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Lacking catalase, a protistan parasite draws on its photosynthetic ancestry to complete an antioxidant repertoire with ascorbate peroxidase.

Schott EJ, Di Lella S, Bachvaroff TR, Amzel LM, Vasta GR.

BMC Evol Biol. 2019 Jul 19;19(1):146. doi: 10.1186/s12862-019-1465-5.


Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.

Yoder JB, Ben-Johny M, Farinelli F, Srinivasan L, Shoemaker SR, Tomaselli GF, Gabelli SB, Amzel LM.

Nat Commun. 2019 Apr 3;10(1):1514. doi: 10.1038/s41467-019-09570-7.


Structure of the zebrafish galectin-1-L2 and model of its interaction with the infectious hematopoietic necrosis virus (IHNV) envelope glycoprotein.

Ghosh A, Banerjee A, Amzel LM, Vasta GR, Bianchet MA.

Glycobiology. 2019 May 1;29(5):419-430. doi: 10.1093/glycob/cwz015.


Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II.

Miller MS, Maheshwari S, Shi W, Gao Y, Chu N, Soares AS, Cole PA, Amzel LM, Fuchs MR, Jakoncic J, Gabelli SB.

Molecules. 2019 Jan 30;24(3). pii: E496. doi: 10.3390/molecules24030496.


Erratum for McCarthy et al., "Identification of a Shared Cytochrome p4502E1 Epitope Found in Anesthetic Drug-Induced and Viral Hepatitis".

McCarthy EK, Vakos A, Cottagiri M, Mantilla JJ, Santhanam L, Thomas DL, Amzel LM, Rose NR, Njoku DB.

mSphere. 2018 Dec 5;3(6). pii: e00654-18. doi: 10.1128/mSphere.00654-18. No abstract available.


Identification of a Shared Cytochrome p4502E1 Epitope Found in Anesthetic Drug-Induced and Viral Hepatitis.

McCarthy EK, Vakos A, Cottagiri M, Mantilla JJ, Santhanam L, Thomas DL, Amzel LM, Rose NR, Njoku DB.

mSphere. 2018 Oct 10;3(5). pii: e00453-18. doi: 10.1128/mSphere.00453-18. Erratum in: mSphere. 2018 Dec 5;3(6):. Mantila, Joel J [corrected to Mantilla, Joel J].


Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase.

Maheshwari S, Shimokawa C, Rudzka K, Kline CD, Eipper BA, Mains RE, Gabelli SB, Blackburn N, Amzel LM.

Commun Biol. 2018 Jun 25;1:74. doi: 10.1038/s42003-018-0082-y. eCollection 2018.


Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.

Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA.

Cell. 2018 Aug 9;174(4):897-907.e14. doi: 10.1016/j.cell.2018.07.003. Epub 2018 Aug 2.


Bilobal architecture is a requirement for calmodulin signaling to CaV1.3 channels.

Banerjee R, Yoder JB, Yue DT, Amzel LM, Tomaselli GF, Gabelli SB, Ben-Johny M.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E3026-E3035. doi: 10.1073/pnas.1716381115. Epub 2018 Mar 12.


F-Type Lectins: A Highly Diversified Family of Fucose-Binding Proteins with a Unique Sequence Motif and Structural Fold, Involved in Self/Non-Self-Recognition.

Vasta GR, Amzel LM, Bianchet MA, Cammarata M, Feng C, Saito K.

Front Immunol. 2017 Nov 29;8:1648. doi: 10.3389/fimmu.2017.01648. eCollection 2017. Review.


Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition.

Maheshwari S, Miller MS, O'Meally R, Cole RN, Amzel LM, Gabelli SB.

J Biol Chem. 2017 Aug 18;292(33):13541-13550. doi: 10.1074/jbc.M116.772426. Epub 2017 Jul 4.


A Tunable Brake for HECT Ubiquitin Ligases.

Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA.

Mol Cell. 2017 May 4;66(3):345-357.e6. doi: 10.1016/j.molcel.2017.03.020.


Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization.

Yang JM, Schiapparelli P, Nguyen HN, Igarashi A, Zhang Q, Abbadi S, Amzel LM, Sesaki H, Quiñones-Hinojosa A, Iijima M.

Oncogene. 2017 Jun 29;36(26):3673-3685. doi: 10.1038/onc.2016.493. Epub 2017 Mar 6.


The Sodium/Iodide Symporter (NIS): Molecular Physiology and Preclinical and Clinical Applications.

Ravera S, Reyna-Neyra A, Ferrandino G, Amzel LM, Carrasco N.

Annu Rev Physiol. 2017 Feb 10;79:261-289. doi: 10.1146/annurev-physiol-022516-034125. Review.


Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design.

Miller MS, Maheshwari S, McRobb FM, Kinzler KW, Amzel LM, Vogelstein B, Gabelli SB.

Bioorg Med Chem. 2017 Feb 15;25(4):1481-1486. doi: 10.1016/j.bmc.2017.01.012. Epub 2017 Jan 16.


Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis.

O'Handley SF, Thirawatananond P, Kang LW, Cunningham JE, Leyva JA, Amzel LM, Gabelli SB.

J Bioenerg Biomembr. 2016 Dec;48(6):557-567. Epub 2016 Sep 28.


Na+ coordination at the Na2 site of the Na+/I- symporter.

Ferrandino G, Nicola JP, Sánchez YE, Echeverria I, Liu Y, Amzel LM, Carrasco N.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5379-88. doi: 10.1073/pnas.1607231113. Epub 2016 Aug 25.


Modulation of MICAL Monooxygenase Activity by its Calponin Homology Domain: Structural and Mechanistic Insights.

Alqassim SS, Urquiza M, Borgnia E, Nagib M, Amzel LM, Bianchet MA.

Sci Rep. 2016 Mar 3;6:22176. doi: 10.1038/srep22176.


Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.

de la Peña AH, Suarez A, Duong-Ly KC, Schoeffield AJ, Pizarro-Dupuy MA, Zarr M, Pineiro SA, Amzel LM, Gabelli SB.

PLoS One. 2015 Nov 2;10(11):e0141716. doi: 10.1371/journal.pone.0141716. eCollection 2015.


Calmodulin and Ca(2+) control of voltage gated Na(+) channels.

Gabelli SB, Yoder JB, Tomaselli GF, Amzel LM.

Channels (Austin). 2016;10(1):45-54. doi: 10.1080/19336950.2015.1075677. Epub 2015 Jul 28. Review.


Sodium/Iodide Symporter Mutant V270E Causes Stunted Growth but No Cognitive Deficiency.

Nicola JP, Reyna-Neyra A, Saenger P, Rodriguez-Buritica DF, Gamez Godoy JD, Muzumdar R, Amzel LM, Carrasco N.

J Clin Endocrinol Metab. 2015 Oct;100(10):E1353-61. doi: 10.1210/jc.2015-1824. Epub 2015 Jul 23.


Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α.

Echeverria I, Liu Y, Gabelli SB, Amzel LM.

FEBS J. 2015 Sep;282(18):3528-42. doi: 10.1111/febs.13365. Epub 2015 Jul 24.


Beyond non-integer Hill coefficients: A novel approach to analyzing binding data, applied to Na+-driven transporters.

Ravera S, Quick M, Nicola JP, Carrasco N, Amzel LM.

J Gen Physiol. 2015 Jun;145(6):555-63. doi: 10.1085/jgp.201511365.


A redox regulatory system critical for mycobacterial survival in macrophages and biofilm development.

Wolff KA, de la Peña AH, Nguyen HT, Pham TH, Amzel LM, Gabelli SB, Nguyen L.

PLoS Pathog. 2015 Apr 17;11(4):e1004839. doi: 10.1371/journal.ppat.1004839. eCollection 2015 Apr.


Role of the outer pore domain in transient receptor potential vanilloid 1 dynamic permeability to large cations.

Munns CH, Chung MK, Sanchez YE, Amzel LM, Caterina MJ.

J Biol Chem. 2015 Feb 27;290(9):5707-24. doi: 10.1074/jbc.M114.597435. Epub 2015 Jan 7.


Regulation of the NaV1.5 cytoplasmic domain by calmodulin.

Gabelli SB, Boto A, Kuhns VH, Bianchet MA, Farinelli F, Aripirala S, Yoder J, Jakoncic J, Tomaselli GF, Amzel LM.

Nat Commun. 2014 Nov 5;5:5126. doi: 10.1038/ncomms6126.


Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects.

Gabelli SB, Echeverria I, Alexander M, Duong-Ly KC, Chaves-Moreira D, Brower ET, Vogelstein B, Amzel LM.

Biophys Rev. 2014 Mar 1;6(1):89-95.


Structural basis of nSH2 regulation and lipid binding in PI3Kα.

Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB.

Oncotarget. 2014 Jul 30;5(14):5198-208.


Physiological sodium concentrations enhance the iodide affinity of the Na+/I- symporter.

Nicola JP, Carrasco N, Amzel LM.

Nat Commun. 2014 Jun 3;5:3948. doi: 10.1038/ncomms4948.


Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.

Aripirala S, Gonzalez-Pacanowska D, Oldfield E, Kaiser M, Amzel LM, Gabelli SB.

Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):802-10. doi: 10.1107/S1399004713033221. Epub 2014 Feb 22.


Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis.

Bolduc D, Rahdar M, Tu-Sekine B, Sivakumaren SC, Raben D, Amzel LM, Devreotes P, Gabelli SB, Cole P.

Elife. 2013 Jul 9;2:e00691. doi: 10.7554/eLife.00691.


A UDP-X diphosphatase from Streptococcus pneumoniae hydrolyzes precursors of peptidoglycan biosynthesis.

Duong-Ly KC, Woo HN, Dunn CA, Xu W, Babič A, Bessman MJ, Amzel LM, Gabelli SB.

PLoS One. 2013 May 15;8(5):e64241. doi: 10.1371/journal.pone.0064241. Print 2013.


Asn441 plays a key role in folding and function of the Na+/I- symporter (NIS).

Li W, Nicola JP, Amzel LM, Carrasco N.

FASEB J. 2013 Aug;27(8):3229-38. doi: 10.1096/fj.13-229138. Epub 2013 May 6.


Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.

Zhang F, Bhat S, Gabelli SB, Chen X, Miller MS, Nacev BA, Cheng YL, Meyers DJ, Tenney K, Shim JS, Crews P, Amzel LM, Ma D, Liu JO.

J Med Chem. 2013 May 23;56(10):3996-4016. doi: 10.1021/jm400227z. Epub 2013 May 1.


Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1.

Zhang P, Yang X, Zhang F, Gabelli SB, Wang R, Zhang Y, Bhat S, Chen X, Furlani M, Amzel LM, Liu JO, Ma D.

Bioorg Med Chem. 2013 May 1;21(9):2600-17. doi: 10.1016/j.bmc.2013.02.023. Epub 2013 Feb 21.


Structural and thermodynamic insights into the recognition of native proteins by anti-peptide antibodies.

Armstrong A, Hildreth JEK, Amzel LM.

J Mol Biol. 2013 Jun 12;425(11):2027-2038. doi: 10.1016/j.jmb.2013.02.031. Epub 2013 Mar 6.


Coordination of peroxide to the Cu(M) center of peptidylglycine α-hydroxylating monooxygenase (PHM): structural and computational study.

Rudzka K, Moreno DM, Eipper B, Mains R, Estrin DA, Amzel LM.

J Biol Inorg Chem. 2013 Feb;18(2):223-32. doi: 10.1007/s00775-012-0967-z. Epub 2012 Dec 18.


Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2.

Erdemli SB, Gupta R, Bishai WR, Lamichhane G, Amzel LM, Bianchet MA.

Structure. 2012 Dec 5;20(12):2103-15. doi: 10.1016/j.str.2012.09.016. Epub 2012 Oct 25.


Diversity in recognition of glycans by F-type lectins and galectins: molecular, structural, and biophysical aspects.

Vasta GR, Ahmed H, Bianchet MA, Fernández-Robledo JA, Amzel LM.

Ann N Y Acad Sci. 2012 Apr;1253:E14-26. doi: 10.1111/j.1749-6632.2012.06698.x. Review.


Estimation of free-energy differences from computed work distributions: an application of Jarzynski's equality.

Echeverria I, Amzel LM.

J Phys Chem B. 2012 Sep 13;116(36):10986-95. doi: 10.1021/jp300527q. Epub 2012 Aug 30.


Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.

Aripirala S, Szajnman SH, Jakoncic J, Rodriguez JB, Docampo R, Gabelli SB, Amzel LM.

J Med Chem. 2012 Jul 26;55(14):6445-54. doi: 10.1021/jm300425y. Epub 2012 Jul 5.


Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS).

Paroder-Belenitsky M, Maestas MJ, Dohán O, Nicola JP, Reyna-Neyra A, Follenzi A, Dadachova E, Eskandari S, Amzel LM, Carrasco N.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17933-8. doi: 10.1073/pnas.1108278108. Epub 2011 Oct 19.


Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels.

Mustafa AK, Sikka G, Gazi SK, Steppan J, Jung SM, Bhunia AK, Barodka VM, Gazi FK, Barrow RK, Wang R, Amzel LM, Berkowitz DE, Snyder SH.

Circ Res. 2011 Nov 11;109(11):1259-68. doi: 10.1161/CIRCRESAHA.111.240242. Epub 2011 Oct 6.


Structural and functional diversity of the lectin repertoire in teleost fish: relevance to innate and adaptive immunity.

Vasta GR, Nita-Lazar M, Giomarelli B, Ahmed H, Du S, Cammarata M, Parrinello N, Bianchet MA, Amzel LM.

Dev Comp Immunol. 2011 Dec;35(12):1388-99. doi: 10.1016/j.dci.2011.08.011. Epub 2011 Aug 30. Review.


Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition.

Boto AN, Xu W, Jakoncic J, Pannuri A, Romeo T, Bessman MJ, Gabelli SB, Amzel LM.

Proteins. 2011 Aug;79(8):2455-66. doi: 10.1002/prot.23069. Epub 2011 Jun 2.


Disaccharide binding to galectin-1: free energy calculations and molecular recognition mechanism.

Echeverria I, Amzel LM.

Biophys J. 2011 May 4;100(9):2283-92. doi: 10.1016/j.bpj.2011.03.032.


The Nudix hydrolase CDP-chase, a CDP-choline pyrophosphatase, is an asymmetric dimer with two distinct enzymatic activities.

Duong-Ly KC, Gabelli SB, Xu W, Dunn CA, Schoeffield AJ, Bessman MJ, Amzel LM.

J Bacteriol. 2011 Jul;193(13):3175-85. doi: 10.1128/JB.00089-11. Epub 2011 Apr 29.


The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor.

Yeh TL, Lee CY, Amzel LM, Espenshade PJ, Bianchet MA.

Structure. 2011 Apr 13;19(4):503-14. doi: 10.1016/j.str.2011.01.017.


Direct activation of Epac by sulfonylurea is isoform selective.

Herbst KJ, Coltharp C, Amzel LM, Zhang J.

Chem Biol. 2011 Feb 25;18(2):243-51. doi: 10.1016/j.chembiol.2010.12.007.


Capitalizing on tumor genotyping: towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase.

Gabelli SB, Duong-Ly KC, Brower ET, Amzel LM.

Adv Enzyme Regul. 2011;51(1):273-9. doi: 10.1016/j.advenzreg.2010.09.013. Epub 2010 Oct 28. Review.

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