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Items: 43

1.

Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro.

Land MA, Chapman HL, Davis-Reyes BD, Felsing DE, Allen JA, Moeller FG, Elferink LA, Cunningham KA, Anastasio NC.

Sci Rep. 2019 Nov 13;9(1):16737. doi: 10.1038/s41598-019-53124-2.

PMID:
31723224
2.

In Vivo and In Vitro Analyses of Novel Peptidomimetic Disruptors for the Serotonin 5-HT2C Receptor Interaction With Phosphatase and Tensin Homolog.

Soto CA, Du HC, Fox RG, Yang T, Hooson J, Anastasio NC, Gilbertson SR, Cunningham KA.

Front Pharmacol. 2019 Aug 23;10:907. doi: 10.3389/fphar.2019.00907. eCollection 2019.

3.

Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder.

Ma L, Steinberg JL, Bjork JM, Taylor BA, Arias AJ, Terplan M, Anastasio NC, Zuniga EA, Lennon M, Cunningham KA, Moeller FG.

Psychiatry Res Neuroimaging. 2019 Aug 13. pii: S0925-4927(19)30026-5. doi: 10.1016/j.pscychresns.2019.08.005. [Epub ahead of print]

PMID:
31439409
4.

Profile of cortical N-methyl-D-aspartate receptor subunit expression associates with inherent motor impulsivity in rats.

Davis-Reyes BD, Campbell VM, Land MA, Chapman HL, Stafford SJ, Anastasio NC.

Biochem Pharmacol. 2019 Oct;168:204-213. doi: 10.1016/j.bcp.2019.07.007. Epub 2019 Jul 8.

PMID:
31295463
5.

Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats.

Anastasio NC, Stutz SJ, Price AE, Davis-Reyes BD, Sholler DJ, Ferguson SM, Neumaier JF, Moeller FG, Hommel JD, Cunningham KA.

Neuropsychopharmacology. 2019 Sep;44(10):1752-1761. doi: 10.1038/s41386-019-0394-8. Epub 2019 Apr 19.

PMID:
31003231
6.

Binge-Type Eating in Rats is Facilitated by Neuromedin U Receptor 2 in the Nucleus Accumbens and Ventral Tegmental Area.

Smith AE, Kasper JM; Ara 13, Anastasio NC, Hommel JD.

Nutrients. 2019 Feb 2;11(2). pii: E327. doi: 10.3390/nu11020327.

7.

Endogenous Serotonin 5-HT2A and 5-HT2C Receptors Associate in the Medial Prefrontal Cortex.

Price AE, Sholler DJ, Stutz SJ, Anastasio NC, Cunningham KA.

ACS Chem Neurosci. 2019 Jul 17;10(7):3241-3248. doi: 10.1021/acschemneuro.8b00669. Epub 2019 Mar 18.

PMID:
30645940
8.

Pimavanserin and Lorcaserin Attenuate Measures of Binge Eating in Male Sprague-Dawley Rats.

Price AE, Brehm VD, Hommel JD, Anastasio NC, Cunningham KA.

Front Pharmacol. 2018 Dec 7;9:1424. doi: 10.3389/fphar.2018.01424. eCollection 2018.

9.

Anterior insula activity regulates the associated behaviors of high fat food binge intake and cue reactivity in male rats.

Price AE, Stutz SJ, Hommel JD, Anastasio NC, Cunningham KA.

Appetite. 2019 Feb 1;133:231-239. doi: 10.1016/j.appet.2018.11.011. Epub 2018 Nov 14.

PMID:
30447231
10.

The 5-HT2A Receptor (5-HT2AR) Regulates Impulsive Action and Cocaine Cue Reactivity in Male Sprague-Dawley Rats.

Sholler DJ, Stutz SJ, Fox RG, Boone EL, Wang Q, Rice KC, Moeller FG, Anastasio NC, Cunningham KA.

J Pharmacol Exp Ther. 2019 Jan;368(1):41-49. doi: 10.1124/jpet.118.251199. Epub 2018 Oct 29.

11.

Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction.

Felsing DE, Anastasio NC, Miszkiel JM, Gilbertson SR, Allen JA, Cunningham KA.

PLoS One. 2018 Aug 29;13(8):e0203137. doi: 10.1371/journal.pone.0203137. eCollection 2018.

12.

Serotonin 5-HT2C Receptor Activation Suppresses Binge Intake and the Reinforcing and Motivational Properties of High-Fat Food.

Price AE, Anastasio NC, Stutz SJ, Hommel JD, Cunningham KA.

Front Pharmacol. 2018 Jul 27;9:821. doi: 10.3389/fphar.2018.00821. eCollection 2018.

13.

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder.

Dimet AL, Cisneros IE, Fox RG, Stutz SJ, Anastasio NC, Cunningham KA, Dineley KT.

J Vis Exp. 2018 Jun 18;(136). doi: 10.3791/55864.

14.

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor.

Wild CT, Miszkiel JM, Wold EA, Soto CA, Ding C, Hartley RM, White MA, Anastasio NC, Cunningham KA, Zhou J.

J Med Chem. 2019 Jan 10;62(1):288-305. doi: 10.1021/acs.jmedchem.8b00401. Epub 2018 Apr 13.

15.

Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist M100907.

Gilbertson SR, Chen YC, Soto CA, Yang Y, Rice KC, Cunningham KA, Anastasio NC.

Bioorg Med Chem Lett. 2018 May 1;28(8):1381-1385. doi: 10.1016/j.bmcl.2018.02.058. Epub 2018 Mar 16.

16.

Novel Bivalent 5-HT2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo.

Soto CA, Shashack MJ, Fox RG, Bubar MJ, Rice KC, Watson CS, Cunningham KA, Gilbertson SR, Anastasio NC.

ACS Chem Neurosci. 2018 Mar 21;9(3):514-521. doi: 10.1021/acschemneuro.7b00309. Epub 2017 Nov 21.

17.

Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine.

Simmler LD, Anacker AMJ, Levin MH, Vaswani NM, Gresch PJ, Nackenoff AG, Anastasio NC, Stutz SJ, Cunningham KA, Wang J, Zhang B, Henry LK, Stewart A, Veenstra-VanderWeele J, Blakely RD.

Br J Pharmacol. 2017 Aug;174(16):2716-2738. doi: 10.1111/bph.13899. Epub 2017 Jul 11.

18.

Synthesis and Structure-Activity Relationships of Tool Compounds Based on WAY163909, a 5-HT2C Receptor Agonist.

Chen YC, Hartley RM, Anastasio NC, Cunningham KA, Gilbertson SR.

ACS Chem Neurosci. 2017 May 17;8(5):1004-1010. doi: 10.1021/acschemneuro.6b00439. Epub 2017 Apr 19.

19.

Lorcaserin Suppresses Oxycodone Self-Administration and Relapse Vulnerability in Rats.

Neelakantan H, Holliday ED, Fox RG, Stutz SJ, Comer SD, Haney M, Anastasio NC, Moeller FG, Cunningham KA.

ACS Chem Neurosci. 2017 May 17;8(5):1065-1073. doi: 10.1021/acschemneuro.6b00413. Epub 2017 Feb 13.

20.

Is There a Causal Relation between Maternal Acetaminophen Administration and ADHD?

Saad A, Hegde S, Kechichian T, Gamble P, Rahman M, Stutz SJ, Anastasio NC, Alshehri W, Lei J, Mori S, Kajs B, Cunningham KA, Saade G, Burd I, Costantine M.

PLoS One. 2016 Jun 13;11(6):e0157380. doi: 10.1371/journal.pone.0157380. eCollection 2016.

21.

Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2CR) system.

Swinford-Jackson SE, Anastasio NC, Fox RG, Stutz SJ, Cunningham KA.

Neuroscience. 2016 Jun 2;324:50-61. doi: 10.1016/j.neuroscience.2016.02.052. Epub 2016 Feb 27.

22.

Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity.

Anastasio NC, Stutz SJ, Fink LH, Swinford-Jackson SE, Sears RM, DiLeone RJ, Rice KC, Moeller FG, Cunningham KA.

ACS Chem Neurosci. 2015 Jul 15;6(7):1248-58. doi: 10.1021/acschemneuro.5b00094. Epub 2015 Jul 7.

23.

Rapid-response impulsivity: definitions, measurement issues, and clinical implications.

Hamilton KR, Littlefield AK, Anastasio NC, Cunningham KA, Fink LHL, Wing VC, Mathias CW, Lane SD, Schütz CG, Swann AC, Lejuez CW, Clark L, Moeller FG, Potenza MN.

Personal Disord. 2015 Apr;6(2):168-181. doi: 10.1037/per0000100. Review.

24.

Individual Differences in Impulsive Action Reflect Variation in the Cortical Serotonin 5-HT2A Receptor System.

Fink LH, Anastasio NC, Fox RG, Rice KC, Moeller FG, Cunningham KA.

Neuropsychopharmacology. 2015 Jul;40(8):1957-68. doi: 10.1038/npp.2015.46. Epub 2015 Feb 10.

25.

Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder.

De La Garza R 2nd, Bubar MJ, Carbone CL, Moeller FG, Newton TF, Anastasio NC, Harper TA, Ware DL, Fuller MA, Holstein GJ, Jayroe JB, Bandak SI, Reiman KZ, Neale AC, Pickford LB, Cunningham KA.

Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jun 3;59:40-48. doi: 10.1016/j.pnpbp.2015.01.009. Epub 2015 Jan 17.

26.

Multi-well plate immunoassays for measuring signaling protein activations/deactivations and membrane vs. intracellular receptor levels.

Watson CS, Jeng YJ, Bulayeva NN, Finnerty CC, Koong LY, Zivadinovic D, Alyea RA, Midoro-Horiuti T, Goldblum RM, Anastasio NC, Cunningham KA, Seitz PK, Smith TD.

Methods Mol Biol. 2014;1204:123-33. doi: 10.1007/978-1-4939-1346-6_11.

PMID:
25182766
27.

Variation within the serotonin (5-HT) 5-HT₂C receptor system aligns with vulnerability to cocaine cue reactivity.

Anastasio NC, Liu S, Maili L, Swinford SE, Lane SD, Fox RG, Hamon SC, Nielsen DA, Cunningham KA, Moeller FG.

Transl Psychiatry. 2014 Mar 11;4:e369. doi: 10.1038/tp.2013.131.

28.

Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence.

Anastasio NC, Stutz SJ, Fox RG, Sears RM, Emeson RB, DiLeone RJ, O'Neil RT, Fink LH, Li D, Green TA, Moeller FG, Cunningham KA.

Neuropsychopharmacology. 2014 Jan;39(2):370-82. doi: 10.1038/npp.2013.199. Epub 2013 Aug 13.

29.

Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction.

Cunningham KA, Anastasio NC.

Neuropharmacology. 2014 Jan;76 Pt B:460-78. doi: 10.1016/j.neuropharm.2013.06.030. Epub 2013 Jul 11. Review.

30.

Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior.

Anastasio NC, Gilbertson SR, Bubar MJ, Agarkov A, Stutz SJ, Jeng Y, Bremer NM, Smith TD, Fox RG, Swinford SE, Seitz PK, Charendoff MN, Craft JW Jr, Laezza FM, Watson CS, Briggs JM, Cunningham KA.

J Neurosci. 2013 Jan 23;33(4):1615-30. doi: 10.1523/JNEUROSCI.2656-12.2013.

31.

Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction.

Cunningham KA, Anastasio NC, Fox RG, Stutz SJ, Bubar MJ, Swinford SE, Watson CS, Gilbertson SR, Rice KC, Rosenzweig-Lipson S, Moeller FG.

ACS Chem Neurosci. 2013 Jan 16;4(1):110-21. doi: 10.1021/cn300072u. Epub 2012 Aug 11.

32.

Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT2C receptor allosteric modulators.

Ding C, Bremer NM, Smith TD, Seitz PK, Anastasio NC, Cunningham KA, Zhou J.

ACS Chem Neurosci. 2012 Jul 18;3(7):538-45. doi: 10.1021/cn300020x. Epub 2012 Apr 19.

33.

Selective serotonin 5-HT(2C) receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues.

Cunningham KA, Fox RG, Anastasio NC, Bubar MJ, Stutz SJ, Moeller FG, Gilbertson SR, Rosenzweig-Lipson S.

Neuropharmacology. 2011 Sep;61(3):513-23. doi: 10.1016/j.neuropharm.2011.04.034. Epub 2011 May 11.

34.

Serotonin (5-hydroxytryptamine) 5-HT(2A) receptor: association with inherent and cocaine-evoked behavioral disinhibition in rats.

Anastasio NC, Stoffel EC, Fox RG, Bubar MJ, Rice KC, Moeller FG, Cunningham KA.

Behav Pharmacol. 2011 Jun;22(3):248-61. doi: 10.1097/FBP.0b013e328345f90d.

35.

Quantification of RNA editing of the serotonin 2C receptor (5-HT(₂C)R) ex vivo.

Lanfranco MF, Anastasio NC, Seitz PK, Cunningham KA.

Methods Enzymol. 2010;485:311-28. doi: 10.1016/B978-0-12-381296-4.00018-X.

PMID:
21050925
36.

The serotonin 5-HT2C receptor in medial prefrontal cortex exerts rheostatic control over the motivational salience of cocaine-associated cues: new observations from preclinical animal research.

Cunningham KA, Bubar MJ, Anastasio NC.

Neuropsychopharmacology. 2010 Nov;35(12):2319-21. doi: 10.1038/npp.2010.119. No abstract available.

37.

Serotonin 5-HT2C receptor protein expression is enriched in synaptosomal and post-synaptic compartments of rat cortex.

Anastasio NC, Lanfranco MF, Bubar MJ, Seitz PK, Stutz SJ, McGinnis AG, Watson CS, Cunningham KA.

J Neurochem. 2010 Jun;113(6):1504-15. doi: 10.1111/j.1471-4159.2010.06694.x. Epub 2010 Mar 24.

38.

Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways.

Xia Y, Wang CZ, Liu J, Anastasio NC, Johnson KM.

Neuropharmacology. 2010 Feb;58(2):330-6. doi: 10.1016/j.neuropharm.2009.10.009. Epub 2009 Nov 1.

39.

Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits.

Anastasio NC, Xia Y, O'Connor ZR, Johnson KM.

Neuroscience. 2009 Nov 10;163(4):1181-91. doi: 10.1016/j.neuroscience.2009.07.058. Epub 2009 Aug 3.

40.

Activation of dopamine D1 receptors blocks phencyclidine-induced neurotoxicity by enhancing N-methyl-D-aspartate receptor-mediated synaptic strength.

Lei G, Anastasio NC, Fu Y, Neugebauer V, Johnson KM.

J Neurochem. 2009 May;109(4):1017-30. doi: 10.1111/j.1471-4159.2009.06030.x. Epub 2009 Mar 10.

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