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Recovery from Copperhead Snake Envenomation: Role of Age, Sex, Bite Location, Severity, and Treatment.

Lavonas EJ, Burnham RI, Schwarz J, Quackenbush E, Lewis B, Rose SR, Greene S, Toschlog EA, Charlton NP, Mullins ME, Schwartz R, Denning D, Sharma K, Kleinschmidt K, Bush SP, Anderson VE, Ginde AA, Gerardo CJ.

J Med Toxicol. 2019 Sep 3. doi: 10.1007/s13181-019-00733-y. [Epub ahead of print]


In reply to Dr. Shah and Dr. Beuhler.

Lavonas EJ, Anderson VE, Gerardo CJ.

Clin Toxicol (Phila). 2019 Jul 17:1-2. doi: 10.1080/15563650.2019.1641607. [Epub ahead of print] No abstract available.


Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation.

Freiermuth CE, Lavonas EJ, Anderson VE, Kleinschmidt KC, Sharma K, Rapp-Olsson M, Gerardo C; Copperhead Recovery Workgroup.

West J Emerg Med. 2019 May;20(3):497-505. doi: 10.5811/westjem.2019.3.42693. Epub 2019 Apr 26.


The Efficacy of Antivenin Latrodectus (Black Widow) Equine Immune F(ab')2 Versus Placebo in the Treatment of Latrodectism: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.

Dart RC, Bush SP, Heard K, Arnold TC, Sutter M, Campagne D, Holstege CP, Seifert SA, Lo JCY, Quan D, Borron S, Meurer DA, Burnham RI, McNally J, Garcia-Ubbelohde W, Anderson VE.

Ann Emerg Med. 2019 Sep;74(3):439-449. doi: 10.1016/j.annemergmed.2019.02.007. Epub 2019 Mar 27.


The validity, reliability and minimal clinically important difference of the patient specific functional scale in snake envenomation.

Gerardo CJ, Vissoci JRN, de Oliveira LP, Anderson VE, Quackenbush E, Lewis B, Rose SR, Greene S, Toschlog EA, Charlton NP, Mullins ME, Schwartz R, Denning D, Sharma K, Kleinschmidt K, Bush SP, Brandehoff NP, Lavonas EJ.

PLoS One. 2019 Mar 5;14(3):e0213077. doi: 10.1371/journal.pone.0213077. eCollection 2019.


Response to carpenter and colleagues.

Lavonas EJ, Anderson VE, Gerardo CJ.

Clin Toxicol (Phila). 2019 Jul;57(7):674-676. doi: 10.1080/15563650.2018.1554816. Epub 2019 Feb 13. No abstract available.


Tuning T-Cell Receptor Affinity to Optimize Clinical Risk-Benefit When Targeting Alpha-Fetoprotein-Positive Liver Cancer.

Docta RY, Ferronha T, Sanderson JP, Weissensteiner T, Pope GR, Bennett AD, Pumphrey NJ, Ferjentsik Z, Quinn LL, Wiedermann GE, Anderson VE, Saini M, Maroto M, Norry E, Gerry AB.

Hepatology. 2019 May;69(5):2061-2075. doi: 10.1002/hep.30477. Epub 2019 Feb 14.


Adverse Events in the Efficacy of Crotalidae Polyvalent Immune Fab Antivenom vs Placebo in Recovery from Copperhead Snakebite Trial.

Mullins ME, Gerardo CJ, Bush SP, Rose SR, Greene S, Quackenbush EB, Lewis B, Anderson VE, Kleinschmidt KC, Schwarz RB, Charlton NP, Toschlog EA, Sharma K, Denning DA, Lavonas EJ.

South Med J. 2018 Dec;111(12):716-720. doi: 10.14423/SMJ.0000000000000902.


Early administration of Fab antivenom resulted in faster limb recovery in copperhead snake envenomation patients.

Anderson VE, Gerardo CJ, Rapp-Olsson M, Bush SP, Mullins ME, Greene S, Toschlog EA, Quackenbush E, Rose SR, Schwartz RB, Charlton NP, Lewis B, Kleinschmidt KC, Sharma K, Lavonas EJ.

Clin Toxicol (Phila). 2019 Jan;57(1):25-30. doi: 10.1080/15563650.2018.1491982. Epub 2018 Sep 3.


Serum paracetamol-protein adducts in ambulatory subjects: Relationship to recent reported paracetamol use.

Heard K, Anderson VE, Lavonas EJ, Dart RC, Green JL.

Biomarkers. 2018 May;23(3):288-292. doi: 10.1080/1354750X.2017.1410857. Epub 2017 Dec 8.



Harris ME, Anderson VE.

Methods Enzymol. 2017;596:xv-xviii. doi: 10.1016/S0076-6879(17)30303-8. No abstract available.


Kinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation.

Harris ME, York DM, Piccirilli JA, Anderson VE.

Methods Enzymol. 2017;596:433-457. doi: 10.1016/bs.mie.2017.07.017. Epub 2017 Sep 5.


Expert Consensus Guidelines for Stocking of Antidotes in Hospitals That Provide Emergency Care.

Dart RC, Goldfrank LR, Erstad BL, Huang DT, Todd KH, Weitz J, Bebarta VS, Caravati EM, Henretig FM, Delbridge TR, Banner W, Schneider SM, Anderson VE.

Ann Emerg Med. 2018 Mar;71(3):314-325.e1. doi: 10.1016/j.annemergmed.2017.05.021. Epub 2017 Jun 29. Review.


The Efficacy of Crotalidae Polyvalent Immune Fab (Ovine) Antivenom Versus Placebo Plus Optional Rescue Therapy on Recovery From Copperhead Snake Envenomation: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.

Gerardo CJ, Quackenbush E, Lewis B, Rose SR, Greene S, Toschlog EA, Charlton NP, Mullins ME, Schwartz R, Denning D, Sharma K, Kleinschmidt K, Bush SP, Ryan S, Gasior M, Anderson VE, Lavonas EJ.

Ann Emerg Med. 2017 Aug;70(2):233-244.e3. doi: 10.1016/j.annemergmed.2017.04.034. Epub 2017 Jun 13.


Accuracy of the Structured Medication History Assessment Tool (MedHAT) Compared with Recorded Real-Time Medication Use.

Heard K, Anderson VE, Dart RC, Green JL.

Pharmacotherapy. 2016 May;36(5):496-504. doi: 10.1002/phar.1750. Epub 2016 May 2.


Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2+).

Zhang S, Gu H, Chen H, Strong E, Ollie EW, Kellerman D, Liang D, Miyagi M, Anderson VE, Piccirilli JA, York DM, Harris ME.

Chem Commun (Camb). 2016 Mar 25;52(24):4462-5. doi: 10.1039/c5cc10212j.


Acute hepatotoxicity associated with therapeutic doses of intravenous acetaminophen.

Seifert SA, Kovnat D, Anderson VE, Green JL, Dart RC, Heard KJ.

Clin Toxicol (Phila). 2016 Mar;54(3):282-5. doi: 10.3109/15563650.2015.1134798. Epub 2016 Jan 14.


Multiple alternative substrate kinetics.

Anderson VE.

Biochim Biophys Acta. 2015 Nov;1854(11):1729-36. doi: 10.1016/j.bbapap.2015.05.016. Epub 2015 Jun 4. Review.


Multiple mass isotopomer tracing of acetyl-CoA metabolism in Langendorff-perfused rat hearts: channeling of acetyl-CoA from pyruvate dehydrogenase to carnitine acetyltransferase.

Li Q, Deng S, Ibarra RA, Anderson VE, Brunengraber H, Zhang GF.

J Biol Chem. 2015 Mar 27;290(13):8121-32. doi: 10.1074/jbc.M114.631549. Epub 2015 Feb 2.


Hidden specificity in an apparently nonspecific RNA-binding protein.

Guenther UP, Yandek LE, Niland CN, Campbell FE, Anderson D, Anderson VE, Harris ME, Jankowsky E.

Nature. 2013 Oct 17;502(7471):385-8. doi: 10.1038/nature12543. Epub 2013 Sep 22.


Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers.

Bey EA, Reinicke KE, Srougi MC, Varnes M, Anderson VE, Pink JJ, Li LS, Patel M, Cao L, Moore Z, Rommel A, Boatman M, Lewis C, Euhus DM, Bornmann WG, Buchsbaum DJ, Spitz DR, Gao J, Boothman DA.

Mol Cancer Ther. 2013 Oct;12(10):2110-20. doi: 10.1158/1535-7163.MCT-12-0962. Epub 2013 Jul 24.


Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation.

Gu H, Zhang S, Wong KY, Radak BK, Dissanayake T, Kellerman DL, Dai Q, Miyagi M, Anderson VE, York DM, Piccirilli JA, Harris ME.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13002-7. doi: 10.1073/pnas.1215086110. Epub 2013 Jul 22.


Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate.

Harris SR, Zhang GF, Sadhukhan S, Wang H, Shi C, Puchowicz MA, Anderson VE, Salomon RG, Tochtrop GP, Brunengraber H.

Chem Res Toxicol. 2013 Feb 18;26(2):213-20. doi: 10.1021/tx3003643. Epub 2012 Dec 6.


Metabolism of γ-hydroxybutyrate in perfused rat livers.

Zhang GF, Sadhukhan S, Ibarra RA, Lauden SM, Chuang CY, Sushailo S, Chatterjee P, Anderson VE, Tochtrop GP, Brunengraber H.

Biochem J. 2012 Jun 1;444(2):333-41. doi: 10.1042/BJ20112046.


Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski oncogene-induced shift from glycolysis to oxidative energy metabolism.

Ye F, Lemieux H, Hoppel CL, Hanson RW, Hakimi P, Croniger CM, Puchowicz M, Anderson VE, Fujioka H, Stavnezer E.

J Biol Chem. 2011 Nov 18;286(46):40013-24. doi: 10.1074/jbc.M111.292029. Epub 2011 Sep 14.


Deconvolution of Raman spectroscopic signals for electrostatic, H-bonding, and inner-sphere interactions between ions and dimethyl phosphate in solution.

Christian EL, Anderson VE, Harris ME.

J Inorg Biochem. 2011 Apr;105(4):538-47. doi: 10.1016/j.jinorgbio.2010.12.006. Epub 2010 Dec 28.


CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.

Anderson VE, Walton MI, Eve PD, Boxall KJ, Antoni L, Caldwell JJ, Aherne W, Pearl LH, Oliver AW, Collins I, Garrett MD.

Cancer Res. 2011 Jan 15;71(2):463-72. doi: 10.1158/0008-5472.CAN-10-1252.


Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2.

Caldwell JJ, Welsh EJ, Matijssen C, Anderson VE, Antoni L, Boxall K, Urban F, Hayes A, Raynaud FI, Rigoreau LJ, Raynham T, Aherne GW, Pearl LH, Oliver AW, Garrett MD, Collins I.

J Med Chem. 2011 Jan 27;54(2):580-90. doi: 10.1021/jm101150b. Epub 2010 Dec 27.


Metabolism of levulinate in perfused rat livers and live rats: conversion to the drug of abuse 4-hydroxypentanoate.

Harris SR, Zhang GF, Sadhukhan S, Murphy AM, Tomcik KA, Vazquez EJ, Anderson VE, Tochtrop GP, Brunengraber H.

J Biol Chem. 2011 Feb 18;286(7):5895-904. doi: 10.1074/jbc.M110.196808. Epub 2010 Dec 1.


Binding to and photo-oxidation of cardiolipin by the phthalocyanine photosensitizer Pc 4.

Rodriguez ME, Kim J, Delos Santos GB, Azizuddin K, Berlin J, Anderson VE, Kenney ME, Oleinick NL.

J Biomed Opt. 2010 Sep-Oct;15(5):051604. doi: 10.1117/1.3484256.


Cardiolipin: characterization of distinct oxidized molecular species.

Kim J, Minkler PE, Salomon RG, Anderson VE, Hoppel CL.

J Lipid Res. 2011 Jan;52(1):125-35. doi: 10.1194/jlr.M010520. Epub 2010 Sep 20.


Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base.

Harris ME, Dai Q, Gu H, Kellerman DL, Piccirilli JA, Anderson VE.

J Am Chem Soc. 2010 Aug 25;132(33):11613-21. doi: 10.1021/ja103550e.


Photo-oxidation of cardiolipin and cytochrome c with bilayer-embedded Pc 4.

Kim J, Rodriguez ME, Oleinick NL, Anderson VE.

Free Radic Biol Med. 2010 Sep 1;49(5):718-25. doi: 10.1016/j.freeradbiomed.2010.05.014. Epub 2010 May 25.


Photosensitization of intact heart mitochondria by the phthalocyanine Pc 4: Correlation of structural and functional deficits with cytochrome c release.

Kim J, Fujioka H, Oleinick NL, Anderson VE.

Free Radic Biol Med. 2010 Sep 1;49(5):726-32. doi: 10.1016/j.freeradbiomed.2010.05.013. Epub 2010 May 25.


A quantitative Raman spectroscopic signal for metal-phosphodiester interactions in solution.

Christian EL, Anderson VE, Carey PR, Harris ME.

Biochemistry. 2010 Apr 6;49(13):2869-79. doi: 10.1021/bi901866u.


Penicillin sulfone inhibitors of class D beta-lactamases.

Drawz SM, Bethel CR, Doppalapudi VR, Sheri A, Pagadala SR, Hujer AM, Skalweit MJ, Anderson VE, Chen SG, Buynak JD, Bonomo RA.

Antimicrob Agents Chemother. 2010 Apr;54(4):1414-24. doi: 10.1128/AAC.00743-09. Epub 2010 Jan 19.


Mass spectrometric evidence for the existence of distinct modifications of different proteins by 2(E),4(E)-decadienal.

Zhu X, Tang X, Zhang J, Tochtrop GP, Anderson VE, Sayre LM.

Chem Res Toxicol. 2010 Mar 15;23(3):467-73. doi: 10.1021/tx900379a.


Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2.

Hilton S, Naud S, Caldwell JJ, Boxall K, Burns S, Anderson VE, Antoni L, Allen CE, Pearl LH, Oliver AW, Wynne Aherne G, Garrett MD, Collins I.

Bioorg Med Chem. 2010 Jan 15;18(2):707-18. doi: 10.1016/j.bmc.2009.11.058. Epub 2009 Dec 6. Erratum in: Bioorg Med Chem. 2010 Jun 15;18(12):4591.


Measuring proteome dynamics in vivo: as easy as adding water?

Rachdaoui N, Austin L, Kramer E, Previs MJ, Anderson VE, Kasumov T, Previs SF.

Mol Cell Proteomics. 2009 Dec;8(12):2653-63. doi: 10.1074/mcp.M900026-MCP200. Epub 2009 Sep 1.


Effects of allergic airway disease on mouse adenovirus type 1 respiratory infection.

Anderson VE, Nguyen Y, Weinberg JB.

Virology. 2009 Aug 15;391(1):25-32. doi: 10.1016/j.virol.2009.06.009. Epub 2009 Jun 28.


Mass spectrometric characterization of protein modification by the products of nonenzymatic oxidation of linoleic acid.

Zhu X, Tang X, Anderson VE, Sayre LM.

Chem Res Toxicol. 2009 Aug;22(8):1386-97. doi: 10.1021/tx9000072.


Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal.

Zhu X, Gallogly MM, Mieyal JJ, Anderson VE, Sayre LM.

Chem Res Toxicol. 2009 Jun;22(6):1050-9. doi: 10.1021/tx9000144.


Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans.

Kombu RS, Zhang GF, Abbas R, Mieyal JJ, Anderson VE, Kelleher JK, Sanabria JR, Brunengraber H.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E260-9. doi: 10.1152/ajpendo.00080.2009. Epub 2009 Apr 28.


Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins.

Ghosh AK, Devenport M, Jethwaney D, Kalume DE, Pandey A, Anderson VE, Sultan AA, Kumar N, Jacobs-Lorena M.

PLoS Pathog. 2009 Jan;5(1):e1000265. doi: 10.1371/journal.ppat.1000265. Epub 2009 Jan 16.


Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone.

Pattanaik P, Bethel CR, Hujer AM, Hujer KM, Distler AM, Taracila M, Anderson VE, Fritsche TR, Jones RN, Pagadala SR, van den Akker F, Buynak JD, Bonomo RA.

J Biol Chem. 2009 Jan 9;284(2):945-53. doi: 10.1074/jbc.M806833200. Epub 2008 Oct 27.


Gammaherpesvirus modulation of mouse adenovirus type 1 pathogenesis.

Nguyen Y, McGuffie BA, Anderson VE, Weinberg JB.

Virology. 2008 Oct 25;380(2):182-90. doi: 10.1016/j.virol.2008.07.031. Epub 2008 Sep 2.


Inhibition of class A beta-lactamases by carbapenems: crystallographic observation of two conformations of meropenem in SHV-1.

Nukaga M, Bethel CR, Thomson JM, Hujer AM, Distler A, Anderson VE, Knox JR, Bonomo RA.

J Am Chem Soc. 2008 Sep 24;130(38):12656-62. doi: 10.1021/ja7111146. Epub 2008 Aug 30.


Inhibition of OXA-1 beta-lactamase by penems.

Bethel CR, Distler AM, Ruszczycky MW, Carey MP, Carey PR, Hujer AM, Taracila M, Helfand MS, Thomson JM, Kalp M, Anderson VE, Leonard DA, Hujer KM, Abe T, Venkatesan AM, Mansour TS, Bonomo RA.

Antimicrob Agents Chemother. 2008 Sep;52(9):3135-43. doi: 10.1128/AAC.01677-07. Epub 2008 Jun 16.


Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle. I. Interrelation between gluconeogenesis and cataplerosis; formation of methoxamates from aminooxyacetate and ketoacids.

Yang L, Kombu RS, Kasumov T, Zhu SH, Cendrowski AV, David F, Anderson VE, Kelleher JK, Brunengraber H.

J Biol Chem. 2008 Aug 8;283(32):21978-87. doi: 10.1074/jbc.M803454200. Epub 2008 Jun 10.

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