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Age-related prevalence and clinical significance of neutropenia - isolated or combined with other cytopenias: Real world data from 373 820 primary care individuals.

Palmblad J, Siersma V, Lind B, Bjerrum OW, Hasselbalch H, Andersen CL.

Am J Hematol. 2020 Feb 13. doi: 10.1002/ajh.25756. [Epub ahead of print]


Machine learning can identify newly diagnosed patients with CLL at high risk of infection.

Agius R, Brieghel C, Andersen MA, Pearson AT, Ledergerber B, Cozzi-Lepri A, Louzoun Y, Andersen CL, Bergstedt J, von Stemann JH, Jørgensen M, Tang ME, Fontes M, Bahlo J, Herling CD, Hallek M, Lundgren J, MacPherson CR, Larsen J, Niemann CU.

Nat Commun. 2020 Jan 17;11(1):363. doi: 10.1038/s41467-019-14225-8.


IMPROVE-IT2: implementing noninvasive circulating tumor DNA analysis to optimize the operative and postoperative treatment for patients with colorectal cancer - intervention trial 2. Study protocol.

Nors J, Henriksen TV, Gotschalck KA, Juul T, Søgaard J, Iversen LH, Andersen CL.

Acta Oncol. 2020 Mar;59(3):336-341. doi: 10.1080/0284186X.2019.1711170. Epub 2020 Jan 10. No abstract available.


Ruxolitinib and interferon-α2 combination therapy for patients with polycythemia vera or myelofibrosis: a phase II study.

Sørensen AL, Mikkelsen SU, Knudsen TA, Bjørn ME, Andersen CL, Bjerrum OW, Brochmann N, Patel DA, Gjerdrum LMR, El Fassi D, Kruse TA, Larsen TS, Mourits-Andersen HT, Nielsen CH, Ellervik C, Pallisgaard N, Thomassen M, Kjær L, Skov V, Hasselbalch HC.

Haematologica. 2019 Dec 26. pii: haematol.2019.235648. doi: 10.3324/haematol.2019.235648. [Epub ahead of print]


Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer.

Thorsen SF, Gromova I, Christensen IJ, Fredriksson S, Andersen CL, Nielsen HJ, Stenvang J, Moreira JMA.

Int J Mol Sci. 2019 Dec 2;20(23). pii: E6082. doi: 10.3390/ijms20236082.


Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.

Sale MJ, Minihane E, Monks NR, Gilley R, Richards FM, Schifferli KP, Andersen CL, Davies EJ, Vicente MA, Ozono E, Markovets A, Dry JR, Drew L, Flemington V, Proia T, Jodrell DI, Smith PD, Cook SJ.

Nat Commun. 2019 Nov 14;10(1):5167. doi: 10.1038/s41467-019-12409-w.


Novel DNA methylation biomarkers show high sensitivity and specificity for blood-based detection of colorectal cancer-a clinical biomarker discovery and validation study.

Jensen SØ, Øgaard N, Ørntoft MW, Rasmussen MH, Bramsen JB, Kristensen H, Mouritzen P, Madsen MR, Madsen AH, Sunesen KG, Iversen LH, Laurberg S, Christensen IJ, Nielsen HJ, Andersen CL.

Clin Epigenetics. 2019 Nov 14;11(1):158. doi: 10.1186/s13148-019-0757-3.


Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients.

Johansen AFB, Kassentoft CG, Knudsen M, Laursen MB, Madsen AH, Iversen LH, Sunesen KG, Rasmussen MH, Andersen CL.

BMC Cancer. 2019 Oct 21;19(1):971. doi: 10.1186/s12885-019-6227-7.


Strategies to improve patient-reported outcome completion rates in longitudinal studies.

Nielsen LK, King M, Möller S, Jarden M, Andersen CL, Frederiksen H, Gregersen H, Klostergaard A, Steffensen MS, Pedersen PT, Hinge M, Frederiksen M, Jensen BA, Helleberg C, Mylin AK, Abildgaard N.

Qual Life Res. 2020 Feb;29(2):335-346. doi: 10.1007/s11136-019-02304-8. Epub 2019 Sep 23.


Mouse placental microRNA profiling upon zearalenone exposure.

Andersen CL, Li R, Ye X.

Biol Reprod. 2020 Feb 12;102(1):5-7. doi: 10.1093/biolre/ioz176. No abstract available.


Synthesis of radiaannulene oligomers to model the elusive carbon allotrope 6,6,12-graphyne.

Kilde MD, Murray AH, Andersen CL, Storm FE, Schmidt K, Kadziola A, Mikkelsen KV, Hampel F, Hammerich O, Tykwinski RR, Nielsen MB.

Nat Commun. 2019 Aug 16;10(1):3714. doi: 10.1038/s41467-019-11700-0.


Correlation between early dynamics in circulating tumour DNA and outcome from FOLFIRI treatment in metastatic colorectal cancer.

Lyskjær I, Kronborg CS, Rasmussen MH, Sørensen BS, Demuth C, Rosenkilde M, Johansen AFB, Knudsen M, Vang S, Krag SRP, Spindler KG, Andersen CL.

Sci Rep. 2019 Aug 8;9(1):11542. doi: 10.1038/s41598-019-47708-1.


Association of the blood eosinophil count with end-organ symptoms.

Bjerrum OW, Siersma V, Hasselbalch HC, Lind B, Andersen CL.

Ann Med Surg (Lond). 2019 Jul 9;45:11-18. doi: 10.1016/j.amsu.2019.06.015. eCollection 2019 Sep.


Association of luteal cell degeneration and progesterone deficiency with lysosomal storage disorder mucolipidosis type IV in Mcoln1-/- mouse model†.

Wang Z, El Zowalaty AE, Li Y, Andersen CL, Ye X.

Biol Reprod. 2019 Oct 25;101(4):782-790. doi: 10.1093/biolre/ioz126.


Microbiota of the Oropharynx and Endoscope Compared to the Esophagus.

Okereke IC, Miller AL, Hamilton CF, Booth AL, Reep GL, Andersen CL, Reynolds ST, Pyles RB.

Sci Rep. 2019 Jul 15;9(1):10201. doi: 10.1038/s41598-019-46747-y.


The impact of cancer on diabetes outcomes.

Arreskov AB, Olsen MÅ, Pouplier SS, Siersma V, Andersen CL, Friis S, de Fine Olivarius N.

BMC Endocr Disord. 2019 Jun 11;19(1):60. doi: 10.1186/s12902-019-0377-0.


Genome-wide cell-free DNA fragmentation in patients with cancer.

Cristiano S, Leal A, Phallen J, Fiksel J, Adleff V, Bruhm DC, Jensen SØ, Medina JE, Hruban C, White JR, Palsgrove DN, Niknafs N, Anagnostou V, Forde P, Naidoo J, Marrone K, Brahmer J, Woodward BD, Husain H, van Rooijen KL, Ørntoft MW, Madsen AH, van de Velde CJH, Verheij M, Cats A, Punt CJA, Vink GR, van Grieken NCT, Koopman M, Fijneman RJA, Johansen JS, Nielsen HJ, Meijer GA, Andersen CL, Scharpf RB, Velculescu VE.

Nature. 2019 Jun;570(7761):385-389. doi: 10.1038/s41586-019-1272-6. Epub 2019 May 29.


Epstein-Barr virus and its association with disease - a review of relevance to general practice.

Fugl A, Andersen CL.

BMC Fam Pract. 2019 May 14;20(1):62. doi: 10.1186/s12875-019-0954-3. Review.


Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma.

Christensen E, Birkenkamp-Demtröder K, Sethi H, Shchegrova S, Salari R, Nordentoft I, Wu HT, Knudsen M, Lamy P, Lindskrog SV, Taber A, Balcioglu M, Vang S, Assaf Z, Sharma S, Tin AS, Srinivasan R, Hafez D, Reinert T, Navarro S, Olson A, Ram R, Dashner S, Rabinowitz M, Billings P, Sigurjonsson S, Andersen CL, Swenerton R, Aleshin A, Zimmermann B, Agerbæk M, Lin CJ, Jensen JB, Dyrskjøt L.

J Clin Oncol. 2019 Jun 20;37(18):1547-1557. doi: 10.1200/JCO.18.02052. Epub 2019 May 6.


Changes in Prescription Routines for Treating Hypothyroidism Between 2001 and 2015: An Observational Study of 929,684 Primary Care Patients in Copenhagen.

Medici BB, Nygaard B, la Cour JL, Grand MK, Siersma V, Nicolaisdottir DR, Lind B, Olivarius NF, Andersen CL.

Thyroid. 2019 Jul;29(7):910-919. doi: 10.1089/thy.2018.0539. Epub 2019 May 23.


In Reply.

Hejl JL, Grand MK, Siersma V, Goetze JP, de Fine Olivarius N, Andersen CL, Lind B.

Clin Chem. 2019 Jun;65(6):812-813. doi: 10.1373/clinchem.2019.302034. Epub 2019 Mar 27. No abstract available.


Ruxolitinib treatment reduces monocytic superoxide radical formation without affecting hydrogen peroxide formation or systemic oxidative nucleoside damage in myelofibrosis.

Bjørn ME, Brimnes MK, Gudbrandsdottir S, Andersen CL, Poulsen HE, Henriksen T, Hasselbalch HC, Nielsen CH.

Leuk Lymphoma. 2019 Oct;60(10):2549-2557. doi: 10.1080/10428194.2019.1579323. Epub 2019 Feb 20.


Dietary exposure to mycotoxin zearalenone (ZEA) during post-implantation adversely affects placental development in mice.

Li R, Andersen CL, Hu L, Wang Z, Li Y, Nagy T, Ye X.

Reprod Toxicol. 2019 Apr;85:42-50. doi: 10.1016/j.reprotox.2019.01.010. Epub 2019 Feb 14.


Anxiety and depression in patients with Philadelphia-negative myeloproliferative neoplasms: a nationwide population-based survey in Denmark.

Brochmann N, Flachs EM, Christensen AI, Bak M, Andersen CL, Juel K, Hasselbalch HC, Zwisler AD, Rottmann N.

Clin Epidemiol. 2018 Dec 18;11:23-33. doi: 10.2147/CLEP.S162688. eCollection 2019.


Chemotherapeutic agent doxorubicin alters uterine gene expression in response to estrogen in ovariectomized CD-1 adult mice†.

Andersen CL, Liu M, Wang Z, Ye X, Xiao S.

Biol Reprod. 2019 Apr 1;100(4):869-871. doi: 10.1093/biolre/ioy259.


Publisher Correction: Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations.

Nielsen HM, Andersen CL, Westman M, Kristensen LS, Asmar F, Kruse TA, Thomassen M, Larsen TS, Skov V, Hansen LL, Bjerrum OW, Hasselbalch HC, Punj V, Grønbæk K.

Sci Rep. 2018 Nov 20;8(1):17311. doi: 10.1038/s41598-018-35596-w.


The development of multimorbidity during 16 years after diagnosis of type 2 diabetes.

Pouplier S, Olsen MÅ, Willadsen TG, Sandholdt H, Siersma V, Andersen CL, Olivarius NF.

J Comorb. 2018 Sep 24;8(1):2235042X18801658. doi: 10.1177/2235042X18801658. eCollection 2018 Jan-Dec.


Brain Natriuretic Peptide in Plasma as Predictor of All-Cause Mortality in a Large Danish Primary Health Care Population Suspected of Heart Failure.

Hejl JL, Grand MK, Siersma V, Goetze JP, de Fine Olivarius N, Andersen CL, Lind B.

Clin Chem. 2018 Dec;64(12):1723-1731. doi: 10.1373/clinchem.2018.293480. Epub 2018 Oct 15.


Classification and Personalized Prognosis in Myeloproliferative Neoplasms.

Grinfeld J, Nangalia J, Baxter EJ, Wedge DC, Angelopoulos N, Cantrill R, Godfrey AL, Papaemmanuil E, Gundem G, MacLean C, Cook J, O'Neil L, O'Meara S, Teague JW, Butler AP, Massie CE, Williams N, Nice FL, Andersen CL, Hasselbalch HC, Guglielmelli P, McMullin MF, Vannucchi AM, Harrison CN, Gerstung M, Green AR, Campbell PJ.

N Engl J Med. 2018 Oct 11;379(15):1416-1430. doi: 10.1056/NEJMoa1716614.


The Evolution of Estrogen Receptor Signaling in the Progression of Endometriosis to Endometriosis-Associated Ovarian Cancer.

Andersen CL, Boisen MM, Sikora MJ, Ma T, Tseng G, Suryawanshi S, Vlad A, Elishaev E, Edwards RP, Oesterreich S.

Horm Cancer. 2018 Dec;9(6):399-407. doi: 10.1007/s12672-018-0350-9. Epub 2018 Oct 9.



Bjerrum OW, Fassi DE, Madsen G, Stentoft J, Vestergaard H, Rønnov-Jessen D, Pedersen PT, Pulczynski S, Overgaard UM, Andersen CL.

Ugeskr Laeger. 2018 Sep 10;180(37). pii: V01180032. Review. Danish.


Clarithromycin added to bortezomib-cyclophosphamide-dexamethasone impairs health-related quality of life in multiple myeloma patients.

Nielsen LK, Klausen TW, Jarden M, Frederiksen H, Vangsted AJ, Do T, Kristensen IB, Frølund UC, Andersen CL, Abildgaard N, Gregersen H.

Eur J Haematol. 2019 Jan;102(1):70-78. doi: 10.1111/ejh.13175. Epub 2018 Oct 29.


Contribution of allelic imbalance to colorectal cancer.

Palin K, Pitkänen E, Turunen M, Sahu B, Pihlajamaa P, Kivioja T, Kaasinen E, Välimäki N, Hänninen UA, Cajuso T, Aavikko M, Tuupanen S, Kilpivaara O, van den Berg L, Kondelin J, Tanskanen T, Katainen R, Grau M, Rauanheimo H, Plaketti RM, Taira A, Sulo P, Hartonen T, Dave K, Schmierer B, Botla S, Sokolova M, Vähärautio A, Gladysz K, Ongen H, Dermitzakis E, Bramsen JB, Ørntoft TF, Andersen CL, Ristimäki A, Lepistö A, Renkonen-Sinisalo L, Mecklin JP, Taipale J, Aaltonen LA.

Nat Commun. 2018 Sep 10;9(1):3664. doi: 10.1038/s41467-018-06132-1.


A randomized placebo-controlled phase II study of clarithromycin or placebo combined with VCD induction therapy prior to high-dose melphalan with stem cell support in patients with newly diagnosed multiple myeloma.

Gregersen H, Do T, Kristensen IB, Frølund UC, Andersen NF, Nielsen LK, Andersen CL, Klausen TW, Vangsted AJ, Abildgaard N.

Exp Hematol Oncol. 2018 Aug 13;7:18. doi: 10.1186/s40164-018-0110-0. eCollection 2018.


Interpretation of HbA1c in primary care and potential influence of anaemia and chronic kidney disease: an analysis from the Copenhagen Primary Care Laboratory (CopLab) Database.

Borg R, Persson F, Siersma V, Lind B, de Fine Olivarius N, Andersen CL.

Diabet Med. 2018 Dec;35(12):1700-1706. doi: 10.1111/dme.13776. Epub 2018 Aug 20.


Avoidable colorectal cancer cases in Denmark - The impact of red and processed meat.

Lourenço S, Gunge VB, Andersson TM, Andersen CLE, Lund AQ, Køster B, Hansen GL.

Cancer Epidemiol. 2018 Aug;55:1-7. doi: 10.1016/j.canep.2018.04.010. Epub 2018 May 25.


Nanosized carriers based on amphiphilic poly-N-vinyl-2-pyrrolidone for intranuclear drug delivery.

Luss AL, Kulikov PP, Romme SB, Andersen CL, Pennisi CP, Docea AO, Kuskov AN, Velonia K, Mezhuev YO, Shtilman MI, Tsatsakis AM, Gurevich L.

Nanomedicine (Lond). 2018 Apr 1;13(7):703-715. doi: 10.2217/nnm-2017-0311. Epub 2018 Apr 9.


The quest for determining one-electron redox potentials of azulene-1-carbonitriles by calculation.

Ree N, Andersen CL, Kilde MD, Hammerich O, Nielsen MB, Mikkelsen KV.

Phys Chem Chem Phys. 2018 Mar 14;20(11):7438-7446. doi: 10.1039/c7cp08687c.


Subphthalocyanine-radiaannulene scaffold - a multi-electron acceptor and strong chromophore.

Lissau H, Andersen CL, Storm FE, Santella M, Hammerich O, Hansen T, Mikkelsen KV, Nielsen MB.

Chem Commun (Camb). 2018 Mar 13;54(22):2763-2766. doi: 10.1039/c8cc00028j.


Thromboembolism prophylaxis in patients with Philadelphia-negative myeloproliferative neoplasms-Clinical practice among Nordic specialists.

Bjerrum OW, Samuelsson J, Ghanima W, Kauppila M, Andersen CL; Nordic Myeloproliferative Neoplasm Study Group.

Eur J Haematol. 2018 May;100(5):475-478. doi: 10.1111/ejh.13043. Epub 2018 Mar 25.


A Danish national effort of BRCA1/2 variant classification.

Pedersen IS, Schmidt AY, Bertelsen B, Ernst A, Andersen CLT, Kruse T, Rossing M, Thomassen M.

Acta Oncol. 2018 Jan;57(1):159-162. doi: 10.1080/0284186X.2017.1400693. Epub 2017 Nov 23. No abstract available.


A genetically inducible porcine model of intestinal cancer.

Callesen MM, Árnadóttir SS, Lyskjaer I, Ørntoft MW, Høyer S, Dagnaes-Hansen F, Liu Y, Li R, Callesen H, Rasmussen MH, Berthelsen MF, Thomsen MK, Schweiger PJ, Jensen KB, Laurberg S, Ørntoft TF, Elverløv-Jakobsen JE, Andersen CL.

Mol Oncol. 2017 Nov;11(11):1616-1629. doi: 10.1002/1878-0261.12136. Epub 2017 Oct 10.


Direct detection of early-stage cancers using circulating tumor DNA.

Phallen J, Sausen M, Adleff V, Leal A, Hruban C, White J, Anagnostou V, Fiksel J, Cristiano S, Papp E, Speir S, Reinert T, Orntoft MW, Woodward BD, Murphy D, Parpart-Li S, Riley D, Nesselbush M, Sengamalay N, Georgiadis A, Li QK, Madsen MR, Mortensen FV, Huiskens J, Punt C, van Grieken N, Fijneman R, Meijer G, Husain H, Scharpf RB, Diaz LA Jr, Jones S, Angiuoli S, Ørntoft T, Nielsen HJ, Andersen CL, Velculescu VE.

Sci Transl Med. 2017 Aug 16;9(403). pii: eaan2415. doi: 10.1126/scitranslmed.aan2415.


Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations.

Nielsen HM, Andersen CL, Westman M, Kristensen LS, Asmar F, Kruse TA, Thomassen M, Larsen TS, Skov V, Hansen LL, Bjerrum OW, Hasselbalch HC, Punj V, Grønbæk K.

Sci Rep. 2017 Jul 28;7(1):6774. doi: 10.1038/s41598-017-07057-3. Erratum in: Sci Rep. 2018 Nov 20;8(1):17311.


An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes.

Bekker-Jensen DB, Kelstrup CD, Batth TS, Larsen SC, Haldrup C, Bramsen JB, Sørensen KD, Høyer S, Ørntoft TF, Andersen CL, Nielsen ML, Olsen JV.

Cell Syst. 2017 Jun 28;4(6):587-599.e4. doi: 10.1016/j.cels.2017.05.009. Epub 2017 Jun 7.


Clinical Implications of Monitoring Circulating Tumor DNA in Patients with Colorectal Cancer.

Schøler LV, Reinert T, Ørntoft MW, Kassentoft CG, Árnadóttir SS, Vang S, Nordentoft I, Knudsen M, Lamy P, Andreasen D, Mortensen FV, Knudsen AR, Stribolt K, Sivesgaard K, Mouritzen P, Nielsen HJ, Laurberg S, Ørntoft TF, Andersen CL.

Clin Cancer Res. 2017 Sep 15;23(18):5437-5445. doi: 10.1158/1078-0432.CCR-17-0510. Epub 2017 Jun 9.


Comparative analysis of 12 different kits for bisulfite conversion of circulating cell-free DNA.

Worm Ørntoft MB, Jensen SØ, Hansen TB, Bramsen JB, Andersen CL.

Epigenetics. 2017 Aug;12(8):626-636. doi: 10.1080/15592294.2017.1334024. Epub 2017 May 30.


Molecular-Subtype-Specific Biomarkers Improve Prediction of Prognosis in Colorectal Cancer.

Bramsen JB, Rasmussen MH, Ongen H, Mattesen TB, Ørntoft MW, Árnadóttir SS, Sandoval J, Laguna T, Vang S, Øster B, Lamy P, Madsen MR, Laurberg S, Esteller M, Dermitzakis ET, Ørntoft TF, Andersen CL.

Cell Rep. 2017 May 9;19(6):1268-1280. doi: 10.1016/j.celrep.2017.04.045.


Anemia is present years before myelodysplastic syndrome diagnosis: Results from the pre-diagnostic period.

Hansen JW, Sandholdt H, Siersma V, Ørskov AD, Holmberg S, Bjerrum OW, Hasselbalch HC, Olivarius NF, Grønbaek K, Andersen CL.

Am J Hematol. 2017 Jul;92(7):E130-E132. doi: 10.1002/ajh.24757. Epub 2017 May 26. No abstract available.


A systematic review of health-related quality of life in longitudinal studies of myeloma patients.

Nielsen LK, Jarden M, Andersen CL, Frederiksen H, Abildgaard N.

Eur J Haematol. 2017 Jul;99(1):3-17. doi: 10.1111/ejh.12882. Epub 2017 Apr 25. Review.


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