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Sorsby Fundus Dystrophy Mutation in Tissue Inhibitor of Metalloproteinase 3 (TIMP3) promotes Choroidal Neovascularization via a Fibroblast Growth Factor-dependent Mechanism.

Qi JH, Bell B, Singh R, Batoki J, Wolk A, Cutler A, Prayson N, Ali M, Stoehr H, Anand-Apte B.

Sci Rep. 2019 Nov 22;9(1):17429. doi: 10.1038/s41598-019-53433-6.


The fenestrae-associated protein Plvap regulates the rate of blood-borne protein passage into the hypophysis.

Gordon L, Blechman J, Shimoni E, Gur D, Anand-Apte B, Levkowitz G.

Development. 2019 Dec 2;146(23). pii: dev177790. doi: 10.1242/dev.177790.


Changes in VEGF-related factors are associated with presence of inflammatory factors in carbohydrate metabolism disorders during pregnancy.

Sugimoto M, Kondo M, Kamimoto Y, Ikeda T, Cutler A, Mariya A, Anand-Apte B.

PLoS One. 2019 Aug 15;14(8):e0220650. doi: 10.1371/journal.pone.0220650. eCollection 2019.


Prolonged ocular exposure leads to retinal lesions in mice.

Bell BA, Bonilha VL, Hagstrom SA, Anand-Apte B, Hollyfield JG, Samuels IS.

Exp Eye Res. 2019 Aug;185:107672. doi: 10.1016/j.exer.2019.05.012. Epub 2019 May 22.


Heterogeneity of cultured melanocyte elongation and proliferation factor in bilateral diffuse uveal melanocytic proliferation.

Lavine JA, Ramos MS, Wolk AM, Baynes K, Sharma S, Rachitskaya AV, Anand-Apte B, Srivastava SK, Yuan A.

Exp Eye Res. 2019 Jul;184:30-37. doi: 10.1016/j.exer.2019.04.006. Epub 2019 Apr 10.


Endogenous insulin signaling in the RPE contributes to the maintenance of rod photoreceptor function in diabetes.

Tarchick MJ, Cutler AH, Trobenter TD, Kozlowski MR, Makowski ER, Holoman N, Shao J, Shen B, Anand-Apte B, Samuels IS.

Exp Eye Res. 2019 Mar;180:63-74. doi: 10.1016/j.exer.2018.11.020. Epub 2018 Dec 10.


Sorsby fundus dystrophy: Insights from the past and looking to the future.

Anand-Apte B, Chao JR, Singh R, Stöhr H.

J Neurosci Res. 2019 Jan;97(1):88-97. doi: 10.1002/jnr.24317. Epub 2018 Aug 21. Review.


Retinoic acid signaling is essential for maintenance of the blood-retinal barrier.

Pollock LM, Xie J, Bell BA, Anand-Apte B.

FASEB J. 2018 Oct;32(10):5674-5684. doi: 10.1096/fj.201701469R. Epub 2018 Jun 6.


Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion.

Xie N, Khabbazi S, Nassar ZD, Gregory K, Vithanage T, Anand-Apte B, Cabot PJ, Sturgess D, Shaw PN, Parat MO.

FASEB J. 2017 Dec;31(12):5208-5216. doi: 10.1096/fj.201700546R. Epub 2017 Aug 7.


A mutagenesis-derived Lrp5 mouse mutant with abnormal retinal vasculature and low bone mineral density.

Charette JR, Earp SE, Bell BA, Ackert-Bicknell CL, Godfrey DA, Rao S, Anand-Apte B, Nishina PM, Peachey NS.

Mol Vis. 2017 Mar 18;23:140-148. eCollection 2017.


Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic Response.

Asosingh K, Vasanji A, Tipton A, Queisser K, Wanner N, Janocha A, Grandon D, Anand-Apte B, Rothenberg ME, Dweik R, Erzurum SC.

J Immunol. 2016 Mar 1;196(5):2377-87. doi: 10.4049/jimmunol.1500770. Epub 2016 Jan 25.


Tissue inhibitor of metalloproteinase-3 (TIMP3) promotes endothelial apoptosis via a caspase-independent mechanism.

Qi JH, Anand-Apte B.

Apoptosis. 2015 Apr;20(4):523-34. doi: 10.1007/s10495-014-1076-y.


Retinal vasculature of adult zebrafish: in vivo imaging using confocal scanning laser ophthalmoscopy.

Bell BA, Xie J, Yuan A, Kaul C, Hollyfield JG, Anand-Apte B.

Exp Eye Res. 2014 Dec;129:107-18. doi: 10.1016/j.exer.2014.10.018. Epub 2014 Oct 24.


Simultaneous assessment of glomerular filtration and barrier function in live zebrafish.

Kotb AM, Müller T, Xie J, Anand-Apte B, Endlich K, Endlich N.

Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1427-34. doi: 10.1152/ajprenal.00029.2014. Epub 2014 Oct 8. Erratum in: Am J Physiol Renal Physiol. 2018 Jan 1;314(1):F142.


Retinal regeneration following OCT-guided laser injury in zebrafish.

DiCicco RM, Bell BA, Kaul C, Hollyfield JG, Anand-Apte B, Perkins BD, Tao YK, Yuan A.

Invest Ophthalmol Vis Sci. 2014 Sep 9;55(10):6281-8. doi: 10.1167/iovs.14-14724.


Inhibition of EGF signaling protects the diabetic retina from insulin-induced vascular leakage.

Sugimoto M, Cutler A, Shen B, Moss SE, Iyengar SK, Klein R, Folkman J, Anand-Apte B.

Am J Pathol. 2013 Sep;183(3):987-95. doi: 10.1016/j.ajpath.2013.05.017. Epub 2013 Jul 3.


Tissue inhibitor of metalloproteinases-3 peptides inhibit angiogenesis and choroidal neovascularization in mice.

Qi JH, Ebrahem Q, Ali M, Cutler A, Bell B, Prayson N, Sears J, Knauper V, Murphy G, Anand-Apte B.

PLoS One. 2013;8(3):e55667. doi: 10.1371/journal.pone.0055667. Epub 2013 Mar 1.


Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.

Hewing NJ, Weskamp G, Vermaat J, Farage E, Glomski K, Swendeman S, Chan RV, Chiang MF, Khokha R, Anand-Apte B, Blobel CP.

Invest Ophthalmol Vis Sci. 2013 Jan 30;54(1):864-70. doi: 10.1167/iovs.12-10954.


Altered angiogenesis in caveolin-1 gene-deficient mice is restored by ablation of endothelial nitric oxide synthase.

Morais C, Ebrahem Q, Anand-Apte B, Parat MO.

Am J Pathol. 2012 Apr;180(4):1702-14. doi: 10.1016/j.ajpath.2011.12.018. Epub 2012 Feb 7.


Regulation of retinal vascular permeability by betacellulin.

Sugimoto M, Cutler A, Grossman G, Anand-Apte B.

Adv Exp Med Biol. 2012;723:293-8. doi: 10.1007/978-1-4614-0631-0_38. Review. No abstract available.


A review and update on the molecular basis of pathogenesis of Sorsby fundus dystrophy.

Stöhr H, Anand-Apte B.

Adv Exp Med Biol. 2012;723:261-7. doi: 10.1007/978-1-4614-0631-0_34. Review. No abstract available.


Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis.

Wu C, Agrawal S, Vasanji A, Drazba J, Sarkaria S, Xie J, Welch CM, Liu M, Anand-Apte B, Horowitz A.

J Biol Chem. 2011 Jul 1;286(26):23511-20. doi: 10.1074/jbc.M111.245209. Epub 2011 May 4.


Increased neovascularization in mice lacking tissue inhibitor of metalloproteinases-3.

Ebrahem Q, Qi JH, Sugimoto M, Ali M, Sears JE, Cutler A, Khokha R, Vasanji A, Anand-Apte B.

Invest Ophthalmol Vis Sci. 2011 Aug 3;52(9):6117-23. doi: 10.1167/iovs.10-5899.


Betacellulin induces increased retinal vascular permeability in mice.

Anand-Apte B, Ebrahem Q, Cutler A, Farage E, Sugimoto M, Hollyfield J, Folkman J.

PLoS One. 2010 Oct 18;5(10):e13444. doi: 10.1371/journal.pone.0013444.


A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development.

Xie J, Farage E, Sugimoto M, Anand-Apte B.

BMC Dev Biol. 2010 Jul 23;10:76. doi: 10.1186/1471-213X-10-76.


Impaired function of circulating CD34(+) CD45(-) cells in patients with proliferative diabetic retinopathy.

Tan K, Lessieur E, Cutler A, Nerone P, Vasanji A, Asosingh K, Erzurum S, Anand-Apte B.

Exp Eye Res. 2010 Aug;91(2):229-37. doi: 10.1016/j.exer.2010.05.012. Epub 2010 May 21.


Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo.

Ebrahem Q, Chaurasia SS, Vasanji A, Qi JH, Klenotic PA, Cutler A, Asosingh K, Erzurum S, Anand-Apte B.

Am J Pathol. 2010 Jan;176(1):496-503. doi: 10.2353/ajpath.2010.080642. Epub 2009 Nov 30.


S156C mutation in tissue inhibitor of metalloproteinases-3 induces increased angiogenesis.

Qi JH, Dai G, Luthert P, Chaurasia S, Hollyfield J, Weber BH, Stöhr H, Anand-Apte B.

J Biol Chem. 2009 Jul 24;284(30):19927-36. doi: 10.1074/jbc.M109.013763. Epub 2009 May 28.


Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy.

Sears JE, Hoppe G, Ebrahem Q, Anand-Apte B.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19898-903. doi: 10.1073/pnas.0805817105. Epub 2008 Dec 4.


Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension.

Asosingh K, Aldred MA, Vasanji A, Drazba J, Sharp J, Farver C, Comhair SA, Xu W, Licina L, Huang L, Anand-Apte B, Yoder MC, Tuder RM, Erzurum SC.

Am J Pathol. 2008 Mar;172(3):615-27. doi: 10.2353/ajpath.2008.070705. Epub 2008 Feb 7.


Carboxyethylpyrrole adducts, age-related macular degeneration and neovascularization.

Renganathan K, Ebrahem Q, Vasanji A, Gu X, Lu L, Sears J, Salomon RG, Anand-Apte B, Crabb JW.

Adv Exp Med Biol. 2008;613:261-7. doi: 10.1007/978-0-387-74904-4_30. Review. No abstract available.


Caveolin-1 polarization in transmigrating endothelial cells requires binding to intermediate filaments.

Santilman V, Baran J, Anand-Apte B, Evans RM, Parat MO.

Angiogenesis. 2007;10(4):297-305. Epub 2007 Oct 23.


Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension.

Masri FA, Xu W, Comhair SA, Asosingh K, Koo M, Vasanji A, Drazba J, Anand-Apte B, Erzurum SC.

Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L548-54. Epub 2007 May 25.


Triamcinolone acetonide inhibits IL-6- and VEGF-induced angiogenesis downstream of the IL-6 and VEGF receptors.

Ebrahem Q, Minamoto A, Hoppe G, Anand-Apte B, Sears JE.

Invest Ophthalmol Vis Sci. 2006 Nov;47(11):4935-41.


Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient.

Santilman V, Baran J, Anand-Apte B, Fox PL, Parat MO.

Cell Motil Cytoskeleton. 2006 Nov;63(11):673-80.


Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration.

Ebrahem Q, Renganathan K, Sears J, Vasanji A, Gu X, Lu L, Salomon RG, Crabb JW, Anand-Apte B.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13480-4. Epub 2006 Aug 25. Erratum in: Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15722.


Definitive evidence of fundamental and inherent alteration in the phenotype of primary pulmonary hypertension endothelial cells in angiogenesis.

Masri FA, Anand-Apte B, Vasanji A, Xu W, Goggans T, Drazba J, Erzurum SC.

Chest. 2005 Dec;128(6 Suppl):571S. No abstract available.


GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.

Kim KS, Ren J, Jiang Y, Ebrahem Q, Tipps R, Cristina K, Xiao YJ, Qiao J, Taylor KL, Lum H, Anand-Apte B, Xu Y.

FASEB J. 2005 May;19(7):819-21. Epub 2005 Feb 17.


A role for caveolae in cell migration.

Navarro A, Anand-Apte B, Parat MO.

FASEB J. 2004 Dec;18(15):1801-11. Review.


Tissue inhibitor of metalloproteinases-3 and Sorsby fundus dystrophy.

Qi JH, Ebrahem Q, Anand-Apte B.

Adv Exp Med Biol. 2003;533:97-105. Review. No abstract available.


ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases.

Hall NG, Klenotic P, Anand-Apte B, Apte SS.

Matrix Biol. 2003 Nov;22(6):501-10.


Differential caveolin-1 polarization in endothelial cells during migration in two and three dimensions.

Parat MO, Anand-Apte B, Fox PL.

Mol Biol Cell. 2003 Aug;14(8):3156-68. Epub 2003 May 3.


A PI-3 kinase-dependent, Stat1-independent signaling pathway regulates interferon-stimulated monocyte adhesion.

Navarro A, Anand-Apte B, Tanabe Y, Feldman G, Larner AC.

J Leukoc Biol. 2003 Apr;73(4):540-5.


A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2.

Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B.

Nat Med. 2003 Apr;9(4):407-15. Epub 2003 Mar 24.


Expression of Sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis.

Qi JH, Ebrahem Q, Yeow K, Edwards DR, Fox PL, Anand-Apte B.

J Biol Chem. 2002 Apr 19;277(16):13394-400. Epub 2002 Jan 30.


Motility and invasion are differentially modulated by Rho family GTPases.

Banyard J, Anand-Apte B, Symons M, Zetter BR.

Oncogene. 2000 Jan 27;19(4):580-91.


Corticotropin-releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin.

Arbiser JL, Karalis K, Viswanathan A, Koike C, Anand-Apte B, Flynn E, Zetter B, Majzoub JA.

J Invest Dermatol. 1999 Nov;113(5):838-42.


Vascular endothelial growth factor-induced migration of vascular smooth muscle cells in vitro.

Grosskreutz CL, Anand-Apte B, Dupláa C, Quinn TP, Terman BI, Zetter B, D'Amore PA.

Microvasc Res. 1999 Sep;58(2):128-36.


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