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Molecular Mechanism for Gramicidin Dimerization and Dissociation in Bilayers of Different Thickness.

Sun D, Peyear TA, Bennett WFD, Andersen OS, Lightstone FC, Ingólfsson HI.

Biophys J. 2019 Oct 10. pii: S0006-3495(19)30850-1. doi: 10.1016/j.bpj.2019.09.044. [Epub ahead of print]


The Authors Reply.

Smiseth OA, Ha JW, Andersen OS, Sletten OJ.

JACC Cardiovasc Imaging. 2019 Oct;12(10):2097-2098. doi: 10.1016/j.jcmg.2019.08.006. No abstract available.


Quantitative Characterization of Protein-Lipid Interactions by Free Energy Simulation between Binary Bilayers.

Park S, Yeom MS, Andersen OS, Pastor RW, Im W.

J Chem Theory Comput. 2019 Nov 12;15(11):6491-6503. doi: 10.1021/acs.jctc.9b00815. Epub 2019 Oct 14.


In Memoriam: David C. Gadsby, PhD.

Andersen OS, Nairn AC, Palmer LG, Shapley RM.

J Gen Physiol. 2019 Aug 5;151(8):967-969. doi: 10.1085/jgp.201912400. Epub 2019 Jul 16. No abstract available.


Diastolic Stress Test: Invasive and Noninvasive Testing.

Ha JW, Andersen OS, Smiseth OA.

JACC Cardiovasc Imaging. 2019 Jun 7. pii: S1936-878X(19)30444-9. doi: 10.1016/j.jcmg.2019.01.037. [Epub ahead of print] Review.


Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor.

Gutzeit VA, Thibado J, Stor DS, Zhou Z, Blanchard SC, Andersen OS, Levitz J.

Elife. 2019 Jun 7;8. pii: e45116. doi: 10.7554/eLife.45116.


Heart failure with preserved ejection fraction.

Smiseth OA, Kjeldsen SE, Andersen ØS, Mistry N, Westheim AS, Skulstad H, Gude E.

Tidsskr Nor Laegeforen. 2019 Mar 22;139(6). doi: 10.4045/tidsskr.18.0523. Print 2019 Mar 26. Review. Norwegian.


Antidepressants are modifiers of lipid bilayer properties.

Kapoor R, Peyear TA, Koeppe RE 2nd, Andersen OS.

J Gen Physiol. 2019 Mar 4;151(3):342-356. doi: 10.1085/jgp.201812263. Epub 2019 Feb 22.


Mechanism of Abnormal Septal Motion in Left Bundle Branch Block: Role of Left Ventricular Wall Interactions and Myocardial Scar.

Aalen JM, Remme EW, Larsen CK, Andersen OS, Krogh M, Duchenne J, Hopp E, Ross S, Beela AS, Kongsgaard E, Bergsland J, Odland HH, Skulstad H, Opdahl A, Voigt JU, Smiseth OA.

JACC Cardiovasc Imaging. 2019 Feb 13. pii: S1936-878X(19)30059-2. doi: 10.1016/j.jcmg.2018.11.030. [Epub ahead of print]


Gramicidin Increases Lipid Flip-Flop in Symmetric and Asymmetric Lipid Vesicles.

Doktorova M, Heberle FA, Marquardt D, Rusinova R, Sanford RL, Peyear TA, Katsaras J, Feigenson GW, Weinstein H, Andersen OS.

Biophys J. 2019 Mar 5;116(5):860-873. doi: 10.1016/j.bpj.2019.01.016. Epub 2019 Jan 25.


Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.

Falzone ME, Rheinberger J, Lee BC, Peyear T, Sasset L, Raczkowski AM, Eng ET, Di Lorenzo A, Andersen OS, Nimigean CM, Accardi A.

Elife. 2019 Jan 16;8. pii: e43229. doi: 10.7554/eLife.43229.


Left ventricular end-systolic volume is a more sensitive marker of acute response to cardiac resynchronization therapy than contractility indices: insights from an experimental study.

Boe E, Smiseth OA, Storsten P, Andersen OS, Aalen J, Eriksen M, Krogh MR, Kongsgaard E, Remme EW, Skulstad H.

Europace. 2019 Feb 1;21(2):347-355. doi: 10.1093/europace/euy221.


Fluorinated Alcohols' Effects on Lipid Bilayer Properties.

Zhang M, Peyear T, Patmanidis I, Greathouse DV, Marrink SJ, Andersen OS, Ingólfsson HI.

Biophys J. 2018 Aug 21;115(4):679-689. doi: 10.1016/j.bpj.2018.07.010. Epub 2018 Aug 1.


Pocket atlas of echocardiography for beginners.

Andersen ØS.

Tidsskr Nor Laegeforen. 2018 May 8;138(8). doi: 10.4045/tidsskr.18.0045. Print 2018 May 8. English, Norwegian. No abstract available.


Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels.

Dockendorff C, Gandhi DM, Kimball IH, Eum KS, Rusinova R, Ingólfsson HI, Kapoor R, Peyear T, Dodge MW, Martin SF, Aldrich RW, Andersen OS, Sack JT.

Biochemistry. 2018 May 8;57(18):2733-2743. doi: 10.1021/acs.biochem.8b00292. Epub 2018 Apr 17.


Mean Right Atrial Pressure for Estimation of Left Ventricular Filling Pressure in Patients with Normal Left Ventricular Ejection Fraction: Invasive and Noninvasive Validation.

Nagueh SF, Smiseth OA, Dokainish H, Andersen OS, Abudiab MM, Schutt RC, Kumar A, Gude E, Sato K, Harb SC, Klein AL.

J Am Soc Echocardiogr. 2018 Jul;31(7):799-806. doi: 10.1016/j.echo.2018.01.025. Epub 2018 Mar 24.


In Reply to Sun et al.

Harding CV, Akabas MH, Andersen OS.

Acad Med. 2018 Feb;93(2):150-151. doi: 10.1097/ACM.0000000000002036. No abstract available.


Stopped-Flow Fluorometric Ion Flux Assay for Ligand-Gated Ion Channel Studies.

Posson DJ, Rusinova R, Andersen OS, Nimigean CM.

Methods Mol Biol. 2018;1684:223-235. doi: 10.1007/978-1-4939-7362-0_17.


Exchange of Gramicidin between Lipid Bilayers: Implications for the Mechanism of Channel Formation.

Lum K, Ingólfsson HI, Koeppe RE 2nd, Andersen OS.

Biophys J. 2017 Oct 17;113(8):1757-1767. doi: 10.1016/j.bpj.2017.08.049.


Characterizing Residue-Bilayer Interactions Using Gramicidin A as a Scaffold and Tryptophan Substitutions as Probes.

Beaven AH, Sodt AJ, Pastor RW, Koeppe RE 2nd, Andersen OS, Im W.

J Chem Theory Comput. 2017 Oct 10;13(10):5054-5064. doi: 10.1021/acs.jctc.7b00400. Epub 2017 Sep 22.


Reply: Issues With Estimating "Diastolic Function" and Left Ventricular Filling Pressure Using the New Guidelines.

Andersen OS, Smiseth OA, Dokainish H, Ha JW, Klein AL, Nagueh SF.

J Am Coll Cardiol. 2017 Aug 29;70(9):1198-1199. doi: 10.1016/j.jacc.2017.05.073. No abstract available.


Divergent effects of anesthetics on lipid bilayer properties and sodium channel function.

Herold KF, Andersen OS, Hemmings HC Jr.

Eur Biophys J. 2017 Oct;46(7):617-626. doi: 10.1007/s00249-017-1239-1. Epub 2017 Jul 10. Review.


History and Outcomes of 50 Years of Physician-Scientist Training in Medical Scientist Training Programs.

Harding CV, Akabas MH, Andersen OS.

Acad Med. 2017 Oct;92(10):1390-1398. doi: 10.1097/ACM.0000000000001779.


Timing and Reset Mechanism of GTP Hydrolysis-Driven Conformational Changes of Atlastin.

O'Donnell JP, Cooley RB, Kelly CM, Miller K, Andersen OS, Rusinova R, Sondermann H.

Structure. 2017 Jul 5;25(7):997-1010.e4. doi: 10.1016/j.str.2017.05.007. Epub 2017 Jun 9.


Introduction to Biophysics Week: What is Biophysics?

Andersen OS.

Biophys J. 2017 May 9;112(9):2019. doi: 10.1016/j.bpj.2017.04.010. No abstract available.


Gateways to the Laboratory: How an MD-PhD Program Increased the Number of Minority Physician-Scientists.

Gotian R, Raymore JC, Rhooms SK, Liberman L, Andersen OS.

Acad Med. 2017 May;92(5):628-634. doi: 10.1097/ACM.0000000000001478.


Estimating Left Ventricular Filling Pressure by Echocardiography.

Andersen OS, Smiseth OA, Dokainish H, Abudiab MM, Schutt RC, Kumar A, Sato K, Harb S, Gude E, Remme EW, Andreassen AK, Ha JW, Xu J, Klein AL, Nagueh SF.

J Am Coll Cardiol. 2017 Apr 18;69(15):1937-1948. doi: 10.1016/j.jacc.2017.01.058.


Gramicidin A Channel Formation Induces Local Lipid Redistribution II: A 3D Continuum Elastic Model.

Sodt AJ, Beaven AH, Andersen OS, Im W, Pastor RW.

Biophys J. 2017 Mar 28;112(6):1198-1213. doi: 10.1016/j.bpj.2017.01.035.


Gramicidin A Channel Formation Induces Local Lipid Redistribution I: Experiment and Simulation.

Beaven AH, Maer AM, Sodt AJ, Rui H, Pastor RW, Andersen OS, Im W.

Biophys J. 2017 Mar 28;112(6):1185-1197. doi: 10.1016/j.bpj.2017.01.028.


Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties.

Herold KF, Sanford RL, Lee W, Andersen OS, Hemmings HC Jr.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3109-3114. doi: 10.1073/pnas.1611717114. Epub 2017 Mar 6.


Effect of Statins on the Nanomechanical Properties of Supported Lipid Bilayers.

Redondo-Morata L, Lea Sanford R, Andersen OS, Scheuring S.

Biophys J. 2016 Jul 26;111(2):363-372. doi: 10.1016/j.bpj.2016.06.016.


Introduction to Biophysics Week: What is Biophysics?

Andersen OS.

Biophys J. 2016 Mar 8;110(5):E01-3. doi: 10.1016/j.bpj.2016.02.012. No abstract available. Erratum in: Biophys J. 2017 May 9;112(9):2019.


A general mechanism for drug promiscuity: Studies with amiodarone and other antiarrhythmics.

Rusinova R, Koeppe RE 2nd, Andersen OS.

J Gen Physiol. 2015 Dec;146(6):463-75. doi: 10.1085/jgp.201511470. Epub 2015 Nov 16.


Bilayer Effects of Antimalarial Compounds.

Ramsey NB, Andersen OS.

PLoS One. 2015 Nov 9;10(11):e0142401. doi: 10.1371/journal.pone.0142401. eCollection 2015.


Calcium ions open a selectivity filter gate during activation of the MthK potassium channel.

Posson DJ, Rusinova R, Andersen OS, Nimigean CM.

Nat Commun. 2015 Sep 23;6:8342. doi: 10.1038/ncomms9342.


Perspectives on: The response to osmotic challenges.

Andersen OS.

J Gen Physiol. 2015 May;145(5):371-2. doi: 10.1085/jgp.201511397. Epub 2015 Apr 13. No abstract available.


Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties.

Herold KF, Sanford RL, Lee W, Schultz MF, Ingólfsson HI, Andersen OS, Hemmings HC Jr.

J Gen Physiol. 2014 Dec;144(6):545-60. doi: 10.1085/jgp.201411172. Epub 2014 Nov 10.


Phytochemicals perturb membranes and promiscuously alter protein function.

Ingólfsson HI, Thakur P, Herold KF, Hobart EA, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K, Maretzky T, Hemmings HC Jr, Blobel C, Marrink SJ, Koçer A, Sack JT, Andersen OS.

ACS Chem Biol. 2014 Aug 15;9(8):1788-98. doi: 10.1021/cb500086e. Epub 2014 Jun 17.


Regulation of ion channel function by the host lipid bilayer examined by a stopped-flow spectrofluorometric assay.

Rusinova R, Kim DM, Nimigean CM, Andersen OS.

Biophys J. 2014 Mar 4;106(5):1070-8. doi: 10.1016/j.bpj.2014.01.027.


A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics.

McCoy JG, Rusinova R, Kim DM, Kowal J, Banerjee S, Jaramillo Cartagena A, Thompson AN, Kolmakova-Partensky L, Stahlberg H, Andersen OS, Nimigean CM.

J Biol Chem. 2014 Apr 4;289(14):9535-46. doi: 10.1074/jbc.M113.543389. Epub 2014 Feb 10.


Ion-induced defect permeation of lipid membranes.

Vorobyov I, Olson TE, Kim JH, Koeppe RE 2nd, Andersen OS, Allen TW.

Biophys J. 2014 Feb 4;106(3):586-97. doi: 10.1016/j.bpj.2013.12.027.


Membrane proteins: Through thick and thin.

Andersen OS.

Nat Chem Biol. 2013 Nov;9(11):667-8. doi: 10.1038/nchembio.1368. No abstract available.


Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis.

Darby CM, Ingólfsson HI, Jiang X, Shen C, Sun M, Zhao N, Burns K, Liu G, Ehrt S, Warren JD, Andersen OS, Brickner SJ, Nathan C.

PLoS One. 2013 Jul 30;8(7):e68942. doi: 10.1371/journal.pone.0068942. Print 2013. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/760b5b07-4922-42c4-b33a-162c1e9ae188. Anderson, Olaf S [corrected to Andersen, Olaf S].


Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation.

Bruno MJ, Rusinova R, Gleason NJ, Koeppe RE 2nd, Andersen OS.

Faraday Discuss. 2013;161:461-80; discussion 563-89.


Small-molecule photostabilizing agents are modifiers of lipid bilayer properties.

Alejo JL, Blanchard SC, Andersen OS.

Biophys J. 2013 Jun 4;104(11):2410-8. doi: 10.1016/j.bpj.2013.04.039.


Phosphoinositides alter lipid bilayer properties.

Rusinova R, Hobart EA, Koeppe RE 2nd, Andersen OS.

J Gen Physiol. 2013 Jun;141(6):673-90. doi: 10.1085/jgp.201310960.


HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.

Tibbs GR, Rowley TJ, Sanford RL, Herold KF, Proekt A, Hemmings HC Jr, Andersen OS, Goldstein PA, Flood PD.

J Pharmacol Exp Ther. 2013 Jun;345(3):363-73. doi: 10.1124/jpet.113.203620. Epub 2013 Apr 2.


Assessing smectic liquid-crystal continuum models for elastic bilayer deformations.

Lee KI, Pastor RW, Andersen OS, Im W.

Chem Phys Lipids. 2013 Apr;169:19-26. doi: 10.1016/j.chemphyslip.2013.01.005. Epub 2013 Jan 21.


Perspectives on: conformational coupling in ion channels.

Andersen OS.

J Gen Physiol. 2012 Dec;140(6):595-7. doi: 10.1085/jgp.201210926. No abstract available.


A designed inhibitor of a CLC antiporter blocks function through a unique binding mode.

Howery AE, Elvington S, Abraham SJ, Choi KH, Dworschak-Simpson S, Phillips S, Ryan CM, Sanford RL, Almqvist J, Tran K, Chew TA, Zachariae U, Andersen OS, Whitelegge J, Matulef K, Du Bois J, Maduke MC.

Chem Biol. 2012 Nov 21;19(11):1460-70. doi: 10.1016/j.chembiol.2012.09.017.

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