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Items: 1 to 50 of 112

1.

International trends in chronic obstructive pulmonary disease mortality, 1995-2017.

Lortet-Tieulent J, Soerjomataram I, López-Campos JL, Ancochea J, Coebergh JW, Soriano JB.

Eur Respir J. 2019 Nov 19. pii: 1901791. doi: 10.1183/13993003.01791-2019. [Epub ahead of print] No abstract available.

PMID:
31744832
2.

The most beautiful COPD chart in the world: All Together to End COPD.

Soriano JB, Ancochea J, Celli BR.

Eur Respir J. 2019 Nov 14. pii: 1902047. doi: 10.1183/13993003.02047-2019. [Epub ahead of print] No abstract available.

PMID:
31699834
3.

Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain: the SEPAR National Registry.

Fernández-Fabrellas E, Molina-Molina M, Soriano JB, Portal JAR, Ancochea J, Valenzuela C, Xaubet A; SEPAR-IPF National Registry.

Respir Res. 2019 Jun 17;20(1):127. doi: 10.1186/s12931-019-1084-0.

4.

Multidisciplinary Perspectives on the Importance of Physical Activity in COPD.

Miravitlles M, Troosters T, Janssens W, Ancochea J.

Arch Bronconeumol. 2019 Nov;55(11):551-552. doi: 10.1016/j.arbres.2019.03.010. Epub 2019 Apr 11. English, Spanish. No abstract available.

5.

External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study.

Almagro P, Martínez-Camblor P, Miravitlles M, Rodríguez-Carballeira M, Navarro A, Lamprecht B, Ramirez-Garcia Luna AS, Kaiser B, Alfageme I, Casanova C, Esteban C, Soler-Cataluña JJ, de-Torres JP, Celli BR, Marin JM, Ter Riet G, Sobradillo P, Lange P, Garcia-Aymerich J, Anto JM, Turner AM, Han MK, Langhammer A, Sternberg A, Leivseth L, Bakke P, Johannessen A, Oga T, Cosío B, Ancochea J, Echazarreta A, Roche N, Burgel PR, Sin DD, Puhan MA, Soriano JB; 3CIA collaboration.

COPD. 2019 Feb;16(1):8-17. doi: 10.1080/15412555.2018.1484440. Epub 2019 Mar 14.

PMID:
30870059
6.

Correction: Inflammation biomarkers in blood as mortality predictors in community-acquired pneumonia admitted patients: Importance of comparison with neutrophil count percentage or neutrophil-lymphocyte ratio.

Curbelo J, Luquero Bueno S, Galván-Román JM, Ortega-Gómez M, Rajas O, Fernández-Jiménez G, Vega-Piris L, Rodríguez-Salvanes F, Arnalich B, Díaz A, Costa R, de la Fuente H, Lancho Á, Suárez C, Ancochea J, Aspa J.

PLoS One. 2019 Feb 22;14(2):e0212915. doi: 10.1371/journal.pone.0212915. eCollection 2019.

7.

10 Years After EPISCAN: A New Study on the Prevalence of COPD in Spain -A Summary of the EPISCAN II Protocol.

Alfageme I, de Lucas P, Ancochea J, Miravitlles M, Soler-Cataluña JJ, García-Río F, Casanova C, Rodríguez González-Moro JM, Cosío BG, Sánchez G, Soriano JB.

Arch Bronconeumol. 2019 Jan;55(1):38-47. doi: 10.1016/j.arbres.2018.05.011. Epub 2018 Jul 7. English, Spanish.

8.

Desaturations During 6-Minute Walk Test and Predicting Nocturnal Desaturations in Adult Subjects With Cystic Fibrosis.

Gómez Punter RM, Girón Moreno RM, Vázquez Espinosa E, Soriano JB, Pastor MT, Zamora E, Valenzuela C, Alonso T, García Castillo E, Ancochea J.

Respir Care. 2019 Jan;64(1):48-54. doi: 10.4187/respcare.06171. Epub 2018 Nov 20.

PMID:
30459242
9.

Correction: Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness.

Ruiz de Garibay G, Herranz C, Llorente A, Boni J, Serra-Musach J, Mateo F, Aguilar H, Gómez-Baldó L, Petit A, Vidal A, Climent F, Hernández-Losa J, Cordero Á, González-Suárez E, Sánchez-Mut JV, Esteller M, Llatjós R, Varela M, López JI, García N, Extremera AI, Gumà A, Ortega R, Plà MJ, Fernández A, Pernas S, Falo C, Morilla I, Campos M, Gil M, Román A, Molina-Molina M, Ussetti P, Laporta R, Valenzuela C, Ancochea J, Xaubet A, Casanova Á, Pujana MA.

PLoS One. 2018 Nov 12;13(11):e0207586. doi: 10.1371/journal.pone.0207586. eCollection 2018.

10.

A multicentre, randomized controlled trial of telehealth for the management of COPD.

Soriano JB, García-Río F, Vázquez-Espinosa E, Conforto JI, Hernando-Sanz A, López-Yepes L, Galera-Martínez R, Peces-Barba G, Gotera-Rivera CM, Pérez-Warnisher MT, Segrelles-Calvo G, Zamarro C, González-Ponce P, Ramos MI, Jafri S, Ancochea J.

Respir Med. 2018 Nov;144:74-81. doi: 10.1016/j.rmed.2018.10.008. Epub 2018 Oct 13.

PMID:
30366588
11.

Biologics in the treatment of diffuse interstitial lung disease associated with connective tissue disease.

Alonso T, Castañeda S, Ancochea J.

Arch Bronconeumol. 2018 Nov;54(11):549-550. doi: 10.1016/j.arbres.2018.06.008. Epub 2018 Jul 14. English, Spanish. No abstract available.

12.

Importance of early diagnosis and treatment in idiopathic pulmonary fibrosis.

Molina-Molina M, Aburto M, Acosta O, Ancochea J, Rodríguez-Portal JA, Sauleda J, Lines C, Xaubet A.

Expert Rev Respir Med. 2018 Jul;12(7):537-539. doi: 10.1080/17476348.2018.1472580. Epub 2018 May 7. No abstract available.

PMID:
29718749
13.

Efficacy and costs of telehealth for the management of COPD: the PROMETE II trial.

Ancochea J, García-Río F, Vázquez-Espinosa E, Hernando-Sanz A, López-Yepes L, Galera-Martínez R, Peces-Barba G, Pérez-Warnisher MT, Segrelles-Calvo G, Zamarro C, González-Ponce P, Ramos MI, Conforto JI, Jafri S, Soriano JB.

Eur Respir J. 2018 May 30;51(5). pii: 1800354. doi: 10.1183/13993003.00354-2018. Print 2018 May. No abstract available.

14.

Interstitial pneumonia with autoimmune features: An update.

Valenzuela C, Cottin V, Ancochea J.

Arch Bronconeumol. 2018 Sep;54(9):447-448. doi: 10.1016/j.arbres.2018.02.003. Epub 2018 Mar 16. English, Spanish. No abstract available.

15.

Creation of the SAQ-COPD Questionnaire to Determine Physical Activity in COPD Patients in Clinical Practice.

Soler-Cataluña JJ, Puente Maestu L, Román-Rodríguez M, Esteban C, Gea J, Bernabeu Mora R, Pleguezuelos Cobo E, Ancochea J, Monteagudo Ruiz G, Garcia Rio F.

Arch Bronconeumol. 2018 Sep;54(9):467-475. doi: 10.1016/j.arbres.2018.01.016. Epub 2018 Mar 13. English, Spanish.

16.

COMET: a multicomponent home-based disease-management programme versus routine care in severe COPD.

Kessler R, Casan-Clara P, Koehler D, Tognella S, Viejo JL, Dal Negro RW, Díaz-Lobato S, Reissig K, Rodríguez González-Moro JM, Devouassoux G, Chavaillon JM, Botrus P, Arnal JM, Ancochea J, Bergeron-Lafaurie A, De Abajo C, Randerath WJ, Bastian A, Cornelissen CG, Nilius G, Texereau JB, Bourbeau J.

Eur Respir J. 2018 Jan 11;51(1). pii: 1701612. doi: 10.1183/13993003.01612-2017. Print 2018 Jan.

17.

Does The Impact Of Cough On Quality Of Life In Bronchiectasis Depend On Prognosis?

Girón Moreno RM, Sánchez Azofra A, Aldave Orzaiz B, Pastor Sanz MT, Ancochea J.

Arch Bronconeumol. 2018 Apr;54(4):238-239. doi: 10.1016/j.arbres.2017.10.011. Epub 2017 Dec 14. English, Spanish. No abstract available.

18.

Efficacy and safety of tiotropium and olodaterol in COPD: a systematic review and meta-analysis.

Miravitlles M, Urrutia G, Mathioudakis AG, Ancochea J.

Respir Res. 2017 Nov 25;18(1):196. doi: 10.1186/s12931-017-0683-x. Review.

19.

A simple algorithm for the identification of clinical COPD phenotypes.

Burgel PR, Paillasseur JL, Janssens W, Piquet J, Ter Riet G, Garcia-Aymerich J, Cosio B, Bakke P, Puhan MA, Langhammer A, Alfageme I, Almagro P, Ancochea J, Celli BR, Casanova C, de-Torres JP, Decramer M, Echazarreta A, Esteban C, Gomez Punter RM, Han MK, Johannessen A, Kaiser B, Lamprecht B, Lange P, Leivseth L, Marin JM, Martin F, Martinez-Camblor P, Miravitlles M, Oga T, Sofia Ramírez A, Sin DD, Sobradillo P, Soler-Cataluña JJ, Turner AM, Verdu Rivera FJ, Soriano JB, Roche N; Initiatives BPCO, EABPCO, Leuven and 3CIA study groups.

Eur Respir J. 2017 Nov 2;50(5). pii: 1701034. doi: 10.1183/13993003.01034-2017. Print 2017 Nov.

20.

Erratum to "Guidelines for the medical treatment of idiopathic pulmonary fibrosis" <[Arch Bronconeumol. 53 (2017) 263-9] >.

Xaubet A, Molina-Molina M, Acosta O, Bollo E, Castillo D, Fernández-Fabrellas E, Rodríguez-Portal JA, Valenzuela C, Ancochea J.

Arch Bronconeumol. 2017 Nov;53(11):657-658. doi: 10.1016/j.arbres.2017.06.010. Epub 2017 Sep 18. English, Spanish. No abstract available.

21.

Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study.

Horner A, Soriano JB, Puhan MA, Studnicka M, Kaiser B, Vanfleteren LEGW, Gnatiuc L, Burney P, Miravitlles M, García-Rio F, Ancochea J, Menezes AM, Perez-Padilla R, Montes de Oca M, Torres-Duque CA, Caballero A, González-García M, Buist S, Flamm M, Lamprecht B; BOLD Collaborative Research Group; EPI-SCAN Team; PLATINO Team; PREPOCOL Study Group.

Respir Res. 2017 Aug 23;18(1):162. doi: 10.1186/s12931-017-0643-5.

22.

Maxillomandibular advancement as the initial treatment of obstructive sleep apnoea: Is the mandibular occlusal plane the key?

Rubio-Bueno P, Landete P, Ardanza B, Vázquez L, Soriano JB, Wix R, Capote A, Zamora E, Ancochea J, Naval-Gías L.

Int J Oral Maxillofac Surg. 2017 Nov;46(11):1363-1371. doi: 10.1016/j.ijom.2017.07.003. Epub 2017 Jul 29.

PMID:
28760319
23.

Spanish Guidelines for Management of Chronic Obstructive Pulmonary Disease (GesEPOC) 2017. Pharmacological Treatment of Stable Phase.

Miravitlles M, Soler-Cataluña JJ, Calle M, Molina J, Almagro P, Quintano JA, Trigueros JA, Cosío BG, Casanova C, Antonio Riesco J, Simonet P, Rigau D, Soriano JB, Ancochea J.

Arch Bronconeumol. 2017 Jun;53(6):324-335. doi: 10.1016/j.arbres.2017.03.018. Epub 2017 May 3. English, Spanish.

24.

Sex bias in diagnostic delay in bronchiectasis: An analysis of the Spanish Historical Registry of Bronchiectasis.

Girón RM, de Gracia Roldán J, Olveira C, Vendrell M, Martínez-García MÁ, de la Rosa D, Máiz L, Ancochea J, Vázquez L, Borderías L, Polverino E, Martínez-Moragón E, Rajas O, Soriano JB.

Chron Respir Dis. 2017 Nov;14(4):360-369. doi: 10.1177/1479972317702139. Epub 2017 Apr 10.

25.

Inflammation biomarkers in blood as mortality predictors in community-acquired pneumonia admitted patients: Importance of comparison with neutrophil count percentage or neutrophil-lymphocyte ratio.

Curbelo J, Luquero Bueno S, Galván-Román JM, Ortega-Gómez M, Rajas O, Fernández-Jiménez G, Vega-Piris L, Rodríguez-Salvanes F, Arnalich B, Díaz A, Costa R, de la Fuente H, Lancho Á, Suárez C, Ancochea J, Aspa J.

PLoS One. 2017 Mar 16;12(3):e0173947. doi: 10.1371/journal.pone.0173947. eCollection 2017. Erratum in: PLoS One. 2019 Feb 22;14(2):e0212915.

26.

Guidelines for the medical treatment of idiopathic pulmonary fibrosis.

Xaubet A, Molina-Molina M, Acosta O, Bollo E, Castillo D, Fernández-Fabrellas E, Rodríguez-Portal JA, Valenzuela C, Ancochea J.

Arch Bronconeumol. 2017 May;53(5):263-269. doi: 10.1016/j.arbres.2016.12.011. Epub 2017 Mar 11. English, Spanish. Erratum in: Arch Bronconeumol. 2017 Nov;53(11):657-658.

27.

Idiopathic pulmonary fibrosis.

Xaubet A, Ancochea J, Molina-Molina M.

Med Clin (Barc). 2017 Feb 23;148(4):170-175. doi: 10.1016/j.medcli.2016.11.004. Epub 2016 Dec 18. Review. English, Spanish.

PMID:
27998476
28.

Identification of non-coding genetic variants in samples from hypoxemic respiratory disease patients that affect the transcriptional response to hypoxia.

Roche O, Deguiz ML, Tiana M, Galiana-Ribote C, Martinez-Alcazar D, Rey-Serra C, Ranz-Ribeiro B, Casitas R, Galera R, Fernández-Navarro I, Sánchez-Cuéllar S, Bernard V, Ancochea J, Wasserman WW, García-Rio F, Jimenez B, Del Peso L.

Nucleic Acids Res. 2016 Nov 2;44(19):9315-9330. Epub 2016 Sep 12.

29.

Role Of Hif2α Oxygen Sensing Pathway In Bronchial Epithelial Club Cell Proliferation.

Torres-Capelli M, Marsboom G, Li QO, Tello D, Rodriguez FM, Alonso T, Sanchez-Madrid F, García-Rio F, Ancochea J, Aragonés J.

Sci Rep. 2016 May 6;6:25357. doi: 10.1038/srep25357.

30.

Lung function testing in idiopathic pulmonary fibrosis: More than just spirometry?

Casan Clarà P, Martínez González C, Ancochea J.

Arch Bronconeumol. 2016 Sep;52(9):457-8. doi: 10.1016/j.arbres.2016.02.017. Epub 2016 Apr 14. English, Spanish. No abstract available.

31.

Erratum to: Knowledge and perceptions of asthma in Zambia: a cross-sectional survey.

Marsden EJ, Somwe SW, Chabala C, Soriano JB, Vallès CP, Ancochea J.

BMC Pulm Med. 2016 Mar 24;16:44. doi: 10.1186/s12890-016-0204-6. No abstract available.

32.

Study of breast cancer incidence in patients of lymphangioleiomyomatosis.

Nuñez O, Román A, Johnson SR, Inoue Y, Hirose M, Casanova Á, de Garibay GR, Herranz C, Bueno-Moreno G, Boni J, Mateo F, Petit A, Climent F, Soler T, Vidal A, Sánchez-Mut JV, Esteller M, López JI, García N, Gumà A, Ortega R, Plà MJ, Campos M, Ansótegui E, Molina-Molina M, Valenzuela C, Ussetti P, Laporta R, Ancochea J, Xaubet A, Pollán M, Pujana MA.

Breast Cancer Res Treat. 2016 Feb;156(1):195-201. doi: 10.1007/s10549-016-3737-8. Epub 2016 Mar 7.

33.

Improving paediatric asthma care in Zambia.

Wa Somwe S, Jumbe-Marsden E, Mateyo K, Senkwe MN, Sotomayor-Ruiz M, Musuku J, Soriano JB, Ancochea J, Fishman MC.

Bull World Health Organ. 2015 Oct 1;93(10):732-736. Epub 2015 Aug 19.

34.

Tobramycin inhalation powder (TOBI Podhaler) for the treatment of lung infection in patients with cystic fibrosis.

Vazquez-Espinosa E, Marcos C, Alonso T, Giron RM, Gomez-Punter RM, Garcia-Castillo E, Zamora E, Cisneros C, Garcia J, Valenzuela C, Ancochea J.

Expert Rev Anti Infect Ther. 2016;14(1):9-17. doi: 10.1586/14787210.2016.1118344. Epub 2015 Dec 4. Review.

PMID:
26559549
35.

Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness.

Ruiz de Garibay G, Herranz C, Llorente A, Boni J, Serra-Musach J, Mateo F, Aguilar H, Gómez-Baldó L, Petit A, Vidal A, Climent F, Hernández-Losa J, Cordero Á, González-Suárez E, Sánchez-Mut JV, Esteller M, Llatjós R, Varela M, López JI, García N, Extremera AI, Gumà A, Ortega R, Plà MJ, Fernández A, Pernas S, Falo C, Morilla I, Campos M, Gil M, Román A, Molina-Molina M, Ussetti P, Laporta R, Valenzuela C, Ancochea J, Xaubet A, Casanova Á, Pujana MA.

PLoS One. 2015 Jul 13;10(7):e0132546. doi: 10.1371/journal.pone.0132546. eCollection 2015. Erratum in: PLoS One. 2018 Nov 12;13(11):e0207586.

36.

Determinants of underdiagnosis of COPD in national and international surveys.

Lamprecht B, Soriano JB, Studnicka M, Kaiser B, Vanfleteren LE, Gnatiuc L, Burney P, Miravitlles M, García-Rio F, Akbari K, Ancochea J, Menezes AM, Perez-Padilla R, Montes de Oca M, Torres-Duque CA, Caballero A, González-García M, Buist S; BOLD Collaborative Research Group, the EPI-SCAN Team, the PLATINO Team, and the PREPOCOL Study Group.

Chest. 2015 Oct;148(4):971-985. doi: 10.1378/chest.14-2535.

PMID:
25950276
37.

Long-term safety and efficacy of tobramycin in the management of cystic fibrosis.

Vázquez-Espinosa E, Girón RM, Gómez-Punter RM, García-Castillo E, Valenzuela C, Cisneros C, Zamora E, García-Pérez FJ, Ancochea J.

Ther Clin Risk Manag. 2015 Mar 12;11:407-15. doi: 10.2147/TCRM.S75208. eCollection 2015. Review.

38.

The incidence of cardiovascular events after hospitalization due to CAP and their association with different inflammatory markers.

Rajas O, Ortega-Gómez M, Galván Román JM, Curbelo J, Fernández Jiménez G, Vega Piris L, Rodríguez Salvanes F, Arnalich B, Luquero Bueno S, Díaz López A, de la Fuente H, Suárez C, Ancochea J, Aspa J.

BMC Pulm Med. 2014 Dec 12;14:197. doi: 10.1186/1471-2466-14-197.

39.

Role of C-reactive protein as a biomarker for prediction of the severity of pulmonary exacerbations in patients with cystic fibrosis.

Girón-Moreno RM, Justicia JL, Yamamoto S, Valenzuela C, Cisneros C, Gómez-Punter RM, Fernandes-Vasconcelos G, Ancochea J.

BMC Pulm Med. 2014 Sep 23;14:150. doi: 10.1186/1471-2466-14-150.

40.

Impact of obesity on the clinical profile of a population-based sample with chronic obstructive pulmonary disease.

García-Rio F, Soriano JB, Miravitlles M, Muñoz L, Duran-Tauleria E, Sánchez G, Sobradillo V, Ancochea J.

PLoS One. 2014 Aug 25;9(8):e105220. doi: 10.1371/journal.pone.0105220. eCollection 2014.

41.

[Early diagnosis of idiopathic pulmonary fibrosis].

Ancochea J, Xaubet A.

Semergen. 2014 Apr;40(3):119-20. doi: 10.1016/j.semerg.2014.03.002. Spanish. No abstract available.

PMID:
24767153
42.

[Idiopathic pulmonary fibrosis: a challenge for primary care].

Molina J, Trigueros JA, Quintano JA, Mascarós E, Xaubet A, Ancochea J.

Semergen. 2014 Apr;40(3):134-42. doi: 10.1016/j.semerg.2014.02.001. Epub 2014 Mar 30. Spanish. No abstract available.

PMID:
24690256
43.

Spanish guideline for COPD (GesEPOC). Update 2014.

Miravitlles M, Soler-Cataluña JJ, Calle M, Molina J, Almagro P, Quintano JA, Riesco JA, Trigueros JA, Piñera P, Simón A, Rodríguez-Hermosa JL, Marco E, López D, Coll R, Coll-Fernández R, Lobo MÁ, Díez J, Soriano JB, Ancochea J.

Arch Bronconeumol. 2014 Jan;50 Suppl 1:1-16. doi: 10.1016/S0300-2896(14)70070-5. No abstract available.

44.

A home telehealth program for patients with severe COPD: the PROMETE study.

Segrelles Calvo G, Gómez-Suárez C, Soriano JB, Zamora E, Gónzalez-Gamarra A, González-Béjar M, Jordán A, Tadeo E, Sebastián A, Fernández G, Ancochea J.

Respir Med. 2014 Mar;108(3):453-62. doi: 10.1016/j.rmed.2013.12.003. Epub 2013 Dec 16.

45.

Pirfenidone for the treatment of idiopathic pulmonary fibrosis.

Xaubet A, Serrano-Mollar A, Ancochea J.

Expert Opin Pharmacother. 2014 Feb;15(2):275-81. doi: 10.1517/14656566.2014.867328. Epub 2013 Dec 6. Review.

46.

Presence of anxiety and depression in patients with bronchiectasis unrelated to cystic fibrosis.

Girón Moreno RM, Fernandes Vasconcelos G, Cisneros C, Gómez-Punter RM, Segrelles Calvo G, Ancochea J.

Arch Bronconeumol. 2013 Oct;49(10):415-20. doi: 10.1016/j.arbres.2013.01.012. Epub 2013 Sep 3. English, Spanish.

47.

Guidelines for the diagnosis and treatment of idiopathic pulmonary fibrosis. Sociedad Española de Neumología y Cirugía Torácica (SEPAR) Research Group on Diffuse Pulmonary Diseases.

Xaubet A, Ancochea J, Bollo E, Fernández-Fabrellas E, Franquet T, Molina-Molina M, Montero MA, Serrano-Mollar A; Sociedad Española de Neumología y Cirugía Torácica (SEPAR) Research Group on Diffuse Pulmonary Diseases.

Arch Bronconeumol. 2013 Aug;49(8):343-53. doi: 10.1016/j.arbres.2013.03.011. Epub 2013 Jun 4. English, Spanish.

48.

Angiotensinogen promoter polymorphisms predict low diffusing capacity in U.S. and Spanish IPF cohorts.

Dang MT, Gu C, Klavanian JI, Jernigan KA, Friderici KH, Cui Y, Molina-Molina M, Ancochea J, Xaubet A, Uhal BD.

Lung. 2013 Aug;191(4):353-60. doi: 10.1007/s00408-013-9476-2. Epub 2013 May 30.

49.

Reply: To PMID 22705258.

Segrelles Calvo G, Zamora García E, Ancochea J.

Arch Bronconeumol. 2014 Feb;50(2):80-1. doi: 10.1016/j.arbres.2013.03.002. Epub 2013 May 10. English, Spanish. No abstract available.

50.

Characterisation of the overlap COPD-asthma phenotype. Focus on physical activity and health status.

Miravitlles M, Soriano JB, Ancochea J, Muñoz L, Duran-Tauleria E, Sánchez G, Sobradillo V, García-Río F.

Respir Med. 2013 Jul;107(7):1053-60. doi: 10.1016/j.rmed.2013.03.007. Epub 2013 Apr 16.

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