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Hypothalamic Gliosis by MRI and Visceral Fat Mass Negatively Correlate with Plasma Testosterone Concentrations in Healthy Men.

Berkseth KE, Rubinow KB, Melhorn SJ, Webb MF, Rosalynn B De Leon M, Marck BT, Matsumoto AM, Amory JK, Page ST, Schur EA.

Obesity (Silver Spring). 2018 Dec;26(12):1898-1904. doi: 10.1002/oby.22324.


Male hormonal contraceptive - are we there yet?

Page ST, Amory JK.

Nat Rev Endocrinol. 2018 Dec;14(12):685-686. doi: 10.1038/s41574-018-0111-4. No abstract available.


Effects of 28 Days of Oral Dimethandrolone Undecanoate in Healthy Men: A Prototype Male Pill.

Thirumalai A, Ceponis J, Amory JK, Swerdloff R, Surampudi V, Liu PY, Bremner WJ, Harvey E, Blithe DL, Lee MS, Hull L, Wang C, Page ST.

J Clin Endocrinol Metab. 2018 Sep 24. doi: 10.1210/jc.2018-01452. [Epub ahead of print]


Safety and Pharmacokinetics of Single Dose Novel Oral Androgen 11β-Methyl-19-Nortestosterone-17β-dodecylcarbonate in Mena.

Wu S, Yuen F, Swerdloff RS, Pak Y, Thirumalai A, Liu PY, Amory JK, Bai F, Hull L, Blithe DL, Anawalt BD, Parman T, Kim K, Lee MS, Bremner WJ, Page ST, Wang C.

J Clin Endocrinol Metab. 2018 Sep 24. doi: 10.1210/jc.2018-01528. [Epub ahead of print]


Effect of Dose and 5α-Reductase Inhibition on the Circulating Testosterone Metabolite Profile of Men Administered Oral Testosterone.

Basit A, Amory JK, Prasad B.

Clin Transl Sci. 2018 Sep;11(5):513-522. doi: 10.1111/cts.12569. Epub 2018 Jun 19.


Can inhibition of retinoic acid biosynthesis function as a non-hormonal female contraceptive?

Paik J, Treuting PM, Haenisch M, Amory JK.

Contraception. 2018 Apr 7. pii: S0010-7824(18)30136-7. doi: 10.1016/j.contraception.2018.03.035. [Epub ahead of print]


Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

Bhatt DK, Basit A, Zhang H, Gaedigk A, Lee SB, Claw KG, Mehrotra A, Chaudhry AS, Pearce RE, Gaedigk R, Broeckel U, Thornton TA, Nickerson DA, Schuetz EG, Amory JK, Leeder JS, Prasad B.

Drug Metab Dispos. 2018 Jun;46(6):888-896. doi: 10.1124/dmd.118.080952. Epub 2018 Mar 30.


Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors.

Chen Y, Zhu JY, Hong KH, Mikles DC, Georg GI, Goldstein AS, Amory JK, Schönbrunn E.

ACS Chem Biol. 2018 Mar 16;13(3):582-590. doi: 10.1021/acschembio.7b00685. Epub 2018 Jan 3.


Isotretinoin administration improves sperm production in men with infertility from oligoasthenozoospermia: a pilot study.

Amory JK, Ostrowski KA, Gannon JR, Berkseth K, Stevison F, Isoherranen N, Muller CH, Walsh T.

Andrology. 2017 Nov;5(6):1115-1123. doi: 10.1111/andr.12420. Epub 2017 Oct 5.


Pharmacological inhibition of ALDH1A enzymes suppresses weight gain in a mouse model of diet-induced obesity.

Haenisch M, Treuting PM, Brabb T, Goldstein AS, Berkseth K, Amory JK, Paik J.

Obes Res Clin Pract. 2018 Jan - Feb;12(1):93-101. doi: 10.1016/j.orcp.2017.08.003. Epub 2017 Sep 12.


Circulating sex steroids coregulate adipose tissue immune cell populations in healthy men.

Rubinow KB, Chao JH, Hagman D, Kratz M, Van Yserloo B, Gaikwad NW, Amory JK, Page ST.

Am J Physiol Endocrinol Metab. 2017 Nov 1;313(5):E528-E539. doi: 10.1152/ajpendo.00075.2017. Epub 2017 Jul 11.


Scholarly productivity and professional advancement of junior researchers receiving KL2, K23, or K08 awards at a large public research institution.

Amory JK, Louden DKN, McKinney C, Rich J, Long-Genovese S, Disis ML.

J Clin Transl Sci. 2017 Apr;1(2):140-143. doi: 10.1017/cts.2016.22. Epub 2017 Apr 19.


Dose-response effects of sex hormone concentrations on body composition and adipokines in medically castrated healthy men administered graded doses of testosterone gel.

Thirumalai A, Rubinow KB, Cooper LA, Amory JK, Marck BT, Matsumoto AM, Page ST.

Clin Endocrinol (Oxf). 2017 Jul;87(1):59-67. doi: 10.1111/cen.13342. Epub 2017 Apr 26.


Physiologically Based Pharmacokinetic Model of All-trans-Retinoic Acid with Application to Cancer Populations and Drug Interactions.

Jing J, Nelson C, Paik J, Shirasaka Y, Amory JK, Isoherranen N.

J Pharmacol Exp Ther. 2017 May;361(2):246-258. doi: 10.1124/jpet.117.240523. Epub 2017 Mar 8.


Treatment of Hypogonadism: Current and Future Therapies.

Thirumalai A, Berkseth KE, Amory JK.

F1000Res. 2017 Jan 23;6:68. doi: 10.12688/f1000research.10102.1. eCollection 2017. Review.


Comparison of the single dose pharmacokinetics, pharmacodynamics, and safety of two novel oral formulations of dimethandrolone undecanoate (DMAU): a potential oral, male contraceptive.

Ayoub R, Page ST, Swerdloff RS, Liu PY, Amory JK, Leung A, Hull L, Blithe D, Christy A, Chao JH, Bremner WJ, Wang C.

Andrology. 2017 Mar;5(2):278-285. doi: 10.1111/andr.12303. Epub 2016 Dec 1.


Male contraception.

Amory JK.

Fertil Steril. 2016 Nov;106(6):1303-1309. doi: 10.1016/j.fertnstert.2016.08.036. Epub 2016 Sep 24. Review.


Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men.

Chao J, Rubinow KB, Kratz M, Amory JK, Matsumoto AM, Page ST.

J Clin Endocrinol Metab. 2016 Oct;101(10):3724-3731. Epub 2016 Aug 2.


Pharmacologic Therapy in Men's Health: Hypogonadism, Erectile Dysfunction, and Benign Prostatic Hyperplasia.

Berkseth KE, Thirumalai A, Amory JK.

Med Clin North Am. 2016 Jul;100(4):791-805. doi: 10.1016/j.mcna.2016.03.006. Review.


Stable Intraprostatic Dihydrotestosterone in Healthy Medically Castrate Men Treated With Exogenous Testosterone.

Thirumalai A, Cooper LA, Rubinow KB, Amory JK, Lin DW, Wright JL, Marck BT, Matsumoto AM, Page ST.

J Clin Endocrinol Metab. 2016 Jul;101(7):2937-44. doi: 10.1210/jc.2016-1483. Epub 2016 May 12.


Beyond the Condom: Frontiers in Male Contraception.

Roth MY, Amory JK.

Semin Reprod Med. 2016 May;34(3):183-90. doi: 10.1055/s-0036-1571435. Epub 2016 Mar 4. Review.


Systemic Lupus Erythematosus in an Elderly Man Diagnosed by the Presence of Pericardial Fluid Lupus Erythematosus Cells.

Lee JC, Amory JK, Don CW.

Am J Med. 2016 Mar;129(3):e17-8. doi: 10.1016/j.amjmed.2015.10.023. Epub 2015 Nov 6. No abstract available.


Testicular fine-needle aspiration for the assessment of intratesticular hormone concentrations.

Lee AP, Roth MY, Nya-Ngatchou JJ, Lin K, Walsh TJ, Page ST, Matsumoto AM, Bremner WJ, Amory JK, Anawalt BD.

Asian J Androl. 2016 Jan-Feb;18(1):21-4. doi: 10.4103/1008-682X.156637.


The association of obesity with sex hormone-binding globulin is stronger than the association with ageing--implications for the interpretation of total testosterone measurements.

Cooper LA, Page ST, Amory JK, Anawalt BD, Matsumoto AM.

Clin Endocrinol (Oxf). 2015 Dec;83(6):828-33. doi: 10.1111/cen.12768. Epub 2015 May 11.


Pharmacological inhibition of ALDH1A in mice decreases all-trans retinoic acid concentrations in a tissue specific manner.

Arnold SL, Kent T, Hogarth CA, Griswold MD, Amory JK, Isoherranen N.

Biochem Pharmacol. 2015 Jun 1;95(3):177-92. doi: 10.1016/j.bcp.2015.03.001. Epub 2015 Mar 9.


Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations.

Arnold SL, Kent T, Hogarth CA, Schlatt S, Prasad B, Haenisch M, Walsh T, Muller CH, Griswold MD, Amory JK, Isoherranen N.

J Lipid Res. 2015 Feb;56(2):342-57. doi: 10.1194/jlr.M054718. Epub 2014 Dec 11.


Providers' beliefs about expressing condolences to the family of a deceased patient: a qualitative and quantitative analysis.

Merel SE, Stafford MM, White AA, Fligner CL, Amory JK, Hagman MM.

J Palliat Med. 2015 Mar;18(3):217-24. doi: 10.1089/jpm.2014.0217. Epub 2014 Dec 10.


Acceptability of a transdermal gel-based male hormonal contraceptive in a randomized controlled trial.

Roth MY, Shih G, Ilani N, Wang C, Page ST, Bremner WJ, Swerdloff RS, Sitruk-Ware R, Blithe DL, Amory JK.

Contraception. 2014 Oct;90(4):407-12. doi: 10.1016/j.contraception.2014.05.013. Epub 2014 Jun 2.


Single, escalating dose pharmacokinetics, safety and food effects of a new oral androgen dimethandrolone undecanoate in man: a prototype oral male hormonal contraceptive.

Surampudi P, Page ST, Swerdloff RS, Nya-Ngatchou JJ, Liu PY, Amory JK, Leung A, Hull L, Blithe DL, Woo J, Bremner WJ, Wang C.

Andrology. 2014 Jul;2(4):579-587. doi: 10.1111/j.2047-2927.2014.00216.x. Epub 2014 May 2.


Melphalan, alone or conjugated to an FSH-β peptide, kills murine testicular cells in vitro and transiently suppresses murine spermatogenesis in vivo.

Amory JK, Hong S, Yu X, Muller CH, Faustman E, Goldstein A.

Theriogenology. 2014 Jul 1;82(1):152-9. doi: 10.1016/j.theriogenology.2014.03.014. Epub 2014 Mar 27.


Inhibition of retinoic acid biosynthesis by the bisdichloroacetyldiamine WIN 18,446 markedly suppresses spermatogenesis and alters retinoid metabolism in mice.

Paik J, Haenisch M, Muller CH, Goldstein AS, Arnold S, Isoherranen N, Brabb T, Treuting PM, Amory JK.

J Biol Chem. 2014 May 23;289(21):15104-17. doi: 10.1074/jbc.M113.540211. Epub 2014 Apr 7.


Levels of the retinoic acid synthesizing enzyme aldehyde dehydrogenase-1A2 are lower in testicular tissue from men with infertility.

Amory JK, Arnold S, Lardone MC, Piottante A, Ebensperger M, Isoherranen N, Muller CH, Walsh T, Castro A.

Fertil Steril. 2014 Apr;101(4):960-6. doi: 10.1016/j.fertnstert.2013.12.053. Epub 2014 Feb 10.


Characteristics associated with suppression of spermatogenesis in a male hormonal contraceptive trial using testosterone and Nestorone(®) gels.

Roth MY, Ilani N, Wang C, Page ST, Bremner WJ, Swerdloff RS, Dart C, Sitruk-Ware R, Kumar N, Blithe D, Amory JK.

Andrology. 2013 Nov;1(6):899-905. doi: 10.1111/j.2047-2927.2013.00135.x. Epub 2013 Sep 30.


Intratesticular 13-cis retinoic acid is lower in men with abnormal semen analyses: a pilot study.

Nya-Ngatchou JJ, Arnold SL, Walsh TJ, Muller CH, Page ST, Isoherranen N, Amory JK.

Andrology. 2013 Mar;1(2):325-31. doi: 10.1111/j.2047-2927.2012.00033.x. Epub 2012 Nov 29.


Androgen synthesis in the gonadotropin-suppressed human testes can be markedly suppressed by ketoconazole.

Roth MY, Nya-Ngatchou JJ, Lin K, Page ST, Anawalt BD, Matsumoto AM, Marck BT, Bremner WJ, Amory JK.

J Clin Endocrinol Metab. 2013 Mar;98(3):1198-206. doi: 10.1210/jc.2012-3527. Epub 2013 Jan 24.


Turning a spermatogenic wave into a tsunami: synchronizing murine spermatogenesis using WIN 18,446.

Hogarth CA, Evanoff R, Mitchell D, Kent T, Small C, Amory JK, Griswold MD.

Biol Reprod. 2013 Feb 14;88(2):40. doi: 10.1095/biolreprod.112.105346. Print 2013 Feb.


Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trial.

Roth MY, Lin K, Bay K, Amory JK, Anawalt BD, Matsumoto AM, Marck BT, Bremner WJ, Page ST.

Fertil Steril. 2013 Jan;99(1):132-9. doi: 10.1016/j.fertnstert.2012.09.009. Epub 2012 Oct 3.


New approaches to male non-hormonal contraception.

Nya-Ngatchou JJ, Amory JK.

Contraception. 2013 Mar;87(3):296-9. doi: 10.1016/j.contraception.2012.08.016. Epub 2012 Sep 17. Review.


Study clarifies associations between hypogonadism and health in aging men.

Amory JK.

Asian J Androl. 2012 Nov;14(6):809-10. doi: 10.1038/aja.2012.78. Epub 2012 Jul 30.


A new combination of testosterone and nestorone transdermal gels for male hormonal contraception.

Ilani N, Roth MY, Amory JK, Swerdloff RS, Dart C, Page ST, Bremner WJ, Sitruk-Ware R, Kumar N, Blithe DL, Wang C.

J Clin Endocrinol Metab. 2012 Oct;97(10):3476-86. doi: 10.1210/jc.2012-1384. Epub 2012 Jul 12.


Impact of male hormonal contraception on prostate androgens and androgen action in healthy men: a randomized, controlled trial.

Mostaghel EA, Lin DW, Amory JK, Wright JL, Marck BT, Nelson PS, Matsumoto AM, Bremner WJ, Page ST.

J Clin Endocrinol Metab. 2012 Aug;97(8):2809-17. doi: 10.1210/jc.2012-1536. Epub 2012 Jun 1.


Impact of mifepristone, a glucocorticoid/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL function.

Page ST, Krauss RM, Gross C, Ishida B, Heinecke JW, Tang C, Amory JK, Schaefer PM, Cox CJ, Kane J, Purnell JQ, Weinstein RL, Vaisar T.

J Clin Endocrinol Metab. 2012 May;97(5):1598-605. doi: 10.1210/jc.2011-2813. Epub 2012 Mar 7.


Acute sex steroid withdrawal increases cholesterol efflux capacity and HDL-associated clusterin in men.

Rubinow KB, Tang C, Hoofnagle AN, Snyder CN, Amory JK, Heinecke JW, Page ST.

Steroids. 2012 Apr;77(5):454-60. doi: 10.1016/j.steroids.2012.01.002. Epub 2012 Jan 15.


A sensitive and specific method for measurement of multiple retinoids in human serum with UHPLC-MS/MS.

Arnold SL, Amory JK, Walsh TJ, Isoherranen N.

J Lipid Res. 2012 Mar;53(3):587-98. doi: 10.1194/jlr.D019745. Epub 2011 Dec 22.


The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance.

Moreb JS, Ucar D, Han S, Amory JK, Goldstein AS, Ostmark B, Chang LJ.

Chem Biol Interact. 2012 Jan 5;195(1):52-60. doi: 10.1016/j.cbi.2011.10.007. Epub 2011 Nov 3.


Pharmacokinetics of modified slow-release oral testosterone over 9 days in normal men with experimental hypogonadism.

Lee A, Rubinow K, Clark RV, Caricofe RB, Bush MA, Zhi H, Roth MY, Page ST, Bremner WJ, Amory JK.

J Androl. 2012 May-Jun;33(3):420-6. doi: 10.2164/jandrol.111.014514. Epub 2011 Aug 25.


Acute testosterone deprivation reduces insulin sensitivity in men.

Rubinow KB, Snyder CN, Amory JK, Hoofnagle AN, Page ST.

Clin Endocrinol (Oxf). 2012 Feb;76(2):281-8. doi: 10.1111/j.1365-2265.2011.04189.x.


Hyperthyroidism from autoimmune thyroiditis in a man with type 1 diabetes mellitus: a case report.

Amory JK, Hirsch IB.

J Med Case Rep. 2011 Jul 3;5:277. doi: 10.1186/1752-1947-5-277.


Androgens exert sexually dimorphic effects on angiogenesis: novel insight into the relationship between androgens and cardiovascular disease.

Rubinow KB, Amory JK, Page ST.

Asian J Androl. 2011 Jul;13(4):626-7. doi: 10.1038/aja.2011.80. Epub 2011 Jun 13. No abstract available.


Dutasteride reduces prostate size and prostate specific antigen in older hypogonadal men with benign prostatic hyperplasia undergoing testosterone replacement therapy.

Page ST, Hirano L, Gilchriest J, Dighe M, Amory JK, Marck BT, Matsumoto AM.

J Urol. 2011 Jul;186(1):191-7. doi: 10.1016/j.juro.2011.03.026. Epub 2011 May 14.

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