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Items: 11


High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers.

Anderhub SJ, Mak GW, Gurden MD, Faisal A, Drosopoulos K, Walsh K, Woodward HL, Innocenti P, Westwood IM, Naud S, Hayes A, Theofani E, Filosto S, Saville H, Burke R, van Montfort RLM, Raynaud FI, Blagg J, Hoelder S, Eccles SA, Linardopoulos S.

Mol Cancer Ther. 2019 Oct;18(10):1696-1707. doi: 10.1158/1535-7163.MCT-18-1203.


Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.

Faisal A, Mak GWY, Gurden MD, Xavier CPR, Anderhub SJ, Innocenti P, Westwood IM, Naud S, Hayes A, Box G, Valenti MR, De Haven Brandon AK, O'Fee L, Schmitt J, Woodward HL, Burke R, vanMontfort RLM, Blagg J, Raynaud FI, Eccles SA, Hoelder S, Linardopoulos S.

Br J Cancer. 2017 Apr 25;116(9):1166-1176. doi: 10.1038/bjc.2017.75. Epub 2017 Mar 23.


Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.

Gurden MD, Anderhub SJ, Faisal A, Linardopoulos S.

Oncotarget. 2016 Jul 18;9(28):19525-19542. doi: 10.18632/oncotarget.10657. eCollection 2018 Apr 13.


Influences of histone deacetylase inhibitors and resveratrol on DNA repair and chromatin compaction.

Keuser B, Khobta A, Gallé K, Anderhub S, Schulz I, Pauly K, Epe B.

Mutagenesis. 2013 Sep;28(5):569-76. doi: 10.1093/mutage/get034. Epub 2013 Jun 29.


The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells.

Maier B, Kirsch M, Anderhub S, Zentgraf H, Krämer A.

Cell Cycle. 2013 May 1;12(9):1457-71. doi: 10.4161/cc.24602. Epub 2013 Apr 10.


GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo.

Raab MS, Breitkreutz I, Anderhub S, Rønnest MH, Leber B, Larsen TO, Weiz L, Konotop G, Hayden PJ, Podar K, Fruehauf J, Nissen F, Mier W, Haberkorn U, Ho AD, Goldschmidt H, Anderson KC, Clausen MH, Krämer A.

Cancer Res. 2012 Oct 15;72(20):5374-85. doi: 10.1158/0008-5472.CAN-12-2026. Epub 2012 Aug 31.


Centrosome amplification in tumorigenesis.

Anderhub SJ, Krämer A, Maier B.

Cancer Lett. 2012 Sep 1;322(1):8-17. doi: 10.1016/j.canlet.2012.02.006. Epub 2012 Feb 14. Review.


Disparate SAR data of griseofulvin analogues for the dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 cancer cells.

Rønnest MH, Raab MS, Anderhub S, Boesen S, Krämer A, Larsen TO, Clausen MH.

J Med Chem. 2012 Jan 26;55(2):652-60. doi: 10.1021/jm200835c. Epub 2012 Jan 17.


Centrosomal targeting of tyrosine kinase activity does not enhance oncogenicity in chronic myeloproliferative disorders.

Bochtler T, Kirsch M, Maier B, Bachmann J, Klingmüller U, Anderhub S, Ho AD, Krämer A.

Leukemia. 2012 Apr;26(4):728-35. doi: 10.1038/leu.2011.283. Epub 2011 Oct 21.


Proteins required for centrosome clustering in cancer cells.

Leber B, Maier B, Fuchs F, Chi J, Riffel P, Anderhub S, Wagner L, Ho AD, Salisbury JL, Boutros M, Krämer A.

Sci Transl Med. 2010 May 26;2(33):33ra38. doi: 10.1126/scitranslmed.3000915.


Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region.

Khobta A, Anderhub S, Kitsera N, Epe B.

Nucleic Acids Res. 2010 Jul;38(13):4285-95. doi: 10.1093/nar/gkq170. Epub 2010 Mar 24.

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