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Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.

Mameishvili E, Serafimidis I, Iwaszkiewicz S, Lesche M, Reinhardt S, Bölicke N, Büttner M, Stellas D, Papadimitropoulou A, Szabolcs M, Anastassiadis K, Dahl A, Theis F, Efstratiadis A, Gavalas A.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20679-20688. doi: 10.1073/pnas.1901075116. Epub 2019 Sep 23.


Prospective isolation of nonhematopoietic cells of the niche and their differential molecular interactions with HSCs.

Mende N, Jolly A, Percin GI, Günther M, Rostovskaya M, Krishnan SM, Oostendorp RAJ, Dahl A, Anastassiadis K, Höfer T, Waskow C.

Blood. 2019 Oct 10;134(15):1214-1226. doi: 10.1182/blood.2019000176.


Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.

Schreiber M, Weigelt M, Karasinsky A, Anastassiadis K, Schallenberg S, Petzold C, Bonifacio E, Kretschmer K, Hommel A.

Front Immunol. 2019 Apr 10;10:742. doi: 10.3389/fimmu.2019.00742. eCollection 2019.


Kmt2b conveys monovalent and bivalent H3K4me3 in mouse spermatogonial stem cells at germline and embryonic promoters.

Tomizawa SI, Kobayashi Y, Shirakawa T, Watanabe K, Mizoguchi K, Hoshi I, Nakajima K, Nakabayashi J, Singh S, Dahl A, Alexopoulou D, Seki M, Suzuki Y, Royo H, Peters AHFM, Anastassiadis K, Stewart AF, Ohbo K.

Development. 2018 Nov 30;145(23). pii: dev169102. doi: 10.1242/dev.169102.


Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.

Chen Y, Jones KL, Anastassiadis K, Kranz A, Stewart AF, Grembecka J, Meyerson M, Ernst P.

Exp Hematol. 2019 Jan;69:37-42. doi: 10.1016/j.exphem.2018.10.001. Epub 2018 Oct 10.


A single reporter mouse line for Vika, Flp, Dre, and Cre-recombination.

Karimova M, Baker O, Camgoz A, Naumann R, Buchholz F, Anastassiadis K.

Sci Rep. 2018 Sep 27;8(1):14453. doi: 10.1038/s41598-018-32802-7.


Human axial progenitors generate trunk neural crest cells in vitro.

Frith TJ, Granata I, Wind M, Stout E, Thompson O, Neumann K, Stavish D, Heath PR, Ortmann D, Hackland JO, Anastassiadis K, Gouti M, Briscoe J, Wilson V, Johnson SL, Placzek M, Guarracino MR, Andrews PW, Tsakiridis A.

Elife. 2018 Aug 10;7. pii: e35786. doi: 10.7554/eLife.35786.


Clonal Analysis Delineates Transcriptional Programs of Osteogenic and Adipogenic Lineages of Adult Mouse Skeletal Progenitors.

Rostovskaya M, Donsante S, Sacchetti B, Alexopoulou D, Klemroth S, Dahl A, Riminucci M, Bianco P, Anastassiadis K.

Stem Cell Reports. 2018 Jul 10;11(1):212-227. doi: 10.1016/j.stemcr.2018.05.014. Epub 2018 Jun 21.


The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.

Schmidt K, Zhang Q, Tasdogan A, Petzold A, Dahl A, Arneth BM, Slany R, Fehling HJ, Kranz A, Stewart AF, Anastassiadis K.

Elife. 2018 Jun 19;7. pii: e27157. doi: 10.7554/eLife.27157.


Inductive and Selective Effects of GSK3 and MEK Inhibition on Nanog Heterogeneity in Embryonic Stem Cells.

Hastreiter S, Skylaki S, Loeffler D, Reimann A, Hilsenbeck O, Hoppe PS, Coutu DL, Kokkaliaris KD, Schwarzfischer M, Anastassiadis K, Theis FJ, Schroeder T.

Stem Cell Reports. 2018 Jul 10;11(1):58-69. doi: 10.1016/j.stemcr.2018.04.019. Epub 2018 May 17.


Identification and Single-Cell Functional Characterization of an Endodermally Biased Pluripotent Substate in Human Embryonic Stem Cells.

Allison TF, Smith AJH, Anastassiadis K, Sloane-Stanley J, Biga V, Stavish D, Hackland J, Sabri S, Langerman J, Jones M, Plath K, Coca D, Barbaric I, Gokhale P, Andrews PW.

Stem Cell Reports. 2018 Jun 5;10(6):1895-1907. doi: 10.1016/j.stemcr.2018.04.015. Epub 2018 May 17.


The Dox-pDC - A murine conditionally immortalized plasmacytoid dendritic cell line with native immune profile.

Thieme S, Holzbaur A, Wiedemuth R, Binner A, Navratiel K, Anastassiadis K, Brenner S, Richter C.

PLoS One. 2018 Feb 28;13(2):e0192437. doi: 10.1371/journal.pone.0192437. eCollection 2018.


lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1.

Chakraborty D, Paszkowski-Rogacz M, Berger N, Ding L, Mircetic J, Fu J, Iesmantavicius V, Choudhary C, Anastassiadis K, Stewart AF, Buchholz F.

Cell Rep. 2017 Dec 12;21(11):3012-3021. doi: 10.1016/j.celrep.2017.11.045.


Single-cell mechanical phenotype is an intrinsic marker of reprogramming and differentiation along the mouse neural lineage.

Urbanska M, Winzi M, Neumann K, Abuhattum S, Rosendahl P, Müller P, Taubenberger A, Anastassiadis K, Guck J.

Development. 2017 Dec 1;144(23):4313-4321. doi: 10.1242/dev.155218.


A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes.

Schwach V, Verkerk AO, Mol M, Monshouwer-Kloots JJ, Devalla HD, Orlova VV, Anastassiadis K, Mummery CL, Davis RP, Passier R.

Stem Cell Reports. 2017 Dec 12;9(6):1765-1779. doi: 10.1016/j.stemcr.2017.10.024. Epub 2017 Nov 22.


Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass.

Borensztein M, Okamoto I, Syx L, Guilbaud G, Picard C, Ancelin K, Galupa R, Diabangouaya P, Servant N, Barillot E, Surani A, Saitou M, Chen CJ, Anastassiadis K, Heard E.

Nat Commun. 2017 Nov 3;8(1):1297. doi: 10.1038/s41467-017-01415-5.


Correction: TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes.

Akpınar M, Lesche M, Fanourgakis G, Fu J, Anastassiadis K, Dahl A, Jessberger R.

PLoS Genet. 2017 Sep 1;13(9):e1006989. doi: 10.1371/journal.pgen.1006989. eCollection 2017 Sep.


Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a maternal effect gene required for the oogenic gene expression program.

Brici D, Zhang Q, Reinhardt S, Dahl A, Hartmann H, Schmidt K, Goveas N, Huang J, Gahurova L, Kelsey G, Anastassiadis K, Stewart AF, Kranz A.

Development. 2017 Jul 15;144(14):2606-2617. doi: 10.1242/dev.143347. Epub 2017 Jun 15.


MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

Chen Y, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Lee Y, Ernst P.

Cancer Cell. 2017 Jun 12;31(6):755-770.e6. doi: 10.1016/j.ccell.2017.05.002.


The contribution of homology arms to nuclease-assisted genome engineering.

Baker O, Tsurkan S, Fu J, Klink B, Rump A, Obst M, Kranz A, Schröck E, Anastassiadis K, Stewart AF.

Nucleic Acids Res. 2017 Jul 27;45(13):8105-8115. doi: 10.1093/nar/gkx497.


TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes.

Akpınar M, Lesche M, Fanourgakis G, Fu J, Anastassiadis K, Dahl A, Jessberger R.

PLoS Genet. 2017 Mar 6;13(3):e1006660. doi: 10.1371/journal.pgen.1006660. eCollection 2017 Mar. Erratum in: PLoS Genet. 2017 Sep 1;13(9):e1006989.


RAC-tagging: Recombineering And Cas9-assisted targeting for protein tagging and conditional analyses.

Baker O, Gupta A, Obst M, Zhang Y, Anastassiadis K, Fu J, Stewart AF.

Sci Rep. 2016 May 24;6:25529. doi: 10.1038/srep25529.


Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis.

Völkner M, Zschätzsch M, Rostovskaya M, Overall RW, Busskamp V, Anastassiadis K, Karl MO.

Stem Cell Reports. 2016 Apr 12;6(4):525-538. doi: 10.1016/j.stemcr.2016.03.001. Epub 2016 Mar 31.


Thy-1/β3 Integrin Interaction-Induced Apoptosis of Dermal Fibroblasts Is Mediated by Up-Regulation of FasL Expression.

Schmidt M, Gutknecht D, Anastassiadis K, Eckes B, Anderegg U, Saalbach A.

J Invest Dermatol. 2016 Feb;136(2):526-529. doi: 10.1016/j.jid.2015.10.063. Epub 2015 Nov 18. No abstract available.


Network plasticity of pluripotency transcription factors in embryonic stem cells.

Filipczyk A, Marr C, Hastreiter S, Feigelman J, Schwarzfischer M, Hoppe PS, Loeffler D, Kokkaliaris KD, Endele M, Schauberger B, Hilsenbeck O, Skylaki S, Hasenauer J, Anastassiadis K, Theis FJ, Schroeder T.

Nat Cell Biol. 2015 Oct;17(10):1235-46. doi: 10.1038/ncb3237. Epub 2015 Sep 21.


Functional Restoration of gp91phox-Oxidase Activity by BAC Transgenesis and Gene Targeting in X-linked Chronic Granulomatous Disease iPSCs.

Laugsch M, Rostovskaya M, Velychko S, Richter C, Zimmer A, Klink B, Schröck E, Haase M, Neumann K, Thieme S, Roesler J, Brenner S, Anastassiadis K.

Mol Ther. 2016 Apr;24(4):812-22. doi: 10.1038/mt.2015.154. Epub 2015 Aug 28.


Sustained Pax6 Expression Generates Primate-like Basal Radial Glia in Developing Mouse Neocortex.

Wong FK, Fei JF, Mora-Bermúdez F, Taverna E, Haffner C, Fu J, Anastassiadis K, Stewart AF, Huttner WB.

PLoS Biol. 2015 Aug 7;13(8):e1002217. doi: 10.1371/journal.pbio.1002217. eCollection 2015 Aug.


Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1.

Hartung E, Becker M, Bachem A, Reeg N, Jäkel A, Hutloff A, Weber H, Weise C, Giesecke C, Henn V, Gurka S, Anastassiadis K, Mages HW, Kroczek RA.

J Immunol. 2015 Feb 1;194(3):1069-79. doi: 10.4049/jimmunol.1401903. Epub 2014 Dec 17.


Nanog induces hyperplasia without initiating tumors.

Fischedick G, Wu G, Adachi K, Araúzo-Bravo MJ, Greber B, Radstaak M, Köhler G, Tapia N, Iacone R, Anastassiadis K, Schöler HR, Zaehres H.

Stem Cell Res. 2014 Sep;13(2):300-15. doi: 10.1016/j.scr.2014.08.001. Epub 2014 Aug 10.


Breast carcinoma cells modulate the chemoattractive activity of human bone marrow-derived mesenchymal stromal cells by interfering with CXCL12.

Wobus M, List C, Dittrich T, Dhawan A, Duryagina R, Arabanian LS, Kast K, Wimberger P, Stiehler M, Hofbauer LC, Jakob F, Ehninger G, Anastassiadis K, Bornhäuser M.

Int J Cancer. 2015 Jan 1;136(1):44-54. doi: 10.1002/ijc.28960. Epub 2014 May 20.


Cellular reporter systems for high-throughput screening of interactions between bioactive matrices and human mesenchymal stromal cells.

Duryagina R, Anastassiadis K, Maitz MF, Gramm S, Schneider S, Wobus M, Thieme S, Brenner S, Werner C, Bornhäuser M.

Tissue Eng Part C Methods. 2014 Oct;20(10):828-37. doi: 10.1089/ten.TEC.2013.0590. Epub 2014 Mar 25.


The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation.

Bledau AS, Schmidt K, Neumann K, Hill U, Ciotta G, Gupta A, Torres DC, Fu J, Kranz A, Stewart AF, Anastassiadis K.

Development. 2014 Mar;141(5):1022-35. doi: 10.1242/dev.098152.


Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.

Denissov S, Hofemeister H, Marks H, Kranz A, Ciotta G, Singh S, Anastassiadis K, Stunnenberg HG, Stewart AF.

Development. 2014 Feb;141(3):526-37. doi: 10.1242/dev.102681. Epub 2014 Jan 14.


Gene targeting and site-specific recombination in mouse ES cells.

Anastassiadis K, Schnütgen F, von Melchner H, Stewart AF.

Methods Enzymol. 2013;533:133-55. doi: 10.1016/B978-0-12-420067-8.00009-X.


Age-dependent labeling and imaging of insulin secretory granules.

Ivanova A, Kalaidzidis Y, Dirkx R, Sarov M, Gerlach M, Schroth-Diez B, Müller A, Liu Y, Andree C, Mulligan B, Münster C, Kurth T, Bickle M, Speier S, Anastassiadis K, Solimena M.

Diabetes. 2013 Nov;62(11):3687-96. doi: 10.2337/db12-1819. Epub 2013 Aug 8.


Biallelic expression of nanog protein in mouse embryonic stem cells.

Filipczyk A, Gkatzis K, Fu J, Hoppe PS, Lickert H, Anastassiadis K, Schroeder T.

Cell Stem Cell. 2013 Jul 3;13(1):12-3. doi: 10.1016/j.stem.2013.04.025. No abstract available.


Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments.

Prewitz MC, Seib FP, von Bonin M, Friedrichs J, Stißel A, Niehage C, Müller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C.

Nat Methods. 2013 Aug;10(8):788-94. doi: 10.1038/nmeth.2523. Epub 2013 Jun 23.


Overexpression of Jagged-1 and its intracellular domain in human mesenchymal stromal cells differentially affect the interaction with hematopoietic stem and progenitor cells.

Duryagina R, Thieme S, Anastassiadis K, Werner C, Schneider S, Wobus M, Brenner S, Bornhäuser M.

Stem Cells Dev. 2013 Oct 15;22(20):2736-50. doi: 10.1089/scd.2012.0638. Epub 2013 Jul 24.


HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.

Singh RP, Franke K, Kalucka J, Mamlouk S, Muschter A, Gembarska A, Grinenko T, Willam C, Naumann R, Anastassiadis K, Stewart AF, Bornstein S, Chavakis T, Breier G, Waskow C, Wielockx B.

Blood. 2013 Jun 27;121(26):5158-66. doi: 10.1182/blood-2012-12-471185. Epub 2013 May 10.


Generation of inducible immortalized dendritic cells with proper immune function in vitro and in vivo.

Richter C, Thieme S, Bandoła J, Laugsch M, Anastassiadis K, Brenner S.

PLoS One. 2013 Apr 23;8(4):e62621. doi: 10.1371/journal.pone.0062621. Print 2013.


A localized Wnt signal orients asymmetric stem cell division in vitro.

Habib SJ, Chen BC, Tsai FC, Anastassiadis K, Meyer T, Betzig E, Nusse R.

Science. 2013 Mar 22;339(6126):1445-8. doi: 10.1126/science.1231077. Erratum in: Science. 2013 May 24;340(6135):924.


The histone demethylase UTX regulates stem cell migration and hematopoiesis.

Thieme S, Gyárfás T, Richter C, Özhan G, Fu J, Alexopoulou D, Muders MH, Michalk I, Jakob C, Dahl A, Klink B, Bandola J, Bachmann M, Schröck E, Buchholz F, Stewart AF, Weidinger G, Anastassiadis K, Brenner S.

Blood. 2013 Mar 28;121(13):2462-73. doi: 10.1182/blood-2012-08-452003. Epub 2013 Jan 30.


Differential expression of surface markers in mouse bone marrow mesenchymal stromal cell subpopulations with distinct lineage commitment.

Rostovskaya M, Anastassiadis K.

PLoS One. 2012;7(12):e51221. doi: 10.1371/journal.pone.0051221. Epub 2012 Dec 7.


Transposon mediated BAC transgenesis via pronuclear injection of mouse zygotes.

Rostovskaya M, Naumann R, Fu J, Obst M, Mueller D, Stewart AF, Anastassiadis K.

Genesis. 2013 Feb;51(2):135-41. doi: 10.1002/dvg.22362. Epub 2013 Jan 25.


A short G1 phase is an intrinsic determinant of naïve embryonic stem cell pluripotency.

Coronado D, Godet M, Bourillot PY, Tapponnier Y, Bernat A, Petit M, Afanassieff M, Markossian S, Malashicheva A, Iacone R, Anastassiadis K, Savatier P.

Stem Cell Res. 2013 Jan;10(1):118-31. doi: 10.1016/j.scr.2012.10.004. Epub 2012 Oct 29.


The mammalian gene function resource: the International Knockout Mouse Consortium.

Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W.

Mamm Genome. 2012 Oct;23(9-10):580-6. doi: 10.1007/s00335-012-9422-2. Epub 2012 Sep 12.


Transposon-mediated BAC transgenesis in human ES cells.

Rostovskaya M, Fu J, Obst M, Baer I, Weidlich S, Wang H, Smith AJ, Anastassiadis K, Stewart AF.

Nucleic Acids Res. 2012 Oct;40(19):e150. doi: 10.1093/nar/gks643. Epub 2012 Jun 30.


Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms.

Wojtasz L, Cloutier JM, Baumann M, Daniel K, Varga J, Fu J, Anastassiadis K, Stewart AF, Reményi A, Turner JM, Tóth A.

Genes Dev. 2012 May 1;26(9):958-73. doi: 10.1101/gad.187559.112.


Targeted isolation of cloned genomic regions by recombineering for haplotype phasing and isogenic targeting.

Nedelkova M, Maresca M, Fu J, Rostovskaya M, Chenna R, Thiede C, Anastassiadis K, Sarov M, Stewart AF.

Nucleic Acids Res. 2011 Nov 1;39(20):e137. doi: 10.1093/nar/gkr668. Epub 2011 Aug 18.


Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.

Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Cooke HJ, Stewart AF, Wassmann K, Jasin M, Keeney S, Tóth A.

Nat Cell Biol. 2011 May;13(5):599-610. doi: 10.1038/ncb2213. Epub 2011 Apr 10.

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