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A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation.

Haider S, Black MB, Parks BB, Foley B, Wetmore BA, Andersen ME, Clewell RA, Mansouri K, McMullen PD.

Front Pharmacol. 2018 Oct 2;9:1072. doi: 10.3389/fphar.2018.01072. eCollection 2018.


Physiologically-based pharmacokinetic modeling suggests similar bioavailability of Mn from diet and drinking water.

Song G, Van Landingham CB, Gentry PR, Taylor MD, Keene AM, Andersen ME, Clewell HJ, Yoon M.

Toxicol Appl Pharmacol. 2018 Nov 15;359:70-81. doi: 10.1016/j.taap.2018.09.023. Epub 2018 Sep 20.


Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system.

Wetmore BA, Clewell RA, Cholewa B, Parks B, Pendse SN, Black MB, Mansouri K, Haider S, Berg EL, Judson RS, Houck KA, Martin M, Clewell HJ 3rd, Andersen ME, Thomas RS, McMullen PD.

Toxicol In Vitro. 2019 Feb;54:41-57. doi: 10.1016/j.tiv.2018.09.006. Epub 2018 Sep 12.


Enhancing and Extending Biological Performance and Resilience.

Leak RK, Calabrese EJ, Kozumbo WJ, Gidday JM, Johnson TE, Mitchell JR, Ozaki CK, Wetzker R, Bast A, Belz RG, Bøtker HE, Koch S, Mattson MP, Simon RP, Jirtle RL, Andersen ME.

Dose Response. 2018 Aug 15;16(3):1559325818784501. doi: 10.1177/1559325818784501. eCollection 2018 Jul-Sep. Review.


Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice.

Hou Y, Liu Z, Zuo Z, Gao T, Fu J, Wang H, Xu Y, Liu D, Yamamoto M, Zhu B, Zhang Y, Andersen ME, Zhang Q, Pi J.

Biochem Biophys Res Commun. 2018 Sep 3;503(1):264-270. doi: 10.1016/j.bbrc.2018.06.013. Epub 2018 Jun 25.


Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment.

Andersen ME, Cruzan G, Black MB, Pendse SN, Dodd DE, Bus JS, Sarang SS, Banton MI, Waites R, Layko DB, McMullen PD.

Regul Toxicol Pharmacol. 2018 Jul;96:153-166. doi: 10.1016/j.yrtph.2018.05.011. Epub 2018 May 17.


Based on an analysis of mode of action, styrene-induced mouse lung tumors are not a human cancer concern.

Cruzan G, Bus JS, Andersen ME, Carlson GP, Banton MI, Sarang SS, Waites R.

Regul Toxicol Pharmacol. 2018 Jun;95:17-28. doi: 10.1016/j.yrtph.2018.02.010. Epub 2018 Feb 26.


Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays.

McMullen PD, Andersen ME, Cholewa B, Clewell HJ 3rd, Dunnick KM, Hartman JK, Mansouri K, Minto MS, Nicolas CI, Phillips MB, Slattery S, Yoon M, Clewell RA.

Toxicol In Vitro. 2018 Apr;48:310-317. doi: 10.1016/j.tiv.2018.01.027. Epub 2018 Jan 31. Review.


Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance.

Cruzan G, Bus JS, Banton MI, Sarang SS, Waites R, Layko DB, Raymond J, Dodd D, Andersen ME.

Toxicol Sci. 2017 Oct 1;159(2):413-421. doi: 10.1093/toxsci/kfx141.


Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures.

Andersen ME, Cruzan G, Black MB, Pendse SN, Dodd D, Bus JS, Sarang SS, Banton MI, Waites R, McMullen PD.

Toxicol Appl Pharmacol. 2017 Nov 15;335:28-40. doi: 10.1016/j.taap.2017.09.015. Epub 2017 Sep 23.


Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts.

Miller MM, McMullen PD, Andersen ME, Clewell RA.

Crit Rev Toxicol. 2017 Aug;47(7):564-580. doi: 10.1080/10408444.2017.1289150. Epub 2017 Jul 4. Review. Erratum in: Crit Rev Toxicol. 2017 Aug;47(7):i.


Refinement of the oral exposure description in the cyclic siloxane PBPK model for rats and humans: Implications for exposure assessment.

Campbell JL Jr, Andersen ME, Van Landingham C, Gentry R, Jensen E, Domoradzki JY, Clewell HJ 3rd.

Toxicol Lett. 2017 Oct 20;279 Suppl 1:125-135. doi: 10.1016/j.toxlet.2017.04.002. Epub 2017 Apr 11.


Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver.

Andersen ME, Black MB, Campbell JL, Pendse SN, Clewell HJ III, Pottenger LH, Bus JS, Dodd DE, Kemp DC, McMullen PD.

Toxicol Appl Pharmacol. 2017 Oct 1;332:149-158. doi: 10.1016/j.taap.2017.04.002. Epub 2017 Apr 7.


Quantitative bias analysis of a reported association between perfluoroalkyl substances (PFAS) and endometriosis: The influence of oral contraceptive use.

Ngueta G, Longnecker MP, Yoon M, Ruark CD, Clewell HJ Rd, Andersen ME, Verner MA.

Environ Int. 2017 Jul;104:118-121. doi: 10.1016/j.envint.2017.03.023. Epub 2017 Apr 6.


A tissue dose-based comparative exposure assessment of manganese using physiologically based pharmacokinetic modeling-The importance of homeostatic control for an essential metal.

Gentry PR, Van Landingham C, Fuller WG, Sulsky SI, Greene TB, Clewell HJ 3rd, Andersen ME, Roels HA, Taylor MD, Keene AM.

Toxicol Appl Pharmacol. 2017 May 1;322:27-40. doi: 10.1016/j.taap.2017.02.015. Epub 2017 Feb 22.


Soot, organics, and ultrafine ash from air- and oxy-fired coal combustion.

Andersen ME, Modak N, Winterrowd CK, Lee CW, Roberts WL, Wendt JOL, Linak WP.

Proc Combust Inst. 2017;36(6):4029-4037. doi: 10.1016/j.proci.2016.08.073.


The application of PBPK models in estimating human brain tissue manganese concentrations.

Ramoju SP, Mattison DR, Milton B, McGough D, Shilnikova N, Clewell HJ, Yoon M, Taylor MD, Krewski D, Andersen ME.

Neurotoxicology. 2017 Jan;58:226-237. doi: 10.1016/j.neuro.2016.12.001. Epub 2016 Dec 15.


Quantitative bias analysis for epidemiological associations of perfluoroalkyl substance serum concentrations and early onset of menopause.

Ruark CD, Song G, Yoon M, Verner MA, Andersen ME, Clewell HJ 3rd, Longnecker MP.

Environ Int. 2017 Feb;99:245-254. doi: 10.1016/j.envint.2016.11.030. Epub 2016 Dec 5.


The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions.

Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS.

Environ Health Perspect. 2016 Nov;124(11):1671-1682. Epub 2016 Apr 19. Review.


An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy.

Zhu J, Wang H, Chen F, Fu J, Xu Y, Hou Y, Kou HH, Zhai C, Nelson MB, Zhang Q, Andersen ME, Pi J.

Free Radic Biol Med. 2016 Oct;99:544-556. doi: 10.1016/j.freeradbiomed.2016.09.010. Epub 2016 Sep 12. Review.


Fluid Dynamic Modeling to Support the Development of Flow-Based Hepatocyte Culture Systems for Metabolism Studies.

Pedersen JM, Shim YS, Hans V, Phillips MB, Macdonald JM, Walker G, Andersen ME, Clewell HJ 3rd, Yoon M.

Front Bioeng Biotechnol. 2016 Sep 30;4:72. eCollection 2016.


Pathway Based Toxicology and Fit-for-Purpose Assays.

Clewell RA, McMullen PD, Adeleye Y, Carmichael PL, Andersen ME.

Adv Exp Med Biol. 2016;856:205-230.


Editor's Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis.

Foley B, Doheny DL, Black MB, Pendse SN, Wetmore BA, Clewell RA, Andersen ME, Deisenroth C.

Toxicol Sci. 2017 Jan;155(1):85-100. doi: 10.1093/toxsci/kfw186. Epub 2016 Sep 23.


Severity scoring of manganese health effects for categorical regression.

Mattison DR, Milton B, Krewski D, Levy L, Dorman DC, Aggett PJ, Roels HA, Andersen ME, Karyakina NA, Shilnikova N, Ramoju S, McGough D.

Neurotoxicology. 2017 Jan;58:203-216. doi: 10.1016/j.neuro.2016.09.001. Epub 2016 Sep 13. Review.


Erratum: Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.

Kleensang A, Vantangoli MM, Odwin-DaCosta S, Andersen ME, Boekelheide K, Bouhifd M, Fornace AJ Jr, Li HH, Livi CB, Madnick S, Maertens A, Rosenberg M, Yager JD, Zhao L, Hartung T.

Sci Rep. 2016 Sep 14;6:33011. doi: 10.1038/srep33011. No abstract available.


Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity.

Pendse SN, Maertens A, Rosenberg M, Roy D, Fasani RA, Vantangoli MM, Madnick SJ, Boekelheide K, Fornace AJ, Odwin SA, Yager JD, Hartung T, Andersen ME, McMullen PD.

Arch Toxicol. 2017 Apr;91(4):1749-1762. doi: 10.1007/s00204-016-1824-6. Epub 2016 Sep 3.


Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation.

Soldatow V, Peffer RC, Trask OJ, Cowie DE, Andersen ME, LeCluyse E, Deisenroth C.

Toxicol In Vitro. 2016 Oct;36:224-237. doi: 10.1016/j.tiv.2016.08.006. Epub 2016 Aug 12.


Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.

Kleensang A, Vantangoli MM, Odwin-DaCosta S, Andersen ME, Boekelheide K, Bouhifd M, Fornace AJ Jr, Li HH, Livi CB, Madnick S, Maertens A, Rosenberg M, Yager JD, Zhao L, Hartung T.

Sci Rep. 2016 Jul 26;6:28994. doi: 10.1038/srep28994. Erratum in: Sci Rep. 2016 Sep 14;6:33011.


Pharmacokinetic bias analysis of the epidemiological associations between serum polybrominated diphenyl ether (BDE-47) and timing of menarche.

Song G, Peeples CR, Yoon M, Wu H, Verner MA, Andersen ME, Clewell HJ 3rd, Longnecker MP.

Environ Res. 2016 Oct;150:541-548. doi: 10.1016/j.envres.2016.07.004. Epub 2016 Jul 16.


An interpolatory ansatz captures the physics of one-dimensional confined Fermi systems.

Andersen ME, Dehkharghani AS, Volosniev AG, Lindgren EJ, Zinner NT.

Sci Rep. 2016 Jun 21;6:28362. doi: 10.1038/srep28362.


Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.

Klapacz J, Pottenger LH, Engelward BP, Heinen CD, Johnson GE, Clewell RA, Carmichael PL, Adeleye Y, Andersen ME.

Mutat Res Rev Mutat Res. 2016 Jan-Mar;767:77-91. doi: 10.1016/j.mrrev.2015.11.001. Epub 2015 Dec 2. Review.


The Human Toxome Collaboratorium: A Shared Environment for Multi-Omic Computational Collaboration within a Consortium.

Fasani RA, Livi CB, Choudhury DR, Kleensang A, Bouhifd M, Pendse SN, McMullen PD, Andersen ME, Hartung T, Rosenberg M.

Front Pharmacol. 2016 Feb 17;6:322. doi: 10.3389/fphar.2015.00322. eCollection 2015.


Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity.

Rose KA, Holman NS, Green AM, Andersen ME, LeCluyse EL.

J Pharm Sci. 2016 Feb;105(2):950-964. doi: 10.1016/S0022-3549(15)00192-6.


Approaches for characterizing threshold dose-response relationships for DNA-damage pathways involved in carcinogenicity in vivo and micronuclei formation in vitro.

Clewell RA, Andersen ME.

Mutagenesis. 2016 May;31(3):333-40. doi: 10.1093/mutage/gev078. Epub 2016 Feb 4. Review.


PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water.

Breckenridge CB, Campbell JL, Clewell HJ, Andersen ME, Valdez-Flores C, Sielken RL Jr.

Toxicol Sci. 2016 Apr;150(2):269-82. doi: 10.1093/toxsci/kfw013. Epub 2016 Jan 21.


PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human.

Campbell JL Jr, Andersen ME, Hinderliter PM, Yi KD, Pastoor TP, Breckenridge CB, Clewell HJ 3rd.

Toxicol Sci. 2016 Apr;150(2):441-53. doi: 10.1093/toxsci/kfw014. Epub 2016 Jan 21.


Development of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes - D4 and D5.

McMullin TS, Yang Y, Campbell J, Clewell HJ, Plotzke K, Andersen ME.

Regul Toxicol Pharmacol. 2016 Feb;74 Suppl:S1-13. doi: 10.1016/j.yrtph.2015.12.010. Epub 2015 Dec 23.


Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells.

Peng H, Wang H, Xue P, Hou Y, Dong J, Zhou T, Qu W, Peng S, Li J, Carmichael PL, Nelson B, Clewell R, Zhang Q, Andersen ME, Pi J.

Toxicol Appl Pharmacol. 2016 Feb 1;292:1-7. doi: 10.1016/j.taap.2015.12.008. Epub 2015 Dec 18.


Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment.

Zhang Q, Bhattacharya S, Pi J, Clewell RA, Carmichael PL, Andersen ME.

Toxicol Sci. 2015 Oct;147(2):302-16. doi: 10.1093/toxsci/kfv130. Review.


Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.

Wetmore BA, Wambaugh JF, Allen B, Ferguson SS, Sochaski MA, Setzer RW, Houck KA, Strope CL, Cantwell K, Judson RS, LeCluyse E, Clewell HJ, Thomas RS, Andersen ME.

Toxicol Sci. 2015 Nov;148(1):121-36. doi: 10.1093/toxsci/kfv171. Epub 2015 Aug 6.


Using gene expression profiling to evaluate cellular responses in mouse lungs exposed to V2O5 and a group of other mouse lung tumorigens and non-tumorigens.

Black MB, Dodd DE, McMullen PD, Pendse S, MacGregor JA, Gollapudi BB, Andersen ME.

Regul Toxicol Pharmacol. 2015 Oct;73(1):339-47. doi: 10.1016/j.yrtph.2015.07.017. Epub 2015 Jul 23.


Can the observed association between serum perfluoroalkyl substances and delayed menarche be explained on the basis of puberty-related changes in physiology and pharmacokinetics?

Wu H, Yoon M, Verner MA, Xue J, Luo M, Andersen ME, Longnecker MP, Clewell HJ 3rd.

Environ Int. 2015 Sep;82:61-8. doi: 10.1016/j.envint.2015.05.006. Epub 2015 May 29.


Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK).

Verner MA, Loccisano AE, Morken NH, Yoon M, Wu H, McDougall R, Maisonet M, Marcus M, Kishi R, Miyashita C, Chen MH, Hsieh WS, Andersen ME, Clewell HJ 3rd, Longnecker MP.

Environ Health Perspect. 2015 Dec;123(12):1317-24. doi: 10.1289/ehp.1408837. Epub 2015 May 22.


Adverse Outcome Pathways can drive non-animal approaches for safety assessment.

Burden N, Sewell F, Andersen ME, Boobis A, Chipman JK, Cronin MT, Hutchinson TH, Kimber I, Whelan M.

J Appl Toxicol. 2015 Sep;35(9):971-5. doi: 10.1002/jat.3165. Epub 2015 May 5.


Developing tools for defining and establishing pathways of toxicity.

Andersen ME, McMullen PD, Krewski D.

Arch Toxicol. 2015 May;89(5):809-12. doi: 10.1007/s00204-015-1512-y. Epub 2015 Apr 8. No abstract available.


The human toxome project.

Bouhifd M, Andersen ME, Baghdikian C, Boekelheide K, Crofton KM, Fornace AJ Jr, Kleensang A, Li H, Livi C, Maertens A, McMullen PD, Rosenberg M, Thomas R, Vantangoli M, Yager JD, Zhao L, Hartung T.

ALTEX. 2015;32(2):112-24. doi: 10.14573/altex.1502091. Epub 2015 Mar 4.


Predicting cytotoxicity of complex mixtures in high cancer incidence regions of the Huai River Basin based on GC-MS spectrum with partial least squares regression.

Tian D, Zheng W, He G, Zheng Y, Andersen ME, Tan H, Qu W.

Environ Res. 2015 Feb;137:391-7. doi: 10.1016/j.envres.2014.12.027. Epub 2015 Jan 20.


CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion.

Zheng H, Fu J, Xue P, Zhao R, Dong J, Liu D, Yamamoto M, Tong Q, Teng W, Qu W, Zhang Q, Andersen ME, Pi J.

Antioxid Redox Signal. 2015 Apr 1;22(10):819-31. doi: 10.1089/ars.2014.6017. Epub 2015 Feb 18.


Iodoacetic acid activates Nrf2-mediated antioxidant response in vitro and in vivo.

Wang S, Zheng W, Liu X, Xue P, Jiang S, Lu D, Zhang Q, He G, Pi J, Andersen ME, Tan H, Qu W.

Environ Sci Technol. 2014 Nov 18;48(22):13478-88. doi: 10.1021/es502855x. Epub 2014 Nov 4.


Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses.

Zhang Q, Bhattacharya S, Conolly RB, Clewell HJ, Kaminski NE, Andersen ME.

Environ Health Perspect. 2014 Dec;122(12):1261-70. doi: 10.1289/ehp.1408244. Epub 2014 Aug 12. Review.

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