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Items: 44


Age-dependent dysregulation of redox genes may contribute to fibrotic pulmonary disease susceptibility.

Elko EA, Mahoney JM, Vacek P, van der Vliet A, Anathy V, van der Velden JLJL, Janssen-Heininger YMW, Seward DJ.

Free Radic Biol Med. 2019 Sep;141:438-446. doi: 10.1016/j.freeradbiomed.2019.07.011. Epub 2019 Jul 14.


Increased extracellular maspin levels after mechanical compression in vitro or allergen challenge in vivo.

Kim SH, Mitchel JA, McGill M, Cremona TP, Baek JW, Kasahara DI, Anathy V, Israel E, Park JA.

J Allergy Clin Immunol. 2019 Jun 19. pii: S0091-6749(19)30801-2. doi: 10.1016/j.jaci.2019.06.006. [Epub ahead of print] No abstract available.


Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresponsiveness by inhibiting UPR transducers.

Nakada EM, Bhakta NR, Korwin-Mihavics BR, Kumar A, Chamberlain N, Bruno SR, Chapman DG, Hoffman SM, Daphtary N, Aliyeva M, Irvin CG, Dixon AE, Woodruff PG, Amin S, Poynter ME, Desai DH, Anathy V.

JCI Insight. 2019 May 2;4(9). pii: 98101. doi: 10.1172/jci.insight.98101. eCollection 2019 May 2.


Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease.

Elko EA, Cunniff B, Seward DJ, Chia SB, Aboushousha R, van de Wetering C, van der Velden J, Manuel A, Shukla A, Heintz NH, Anathy V, van der Vliet A, Janssen-Heininger YMW.

Antioxid Redox Signal. 2019 Apr 5. doi: 10.1089/ars.2019.7752. [Epub ahead of print]


Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics.

Chamberlain N, Korwin-Mihavics BR, Nakada EM, Bruno SR, Heppner DE, Chapman DG, Hoffman SM, van der Vliet A, Suratt BT, Dienz O, Alcorn JF, Anathy V.

Redox Biol. 2019 Apr;22:101129. doi: 10.1016/j.redox.2019.101129. Epub 2019 Jan 29.


Serum Amyloid A3 is required for normal lung development and survival following influenza infection.

Ather JL, Dienz O, Boyson JE, Anathy V, Amiel E, Poynter ME.

Sci Rep. 2018 Nov 8;8(1):16571. doi: 10.1038/s41598-018-34901-x.


Skeletal muscle atrophy and dysfunction in breast cancer patients: role for chemotherapy-derived oxidant stress.

Guigni BA, Callahan DM, Tourville TW, Miller MS, Fiske B, Voigt T, Korwin-Mihavics B, Anathy V, Dittus K, Toth MJ.

Am J Physiol Cell Physiol. 2018 Nov 1;315(5):C744-C756. doi: 10.1152/ajpcell.00002.2018. Epub 2018 Sep 12.


Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling.

van der Vliet A, Janssen-Heininger YMW, Anathy V.

Mol Aspects Med. 2018 Oct;63:59-69. doi: 10.1016/j.mam.2018.08.001. Epub 2018 Aug 22. Review.


Reducing protein oxidation reverses lung fibrosis.

Anathy V, Lahue KG, Chapman DG, Chia SB, Casey DT, Aboushousha R, van der Velden JLJ, Elko E, Hoffman SM, McMillan DH, Jones JT, Nolin JD, Abdalla S, Schneider R, Seward DJ, Roberson EC, Liptak MD, Cousins ME, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, Ho YS, Hakem R, Brown KK, Matsui R, Bachschmid MM, Gomez JL, Kaminski N, van der Vliet A, Janssen-Heininger YMW.

Nat Med. 2018 Aug;24(8):1128-1135. doi: 10.1038/s41591-018-0090-y. Epub 2018 Jul 9.


Glycolysis promotes caspase-3 activation in lipid rafts in T cells.

Secinaro MA, Fortner KA, Dienz O, Logan A, Murphy MP, Anathy V, Boyson JE, Budd RC.

Cell Death Dis. 2018 Jan 19;9(2):62. doi: 10.1038/s41419-017-0099-z.


IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease.

Qian X, Aboushousha R, van de Wetering C, Chia SB, Amiel E, Schneider RW, van der Velden JLJ, Lahue KG, Hoagland DA, Casey DT, Daphtary N, Ather JL, Randall MJ, Aliyeva M, Black KE, Chapman DG, Lundblad LKA, McMillan DH, Dixon AE, Anathy V, Irvin CG, Poynter ME, Wouters EFM, Vacek PM, Henket M, Schleich F, Louis R, van der Vliet A, Janssen-Heininger YMW.

J Allergy Clin Immunol. 2018 Aug;142(2):435-450.e10. doi: 10.1016/j.jaci.2017.08.043. Epub 2017 Nov 3.


Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection.

Pociask DA, Robinson KM, Chen K, McHugh KJ, Clay ME, Huang GT, Benos PV, Janssen-Heininger YMW, Kolls JK, Anathy V, Alcorn JF.

Am J Pathol. 2017 Apr;187(4):851-863. doi: 10.1016/j.ajpath.2016.12.012. Epub 2017 Feb 10.


Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

McMillan DH, van der Velden JL, Lahue KG, Qian X, Schneider RW, Iberg MS, Nolin JD, Abdalla S, Casey DT, Tew KD, Townsend DM, Henderson CJ, Wolf CR, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, van der Vliet A, Flemer S, Anathy V, Janssen-Heininger YM.

JCI Insight. 2016 Jun 2;1(8). pii: 85717. doi: 10.1172/jci.insight.85717.


Effect of a chemical chaperone, tauroursodeoxycholic acid, on HDM-induced allergic airway disease.

Siddesha JM, Nakada EM, Mihavics BR, Hoffman SM, Rattu GK, Chamberlain N, Cahoon JM, Lahue KG, Daphtary N, Aliyeva M, Chapman DG, Desai DH, Poynter ME, Anathy V.

Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1243-59. doi: 10.1152/ajplung.00396.2015. Epub 2016 May 6.


Glutathione S-transferase pi modulates NF-κB activation and pro-inflammatory responses in lung epithelial cells.

Jones JT, Qian X, van der Velden JL, Chia SB, McMillan DH, Flemer S, Hoffman SM, Lahue KG, Schneider RW, Nolin JD, Anathy V, van der Vliet A, Townsend DM, Tew KD, Janssen-Heininger YM.

Redox Biol. 2016 Aug;8:375-82. doi: 10.1016/j.redox.2016.03.005. Epub 2016 Mar 26.


Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice.

Hoffman SM, Qian X, Nolin JD, Chapman DG, Chia SB, Lahue KG, Schneider R, Ather JL, Randall MJ, McMillan DH, Jones JT, Taatjes DJ, Aliyeva M, Daphtary N, Abdalla S, Lundblad LK, Ho YS, Anathy V, Irvin CG, Wouters EF, Reynaert NL, Dixon AE, van der Vliet A, Poynter ME, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2016 Sep;55(3):377-86. doi: 10.1165/rcmb.2015-0401OC.


Ablation of the Thiol Transferase Glutaredoxin-1 Augments Protein S-Glutathionylation and Modulates Type 2 Inflammatory Responses and IL-17 in a House Dust Mite Model of Allergic Airway Disease in Mice.

Hoffman SM, Nolin JD, Jones JT, Lahue KG, Chapman DG, Aliyeva M, Daphtary N, Lundblad LK, Abdalla S, Ather JL, Ho YS, Irvin CG, Anathy V, Wouters EF, Poynter ME, Janssen-Heininger YM.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S97. doi: 10.1513/AnnalsATS.201510-656MG.


Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness.

Hoffman SM, Chapman DG, Lahue KG, Cahoon JM, Rattu GK, Daphtary N, Aliyeva M, Fortner KA, Erzurum SC, Comhair SA, Woodruff PG, Bhakta N, Dixon AE, Irvin CG, Janssen-Heininger YM, Poynter ME, Anathy V.

J Allergy Clin Immunol. 2016 Mar;137(3):822-32.e7. doi: 10.1016/j.jaci.2015.08.018. Epub 2015 Oct 4.


Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes.

Kien CL, Bunn JY, Fukagawa NK, Anathy V, Matthews DE, Crain KI, Ebenstein DB, Tarleton EK, Pratley RE, Poynter ME.

J Nutr Biochem. 2015 Dec;26(12):1599-606. doi: 10.1016/j.jnutbio.2015.07.014. Epub 2015 Aug 1.


The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor κB family proteins.

Nolin JD, Tully JE, Hoffman SM, Guala AS, van der Velden JL, Poynter ME, van der Vliet A, Anathy V, Janssen-Heininger YM.

Free Radic Biol Med. 2014 Aug;73:143-53. doi: 10.1016/j.freeradbiomed.2014.04.028. Epub 2014 May 9.


Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis.

Hoffman SM, Tully JE, Nolin JD, Lahue KG, Goldman DH, Daphtary N, Aliyeva M, Irvin CG, Dixon AE, Poynter ME, Anathy V.

Respir Res. 2013 Dec 24;14:141. doi: 10.1186/1465-9921-14-141.


Glutaredoxin-1 attenuates S-glutathionylation of the death receptor fas and decreases resolution of Pseudomonas aeruginosa pneumonia.

Anathy V, Aesif SW, Hoffman SM, Bement JL, Guala AS, Lahue KG, Leclair LW, Suratt BT, Cool CD, Wargo MJ, Janssen-Heininger YM.

Am J Respir Crit Care Med. 2014 Feb 15;189(4):463-74. doi: 10.1164/rccm.201310-1905OC.


Epithelial NF-κB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling.

Tully JE, Hoffman SM, Lahue KG, Nolin JD, Anathy V, Lundblad LK, Daphtary N, Aliyeva M, Black KE, Dixon AE, Poynter ME, Irvin CG, Janssen-Heininger YM.

J Immunol. 2013 Dec 15;191(12):5811-21. doi: 10.4049/jimmunol.1301329. Epub 2013 Nov 13.


Serum amyloid A inhibits dendritic cell apoptosis to induce glucocorticoid resistance in CD4(+) T cells.

Ather JL, Fortner KA, Budd RC, Anathy V, Poynter ME.

Cell Death Dis. 2013 Sep 5;4:e786. doi: 10.1038/cddis.2013.327.


Emerging mechanisms of glutathione-dependent chemistry in biology and disease.

Janssen-Heininger YM, Nolin JD, Hoffman SM, van der Velden JL, Tully JE, Lahue KG, Abdalla ST, Chapman DG, Reynaert NL, van der Vliet A, Anathy V.

J Cell Biochem. 2013 Sep;114(9):1962-8. doi: 10.1002/jcb.24551. Review.


Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease.

Hoffman SM, Tully JE, Lahue KG, Anathy V, Nolin JD, Guala AS, van der Velden JL, Ho YS, Aliyeva M, Daphtary N, Lundblad LK, Irvin CG, Janssen-Heininger YM.

Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303(6):L528-38. doi: 10.1152/ajplung.00167.2012. Epub 2012 Jun 29.


Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis.

Anathy V, Roberson E, Cunniff B, Nolin JD, Hoffman S, Spiess P, Guala AS, Lahue KG, Goldman D, Flemer S, van der Vliet A, Heintz NH, Budd RC, Tew KD, Janssen-Heininger YM.

Mol Cell Biol. 2012 Sep;32(17):3464-78. doi: 10.1128/MCB.00125-12. Epub 2012 Jul 2.


Cooperation between classical and alternative NF-κB pathways regulates proinflammatory responses in epithelial cells.

Tully JE, Nolin JD, Guala AS, Hoffman SM, Roberson EC, Lahue KG, van der Velden J, Anathy V, Blackwell TS, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2012 Oct;47(4):497-508. doi: 10.1165/rcmb.2012-0014OC. Epub 2012 May 31.


Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death.

Anathy V, Roberson EC, Guala AS, Godburn KE, Budd RC, Janssen-Heininger YM.

Antioxid Redox Signal. 2012 Mar 15;16(6):496-505. doi: 10.1089/ars.2011.4281. Epub 2011 Dec 22. Review.


Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-β release in lung epithelial cells.

Roberson EC, Tully JE, Guala AS, Reiss JN, Godburn KE, Pociask DA, Alcorn JF, Riches DW, Dienz O, Janssen-Heininger YM, Anathy V.

Am J Respir Cell Mol Biol. 2012 May;46(5):573-81. doi: 10.1165/rcmb.2010-0460OC. Epub 2011 Jul 28.


Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling.

Aesif SW, Kuipers I, van der Velden J, Tully JE, Guala AS, Anathy V, Sheely JI, Reynaert NL, Wouters EF, van der Vliet A, Janssen-Heininger YM.

Free Radic Biol Med. 2011 Sep 15;51(6):1249-57. doi: 10.1016/j.freeradbiomed.2011.06.025. Epub 2011 Jun 27.


Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease.

Janssen-Heininger YM, Aesif SW, van der Velden J, Guala AS, Reiss JN, Roberson EC, Budd RC, Reynaert NL, Anathy V.

Ann N Y Acad Sci. 2010 Aug;1203:23-8. doi: 10.1111/j.1749-6632.2010.05553.x. Review.


Ablation of glutaredoxin-1 attenuates lipopolysaccharide-induced lung inflammation and alveolar macrophage activation.

Aesif SW, Anathy V, Kuipers I, Guala AS, Reiss JN, Ho YS, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2011 Apr;44(4):491-9. doi: 10.1165/rcmb.2009-0136OC. Epub 2010 Jun 10.


In situ analysis of protein S-glutathionylation in lung tissue using glutaredoxin-1-catalyzed cysteine derivatization.

Aesif SW, Anathy V, Havermans M, Guala AS, Ckless K, Taatjes DJ, Janssen-Heininger YM.

Am J Pathol. 2009 Jul;175(1):36-45. doi: 10.2353/ajpath.2009.080736.


Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control.

Janssen-Heininger YM, Poynter ME, Aesif SW, Pantano C, Ather JL, Reynaert NL, Ckless K, Anathy V, van der Velden J, Irvin CG, van der Vliet A.

Proc Am Thorac Soc. 2009 May 1;6(3):249-55. doi: 10.1513/pats.200806-054RM. Review.


Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas.

Anathy V, Aesif SW, Guala AS, Havermans M, Reynaert NL, Ho YS, Budd RC, Janssen-Heininger YM.

J Cell Biol. 2009 Jan 26;184(2):241-52. doi: 10.1083/jcb.200807019.


Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery.

Phalen TJ, Weirather K, Deming PB, Anathy V, Howe AK, van der Vliet A, Jönsson TJ, Poole LB, Heintz NH.

J Cell Biol. 2006 Dec 4;175(5):779-89.


Nonphagocytic oxidase 1 causes death in lung epithelial cells via a TNF-RI-JNK signaling axis.

Pantano C, Anathy V, Ranjan P, Heintz NH, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2007 Apr;36(4):473-9. Epub 2006 Nov 1.


Redox-dependent expression of cyclin D1 and cell proliferation by Nox1 in mouse lung epithelial cells.

Ranjan P, Anathy V, Burch PM, Weirather K, Lambeth JD, Heintz NH.

Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1447-59.


Growth enhancement and food conversion efficiency of transgenic fish Labeo rohita.

Thayanithy V, Anathy V, Kirankumar S, Pandian TJ.

J Exp Zool A Comp Exp Biol. 2004 Jun 1;301(6):477-90. Erratum in: J Exp Zool A Comp Exp Biol. 2010 Dec 1;313(10):704. Venugopal, Thayanithy [corrected to Thayanithy, Venugopal].


Hormonal induction of supermale golden rosy barb and isolation of Y-chromosome specific markers.

Kirankumar S, Anathy V, Pandian TJ.

Gen Comp Endocrinol. 2003 Oct 15;134(1):62-71.


Enhanced expression of beta-thymosin mRNA in the ovary of GnRH analog or estradiol-17beta-treated paradise fish, Macropodus opercularis.

Anathy V, Kirankumar S, Pandian TJ.

Comp Biochem Physiol A Mol Integr Physiol. 2003 Mar;134(3):639-45.


Molecular cloning of growth hormone-encoding cDNA of an Indian major carp, Labeo rohita, and its expression in Escherichia coli and zebrafish.

Thayanithy V, Anathy V, Pandian TJ, Gong GZ, Mathavan S.

Gen Comp Endocrinol. 2002 Feb 1;125(2):236-47. Erratum in: Gen Comp Endocrinol. 2010 May 15;167(1):180. Venugopal, T [corrected to Thayanithy, V].


Cloning, sequencing and expression of cDNA encoding growth hormone from Indian catfish (Heteropneustes fossilis).

Anathy V, Venugopal T, Koteeswaran R, Pandian TJ, Mathavan S.

J Biosci. 2001 Sep;26(3):315-24.

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