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Items: 1 to 50 of 103


Airway smooth muscle cells are insensitive to the anti-proliferative effects of corticosteroids: The novel role of insulin growth factor binding Protein-1 in asthma.

Bui H, Amrani Y, Deeney B, Panettieri RA, Tliba O.

Immunobiology. 2019 Jul;224(4):490-496. doi: 10.1016/j.imbio.2019.05.006. Epub 2019 May 23.


Non-genomic Effects of Glucocorticoids: An Updated View.

Panettieri RA, Schaafsma D, Amrani Y, Koziol-White C, Ostrom R, Tliba O.

Trends Pharmacol Sci. 2019 Jan;40(1):38-49. doi: 10.1016/ Epub 2018 Nov 26. Review.


Increased β2-adrenoceptor phosphorylation in airway smooth muscle in severe asthma: possible role of mast cell-derived growth factors.

Chachi L, Alzahrani A, Koziol-White C, Biddle M, Bagadood R, Panettieri RA Jr, Bradding P, Amrani Y.

Clin Exp Immunol. 2018 Nov;194(2):253-258. doi: 10.1111/cei.13191. Epub 2018 Sep 30.


A model of human lung fibrogenesis for the assessment of anti-fibrotic strategies in idiopathic pulmonary fibrosis.

Roach KM, Sutcliffe A, Matthews L, Elliott G, Newby C, Amrani Y, Bradding P.

Sci Rep. 2018 Jan 10;8(1):342. doi: 10.1038/s41598-017-18555-9.


β2-Adrenoceptor Function in Asthma.

Amrani Y, Bradding P.

Adv Immunol. 2017;136:1-28. doi: 10.1016/ Epub 2017 Jul 27. Review.


Alternatives to connective tissue graft in the treatment of localized gingival recessions: A systematic review.

Amine K, El Amrani Y, Chemlali S, Kissa J.

J Stomatol Oral Maxillofac Surg. 2018 Feb;119(1):25-32. doi: 10.1016/j.jormas.2017.09.005. Epub 2017 Sep 9.


Long standing well-tolerated intracorneal thorns.

Regragui A, El Atiqi A, Sabrane I, Handor H, Hafidi Z, Berradi S, Amrani Y, Laghmari M.

J Fr Ophtalmol. 2016 Dec;39(10):e283-e284. doi: 10.1016/j.jfo.2016.03.013. Epub 2016 Oct 13. No abstract available.


Traumatic subconjunctival dislocation of lens.

Regragui A, Hafidi Z, El Atiqi A, Sabrane I, Handor H, Berradi S, Amrani Y, Daoudi R.

J Fr Ophtalmol. 2016 Sep;39(7):658-9. doi: 10.1016/j.jfo.2016.07.002. Epub 2016 Aug 21. No abstract available.


Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma.

Chachi L, Abbasian M, Gavrila A, Alzahrani A, Tliba O, Bradding P, Wardlaw AJ, Brightling C, Amrani Y.

Allergy. 2017 Jan;72(1):126-136. doi: 10.1111/all.13003. Epub 2016 Sep 15.


Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.

Bradley SJ, Wiegman CH, Iglesias MM, Kong KC, Butcher AJ, Plouffe B, Goupil E, Bourgognon JM, Macedo-Hatch T, LeGouill C, Russell K, Laporte SA, König GM, Kostenis E, Bouvier M, Chung KF, Amrani Y, Tobin AB.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4524-9. doi: 10.1073/pnas.1521706113. Epub 2016 Apr 8.


Bidirectional Counterregulation of Human Lung Mast Cell and Airway Smooth Muscle β2 Adrenoceptors.

Lewis RJ, Chachi L, Newby C, Amrani Y, Bradding P.

J Immunol. 2016 Jan 1;196(1):55-63. doi: 10.4049/jimmunol.1402232. Epub 2015 Nov 25.


Fetal human airway smooth muscle cell production of leukocyte chemoattractants is differentially regulated by fluticasone.

Pearson H, Britt RD Jr, Pabelick CM, Prakash YS, Amrani Y, Pandya HC.

Pediatr Res. 2015 Dec;78(6):650-6. doi: 10.1038/pr.2015.168. Epub 2015 Sep 2.


Lipoxin A4 Attenuates Constitutive and TGF-β1-Dependent Profibrotic Activity in Human Lung Myofibroblasts.

Roach KM, Feghali-Bostwick CA, Amrani Y, Bradding P.

J Immunol. 2015 Sep 15;195(6):2852-60. doi: 10.4049/jimmunol.1500936. Epub 2015 Aug 14.


IFN-γ-induced JAK/STAT, but not NF-κB, signaling pathway is insensitive to glucocorticoid in airway epithelial cells.

O'Connell D, Bouazza B, Kokalari B, Amrani Y, Khatib A, Ganther JD, Tliba O.

Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L348-59. doi: 10.1152/ajplung.00099.2015. Epub 2015 Jun 19.


Abnormal corticosteroid signalling in airway smooth muscle: mechanisms and perspectives for the treatment of severe asthma.

Chachi L, Gavrila A, Tliba O, Amrani Y.

Clin Exp Allergy. 2015 Nov;45(11):1637-46. doi: 10.1111/cea.12577. Review.


Effect of the plant derivative Compound A on the production of corticosteroid-resistant chemokines in airway smooth muscle cells.

Gavrila A, Chachi L, Tliba O, Brightling C, Amrani Y.

Am J Respir Cell Mol Biol. 2015 Nov;53(5):728-37. doi: 10.1165/rcmb.2014-0477OC.


Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca(2+)-dependent and regulated by KCa3.1 K(+) channels.

Roach KM, Feghali-Bostwick C, Wulff H, Amrani Y, Bradding P.

Fibrogenesis Tissue Repair. 2015 Mar 26;8:5. doi: 10.1186/s13069-015-0022-0. eCollection 2015.


IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk.

Kaur D, Gomez E, Doe C, Berair R, Woodman L, Saunders R, Hollins F, Rose FR, Amrani Y, May R, Kearley J, Humbles A, Cohen ES, Brightling CE.

Allergy. 2015 May;70(5):556-67. doi: 10.1111/all.12593. Epub 2015 Mar 16.


Secondary hemorrhage in traumatic hyphema.

Hafidi Z, Amrani Y, Berradi S, Handor H, Daoudi R.

QJM. 2015 Jul;108(7):593. doi: 10.1093/qjmed/hcu244. Epub 2014 Dec 17. No abstract available.


Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent.

Roach KM, Wulff H, Feghali-Bostwick C, Amrani Y, Bradding P.

Respir Res. 2014 Dec 5;15:155. doi: 10.1186/s12931-014-0155-5.


D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells.

Stinson SE, Amrani Y, Brightling CE.

J Allergy Clin Immunol. 2015 Feb;135(2):395-406. doi: 10.1016/j.jaci.2014.08.027. Epub 2014 Oct 11.


Vitamin D attenuates cytokine-induced remodeling in human fetal airway smooth muscle cells.

Britt RD Jr, Faksh A, Vogel ER, Thompson MA, Chu V, Pandya HC, Amrani Y, Martin RJ, Pabelick CM, Prakash YS.

J Cell Physiol. 2015 Jun;230(6):1189-98. doi: 10.1002/jcp.24814.


[Congenital ptosis: experience of a tertiary Moroccan center and latest development].

Handor H, Hafidi Z, Bencherif M, Amrani Y, belmokhtar A, Laghmari M, Daoudi R.

Pan Afr Med J. 2014 Oct 15;19:150. doi: 10.11604/pamj.2014.19.150.3072. eCollection 2014. French. No abstract available.


Basal p38 mitogen-activated protein kinase regulates unliganded glucocorticoid receptor function in airway smooth muscle cells.

Bouazza B, Debba-Pavard M, Amrani Y, Isaacs L, O'Connell D, Ahamed S, Formella D, Tliba O.

Am J Respir Cell Mol Biol. 2014 Feb;50(2):301-15. doi: 10.1165/rcmb.2012-0522OC.


Functional KCa3.1 channels regulate steroid insensitivity in bronchial smooth muscle cells.

Chachi L, Shikotra A, Duffy SM, Tliba O, Brightling C, Bradding P, Amrani Y.

J Immunol. 2013 Sep 1;191(5):2624-2636. doi: 10.4049/jimmunol.1300104. Epub 2013 Jul 31.


Smooth muscle hypercontractility in airway hyperresponsiveness: innate, acquired, or nonexistent?

Bossé Y, Rousseau E, Amrani Y, Grunstein MM.

J Allergy (Cairo). 2013;2013:938046. doi: 10.1155/2013/938046. Epub 2013 Jun 17. No abstract available.


Toll-like receptor 9 activation induces expression of membrane-bound B-cell activating factor (BAFF) on human B cells and leads to increased proliferation in response to both soluble and membrane-bound BAFF.

Abu-Rish EY, Amrani Y, Browning MJ.

Rheumatology (Oxford). 2013 Jul;52(7):1190-201. doi: 10.1093/rheumatology/ket006. Epub 2013 Feb 21.


Oxygen dose responsiveness of human fetal airway smooth muscle cells.

Hartman WR, Smelter DF, Sathish V, Karass M, Kim S, Aravamudan B, Thompson MA, Amrani Y, Pandya HC, Martin RJ, Prakash YS, Pabelick CM.

Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15;303(8):L711-9. doi: 10.1152/ajplung.00037.2012. Epub 2012 Aug 24.


Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases.

Bouazza B, Krytska K, Debba-Pavard M, Amrani Y, Honkanen RE, Tran J, Tliba O.

Am J Respir Cell Mol Biol. 2012 Oct;47(4):464-73. doi: 10.1165/rcmb.2011-0364OC. Epub 2012 May 16.


Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes.

Dukes F, Kanterakis S, Lee J, Pietrofesa R, Andersen ES, Arguiri E, Tyagi S, Showe L, Amrani Y, Christofidou-Solomidou M.

BMC Complement Altern Med. 2012 Apr 20;12:47. doi: 10.1186/1472-6882-12-47.


An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma.

Damera G, Druey KM, Cooper PR, Krymskaya VP, Soberman RJ, Amrani Y, Hoshi T, Brightling CE, Panettieri RA Jr.

PLoS One. 2012;7(1):e28504. doi: 10.1371/journal.pone.0028504. Epub 2012 Jan 12.


The Paf oncogene is essential for hematopoietic stem cell function and development.

Amrani YM, Gill J, Matevossian A, Alonzo ES, Yang C, Shieh JH, Moore MA, Park CY, Sant'Angelo DB, Denzin LK.

J Exp Med. 2011 Aug 29;208(9):1757-65. doi: 10.1084/jem.20102170. Epub 2011 Aug 15.


Immunopathogenesis of severe asthma.

Brightling CE, Gupta S, Hollins F, Sutcliffe A, Amrani Y.

Curr Pharm Des. 2011;17(7):667-73. Review.


Identification and in vivo analysis of murine hematopoietic stem cells.

Avagyan S, Amrani YM, Snoeck HW.

Methods Enzymol. 2010;476:429-47. doi: 10.1016/S0076-6879(10)76023-7.


Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13.

Amrani Y, Syed F, Huang C, Li K, Liu V, Jain D, Keslacy S, Sims MW, Baidouri H, Cooper PR, Zhao H, Siddiqui S, Brightling CE, Griswold D, Li L, Panettieri RA Jr.

Respir Res. 2010 Jul 29;11:104. doi: 10.1186/1465-9921-11-104.


Counterregulation of beta(2)-adrenoceptor function in human mast cells by stem cell factor.

Cruse G, Yang W, Duffy SM, Chachi L, Leyland M, Amrani Y, Bradding P.

J Allergy Clin Immunol. 2010 Jan;125(1):257-63.e1-5. doi: 10.1016/j.jaci.2009.08.020. Epub 2009 Oct 27.


Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells.

Bhandare R, Damera G, Banerjee A, Flammer JR, Keslacy S, Rogatsky I, Panettieri RA, Amrani Y, Tliba O.

Am J Respir Cell Mol Biol. 2010 Jan;42(1):9-15. doi: 10.1165/rcmb.2009-0239RC. Epub 2009 Oct 5.


Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis.

Goncharova EA, Goncharov DA, Damera G, Tliba O, Amrani Y, Panettieri RA Jr, Krymskaya VP.

Mol Pharmacol. 2009 Oct;76(4):766-77. doi: 10.1124/mol.109.057042. Epub 2009 Jul 13.


Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production.

Bailey MT, Kierstein S, Sharma S, Spaits M, Kinsey SG, Tliba O, Amrani Y, Sheridan JF, Panettieri RA, Haczku A.

J Immunol. 2009 Jun 15;182(12):7888-96. doi: 10.4049/jimmunol.0800891. Erratum in: J Immunol. 2009 Sep 1;183(5):3551. Amrani, Yassine [added].


Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsiveness.

Jain D, Keslacy S, Tliba O, Cao Y, Kierstein S, Amin K, Panettieri RA Jr, Haczku A, Amrani Y.

Immunobiology. 2008;213(6):499-509. doi: 10.1016/j.imbio.2007.12.002. Epub 2008 Jan 29.


Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized mice.

Kierstein S, Krytska K, Sharma S, Amrani Y, Salmon M, Panettieri RA Jr, Zangrilli J, Haczku A.

Allergy. 2008 Apr;63(4):438-46. doi: 10.1111/j.1398-9995.2007.01587.x.


Is airway smooth muscle the "missing link" modulating airway inflammation in asthma?

Tliba O, Amrani Y, Panettieri RA Jr.

Chest. 2008 Jan;133(1):236-42. doi: 10.1378/chest.07-0262. Review.


Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation.

Goncharova EA, Goncharov DA, Chisolm A, Spaits MS, Lim PN, Cesarone G, Khavin I, Tliba O, Amrani Y, Panettieri RA Jr, Krymskaya VP.

Mol Pharmacol. 2008 Mar;73(3):778-88. Epub 2007 Dec 19.


Targeting TNF-alpha: a novel therapeutic approach for asthma.

Brightling C, Berry M, Amrani Y.

J Allergy Clin Immunol. 2008 Jan;121(1):5-10; quiz 11-2. Epub 2007 Nov 26. Review.


Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1.

Tliba O, Damera G, Banerjee A, Gu S, Baidouri H, Keslacy S, Amrani Y.

Am J Respir Cell Mol Biol. 2008 Apr;38(4):463-72. Epub 2007 Oct 18.


TNF-alpha and calcium signaling in airway smooth muscle cells: a never-ending story with promising therapeutic relevance.

Amrani Y.

Am J Respir Cell Mol Biol. 2007 Mar;36(3):387-8. No abstract available.


[Gallbladder volvulus: Two cases].

Amrani Y, Ounani M, Beavogui L, Sedki N, Elabsi M, Echerrab M, Alami F, Amraoui M, Errougani A, Chkoff R, Zizi A.

Presse Med. 2006 Oct;35(10 Pt 1):1479-81. French.


Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice.

Kinniry P, Amrani Y, Vachani A, Solomides CC, Arguiri E, Workman A, Carter J, Christofidou-Solomidou M.

J Nutr. 2006 Jun;136(6):1545-51.


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