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Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone.

Krishnamachary B, Subramaniam D, Dandawate P, Ponnurangam S, Srinivasan P, Ramamoorthy P, Umar S, Thomas SM, Dhar A, Septer S, Weir SJ, Attard T, Anant S.

Oncotarget. 2019 Sep 24;10(54):5576-5591. doi: 10.18632/oncotarget.27159. eCollection 2019 Sep 24.


Glycemic impact of a diet and lifestyle intervention on diabetics and prediabetics during treatment for non-muscle invasive bladder cancer.

Chestnut C, Smelser W, Dum T, Bechtel M, Hand L, Michel C, Bawajeeh A, Zohreh S, Liu W, Anant S, Robbins D, Holzbeierlein JM, Hamilton-Reeves J, Lee EK.

Nutr Cancer. 2019 Oct 7:1-6. doi: 10.1080/01635581.2019.1672761. [Epub ahead of print]


The Histone Demethylase KDM3A, Increased in Human Pancreatic Tumors, Regulates Expression of DCLK1 in and Promotes Tumorigenesis in Mice.

Dandawate P, Ghosh C, Palaniyandi K, Paul S, Rawal S, Pradhan R, Ali Sayed AA, Choudhury S, Standing D, Subramaniam D, Padhye S, Gunewardena S, Thomas SM, Neil MO, Tawfik O, Welch DR, Jensen RA, Maliski S, Weir S, Iwakuma T, Anant S, Dhar A.

Gastroenterology. 2019 Aug 20. pii: S0016-5085(19)41232-8. doi: 10.1053/j.gastro.2019.08.018. [Epub ahead of print]


Tumor M2-PK: A novel urine marker of bladder cancer.

Liu W, Woolbright BL, Pirani K, Didde R, Abbott E, Kaushik G, Martin P, Hamilton-Reeves J, Taylor JA 3rd, Holzbeierlein JM, Anant S, Lee EK.

PLoS One. 2019 Jun 27;14(6):e0218737. doi: 10.1371/journal.pone.0218737. eCollection 2019.


Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs.

Weir SJ, Wood R, Schorno K, Brinker AE, Ramamoorthy P, Heppert K, Rajewski L, Tanol M, Ham T, McKenna MJ, McCulloch W, Dalton M, Reed GA, Jensen RA, Baltezor MJ, Anant S, Taylor JA 3rd.

J Pharmacol Exp Ther. 2019 Aug;370(2):148-159. doi: 10.1124/jpet.119.257972. Epub 2019 May 21.


Co-localization of autophagy-related protein p62 with cancer stem cell marker dclk1 may hamper dclk1's elimination during colon cancer development and progression.

Roy BC, Ahmed I, Ramalingam S, Jala V, Haribabu B, Ramamoorthy P, Ashcraft J, Valentino J, Anant S, Sampath V, Umar S.

Oncotarget. 2019 Mar 22;10(24):2340-2354. doi: 10.18632/oncotarget.26684. eCollection 2019 Mar 22.


Pleotropic role of RNA binding protein CELF2 in autophagy induction.

New J, Subramaniam D, Ramalingam S, Enders J, Sayed AAA, Ponnurangam S, Standing D, Ramamoorthy P, O'Neil M, Dixon DA, Saha S, Umar S, Gunewardena S, Jensen RA, Thomas SM, Anant S.

Mol Carcinog. 2019 Aug;58(8):1400-1409. doi: 10.1002/mc.23023. Epub 2019 Apr 24.


Super-enhancers: novel target for pancreatic ductal adenocarcinoma.

Ghosh C, Paul S, Dandawate P, Gunewardena SS, Subramaniam D, West C, Anant S, Dhar A.

Oncotarget. 2019 Feb 22;10(16):1554-1571. doi: 10.18632/oncotarget.26704. eCollection 2019 Feb 22.


Anticancer and antimetastatic potential of enterolactone: Clinical, preclinical and mechanistic perspectives.

Mali AV, Padhye SB, Anant S, Hegde MV, Kadam SS.

Eur J Pharmacol. 2019 Jun 5;852:107-124. doi: 10.1016/j.ejphar.2019.02.022. Epub 2019 Feb 14. Review.


Metastatic Tumor-in-a-Dish, a Novel Multicellular Organoid to Study Lung Colonization and Predict Therapeutic Response.

Ramamoorthy P, Thomas SM, Kaushik G, Subramaniam D, Chastain KM, Dhar A, Tawfik O, Kasi A, Sun W, Ramalingam S, Gunewardena S, Umar S, Mammen JM, Padhye SB, Weir SJ, Jensen RA, Sittampalam GS, Anant S.

Cancer Res. 2019 Apr 1;79(7):1681-1695. doi: 10.1158/0008-5472.CAN-18-2602. Epub 2019 Jan 23.


Functional cooperativity of p97 and histone deacetylase 6 in mediating DNA repair in mantle cell lymphoma cells.

Vekaria PH, Kumar A, Subramaniam D, Dunavin N, Vallurupalli A, Schoenen F, Ganguly S, Anant S, McGuirk JP, Jensen RA, Rao R.

Leukemia. 2019 Jul;33(7):1675-1686. doi: 10.1038/s41375-018-0355-y. Epub 2019 Jan 21.


Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis.

Ahmed I, Roy BC, Raach RT, Owens SM, Xia L, Anant S, Sampath V, Umar S.

PLoS One. 2018 Nov 1;13(11):e0206701. doi: 10.1371/journal.pone.0206701. eCollection 2018.


Cancer Stem Cell Metabolism and Potential Therapeutic Targets.

Snyder V, Reed-Newman TC, Arnold L, Thomas SM, Anant S.

Front Oncol. 2018 Jun 5;8:203. doi: 10.3389/fonc.2018.00203. eCollection 2018. Review.


Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression.

Kumar D, New J, Vishwakarma V, Joshi R, Enders J, Lin F, Dasari S, Gutierrez WR, Leef G, Ponnurangam S, Chavan H, Ganaden L, Thornton MM, Dai H, Tawfik O, Straub J, Shnayder Y, Kakarala K, Tsue TT, Girod DA, Van Houten B, Anant S, Krishnamurthy P, Thomas SM.

Cancer Res. 2018 Jul 15;78(14):3769-3782. doi: 10.1158/0008-5472.CAN-17-1076. Epub 2018 May 16.


A Review of Promising Natural Chemopreventive Agents for Head and Neck Cancer.

Crooker K, Aliani R, Ananth M, Arnold L, Anant S, Thomas SM.

Cancer Prev Res (Phila). 2018 Aug;11(8):441-450. doi: 10.1158/1940-6207.CAPR-17-0419. Epub 2018 Mar 30. Review.


Halogenated Bis(methoxybenzylidene)-4-piperidone Curcuminoids with Improved Anticancer Activity.

Schmitt F, Subramaniam D, Anant S, Padhye S, Begemann G, Schobert R, Biersack B.

ChemMedChem. 2018 Jun 6;13(11):1115-1123. doi: 10.1002/cmdc.201800135. Epub 2018 Apr 23.


Development and Characterization of an In Vitro Model for Radiation-Induced Fibrosis.

Kumar D, Yalamanchali S, New J, Parsel S, New N, Holcomb A, Gunewardena S, Tawfik O, Lominska C, Kimler BF, Anant S, Kakarala K, Tsue T, Shnayder Y, Sykes K, Padhye S, Thomas SM.

Radiat Res. 2018 Mar;189(3):326-336. doi: 10.1667/RR14926.1. Epub 2018 Jan 19.


Current Approaches to Diagnosis and Treatment of Ductal Carcinoma In Situ and Future Directions.

Ryan R, Tawfik O, Jensen RA, Anant S.

Prog Mol Biol Transl Sci. 2017;151:33-80. doi: 10.1016/bs.pmbts.2017.08.001. Epub 2017 Sep 15. Review.


Secretory Autophagy in Cancer-Associated Fibroblasts Promotes Head and Neck Cancer Progression and Offers a Novel Therapeutic Target.

New J, Arnold L, Ananth M, Alvi S, Thornton M, Werner L, Tawfik O, Dai H, Shnayder Y, Kakarala K, Tsue TT, Girod DA, Ding WX, Anant S, Thomas SM.

Cancer Res. 2017 Dec 1;77(23):6679-6691. doi: 10.1158/0008-5472.CAN-17-1077. Epub 2017 Sep 28.


Targeting Cancer Stem Cells for Chemoprevention of Pancreatic Cancer.

Subramaniam D, Kaushik G, Dandawate P, Anant S.

Curr Med Chem. 2018;25(22):2585-2594. doi: 10.2174/0929867324666170127095832. Review.


Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy.

Angulo P, Kaushik G, Subramaniam D, Dandawate P, Neville K, Chastain K, Anant S.

J Hematol Oncol. 2017 Jan 7;10(1):10. doi: 10.1186/s13045-016-0373-z. Review.


Stromal contributions to the carcinogenic process.

Spaw M, Anant S, Thomas SM.

Mol Carcinog. 2017 Apr;56(4):1199-1213. doi: 10.1002/mc.22583. Epub 2016 Nov 5. Review.


Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis.

Blanco FF, Preet R, Aguado A, Vishwakarma V, Stevens LE, Vyas A, Padhye S, Xu L, Weir SJ, Anant S, Meisner-Kober N, Brody JR, Dixon DA.

Oncotarget. 2016 Nov 8;7(45):74043-74058. doi: 10.18632/oncotarget.12189.


Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy.

Dandawate PR, Subramaniam D, Jensen RA, Anant S.

Semin Cancer Biol. 2016 Oct;40-41:192-208. doi: 10.1016/j.semcancer.2016.09.001. Epub 2016 Sep 5. Review.


Bitter melon: a panacea for inflammation and cancer.

Dandawate PR, Subramaniam D, Padhye SB, Anant S.

Chin J Nat Med. 2016 Feb;14(2):81-100. doi: 10.1016/S1875-5364(16)60002-X. Review.


An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis.

Ahmed I, Roy BC, Subramaniam D, Ganie SA, Kwatra D, Dixon D, Anant S, Zargar MA, Umar S.

Carcinogenesis. 2016 Apr;37(4):385-96. doi: 10.1093/carcin/bgw009. Epub 2016 Jan 19.


Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells.

Ponnurangam S, Dandawate PR, Dhar A, Tawfik OW, Parab RR, Mishra PD, Ranadive P, Sharma R, Mahajan G, Umar S, Weir SJ, Sugumar A, Jensen RA, Padhye SB, Balakrishnan A, Anant S, Subramaniam D.

Oncotarget. 2016 Jan 19;7(3):3217-32. doi: 10.18632/oncotarget.6560.


RNA binding protein RBM3 increases β-catenin signaling to increase stem cell characteristics in colorectal cancer cells.

Venugopal A, Subramaniam D, Balmaceda J, Roy B, Dixon DA, Umar S, Weir SJ, Anant S.

Mol Carcinog. 2016 Nov;55(11):1503-1516. doi: 10.1002/mc.22404. Epub 2015 Aug 31.


Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells.

Rangarajan P, Subramaniam D, Paul S, Kwatra D, Palaniyandi K, Islam S, Harihar S, Ramalingam S, Gutheil W, Putty S, Pradhan R, Padhye S, Welch DR, Anant S, Dhar A.

Oncotarget. 2015 Sep 29;6(29):27661-73. doi: 10.18632/oncotarget.4871.


Manipulating miRNA Expression: A Novel Approach for Colon Cancer Prevention and Chemotherapy.

Ramalingam S, Subramaniam D, Anant S.

Curr Pharmacol Rep. 2015 Jun 1;1(3):141-153.


Histone Demethylases in Colon Cancer.

Paul S, Ramalingam S, Subramaniam D, Baranda J, Anant S, Dhar A.

Curr Colorectal Cancer Rep. 2014 Dec 1;10(4):417-424.


Honokiol inhibits melanoma stem cells by targeting notch signaling.

Kaushik G, Venugopal A, Ramamoorthy P, Standing D, Subramaniam D, Umar S, Jensen RA, Anant S, Mammen JM.

Mol Carcinog. 2015 Dec;54(12):1710-21. doi: 10.1002/mc.22242. Epub 2014 Dec 9.


Role of bacterial infection in the epigenetic regulation of Wnt antagonist WIF1 by PRC2 protein EZH2.

Roy BC, Subramaniam D, Ahmed I, Jala VR, Hester CM, Greiner KA, Haribabu B, Anant S, Umar S.

Oncogene. 2015 Aug 20;34(34):4519-30. doi: 10.1038/onc.2014.386. Epub 2014 Dec 8.


Honokiol affects melanoma cell growth by targeting the AMP-activated protein kinase signaling pathway.

Kaushik G, Kwatra D, Subramaniam D, Jensen RA, Anant S, Mammen JM.

Am J Surg. 2014 Dec;208(6):995-1002; discussion 1001-2. doi: 10.1016/j.amjsurg.2014.09.014. Epub 2014 Oct 2.


DNA methyltransferases: a novel target for prevention and therapy.

Subramaniam D, Thombre R, Dhar A, Anant S.

Front Oncol. 2014 May 1;4:80. doi: 10.3389/fonc.2014.00080. eCollection 2014. Review.


Integrative oncology.

Dobos G, Cramer H, Anant S, Witt CM, Cohen L.

Evid Based Complement Alternat Med. 2013;2013:124032. doi: 10.1155/2013/124032. Epub 2013 Dec 19. No abstract available.


Honokiol as a Radiosensitizing Agent for Colorectal cancers.

He Z, Subramaniam D, Zhang Z, Zhang Y, Anant S.

Curr Colorectal Cancer Rep. 2013 Dec;9(4). doi: 10.1007/s11888-013-0191-4.


Proceedings of the Indo-U.S. bilateral workshop on accelerating botanicals/biologics agent development research for cancer chemoprevention, treatment, and survival.

Kumar NB, Dhurandhar M, Aggarwal B, Anant S, Daniel K, Deng G, Djeu J, Dou J, Hawk E, Jayaram B, Jia L, Joshi R, Kararala M, Karunagaran D, Kucuk O, Kumar L, Malafa M, Samathanam GJ, Sarkar F, Siddiqi M, Singh RP, Srivastava A, White JD.

Cancer Med. 2013 Feb;2(1):108-15.


Differential effects of β-catenin and NF-κB interplay in the regulation of cell proliferation, inflammation and tumorigenesis in response to bacterial infection.

Chandrakesan P, Jakkula LU, Ahmed I, Roy B, Anant S, Umar S.

PLoS One. 2013 Nov 21;8(11):e79432. doi: 10.1371/journal.pone.0079432. eCollection 2013.


Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner.

Neradugomma NK, Subramaniam D, Tawfik OW, Goffin V, Kumar TR, Jensen RA, Anant S.

Carcinogenesis. 2014 Apr;35(4):795-806. doi: 10.1093/carcin/bgt379. Epub 2013 Nov 21.


Reg4-induced mitogenesis involves Akt-GSK3β-β-Catenin-TCF-4 signaling in human colorectal cancer.

Bishnupuri KS, Sainathan SK, Bishnupuri K, Leahy DR, Luo Q, Anant S, Houchen CW, Dieckgraefe BK.

Mol Carcinog. 2014 Feb;53 Suppl 1:E169-80. doi: 10.1002/mc.22088. Epub 2013 Oct 22.


Bitter melon extracts enhance the activity of chemotherapeutic agents through the modulation of multiple drug resistance.

Kwatra D, Venugopal A, Standing D, Ponnurangam S, Dhar A, Mitra A, Anant S.

J Pharm Sci. 2013 Dec;102(12):4444-54. doi: 10.1002/jps.23753. Epub 2013 Oct 15.


Utility of a bacterial infection model to study epithelial-mesenchymal transition, mesenchymal-epithelial transition or tumorigenesis.

Chandrakesan P, Roy B, Jakkula LU, Ahmed I, Ramamoorthy P, Tawfik O, Papineni R, Houchen C, Anant S, Umar S.

Oncogene. 2014 May 15;33(20):2639-54. doi: 10.1038/onc.2013.210. Epub 2013 Jun 10.


Ethnopharmacological approaches to wound repair.

Küpeli Akkol E, Afifi FU, Baie SH, Taranalli AD, Anant S.

Evid Based Complement Alternat Med. 2013;2013:804039. doi: 10.1155/2013/804039. Epub 2013 Feb 27. No abstract available.


Methanolic extracts of bitter melon inhibit colon cancer stem cells by affecting energy homeostasis and autophagy.

Kwatra D, Subramaniam D, Ramamoorthy P, Standing D, Moran E, Velayutham R, Mitra A, Umar S, Anant S.

Evid Based Complement Alternat Med. 2013;2013:702869. doi: 10.1155/2013/702869. Epub 2013 Mar 6.


Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells.

Kaushik G, Ramalingam S, Subramaniam D, Rangarajan P, Protti P, Rammamoorthy P, Anant S, Mammen JM.

Am J Surg. 2012 Dec;204(6):868-73. doi: 10.1016/j.amjsurg.2012.09.001.


Evidence of functional cross talk between the Notch and NF-κB pathways in nonneoplastic hyperproliferating colonic epithelium.

Ahmed I, Roy B, Chandrakesan P, Venugopal A, Xia L, Jensen R, Anant S, Umar S.

Am J Physiol Gastrointest Liver Physiol. 2013 Feb 15;304(4):G356-70. doi: 10.1152/ajpgi.00372.2012. Epub 2012 Nov 29.


The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis.

Vo DT, Subramaniam D, Remke M, Burton TL, Uren PJ, Gelfond JA, de Sousa Abreu R, Burns SC, Qiao M, Suresh U, Korshunov A, Dubuc AM, Northcott PA, Smith AD, Pfister SM, Taylor MD, Janga SC, Anant S, Vogel C, Penalva LO.

Am J Pathol. 2012 Nov;181(5):1762-72. doi: 10.1016/j.ajpath.2012.07.031. Epub 2012 Sep 14.


p53 inactivation upregulates p73 expression through E2F-1 mediated transcription.

Tophkhane C, Yang SH, Jiang Y, Ma Z, Subramaniam D, Anant S, Yogosawa S, Sakai T, Liu WG, Edgerton S, Thor A, Yang X.

PLoS One. 2012;7(8):e43564. doi: 10.1371/journal.pone.0043564. Epub 2012 Aug 30.

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