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Inhibition of translation termination by small molecules targeting ribosomal release factors.

Ge X, Oliveira A, Hjort K, Bergfors T, de Terán HG, Andersson DI, Sanyal S, Åqvist J.

Sci Rep. 2019 Oct 28;9(1):15424. doi: 10.1038/s41598-019-51977-1.


Mutations that increase expression of the EmrAB-TolC efflux pump confer increased resistance to nitroxoline in Escherichia coli.

Puértolas-Balint F, Warsi O, Linkevicius M, Tang PC, Andersson DI.

J Antimicrob Chemother. 2019 Oct 21. pii: dkz434. doi: 10.1093/jac/dkz434. [Epub ahead of print]


A portable epigenetic switch for bistable gene expression in bacteria.

Olivenza DR, Nicoloff H, Antonia Sánchez-Romero M, Cota I, Andersson DI, Casadesús J.

Sci Rep. 2019 Aug 2;9(1):11261. doi: 10.1038/s41598-019-47650-2.


Upregulation of PBP1B and LpoB in cysB Mutants Confers Mecillinam (Amdinocillin) Resistance in Escherichia coli.

Thulin E, Andersson DI.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00612-19. doi: 10.1128/AAC.00612-19. Print 2019 Oct.


Mechanisms and clinical relevance of bacterial heteroresistance.

Andersson DI, Nicoloff H, Hjort K.

Nat Rev Microbiol. 2019 Aug;17(8):479-496. doi: 10.1038/s41579-019-0218-1. Epub 2019 Jun 24. Review.


De Novo Emergence of Peptides That Confer Antibiotic Resistance.

Knopp M, Gudmundsdottir JS, Nilsson T, König F, Warsi O, Rajer F, Ädelroth P, Andersson DI.

MBio. 2019 Jun 4;10(3). pii: e00837-19. doi: 10.1128/mBio.00837-19.


Occurrence of Yersinia rohdei among feral reindeer (Rangifer t. tarandus) and kelp gulls (Larus dominicanus) on the Sub-Antarctic island South Georgia.

Bonnedahl J, Berg C, Andersson DI, Söderlund R, Vågsholm I, Olsen B.

Infect Ecol Epidemiol. 2018 Sep 11;8(1):1517582. doi: 10.1080/20008686.2018.1517582. eCollection 2018.


Publisher Correction: Definitions and guidelines for research on antibiotic persistence.

Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A.

Nat Rev Microbiol. 2019 Jul;17(7):460. doi: 10.1038/s41579-019-0207-4.


Definitions and guidelines for research on antibiotic persistence.

Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A.

Nat Rev Microbiol. 2019 Jul;17(7):441-448. doi: 10.1038/s41579-019-0196-3. Review. Erratum in: Nat Rev Microbiol. 2019 Apr 29;:.


Selection for novel metabolic capabilities in Salmonella enterica.

Warsi O, Lundin E, Lustig U, Näsvall J, Andersson DI.

Evolution. 2019 May;73(5):990-1000. doi: 10.1111/evo.13713. Epub 2019 Mar 22.


The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification.

Nicoloff H, Hjort K, Levin BR, Andersson DI.

Nat Microbiol. 2019 Mar;4(3):504-514. doi: 10.1038/s41564-018-0342-0. Epub 2019 Feb 11.


Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase.

Rosenkilde CEH, Munck C, Porse A, Linkevicius M, Andersson DI, Sommer MOA.

Nat Commun. 2019 Feb 6;10(1):618. doi: 10.1038/s41467-019-08529-y.


Public awareness and individual responsibility needed for judicious use of antibiotics: a qualitative study of public beliefs and perceptions.

Ancillotti M, Eriksson S, Veldwijk J, Nihlén Fahlquist J, Andersson DI, Godskesen T.

BMC Public Health. 2018 Oct 3;18(1):1153. doi: 10.1186/s12889-018-6047-8.


Cellular hysteresis as a principle to maximize the efficacy of antibiotic therapy.

Roemhild R, Gokhale CS, Dirksen P, Blake C, Rosenstiel P, Traulsen A, Andersson DI, Schulenburg H.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9767-9772. doi: 10.1073/pnas.1810004115. Epub 2018 Sep 12.


Long-term carriage and rapid transmission of extended spectrum beta-lactamase-producing E. coli within a flock of Mallards in the absence of antibiotic selection.

Sandegren L, Stedt J, Lustig U, Bonnedahl J, Andersson DI, Järhult JD.

Environ Microbiol Rep. 2018 Oct;10(5):576-582. doi: 10.1111/1758-2229.12681. Epub 2018 Sep 18.


No beneficial fitness effects of random peptides.

Knopp M, Andersson DI.

Nat Ecol Evol. 2018 Jul;2(7):1046-1047. doi: 10.1038/s41559-018-0585-4. No abstract available.


A bacteriophage enzyme induces bacterial metabolic perturbation that confers a novel promiscuous function.

Jerlström Hultqvist J, Warsi O, Söderholm A, Knopp M, Eckhard U, Vorontsov E, Selmer M, Andersson DI.

Nat Ecol Evol. 2018 Aug;2(8):1321-1330. doi: 10.1038/s41559-018-0568-5. Epub 2018 May 28.


Different adaptive strategies in E. coli populations evolving under macronutrient limitation and metal ion limitation.

Warsi OM, Andersson DI, Dykhuizen DE.

BMC Evol Biol. 2018 May 18;18(1):72. doi: 10.1186/s12862-018-1191-4.


Predictable Phenotypes of Antibiotic Resistance Mutations.

Knopp M, Andersson DI.

MBio. 2018 May 15;9(3). pii: e00770-18. doi: 10.1128/mBio.00770-18.


Genetic Adaptation to Growth Under Laboratory Conditions in Escherichia coli and Salmonella enterica.

Knöppel A, Knopp M, Albrecht LM, Lundin E, Lustig U, Näsvall J, Andersson DI.

Front Microbiol. 2018 Apr 26;9:756. doi: 10.3389/fmicb.2018.00756. eCollection 2018.


Evolution of high-level resistance during low-level antibiotic exposure.

Wistrand-Yuen E, Knopp M, Hjort K, Koskiniemi S, Berg OG, Andersson DI.

Nat Commun. 2018 Apr 23;9(1):1599. doi: 10.1038/s41467-018-04059-1.


Pharmacokinetics and Pharmacodynamics of Fosfomycin and Its Activity against Extended-Spectrum-β-Lactamase-, Plasmid-Mediated AmpC-, and Carbapenemase-Producing Escherichia coli in a Murine Urinary Tract Infection Model.

Zykov IN, Samuelsen Ø, Jakobsen L, Småbrekke L, Andersson DI, Sundsfjord A, Frimodt-Møller N.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02560-17. doi: 10.1128/AAC.02560-17. Print 2018 Jun.


Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA.

Lundin E, Tang PC, Guy L, Näsvall J, Andersson DI.

Mol Biol Evol. 2018 Mar 1;35(3):704-718. doi: 10.1093/molbev/msx325.


Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli.

Khan DD, Lagerbäck P, Malmberg C, Kristoffersson AN, Wistrand-Yuen E, Sha C, Cars O, Andersson DI, Hughes D, Nielsen EI, Friberg LE.

Int J Antimicrob Agents. 2018 Mar;51(3):399-406. doi: 10.1016/j.ijantimicag.2017.10.019. Epub 2017 Nov 7.


Transfer and Persistence of a Multi-Drug Resistance Plasmid in situ of the Infant Gut Microbiota in the Absence of Antibiotic Treatment.

Gumpert H, Kubicek-Sutherland JZ, Porse A, Karami N, Munck C, Linkevicius M, Adlerberth I, Wold AE, Andersson DI, Sommer MOA.

Front Microbiol. 2017 Sep 26;8:1852. doi: 10.3389/fmicb.2017.01852. eCollection 2017.


Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data.

Nielsen EI, Khan DD, Cao S, Lustig U, Hughes D, Andersson DI, Friberg LE.

J Antimicrob Chemother. 2017 Nov 1;72(11):3108-3116. doi: 10.1093/jac/dkx269.


Evolution of Antibiotic Resistance without Antibiotic Exposure.

Knöppel A, Näsvall J, Andersson DI.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01495-17. doi: 10.1128/AAC.01495-17. Print 2017 Nov.


Reversion of High-level Mecillinam Resistance to Susceptibility in Escherichia coli During Growth in Urine.

Thulin E, Thulin M, Andersson DI.

EBioMedicine. 2017 Sep;23:111-118. doi: 10.1016/j.ebiom.2017.08.021. Epub 2017 Aug 24.


Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs.

Kacar B, Garmendia E, Tuncbag N, Andersson DI, Hughes D.

MBio. 2017 Aug 29;8(4). pii: e01276-17. doi: 10.1128/mBio.01276-17.


Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging.

Baltekin Ö, Boucharin A, Tano E, Andersson DI, Elf J.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9170-9175. doi: 10.1073/pnas.1708558114. Epub 2017 Aug 8.


Prediction of antibiotic resistance: time for a new preclinical paradigm?

Sommer MOA, Munck C, Toft-Kehler RV, Andersson DI.

Nat Rev Microbiol. 2017 Nov;15(11):689-696. doi: 10.1038/nrmicro.2017.75. Epub 2017 Jul 31. Review.


Selection and Transmission of Antibiotic-Resistant Bacteria.

Andersson DI, Hughes D.

Microbiol Spectr. 2017 Jul;5(4). doi: 10.1128/microbiolspec.MTBP-0013-2016. Review.


Evolutionary Trajectories to Antibiotic Resistance.

Hughes D, Andersson DI.

Annu Rev Microbiol. 2017 Sep 8;71:579-596. doi: 10.1146/annurev-micro-090816-093813. Epub 2017 Jul 11. Review.


Resistance to the Cyclotide Cycloviolacin O2 in Salmonella enterica Caused by Different Mutations That Often Confer Cross-Resistance or Collateral Sensitivity to Other Antimicrobial Peptides.

Malik SZ, Linkevicius M, Göransson U, Andersson DI.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00684-17. doi: 10.1128/AAC.00684-17. Print 2017 Aug.


Rapid Antibiotic Susceptibility Testing for Urinary Tract Infections.

Mezger A, Nilsson M, Andersson DI.

Methods Mol Biol. 2017;1616:147-153. doi: 10.1007/978-1-4939-7037-7_9.


Genome Dynamics of Escherichia coli during Antibiotic Treatment: Transfer, Loss, and Persistence of Genetic Elements In situ of the Infant Gut.

Porse A, Gumpert H, Kubicek-Sutherland JZ, Karami N, Adlerberth I, Wold AE, Andersson DI, Sommer MOA.

Front Cell Infect Microbiol. 2017 Apr 12;7:126. doi: 10.3389/fcimb.2017.00126. eCollection 2017.


Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes.

Newton MS, Guo X, Söderholm A, Näsvall J, Lundström P, Andersson DI, Selmer M, Patrick WM.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4727-4732. doi: 10.1073/pnas.1618552114. Epub 2017 Apr 17.


Environmental and genetic modulation of the phenotypic expression of antibiotic resistance.

Hughes D, Andersson DI.

FEMS Microbiol Rev. 2017 May 1;41(3):374-391. doi: 10.1093/femsre/fux004. Review.


Variation in Mutational Robustness between Different Proteins and the Predictability of Fitness Effects.

Lind PA, Arvidsson L, Berg OG, Andersson DI.

Mol Biol Evol. 2017 Feb 1;34(2):408-418. doi: 10.1093/molbev/msw239.


Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria.

Näsvall J, Knöppel A, Andersson DI.

Nucleic Acids Res. 2017 Mar 17;45(5):e33. doi: 10.1093/nar/gkw1078.


Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase.

Freihofer P, Akbergenov R, Teo Y, Juskeviciene R, Andersson DI, Böttger EC.

RNA. 2016 Dec;22(12):1836-1843. Epub 2016 Oct 3.


Antimicrobial peptide exposure selects for Staphylococcus aureus resistance to human defence peptides.

Kubicek-Sutherland JZ, Lofton H, Vestergaard M, Hjort K, Ingmer H, Andersson DI.

J Antimicrob Chemother. 2017 Jan;72(1):115-127. Epub 2016 Sep 20.


Unstable tandem gene amplification generates heteroresistance (variation in resistance within a population) to colistin in Salmonella enterica.

Hjort K, Nicoloff H, Andersson DI.

Mol Microbiol. 2016 Oct;102(2):274-289. doi: 10.1111/mmi.13459. Epub 2016 Aug 2.


Mechanisms and consequences of bacterial resistance to antimicrobial peptides.

Andersson DI, Hughes D, Kubicek-Sutherland JZ.

Drug Resist Updat. 2016 May;26:43-57. doi: 10.1016/j.drup.2016.04.002. Epub 2016 Apr 20. Review.


Compensating the Fitness Costs of Synonymous Mutations.

Knöppel A, Näsvall J, Andersson DI.

Mol Biol Evol. 2016 Jun;33(6):1461-77. doi: 10.1093/molbev/msw028. Epub 2016 Feb 16.


Combinations of mutations in envZ, ftsI, mrdA, acrB and acrR can cause high-level carbapenem resistance in Escherichia coli.

Adler M, Anjum M, Andersson DI, Sandegren L.

J Antimicrob Chemother. 2016 May;71(5):1188-98. doi: 10.1093/jac/dkv475. Epub 2016 Feb 10.


Fitness of Escherichia coli mutants with reduced susceptibility to tigecycline.

Linkevicius M, Anderssen JM, Sandegren L, Andersson DI.

J Antimicrob Chemother. 2016 May;71(5):1307-13. doi: 10.1093/jac/dkv486. Epub 2016 Feb 6.


Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance.

Linkevicius M, Sandegren L, Andersson DI.

Antimicrob Agents Chemother. 2015 Nov 23;60(2):789-96. doi: 10.1128/AAC.02465-15. Print 2016 Feb.


Intestinal spirochaetes (genus Brachyspira) colonise wild birds in the southern Atlantic region and Antarctica.

Jansson DS, Mushtaq M, Johansson KE, Bonnedahl J, Waldenström J, Andersson DI, Broman T, Berg C, Olsen B.

Infect Ecol Epidemiol. 2015 Nov 18;5:29296. doi: 10.3402/iee.v5.29296. eCollection 2015.


Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase.

Chen Y, Näsvall J, Wu S, Andersson DI, Selmer M.

Acta Crystallogr D Biol Crystallogr. 2015 Nov;71(Pt 11):2267-77. doi: 10.1107/S1399004715016429. Epub 2015 Oct 31.

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