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Items: 1 to 50 of 71

1.

Removing physiological motion from intravital and clinical functional imaging data.

Warren SC, Nobis M, Magenau A, Mohammed YH, Herrmann D, Moran I, Vennin C, Conway JR, Mélénec P, Cox TR, Wang Y, Morton JP, Welch HC, Strathdee D, Anderson KI, Phan TG, Roberts MS, Timpson P.

Elife. 2018 Jul 9;7. pii: e35800. doi: 10.7554/eLife.35800.

2.

Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse.

Nobis M, Herrmann D, Warren SC, Strathdee D, Cox TR, Anderson KI, Timpson P.

Small GTPases. 2018 Mar 21:1-8. doi: 10.1080/21541248.2018.1438024. [Epub ahead of print]

PMID:
29457531
3.

Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments.

Martin KJ, McGhee EJ, Schwarz JP, Drysdale M, Brachmann SM, Stucke V, Sansom OJ, Anderson KI.

PLoS One. 2018 Jan 2;13(1):e0183585. doi: 10.1371/journal.pone.0183585. eCollection 2018.

4.

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

Nobis M, Herrmann D, Warren SC, Kadir S, Leung W, Killen M, Magenau A, Stevenson D, Lucas MC, Reischmann N, Vennin C, Conway JRW, Boulghourjian A, Zaratzian A, Law AM, Gallego-Ortega D, Ormandy CJ, Walters SN, Grey ST, Bailey J, Chtanova T, Quinn JMW, Baldock PA, Croucher PI, Schwarz JP, Mrowinska A, Zhang L, Herzog H, Masedunskas A, Hardeman EC, Gunning PW, Del Monte-Nieto G, Harvey RP, Samuel MS, Pajic M, McGhee EJ, Johnsson AE, Sansom OJ, Welch HCE, Morton JP, Strathdee D, Anderson KI, Timpson P.

Cell Rep. 2017 Oct 3;21(1):274-288. doi: 10.1016/j.celrep.2017.09.022.

5.

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

Vennin C, Chin VT, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec P, Walters SN, Del Monte-Nieto G, Conway JR, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam AA, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NL, Phan T, Jain R, Weninger W, McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP, Biankin AV; Australian Pancreatic Cancer Genome Initiative (APGI), Evans TR, Anderson KI, Grey ST, Ormandy CJ, Gallego-Ortega D, Wang Y, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M, Timpson P.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaai8504. doi: 10.1126/scitranslmed.aai8504.

6.

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.

Rath N, Morton JP, Julian L, Helbig L, Kadir S, McGhee EJ, Anderson KI, Kalna G, Mullin M, Pinho AV, Rooman I, Samuel MS, Olson MF.

EMBO Mol Med. 2017 Feb;9(2):198-218. doi: 10.15252/emmm.201606743.

7.

The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines.

Wildenberg ME, Koelink PJ, Diederen K, Te Velde AA, Wolfkamp SC, Nuij VJ, Peppelenbosch MP, Nobis M, Sansom OJ, Anderson KI, van der Woude CJ, D'Haens GR, van den Brink GR.

Mucosal Immunol. 2017 Mar;10(2):352-360. doi: 10.1038/mi.2016.65. Epub 2016 Jul 20.

PMID:
27435106
8.

Correction: Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.

Kumar A, Ouyang M, Van den Dries K, McGhee EJ, Tanaka K, Anderson MD, Groisman A, Goult BT, Anderson KI, Schwartz MA.

J Cell Biol. 2016 Jul 18;214(2):231. doi: 10.1083/jcb.20151001207062016c. No abstract available.

9.

In-Depth Proteomics Identifies a Role for Autophagy in Controlling Reactive Oxygen Species Mediated Endothelial Permeability.

Patella F, Neilson LJ, Athineos D, Erami Z, Anderson KI, Blyth K, Ryan KM, Zanivan S.

J Proteome Res. 2016 Jul 1;15(7):2187-97. doi: 10.1021/acs.jproteome.6b00166. Epub 2016 Jun 15.

PMID:
27246970
10.

MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth.

Kalafatovic D, Nobis M, Son J, Anderson KI, Ulijn RV.

Biomaterials. 2016 Aug;98:192-202. doi: 10.1016/j.biomaterials.2016.04.039. Epub 2016 Apr 30.

PMID:
27192421
11.

Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.

Kumar A, Ouyang M, Van den Dries K, McGhee EJ, Tanaka K, Anderson MD, Groisman A, Goult BT, Anderson KI, Schwartz MA.

J Cell Biol. 2016 May 9;213(3):371-83. doi: 10.1083/jcb.201510012. Erratum in: J Cell Biol. 2016 Jul 18;214(2):231.

12.

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue.

Erami Z, Herrmann D, Warren SC, Nobis M, McGhee EJ, Lucas MC, Leung W, Reischmann N, Mrowinska A, Schwarz JP, Kadir S, Conway JRW, Vennin C, Karim SA, Campbell AD, Gallego-Ortega D, Magenau A, Murphy KJ, Ridgway RA, Law AM, Walters SN, Grey ST, Croucher DR, Zhang L, Herzog H, Hardeman EC, Gunning PW, Ormandy CJ, Evans TRJ, Strathdee D, Sansom OJ, Morton JP, Anderson KI, Timpson P.

Cell Rep. 2016 Jan 5;14(1):152-167. doi: 10.1016/j.celrep.2015.12.020. Epub 2015 Dec 24.

13.

There are four dynamically and functionally distinct populations of E-cadherin in cell junctions.

Erami Z, Timpson P, Yao W, Zaidel-Bar R, Anderson KI.

Biol Open. 2015 Oct 15;4(11):1481-9. doi: 10.1242/bio.014159.

14.

Fibroblasts keep melanoma safe from harm.

Anderson KI.

Intravital. 2015 Jul 30;4(2):e1074788. doi: 10.1080/21659087.2015.1074788. eCollection 2015 May-Aug. No abstract available.

15.

MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin.

Kalafatovic D, Nobis M, Javid N, Frederix PW, Anderson KI, Saunders BR, Ulijn RV.

Biomater Sci. 2015 Feb;3(2):246-9. doi: 10.1039/c4bm00297k. Epub 2014 Oct 28.

PMID:
26218115
16.

Polarized cell motility induces hydrogen peroxide to inhibit cofilin via cysteine oxidation.

Cameron JM, Gabrielsen M, Chim YH, Munro J, McGhee EJ, Sumpton D, Eaton P, Anderson KI, Yin H, Olson MF.

Curr Biol. 2015 Jun 1;25(11):1520-5. doi: 10.1016/j.cub.2015.04.020. Epub 2015 May 14.

17.

Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis.

von Karstedt S, Conti A, Nobis M, Montinaro A, Hartwig T, Lemke J, Legler K, Annewanter F, Campbell AD, Taraborrelli L, Grosse-Wilde A, Coy JF, El-Bahrawy MA, Bergmann F, Koschny R, Werner J, Ganten TM, Schweiger T, Hoetzenecker K, Kenessey I, Hegedüs B, Bergmann M, Hauser C, Egberts JH, Becker T, Röcken C, Kalthoff H, Trauzold A, Anderson KI, Sansom OJ, Walczak H.

Cancer Cell. 2015 Apr 13;27(4):561-73. doi: 10.1016/j.ccell.2015.02.014. Epub 2015 Apr 2.

18.

HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.

Rai TS, Cole JJ, Nelson DM, Dikovskaya D, Faller WJ, Vizioli MG, Hewitt RN, Anannya O, McBryan T, Manoharan I, van Tuyn J, Morrice N, Pchelintsev NA, Ivanov A, Brock C, Drotar ME, Nixon C, Clark W, Sansom OJ, Anderson KI, King A, Blyth K, Adams PD.

Genes Dev. 2014 Dec 15;28(24):2712-25. doi: 10.1101/gad.247528.114.

19.

An open data ecosystem for cell migration research.

Masuzzo P, Martens L; 2014 Cell Migration Workshop Participants, Ampe C, Anderson KI, Barry J, De Wever O, Debeir O, Decaestecker C, Dolznig H, Friedl P, Gaggioli C, Geiger B, Goldberg IG, Horn E, Horwitz R, Kam Z, Le Dévédec SE, Vignjevic DM, Moore J, Olivo-Marin JC, Sahai E, Sansone SA, Sanz-Moreno V, Strömblad S, Swedlow J, Textor J, Van Troys M, Zantl R.

Trends Cell Biol. 2015 Feb;25(2):55-8. doi: 10.1016/j.tcb.2014.11.005. Epub 2014 Dec 5.

PMID:
25484346
20.

Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging.

Nobis M, McGhee EJ, Herrmann D, Magenau A, Morton JP, Anderson KI, Timpson P.

Cell Adh Migr. 2014;8(5):478-86. doi: 10.4161/19336918.2014.970004.

21.

Synthesis of migrastatin and its macroketone analogue and in vivo FRAP analysis of the macroketone on E-cadherin dynamics.

Lo Re D, Zhou Y, Nobis M, Anderson KI, Murphy PV.

Chembiochem. 2014 Jul 7;15(10):1459-64. doi: 10.1002/cbic.201402061. Epub 2014 Jun 11.

PMID:
24919421
22.

Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques.

Ioannidou K, Anderson KI, Strachan D, Edgar JM, Barnett SC.

BMC Neurosci. 2014 May 2;15:59. doi: 10.1186/1471-2202-15-59.

23.

Targeting mTOR dependency in pancreatic cancer.

Morran DC, Wu J, Jamieson NB, Mrowinska A, Kalna G, Karim SA, Au AY, Scarlett CJ, Chang DK, Pajak MZ; Australian Pancreatic Cancer Genome Initiative (APGI), Oien KA, McKay CJ, Carter CR, Gillen G, Champion S, Pimlott SL, Anderson KI, Evans TR, Grimmond SM, Biankin AV, Sansom OJ, Morton JP.

Gut. 2014 Sep;63(9):1481-9. doi: 10.1136/gutjnl-2013-306202. Epub 2014 Apr 9.

24.

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues.

Johnsson AE, Dai Y, Nobis M, Baker MJ, McGhee EJ, Walker S, Schwarz JP, Kadir S, Morton JP, Myant KB, Huels DJ, Segonds-Pichon A, Sansom OJ, Anderson KI, Timpson P, Welch HCE.

Cell Rep. 2014 Mar 27;6(6):1153-1164. doi: 10.1016/j.celrep.2014.02.024. Epub 2014 Mar 13.

25.

Strategies to overcome photobleaching in algorithm-based adaptive optics for nonlinear in-vivo imaging.

Caroline Müllenbroich M, McGhee EJ, Wright AJ, Anderson KI, Mathieson K.

J Biomed Opt. 2014 Jan;19(1):16021. doi: 10.1117/1.JBO.19.1.016021.

PMID:
24474507
26.

p53 status determines the role of autophagy in pancreatic tumour development.

Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, Adams PD, Anderson KI, Gottlieb E, Sansom OJ, Ryan KM.

Nature. 2013 Dec 12;504(7479):296-300. doi: 10.1038/nature12865. Epub 2013 Dec 4.

PMID:
24305049
27.

Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity.

von Thun A, Preisinger C, Rath O, Schwarz JP, Ward C, Monsefi N, Rodríguez J, Garcia-Munoz A, Birtwistle M, Bienvenut W, Anderson KI, Kolch W, von Kriegsheim A.

Mol Cell Biol. 2013 Nov;33(22):4526-37. doi: 10.1128/MCB.00585-13. Epub 2013 Sep 16.

28.

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer.

Nobis M, McGhee EJ, Morton JP, Schwarz JP, Karim SA, Quinn J, Edward M, Campbell AD, McGarry LC, Evans TR, Brunton VG, Frame MC, Carragher NO, Wang Y, Sansom OJ, Timpson P, Anderson KI.

Cancer Res. 2013 Aug 1;73(15):4674-86. doi: 10.1158/0008-5472.CAN-12-4545. Epub 2013 Jun 7.

29.

Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue.

Nobis M, Carragher NO, McGhee EJ, Morton JP, Sansom OJ, Anderson KI, Timpson P.

FEBS J. 2013 Nov;280(21):5177-97. doi: 10.1111/febs.12348. Epub 2013 Jun 28. Review.

30.

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.

Myant KB, Cammareri P, McGhee EJ, Ridgway RA, Huels DJ, Cordero JB, Schwitalla S, Kalna G, Ogg EL, Athineos D, Timpson P, Vidal M, Murray GI, Greten FR, Anderson KI, Sansom OJ.

Cell Stem Cell. 2013 Jun 6;12(6):761-73. doi: 10.1016/j.stem.2013.04.006. Epub 2013 May 9.

31.

β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity.

Mack NA, Porter AP, Whalley HJ, Schwarz JP, Jones RC, Khaja AS, Bjartell A, Anderson KI, Malliri A.

Nat Cell Biol. 2012 Nov;14(11):1169-80. doi: 10.1038/ncb2608. Epub 2012 Oct 28.

32.

Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Abl-positive chronic myeloid leukemia cells.

Preisinger C, Schwarz JP, Bleijerveld OB, Corradini E, Müller PJ, Anderson KI, Kolch W, Scholten A, Heck AJ.

Leukemia. 2013 Mar;27(3):743-6. doi: 10.1038/leu.2012.243. Epub 2012 Aug 27. No abstract available.

PMID:
22976128
33.

Inhibition of autophagy impairs tumor cell invasion in an organotypic model.

Macintosh RL, Timpson P, Thorburn J, Anderson KI, Thorburn A, Ryan KM.

Cell Cycle. 2012 May 15;11(10):2022-9. doi: 10.4161/cc.20424. Epub 2012 May 15.

34.

Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo.

Ioannidou K, Anderson KI, Strachan D, Edgar JM, Barnett SC.

PLoS One. 2012;7(1):e30775. doi: 10.1371/journal.pone.0030775. Epub 2012 Jan 27.

35.

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion.

McGhee EJ, Morton JP, Von Kriegsheim A, Schwarz JP, Karim SA, Carragher NO, Sansom OJ, Anderson KI, Timpson P.

Small GTPases. 2011 Jul;2(4):239-244. Epub 2011 Jul 1.

36.

Linear approaches to intramolecular Förster resonance energy transfer probe measurements for quantitative modeling.

Birtwistle MR, von Kriegsheim A, Kida K, Schwarz JP, Anderson KI, Kolch W.

PLoS One. 2011;6(11):e27823. doi: 10.1371/journal.pone.0027823. Epub 2011 Nov 16.

37.

Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context.

Timpson P, McGhee EJ, Erami Z, Nobis M, Quinn JA, Edward M, Anderson KI.

J Vis Exp. 2011 Oct 13;(56):e3089. doi: 10.3791/3089.

38.

Imaging molecular dynamics in vivo--from cell biology to animal models.

Timpson P, McGhee EJ, Anderson KI.

J Cell Sci. 2011 Sep 1;124(Pt 17):2877-90. doi: 10.1242/jcs.085191. Review.

39.

Characterizing system performance in total internal reflection fluorescence microscopy.

Schwarz JP, König I, Anderson KI.

Methods Mol Biol. 2011;769:373-86. doi: 10.1007/978-1-61779-207-6_25.

PMID:
21748689
40.

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.

Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF.

Cancer Cell. 2011 Jun 14;19(6):776-91. doi: 10.1016/j.ccr.2011.05.008.

41.

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53.

Timpson P, McGhee EJ, Morton JP, von Kriegsheim A, Schwarz JP, Karim SA, Doyle B, Quinn JA, Carragher NO, Edward M, Olson MF, Frame MC, Brunton VG, Sansom OJ, Anderson KI.

Cancer Res. 2011 Feb 1;71(3):747-57. doi: 10.1158/0008-5472.CAN-10-2267. Epub 2011 Jan 25.

42.

Live cell in vitro and in vivo imaging applications: accelerating drug discovery.

Isherwood B, Timpson P, McGhee EJ, Anderson KI, Canel M, Serrels A, Brunton VG, Carragher NO.

Pharmaceutics. 2011 Apr 4;3(2):141-70. doi: 10.3390/pharmaceutics3020141.

43.

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.

Scott RW, Hooper S, Crighton D, Li A, König I, Munro J, Trivier E, Wickman G, Morin P, Croft DR, Dawson J, Machesky L, Anderson KI, Sahai EA, Olson MF.

J Cell Biol. 2010 Oct 4;191(1):169-85. doi: 10.1083/jcb.201002041. Epub 2010 Sep 27.

44.

Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane.

Canel M, Serrels A, Anderson KI, Frame MC, Brunton VG.

Cell Adh Migr. 2010 Oct-Dec;4(4):491-501.

45.

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.

Serrels B, Sandilands E, Serrels A, Baillie G, Houslay MD, Brunton VG, Canel M, Machesky LM, Anderson KI, Frame MC.

Curr Biol. 2010 Jun 22;20(12):1086-92. doi: 10.1016/j.cub.2010.04.042. Epub 2010 May 20.

46.

The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly.

Rooney C, White G, Nazgiewicz A, Woodcock SA, Anderson KI, Ballestrem C, Malliri A.

EMBO Rep. 2010 Apr;11(4):292-8. doi: 10.1038/embor.2010.10. Epub 2010 Mar 12.

47.

Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo.

Timpson P, Serrels A, Canel M, Frame MC, Brunton VG, Anderson KI.

Cell Adh Migr. 2009 Oct-Dec;3(4):351-4. Epub 2009 Oct 7. Review.

48.

Partial characterization of feline myeloperoxidase and investigation of its potential role as an autoantigen in hyperthyroid cats.

Pressler BM, Robarge ME, Anderson KI.

Am J Vet Res. 2009 Jul;70(7):869-78. doi: 10.2460/ajvr.70.7.869.

PMID:
19566472
49.

Sequencing of the von Hippel-Lindau gene in canine renal carcinoma.

Pressler BM, Williams LE, Ramos-Vara JA, Anderson KI.

J Vet Intern Med. 2009 May-Jun;23(3):592-7. doi: 10.1111/j.1939-1676.2009.0310.x. Epub 2009 Apr 21.

50.

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development.

Serrels A, Timpson P, Canel M, Schwarz JP, Carragher NO, Frame MC, Brunton VG, Anderson KI.

Cancer Res. 2009 Apr 1;69(7):2714-9. doi: 10.1158/0008-5472.CAN-08-4308. Epub 2009 Mar 24.

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