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Integration of Comprehensive Genomic Analysis and Functional Screening of Affected Molecular Pathways to Inform Cancer Therapy.

Vasmatzis G, Liu MC, Reganti S, Feathers RW, Smadbeck J, Johnson SH, Schaefer Klein JL, Harris FR, Yang L, Kosari F, Murphy SJ, Borad MJ, Thompson EA, Cheville JC, Anastasiadis PZ.

Mayo Clin Proc. 2019 Nov 1. pii: S0025-6196(19)30746-3. doi: 10.1016/j.mayocp.2019.07.019. [Epub ahead of print]


A phase 1 and randomized, placebo-controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872.

Galanis E, Anderson SK, Twohy EL, Carrero XW, Dixon JG, Tran DD, Jeyapalan SA, Anderson DM, Kaufmann TJ, Feathers RW, Giannini C, Buckner JC, Anastasiadis PZ, Schiff D.

Cancer. 2019 Nov 1;125(21):3790-3800. doi: 10.1002/cncr.32340. Epub 2019 Jul 10.


Design, characterization and evaluation of a laser-guided focused ultrasound system for preclinical investigations.

Anastasiadis P, Mohammadabadi A, Fishman MJ, Smith JA, Nguyen BA, Hersh DS, Frenkel V.

Biomed Eng Online. 2019 Mar 28;18(1):36. doi: 10.1186/s12938-019-0656-z.


Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth.

Rea K, Roggiani F, De Cecco L, Raspagliesi F, Carcangiu ML, Nair-Menon J, Bagnoli M, Bortolomai I, Mezzanzanica D, Canevari S, Kourtidis A, Anastasiadis PZ, Tomassetti A.

J Exp Clin Cancer Res. 2018 Jul 11;37(1):146. doi: 10.1186/s13046-018-0796-1.


Efficacy of the MDM2 Inhibitor SAR405838 in Glioblastoma Is Limited by Poor Distribution Across the Blood-Brain Barrier.

Kim M, Ma DJ, Calligaris D, Zhang S, Feathers RW, Vaubel RA, Meaux I, Mladek AC, Parrish KE, Jin F, Barriere C, Debussche L, Watters J, Tian S, Decker PA, Eckel-Passow JE, Kitange GJ, Johnson AJ, Parney IF, Anastasiadis PZ, Agar NYR, Elmquist WF, Sarkaria JN.

Mol Cancer Ther. 2018 Sep;17(9):1893-1901. doi: 10.1158/1535-7163.MCT-17-0600. Epub 2018 Jul 3.


Close encounters of the RNAi kind: the silencing life of the adherens junctions.

Kourtidis A, Anastasiadis PZ.

Curr Opin Cell Biol. 2018 Oct;54:30-36. doi: 10.1016/ Epub 2018 Mar 26. Review.


Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma.

DeLeon TT, Ahn DH, Bogenberger JM, Anastasiadis PZ, Arora M, Ramanathan RK, Aqel BA, Vasmatzis G, Truty MJ, Oklu R, Bekaii-Saab TS, Borad MJ.

Future Oncol. 2018 Mar;14(6):553-566. doi: 10.2217/fon-2017-0451. Epub 2018 Feb 20. Review.


MR-guided transcranial focused ultrasound safely enhances interstitial dispersion of large polymeric nanoparticles in the living brain.

Hersh DS, Anastasiadis P, Mohammadabadi A, Nguyen BA, Guo S, Winkles JA, Kim AJ, Gullapalli R, Keller A, Frenkel V, Woodworth GF.

PLoS One. 2018 Feb 7;13(2):e0192240. doi: 10.1371/journal.pone.0192240. eCollection 2018.


Magnetic Enhancement of Stem Cell-Targeted Delivery into the Brain Following MR-Guided Focused Ultrasound for Opening the Blood-Brain Barrier.

Shen WB, Anastasiadis P, Nguyen B, Yarnell D, Yarowsky PJ, Frenkel V, Fishman PS.

Cell Transplant. 2017 Jul;26(7):1235-1246. doi: 10.1177/0963689717715824.


Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling.

Kourtidis A, Necela B, Lin WH, Lu R, Feathers RW, Asmann YW, Thompson EA, Anastasiadis PZ.

J Cell Biol. 2017 Oct 2;216(10):3073-3085. doi: 10.1083/jcb.201612125. Epub 2017 Sep 6.


A central role for cadherin signaling in cancer.

Kourtidis A, Lu R, Pence LJ, Anastasiadis PZ.

Exp Cell Res. 2017 Sep 1;358(1):78-85. doi: 10.1016/j.yexcr.2017.04.006. Epub 2017 Apr 12. Review.


Tumor-targeted nanotherapeutics: overcoming treatment barriers for glioblastoma.

Wadajkar AS, Dancy JG, Hersh DS, Anastasiadis P, Tran NL, Woodworth GF, Winkles JA, Kim AJ.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Jul;9(4). doi: 10.1002/wnan.1439. Epub 2016 Nov 4. Review.


The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity.

Fiorotto R, Villani A, Kourtidis A, Scirpo R, Amenduni M, Geibel PJ, Cadamuro M, Spirli C, Anastasiadis PZ, Strazzabosco M.

Hepatology. 2016 Dec;64(6):2118-2134. doi: 10.1002/hep.28817. Epub 2016 Oct 27.


Biomagnetic activity and non linear analysis in obstetrics and gynecology in a Greek population.

Anninos P, Anastasiadis P, Adamopoulos A, Kotini A.

Clin Exp Obstet Gynecol. 2016;43(3):406-8. Review.


Assessment of Tumor Heterogeneity, as Evidenced by Gene Expression Profiles, Pathway Activation, and Gene Copy Number, in Patients with Multifocal Invasive Lobular Breast Tumors.

Norton N, Advani PP, Serie DJ, Geiger XJ, Necela BM, Axenfeld BC, Kachergus JM, Feathers RW, Carr JM, Crook JE, Moreno-Aspitia A, Anastasiadis PZ, Perez EA, Thompson EA.

PLoS One. 2016 Apr 14;11(4):e0153411. doi: 10.1371/journal.pone.0153411. eCollection 2016.


Bringing together cell-to-cell adhesion and miRNA biology in cancer research.

Kourtidis A, Anastasiadis PZ.

Future Oncol. 2016 May;12(10):1211-4. doi: 10.2217/fon-2016-0012. Epub 2016 Feb 29. No abstract available.


PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications.

Kourtidis A, Anastasiadis PZ.

Cell Cycle. 2016;15(4):498-505. doi: 10.1080/15384101.2016.1141840.


Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.

Kourtidis A, Ngok SP, Pulimeno P, Feathers RW, Carpio LR, Baker TR, Carr JM, Yan IK, Borges S, Perez EA, Storz P, Copland JA, Patel T, Thompson EA, Citi S, Anastasiadis PZ.

Nat Cell Biol. 2015 Sep;17(9):1145-57. doi: 10.1038/ncb3227. Epub 2015 Aug 24.


Src family kinases differentially influence glioma growth and motility.

Lewis-Tuffin LJ, Feathers R, Hari P, Durand N, Li Z, Rodriguez FJ, Bakken K, Carlson B, Schroeder M, Sarkaria JN, Anastasiadis PZ.

Mol Oncol. 2015 Nov;9(9):1783-98. doi: 10.1016/j.molonc.2015.06.001. Epub 2015 Jun 10.


Pro-Tumorigenic Phosphorylation of p120 Catenin in Renal and Breast Cancer.

Kourtidis A, Yanagisawa M, Huveldt D, Copland JA, Anastasiadis PZ.

PLoS One. 2015 Jun 11;10(6):e0129964. doi: 10.1371/journal.pone.0129964. eCollection 2015.


Expression of polarity genes in human cancer.

Lin WH, Asmann YW, Anastasiadis PZ.

Cancer Inform. 2015 Mar 30;14(Suppl 3):15-28. doi: 10.4137/CIN.S18964. eCollection 2015.


Endovascular Repair of Abdominal Aortic Aneurysms with the Anaconda™ Stent Graft: Mid-term Results from a Single Center.

Karkos CD, Kapetanios DM, Anastasiadis PT, Grigoropoulou FS, Kalogirou TE, Giagtzidis IT, Papazoglou KO.

Cardiovasc Intervent Radiol. 2015 Dec;38(6):1416-24. doi: 10.1007/s00270-015-1081-8. Epub 2015 Mar 24.


Detection and quantification of bacterial biofilms combining high-frequency acoustic microscopy and targeted lipid microparticles.

Anastasiadis P, Mojica KD, Allen JS, Matter ML.

J Nanobiotechnology. 2014 Jul 6;12:24. doi: 10.1186/1477-3155-12-24.


Establishment of epithelial polarity--GEF who's minding the GAP?

Ngok SP, Lin WH, Anastasiadis PZ.

J Cell Sci. 2014 Aug 1;127(Pt 15):3205-15. doi: 10.1242/jcs.153197. Epub 2014 Jul 2. Review.


Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4.

von Roemeling CA, Radisky DC, Marlow LA, Cooper SJ, Grebe SK, Anastasiadis PZ, Tun HW, Copland JA.

Cancer Res. 2014 Sep 1;74(17):4796-810. doi: 10.1158/0008-5472.CAN-14-0210. Epub 2014 Jun 24.


Rho GEFs in endothelial junctions: Effector selectivity and signaling integration determine junctional response.

Ngok SP, Anastasiadis PZ.

Tissue Barriers. 2013 Dec 1;1(5):e27132. doi: 10.4161/tisb.27132. Epub 2013 Nov 15.


Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies.

Assefnia S, Dakshanamurthy S, Guidry Auvil JM, Hampel C, Anastasiadis PZ, Kallakury B, Uren A, Foley DW, Brown ML, Shapiro L, Brenner M, Haigh D, Byers SW.

Oncotarget. 2014 Mar 30;5(6):1458-74.


PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity.

Espejo R, Jeng Y, Paulucci-Holthauzen A, Rengifo-Cam W, Honkus K, Anastasiadis PZ, Sastry SK.

J Cell Sci. 2014 Feb 1;127(Pt 3):497-508. doi: 10.1242/jcs.120154. Epub 2013 Nov 27.


Judo-related traumatic posterior sternoclavicular joint dislocation in a child.

Galanis N, Anastasiadis P, Grigoropoulou F, Kirkos J, Kapetanos G.

Clin J Sport Med. 2014 May;24(3):271-3. doi: 10.1097/JSM.0000000000000020.


The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration.

Dachsel JC, Ngok SP, Lewis-Tuffin LJ, Kourtidis A, Geyer R, Johnston L, Feathers R, Anastasiadis PZ.

Mol Cell Biol. 2013 Dec;33(24):4909-18. doi: 10.1128/MCB.00565-13. Epub 2013 Oct 14.


Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis.

Borges S, Döppler H, Perez EA, Andorfer CA, Sun Z, Anastasiadis PZ, Thompson E, Geiger XJ, Storz P.

Breast Cancer Res. 2013 Aug 23;15(2):R66. doi: 10.1186/bcr3460.


Protein kinase D1-mediated phosphorylations regulate vasodilator-stimulated phosphoprotein (VASP) localization and cell migration.

Döppler HR, Bastea LI, Lewis-Tuffin LJ, Anastasiadis PZ, Storz P.

J Biol Chem. 2013 Aug 23;288(34):24382-93. doi: 10.1074/jbc.M113.474676. Epub 2013 Jul 11.


TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function.

Ngok SP, Geyer R, Kourtidis A, Mitin N, Feathers R, Der C, Anastasiadis PZ.

J Cell Sci. 2013 Aug 1;126(Pt 15):3271-7. doi: 10.1242/jcs.123869. Epub 2013 May 31.


p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression.

Kourtidis A, Ngok SP, Anastasiadis PZ.

Prog Mol Biol Transl Sci. 2013;116:409-32. doi: 10.1016/B978-0-12-394311-8.00018-2. Review.


Targeting Src family kinases inhibits bevacizumab-induced glioma cell invasion.

Huveldt D, Lewis-Tuffin LJ, Carlson BL, Schroeder MA, Rodriguez F, Giannini C, Galanis E, Sarkaria JN, Anastasiadis PZ.

PLoS One. 2013;8(2):e56505. doi: 10.1371/journal.pone.0056505. Epub 2013 Feb 14.


Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) Syx.

Ngok SP, Geyer R, Kourtidis A, Storz P, Anastasiadis PZ.

J Biol Chem. 2013 Mar 1;288(9):6640-50. doi: 10.1074/jbc.M112.432682. Epub 2013 Jan 18.


VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx.

Ngok SP, Geyer R, Liu M, Kourtidis A, Agrawal S, Wu C, Seerapu HR, Lewis-Tuffin LJ, Moodie KL, Huveldt D, Marx R, Baraban JM, Storz P, Horowitz A, Anastasiadis PZ.

J Cell Biol. 2012 Dec 24;199(7):1103-15. doi: 10.1083/jcb.201207009. Epub 2012 Dec 17.


E-cadherin's dark side: possible role in tumor progression.

Rodriguez FJ, Lewis-Tuffin LJ, Anastasiadis PZ.

Biochim Biophys Acta. 2012 Aug;1826(1):23-31. doi: 10.1016/j.bbcan.2012.03.002. Epub 2012 Mar 13. Review.


The contribution of rapid intraoperative cytology in the evaluation of endometrial cancer spread.

Anastasiadis P, Koutlaki N, Liberis V, Tsikouras P, Dimitraki M, Liberis A, Galazios G.

Ann Acad Med Singapore. 2011 Feb;40(2):80-3.


Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype.

Lewis-Tuffin LJ, Rodriguez F, Giannini C, Scheithauer B, Necela BM, Sarkaria JN, Anastasiadis PZ.

PLoS One. 2010 Oct 27;5(10):e13665. doi: 10.1371/journal.pone.0013665.


Pathway signature and cellular differentiation in clear cell renal cell carcinoma.

Tun HW, Marlow LA, von Roemeling CA, Cooper SJ, Kreinest P, Wu K, Luxon BA, Sinha M, Anastasiadis PZ, Copland JA.

PLoS One. 2010 May 18;5(5):e10696. doi: 10.1371/journal.pone.0010696.


The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin.

Orlichenko L, Geyer R, Yanagisawa M, Khauv D, Radisky ES, Anastasiadis PZ, Radisky DC.

J Biol Chem. 2010 Jun 18;285(25):19153-61. doi: 10.1074/jbc.M109.099382. Epub 2010 Apr 15.


Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin.

Lee SH, Peng IF, Ng YG, Yanagisawa M, Bamji SX, Elia LP, Balsamo J, Lilien J, Anastasiadis PZ, Ullian EM, Reichardt LF.

J Cell Biol. 2008 Dec 1;183(5):893-908. doi: 10.1083/jcb.200807188.


p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression.

Soto E, Yanagisawa M, Marlow LA, Copland JA, Perez EA, Anastasiadis PZ.

J Cell Biol. 2008 Nov 17;183(4):737-49. doi: 10.1083/jcb.200805113.


A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease.

Yanagisawa M, Huveldt D, Kreinest P, Lohse CM, Cheville JC, Parker AS, Copland JA, Anastasiadis PZ.

J Biol Chem. 2008 Jun 27;283(26):18344-54. doi: 10.1074/jbc.M801192200. Epub 2008 Apr 11.


Mechanical properties of single cells by high-frequency time-resolved acoustic microscopy.

Weiss EC, Anastasiadis P, Pilarczyk G, Lemor RM, Zinin PV.

IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Nov;54(11):2257-71.


Hypertensive disorders in pregnancy: risk factors and epidemiologic analysis.

Anastasiadis P, Tsikouras P, Galazios G, Liberis V, Grapsas X, Koutlaki N, Anastasiadis AF.

Clin Exp Obstet Gynecol. 2007;34(3):154-8.


Metastatic female adnexal tumour of probable Wolffian origin. A histocytopathological correlation.

Tamiolakis D, Anastasiadis P.

Cytopathology. 2007 Aug;18(4):264-6. No abstract available.


Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor gamma and calcium signaling in human colorectal cancer cells.

Bush CR, Havens JM, Necela BM, Su W, Chen L, Yanagisawa M, Anastasiadis PZ, Guerra R, Luxon BA, Thompson EA.

J Biol Chem. 2007 Aug 10;282(32):23387-401. Epub 2007 Jun 12.


Imaging of focal contacts of chicken heart muscle cells by high-frequency acoustic microscopy.

Weiss EC, Lemor RM, Pilarczyk G, Anastasiadis P, Zinin PV.

Ultrasound Med Biol. 2007 Aug;33(8):1320-6. Epub 2007 Jun 11.


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