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Items: 4


Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme.

Amunugama HT, Zhang H, Hollenberg PF.

Drug Metab Dispos. 2012 Sep;40(9):1765-70. doi: 10.1124/dmd.112.045971. Epub 2012 Jun 8.


Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of heme.

Zhang H, Amunugama H, Ney S, Cooper N, Hollenberg PF.

Mol Pharmacol. 2011 Nov;80(5):839-47. doi: 10.1124/mol.111.073783. Epub 2011 Aug 23.


Design of polyamine-based therapeutic agents: new targets and new directions.

Senanayake MD, Amunugama H, Boncher TD, Casero RA, Woster PM.

Essays Biochem. 2009 Nov 4;46:77-94. doi: 10.1042/bse0460006. Review.

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