent on interleukin-23.

Haines CJ, Chen Y, Blumenschein WM, Jain R, Chang C, Joyce-Shaikh B, Porth K, Boniface K, Mattson J, Basham B, Anderton SM, McClanahan TK, Sadekova S, Cua DJ, McGeachy MJ.

Cell Rep. 2013 May 30;3(5):1378-88. doi: 10.1016/j.celrep.2013.03.035. Epub 2013 Apr 25.


Modification of the FoxP3 transcription factor principally affects inducible T regulatory cells in a model of experimental autoimmune encephalomyelitis.

Verhagen J, Burton BR, Britton GJ, Shepard ER, Anderton SM, Wraith DC.

PLoS One. 2013 Apr 8;8(4):e61334. doi: 10.1371/journal.pone.0061334. Print 2013.


Adaptive immune responses in CNS autoimmune disease: mechanisms and therapeutic opportunities.

McPherson RC, Anderton SM.

J Neuroimmune Pharmacol. 2013 Sep;8(4):774-90. doi: 10.1007/s11481-013-9453-9. Epub 2013 Apr 9. Review.


Cutting edge: IL-6-dependent autoimmune disease: dendritic cells as a sufficient, but transient, source.

Leech MD, Barr TA, Turner DG, Brown S, O'Connor RA, Gray D, Mellanby RJ, Anderton SM.

J Immunol. 2013 Feb 1;190(3):881-5. doi: 10.4049/jimmunol.1202925. Epub 2012 Dec 24.


Ischemic preconditioning in the liver is independent of regulatory T cell activity.

Devey LR, Richards JA, O'Connor RA, Borthwick G, Clay S, Howie AF, Wigmore SJ, Anderton SM, Howie SE.

PLoS One. 2012;7(11):e49647. doi: 10.1371/journal.pone.0049647. Epub 2012 Nov 21.


Combination peptide immunotherapy based on T-cell epitope mapping reduces allergen-specific IgE and eosinophilia in allergic airway inflammation.

Mackenzie KJ, Fitch PM, Leech MD, Ilchmann A, Wilson C, McFarlane AJ, Howie SE, Anderton SM, Schwarze J.

Immunology. 2013 Mar;138(3):258-68. doi: 10.1111/imm.12032.


TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis.

Mellanby RJ, Cambrook H, Turner DG, O'Connor RA, Leech MD, Kurschus FC, MacDonald AS, Arnold B, Anderton SM.

J Neuroinflammation. 2012 Oct 30;9:248. doi: 10.1186/1742-2094-9-248.


Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis.

van Herwijnen MJ, Wieten L, van der Zee R, van Kooten PJ, Wagenaar-Hilbers JP, Hoek A, den Braber I, Anderton SM, Singh M, Meiring HD, van Els CA, van Eden W, Broere F.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14134-9. doi: 10.1073/pnas.1206803109. Epub 2012 Aug 13.


B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells.

Barr TA, Shen P, Brown S, Lampropoulou V, Roch T, Lawrie S, Fan B, O'Connor RA, Anderton SM, Bar-Or A, Fillatreau S, Gray D.

J Exp Med. 2012 May 7;209(5):1001-10. doi: 10.1084/jem.20111675. Epub 2012 Apr 30.


Foxp3⁺ Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production.

O'Connor RA, Floess S, Huehn J, Jones SA, Anderton SM.

Eur J Immunol. 2012 May;42(5):1174-9. doi: 10.1002/eji.201142216.


Activation of CD4⁺ Foxp3⁺ regulatory T cells proceeds normally in the absence of B cells during EAE.

Hoehlig K, Shen P, Lampropoulou V, Roch T, Malissen B, O'Connor R, Ries S, Hilgenberg E, Anderton SM, Fillatreau S.

Eur J Immunol. 2012 May;42(5):1164-73. doi: 10.1002/eji.201142242.


Bystander suppression of experimental arthritis by nasal administration of a heat shock protein peptide.

Zonneveld-Huijssoon E, Roord ST, de Jager W, Klein M, Albani S, Anderton SM, Kuis W, van Wijk F, Prakken BJ.

Ann Rheum Dis. 2011 Dec;70(12):2199-206. doi: 10.1136/ard.2010.136994. Epub 2011 Sep 12.


Reprogrammed quiescent B cells provide an effective cellular therapy against chronic experimental autoimmune encephalomyelitis.

Calderón-Gómez E, Lampropoulou V, Shen P, Neves P, Roch T, Stervbo U, Rutz S, Kühl AA, Heppner FL, Loddenkemper C, Anderton SM, Kanellopoulos JM, Charneau P, Fillatreau S.

Eur J Immunol. 2011 Jun;41(6):1696-708. doi: 10.1002/eji.201041041. Epub 2011 May 25.


Recognition of a high affinity MHC class I-restricted epitope of myelin oligodendrocyte glycoprotein by CD8⁺ T cells derived from autoantigen-deficient mice.

Leech MD, Carrillo-Vico A, Liblau RS, Anderton SM.

Front Immunol. 2011 May 24;2:17. doi: 10.3389/fimmu.2011.00017. eCollection 2011.


Peptide immunotherapy for childhood allergy - addressing translational challenges.

Mackenzie KJ, Anderton SM, Schwarze J.

Clin Transl Allergy. 2011 Nov 7;1(1):13. doi: 10.1186/2045-7022-1-13.

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