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Longer Preoperative Duration of Symptoms Negatively Affects Health-Related Quality of Life After Surgery for Cervical Radiculopathy.

Tarazona D, Boody B, Hilibrand AS, Stull J, Bell K, Fang T, Goyal D, Galetta M, Kaye D, Kepler CK, Kurd MF, Woods BI, Radcliff KE, Rihn JA, Anderson DG, Vaccaro AR, Schroeder GD.

Spine (Phila Pa 1976). 2018 Nov 1. doi: 10.1097/BRS.0000000000002924. [Epub ahead of print]


Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis.

Meyer IS, Goetzke CC, Kespohl M, Sauter M, Heuser A, Eckstein V, Vornlocher HP, Anderson DG, Haas J, Meder B, Katus HA, Klingel K, Beling A, Leuschner F.

Front Immunol. 2018 Oct 8;9:2303. doi: 10.3389/fimmu.2018.02303. eCollection 2018.


Utilization of Time-driven Activity-based Costing to Determine the True Cost of a Single or 2-level Anterior Cervical Discectomy and Fusion.

Schroeder GD, Hilibrand AS, Kepler CK, McKenzie JC, Nicholson KJ, Stawicki C, Paul J, Kumar P, Hollern DA, Murphy H, Milhouse PW, Kurd MF, Woods BI, Radcliff KE, Anderson DG, Vaccaro AR, Rihn JA.

Clin Spine Surg. 2018 Dec;31(10):452-456. doi: 10.1097/BSD.0000000000000728.


Optimization of a Degradable Polymer-Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells.

Kaczmarek JC, Kauffman KJ, Fenton OS, Sadtler K, Patel AK, Heartlein MW, DeRosa F, Anderson DG.

Nano Lett. 2018 Oct 10;18(10):6449-6454. doi: 10.1021/acs.nanolett.8b02917. Epub 2018 Sep 20.


Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs.

Fenton OS, Kauffman KJ, McClellan RL, Kaczmarek JC, Zeng MD, Andresen JL, Rhym LH, Heartlein MW, DeRosa F, Anderson DG.

Angew Chem Int Ed Engl. 2018 Oct 8;57(41):13582-13586. doi: 10.1002/anie.201809056. Epub 2018 Sep 14.


Engineering circular RNA for potent and stable translation in eukaryotic cells.

Wesselhoeft RA, Kowalski PS, Anderson DG.

Nat Commun. 2018 Jul 6;9(1):2629. doi: 10.1038/s41467-018-05096-6.


Ionizable Amino-Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino-Alcohols for Tissue Selective mRNA Delivery.

Kowalski PS, Capasso Palmiero U, Huang Y, Rudra A, Langer R, Anderson DG.

Adv Mater. 2018 Jul 5:e1801151. doi: 10.1002/adma.201801151. [Epub ahead of print]


Endothelial siRNA delivery in nonhuman primates using ionizable low-molecular weight polymeric nanoparticles.

Khan OF, Kowalski PS, Doloff JC, Tsosie JK, Bakthavatchalu V, Winn CB, Haupt J, Jamiel M, Langer R, Anderson DG.

Sci Adv. 2018 Jun 27;4(6):eaar8409. doi: 10.1126/sciadv.aar8409. eCollection 2018 Jun.


Five-year results of a clinical pilot study utilizing a pedicle-lengthening osteotomy for the treatment of lumbar spinal stenosis.

Mlyavykh S, Ludwig SC, Kepler CK, Anderson DG.

J Neurosurg Spine. 2018 Sep;29(3):241-249. doi: 10.3171/2017.11.SPINE16664. Epub 2018 Jun 1.


Are Patients Undergoing an Anterior Cervical Discectomy and Fusion Treated Differently at a Physician-owned Hospital?

Schroeder GD, Kurd MF, Kepler CK, Radcliff KE, Maltenfort MG, Murphy H, Rihn JA, Anderson DG, Hilibrand AS, Vaccaro AR.

Clin Spine Surg. 2018 Jun;31(5):211-215. doi: 10.1097/BSD.0000000000000577.


Perinatal insults and neurodevelopmental disorders may impact Huntington's disease age of diagnosis.

Barkhuizen M, Rodrigues FB, Anderson DG, Winkens B; REGISTRY Investigators of the European Huntington's Disease Network, Wild EJ, Kramer BW, Gavilanes AWD.

Parkinsonism Relat Disord. 2018 Oct;55:55-60. doi: 10.1016/j.parkreldis.2018.05.016. Epub 2018 May 18.


MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling.

Espinosa-Diez C, Wilson R, Chatterjee N, Hudson C, Ruhl R, Hipfinger C, Helms E, Khan OF, Anderson DG, Anand S.

Cell Death Dis. 2018 May 24;9(6):632. doi: 10.1038/s41419-018-0690-y.


Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.

Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A.

Transplantation. 2018 Aug;102(8):1223-1229. doi: 10.1097/TP.0000000000002217.


Poly(β-amino ester)-co-poly(caprolactone) Terpolymers as Nonviral Vectors for mRNA Delivery In Vitro and In Vivo.

Capasso Palmiero U, Kaczmarek JC, Fenton OS, Anderson DG.

Adv Healthc Mater. 2018 Jul;7(14):e1800249. doi: 10.1002/adhm.201800249. Epub 2018 May 14.


Descriptive Analysis of Associated Factors for Urgent Versus Nonurgent Inpatient Spine Transfers to a Tertiary Care Hospital.

Schroeder GD, McKenzie JC, Casper DS, Stake S, Buchholz J, Kepler C, Rihn JA, Woods BI, Radcliff KE, Kaye ID, Nicholson K, Anderson DG, Hilibrand AS, Vaccaro AR, Khan S, Kurd MF.

Am J Med Qual. 2018 Nov/Dec;33(6):623-628. doi: 10.1177/1062860618776080. Epub 2018 May 14.


Surface tension-assisted additive manufacturing.

Ragelle H, Tibbitt MW, Wu SY, Castillo MA, Cheng GZ, Gangadharan SP, Anderson DG, Cima MJ, Langer R.

Nat Commun. 2018 Mar 22;9(1):1184. doi: 10.1038/s41467-018-03391-w.


The local cytokine and growth factor response to recombinant human bone morphogenetic protein-2 (rhBMP-2) after spinal fusion.

Koerner JD, Markova DZ, Schroeder GD, Calio BP, Shah A, Brooks CW, Vaccaro AR, Anderson DG, Kepler CK.

Spine J. 2018 Aug;18(8):1424-1433. doi: 10.1016/j.spinee.2018.03.006. Epub 2018 Mar 14.


Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse.

Kauffman KJ, Oberli MA, Dorkin JR, Hurtado JE, Kaczmarek JC, Bhadani S, Wyckoff J, Langer R, Jaklenec A, Anderson DG.

Mol Ther Nucleic Acids. 2018 Mar 2;10:55-63. doi: 10.1016/j.omtn.2017.11.005. Epub 2017 Nov 21.


Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: a prospective randomized double-blind sham-controlled multi-center study.

Fischgrund JS, Rhyne A, Franke J, Sasso R, Kitchel S, Bae H, Yeung C, Truumees E, Schaufele M, Yuan P, Vajkoczy P, DePalma M, Anderson DG, Thibodeau L, Meyer B.

Eur Spine J. 2018 May;27(5):1146-1156. doi: 10.1007/s00586-018-5496-1. Epub 2018 Feb 8.


Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis.

Budatha M, Zhang J, Zhuang ZW, Yun S, Dahlman JE, Anderson DG, Schwartz MA.

J Am Heart Assoc. 2018 Jan 30;7(3). pii: e007501. doi: 10.1161/JAHA.117.007501.


Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.

Yin H, Song CQ, Suresh S, Kwan SY, Wu Q, Walsh S, Ding J, Bogorad RL, Zhu LJ, Wolfe SA, Koteliansky V, Xue W, Langer R, Anderson DG.

Nat Chem Biol. 2018 Mar;14(3):311-316. doi: 10.1038/nchembio.2559. Epub 2018 Jan 29.


Engineered 3D-printed artificial axons.

Espinosa-Hoyos D, Jagielska A, Homan KA, Du H, Busbee T, Anderson DG, Fang NX, Lewis JA, Van Vliet KJ.

Sci Rep. 2018 Jan 11;8(1):478. doi: 10.1038/s41598-017-18744-6.


Erratum: Glucose-responsive insulin by molecular and physical design.

Bakh NA, Cortinas AB, Weiss MA, Langer RS, Anderson DG, Gu Z, Dutta S, Strano MS.

Nat Chem. 2017 Dec 19;10(1):109. doi: 10.1038/nchem.2898.


Absence of Acanthocytosis in Huntington's Disease-like 2: A Prospective Comparison with Huntington's Disease.

Anderson DG, Carmona S, Naidoo K, Coetzer TL, Carr J, Rudnicki DD, Walker RH, Margolis RL, Krause A.

Tremor Other Hyperkinet Mov (N Y). 2017 Dec 5;7:512. doi: 10.7916/D81J9PDX. eCollection 2017.


Comparing Health-Related Quality of Life Outcomes in Patients Undergoing Either Primary or Revision Anterior Cervical Discectomy and Fusion.

Schroeder GD, Boody BS, Kepler CK, Kurd MF, Silva S, Nicholson K, Wilson JR, Woods BI, Radcliff KE, Anderson DG, Hilibrand AS, Vaccaro AR, Rihn JA.

Spine (Phila Pa 1976). 2018 Jul 1;43(13):E752-E757. doi: 10.1097/BRS.0000000000002511.


Sea-level rise and archaeological site destruction: An example from the southeastern United States using DINAA (Digital Index of North American Archaeology).

Anderson DG, Bissett TG, Yerka SJ, Wells JJ, Kansa EC, Kansa SW, Myers KN, DeMuth RC, White DA.

PLoS One. 2017 Nov 29;12(11):e0188142. doi: 10.1371/journal.pone.0188142. eCollection 2017.


South African guideline on deep brain stimulation for Parkinson's disease.

Anderson DG, Van Coller R, Carr J.

S Afr Med J. 2017 Nov 6;107(10):1027-1032.


Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.

Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, Zatsepin T, Koteliansky V, Wolfe SA, Xue W, Langer R, Anderson DG.

Nat Biotechnol. 2017 Dec;35(12):1179-1187. doi: 10.1038/nbt.4005. Epub 2017 Nov 13.


Identification of cell cycle-targeting microRNAs through genome-wide screens.

Hydbring P, Wang Y, Bogorad RL, Yin H, Anderson DG, Li C, Sicinski P.

Cell Cycle. 2017;16(23):2241-2248. doi: 10.1080/15384101.2017.1380132. Epub 2017 Nov 14.


Cervical Sagittal Range of Motion as a Predictor of Symptom Severity in Cervical Spondylotic Myelopathy.

Nicholson KJ, Millhouse PW, Pflug E, Woods B, Schroeder GD, Anderson DG, Hilibrand AS, Kepler CK, Kurd MF, Rihn JA, Vaccaro A, Radcliff KE.

Spine (Phila Pa 1976). 2018 Jul 1;43(13):883-889. doi: 10.1097/BRS.0000000000002478.


Glucose-responsive insulin by molecular and physical design.

Bakh NA, Cortinas AB, Weiss MA, Langer RS, Anderson DG, Gu Z, Dutta S, Strano MS.

Nat Chem. 2017 Sep 22;9(10):937-943. doi: 10.1038/nchem.2857. Erratum in: Nat Chem. 2017 Dec 19;10 (1):109.


Maintaining genetic integrity of coexisting wild and domestic populations: Genetic differentiation between wild and domestic Rangifer with long traditions of intentional interbreeding.

Anderson DG, Kvie KS, Davydov VN, Røed KH.

Ecol Evol. 2017 Jul 26;7(17):6790-6802. doi: 10.1002/ece3.3230. eCollection 2017 Sep.


Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration.

Bachofner M, Speicher T, Bogorad RL, Muzumdar S, Derrer CP, Hürlimann F, Böhm F, Nanni P, Kockmann T, Kachaylo E, Meyer M, Padrissa-Altés S, Graf R, Anderson DG, Koteliansky V, Auf dem Keller U, Werner S.

Dev Cell. 2017 Sep 25;42(6):616-625.e8. doi: 10.1016/j.devcel.2017.07.025. Epub 2017 Sep 7.


University students' perceived risk of and intention to use waterpipe tobacco.

Rayens MK, Ickes MJ, Butler KM, Wiggins AT, Anderson DG, Hahn EJ.

Health Educ Res. 2017 Aug 1;32(4):306-317. doi: 10.1093/her/cyx049.


The Effect of Hospital Ownership on Health Care Utilization in Orthopedic Surgery.

Schroeder GD, Kurd MF, Kepler CK, Radcliff KE, Maltenfort MG, Murphy H, Rihn JA, Anderson DG, Hilibrand AS, Vaccaro AR.

Clin Spine Surg. 2018 Mar;31(2):73-79. doi: 10.1097/BSD.0000000000000565.


Reliability and Clinical Utility of the CARDS Classification for Degenerative Spondylolisthesis.

Sobol GL, Hilibrand A, Davis A, Millhouse P, Koerner J, Kepler C, Schroeder GD, Krystal JD, Olsson EC, Rihn J, Anderson DG, Vaccaro A, Radcliff K.

Clin Spine Surg. 2018 Feb;31(1):E69-E73. doi: 10.1097/BSD.0000000000000571.


Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression.

Yu D, Khan OF, Suvà ML, Dong B, Panek WK, Xiao T, Wu M, Han Y, Ahmed AU, Balyasnikova IV, Zhang HF, Sun C, Langer R, Anderson DG, Lesniak MS.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6147-E6156. doi: 10.1073/pnas.1701911114. Epub 2017 Jul 10.


Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.

Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D.

J Clin Invest. 2017 Aug 1;127(8):3039-3051. doi: 10.1172/JCI93182. Epub 2017 Jul 10.


Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes.

Fenton OS, Kauffman KJ, Kaczmarek JC, McClellan RL, Jhunjhunwala S, Tibbitt MW, Zeng MD, Appel EA, Dorkin JR, Mir FF, Yang JH, Oberli MA, Heartlein MW, DeRosa F, Langer R, Anderson DG.

Adv Mater. 2017 Sep;29(33). doi: 10.1002/adma.201606944. Epub 2017 Jul 6.


Advances in the delivery of RNA therapeutics: from concept to clinical reality.

Kaczmarek JC, Kowalski PS, Anderson DG.

Genome Med. 2017 Jun 27;9(1):60. doi: 10.1186/s13073-017-0450-0. Review.


Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins.

Yang NJ, Kauke MJ, Sun F, Yang LF, Maass KF, Traxlmayr MW, Yu Y, Xu Y, Langer RS, Anderson DG, Wittrup KD.

Nucleic Acids Res. 2017 Jul 27;45(13):7602-7614. doi: 10.1093/nar/gkx546.


Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing.

Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V, Kisseleva T, Brenner D, Duffield J, Burkly LC.

Mol Ther Nucleic Acids. 2017 Jun 16;7:314-323. doi: 10.1016/j.omtn.2017.04.014. Epub 2017 Apr 20.


CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion.

Mou H, Smith JL, Peng L, Yin H, Moore J, Zhang XO, Song CQ, Sheel A, Wu Q, Ozata DM, Li Y, Anderson DG, Emerson CP, Sontheimer EJ, Moore MJ, Weng Z, Xue W.

Genome Biol. 2017 Jun 14;18(1):108. doi: 10.1186/s13059-017-1237-8.


Cryopreserved Amniotic Membrane Improves Clinical Outcomes Following Microdiscectomy.

Anderson DG, Popov V, Raines AL, O'Connell J.

Clin Spine Surg. 2017 Nov;30(9):413-418. doi: 10.1097/BSD.0000000000000544.


Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers.

Hydbring P, Wang Y, Fassl A, Li X, Matia V, Otto T, Choi YJ, Sweeney KE, Suski JM, Yin H, Bogorad RL, Goel S, Yuzugullu H, Kauffman KJ, Yang J, Jin C, Li Y, Floris D, Swanson R, Ng K, Sicinska E, Anders L, Zhao JJ, Polyak K, Anderson DG, Li C, Sicinski P.

Cancer Cell. 2017 Apr 10;31(4):576-590.e8. doi: 10.1016/j.ccell.2017.03.004.


A molecular analysis of the GBA gene in Caucasian South Africans with Parkinson's disease.

Barkhuizen M, Anderson DG, van der Westhuizen FH, Grobler AF.

Mol Genet Genomic Med. 2017 Feb 8;5(2):147-156. doi: 10.1002/mgg3.267. eCollection 2017 Mar.


A Systematic Review of the Huntington Disease-Like 2 Phenotype.

Anderson DG, Walker RH, Connor M, Carr J, Margolis RL, Krause A.

J Huntingtons Dis. 2017;6(1):37-46. doi: 10.3233/JHD-160232. Review.


Delivery technologies for genome editing.

Yin H, Kauffman KJ, Anderson DG.

Nat Rev Drug Discov. 2017 Jun;16(6):387-399. doi: 10.1038/nrd.2016.280. Epub 2017 Mar 24. Review.


Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

Ragelle H, Naba A, Larson BL, Zhou F, Prijić M, Whittaker CA, Del Rosario A, Langer R, Hynes RO, Anderson DG.

Biomaterials. 2017 Jun;128:147-159. doi: 10.1016/j.biomaterials.2017.03.008. Epub 2017 Mar 7.


An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model.

Chahal JS, Fang T, Woodham AW, Khan OF, Ling J, Anderson DG, Ploegh HL.

Sci Rep. 2017 Mar 21;7(1):252. doi: 10.1038/s41598-017-00193-w.

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