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Items: 1 to 50 of 104

1.

Repurposing of statins via inhalation to treat lung inflammatory conditions.

Bradbury P, Traini D, Ammit AJ, Young PM, Ong HX.

Adv Drug Deliv Rev. 2018 Jun 8. pii: S0169-409X(18)30142-X. doi: 10.1016/j.addr.2018.06.005. [Epub ahead of print]

PMID:
29890243
2.

Selectively targeting prostanoid E (EP) receptor-mediated cell signalling pathways: Implications for lung health and disease.

Lebender LF, Prünte L, Rumzhum NN, Ammit AJ.

Pulm Pharmacol Ther. 2018 Apr;49:75-87. doi: 10.1016/j.pupt.2018.01.008. Epub 2018 Jan 31. Review.

PMID:
29408043
3.

MAPK p38 regulates inflammatory gene expression via tristetraprolin: Doing good by stealth.

O'Neil JD, Ammit AJ, Clark AR.

Int J Biochem Cell Biol. 2018 Jan;94:6-9. doi: 10.1016/j.biocel.2017.11.003. Epub 2017 Nov 8.

4.

para-Sulfonatocalix[4]arene and polyamidoamine dendrimer nanocomplexes as delivery vehicles for a novel platinum anticancer agent.

Pang CT, Ammit AJ, Ong YQE, Wheate NJ.

J Inorg Biochem. 2017 Nov;176:1-7. doi: 10.1016/j.jinorgbio.2017.08.002. Epub 2017 Aug 8.

PMID:
28810174
5.

Role and regulation of MKP-1 in airway inflammation.

Moosavi SM, Prabhala P, Ammit AJ.

Respir Res. 2017 Aug 10;18(1):154. doi: 10.1186/s12931-017-0637-3. Review.

6.

Targeting PP2A and proteasome activity ameliorates features of allergic airway disease in mice.

Nair PM, Starkey MR, Haw TJ, Liu G, Horvat JC, Morris JC, Verrills NM, Clark AR, Ammit AJ, Hansbro PM.

Allergy. 2017 Dec;72(12):1891-1903. doi: 10.1111/all.13212. Epub 2017 Jun 21.

PMID:
28543283
7.

Doxofylline does not increase formoterol-induced cAMP nor MKP-1 expression in ASM cells resulting in lack of anti-inflammatory effect.

Patel BS, Kugel MJ, Baehring G, Ammit AJ.

Pulm Pharmacol Ther. 2017 Aug;45:34-39. doi: 10.1016/j.pupt.2017.04.006. Epub 2017 Apr 13.

PMID:
28414142
8.

Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation.

Chai AB, Ammit AJ, Gelissen IC.

Respir Res. 2017 Feb 28;18(1):41. doi: 10.1186/s12931-017-0526-9. Review.

9.

Roflumilast N-Oxide in Combination with Formoterol Enhances the Antiinflammatory Effect of Dexamethasone in Airway Smooth Muscle Cells.

Patel BS, Rahman MM, Baehring G, Xenaki D, Tang FS, Oliver BG, Ammit AJ.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):532-538. doi: 10.1165/rcmb.2016-0191OC.

PMID:
27997807
10.

The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells.

Rahman MM, Prünte L, Lebender LF, Patel BS, Gelissen I, Hansbro PM, Morris JC, Clark AR, Verrills NM, Ammit AJ.

Sci Rep. 2016 Nov 16;6:37297. doi: 10.1038/srep37297.

11.

TLR2 ligation induces corticosteroid insensitivity in A549 lung epithelial cells: Anti-inflammatory impact of PP2A activators.

Rahman MM, Prabhala P, Rumzhum NN, Patel BS, Wickop T, Hansbro PM, Verrills NM, Ammit AJ.

Int J Biochem Cell Biol. 2016 Sep;78:279-287. doi: 10.1016/j.biocel.2016.07.030. Epub 2016 Jul 28.

PMID:
27477309
12.

A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro.

Tang FS, Hansbro PM, Burgess JK, Ammit AJ, Baines KJ, Oliver BG.

Thorax. 2016 Nov;71(11):1039-1049. doi: 10.1136/thoraxjnl-2015-207781. Epub 2016 Jun 10.

13.

Prostaglandin E2 induces expression of MAPK phosphatase 1 (MKP-1) in airway smooth muscle cells.

Rumzhum NN, Ammit AJ.

Eur J Pharmacol. 2016 Jul 5;782:1-5. doi: 10.1016/j.ejphar.2016.04.041. Epub 2016 Apr 21.

PMID:
27108790
14.

Corticosteroid-Induced MKP-1 Represses Pro-Inflammatory Cytokine Secretion by Enhancing Activity of Tristetraprolin (TTP) in ASM Cells.

Prabhala P, Bunge K, Ge Q, Ammit AJ.

J Cell Physiol. 2016 Oct;231(10):2153-8. doi: 10.1002/jcp.25327. Epub 2016 Feb 16.

PMID:
26825339
15.

Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells.

Rahman MM, Rumzhum NN, Hansbro PM, Morris JC, Clark AR, Verrills NM, Ammit AJ.

Cell Signal. 2016 Apr;28(4):325-34. doi: 10.1016/j.cellsig.2016.01.009. Epub 2016 Jan 26.

PMID:
26820662
16.

Cyclooxygenase 2: its regulation, role and impact in airway inflammation.

Rumzhum NN, Ammit AJ.

Clin Exp Allergy. 2016 Mar;46(3):397-410. doi: 10.1111/cea.12697. Review.

PMID:
26685098
17.

IL-17A increases TNF-α-induced COX-2 protein stability and augments PGE2 secretion from airway smooth muscle cells: impact on β2 -adrenergic receptor desensitization.

Rumzhum NN, Patel BS, Prabhala P, Gelissen IC, Oliver BG, Ammit AJ.

Allergy. 2016 Mar;71(3):387-96. doi: 10.1111/all.12810. Epub 2015 Dec 21.

PMID:
26606373
18.

Theophylline Represses IL-8 Secretion from Airway Smooth Muscle Cells Independently of Phosphodiesterase Inhibition. Novel Role as a Protein Phosphatase 2A Activator.

Patel BS, Rahman MM, Rumzhum NN, Oliver BG, Verrills NM, Ammit AJ.

Am J Respir Cell Mol Biol. 2016 Jun;54(6):792-801. doi: 10.1165/rcmb.2015-0308OC.

PMID:
26574643
19.

Effect of Sphingosine 1-Phosphate on Cyclo-Oxygenase-2 Expression, Prostaglandin E2 Secretion, and β2-Adrenergic Receptor Desensitization.

Rumzhum NN, Rahman MM, Oliver BG, Ammit AJ.

Am J Respir Cell Mol Biol. 2016 Jan;54(1):128-35. doi: 10.1165/rcmb.2014-0443OC.

PMID:
26098693
20.

Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide.

Smallie T, Ross EA, Ammit AJ, Cunliffe HE, Tang T, Rosner DR, Ridley ML, Buckley CD, Saklatvala J, Dean JL, Clark AR.

J Immunol. 2015 Jul 1;195(1):277-88. doi: 10.4049/jimmunol.1402830. Epub 2015 May 27.

21.

Basal protein phosphatase 2A activity restrains cytokine expression: role for MAPKs and tristetraprolin.

Rahman MM, Rumzhum NN, Morris JC, Clark AR, Verrills NM, Ammit AJ.

Sci Rep. 2015 May 18;5:10063. doi: 10.1038/srep10063.

22.

Repression of breast cancer cell growth by proteasome inhibitors in vitro: impact of mitogen-activated protein kinase phosphatase 1.

Patel BS, Co WS, Donat C, Wang M, Che W, Prabhala P, Schuster F, Schulz V, Martin JL, Ammit AJ.

Cancer Biol Ther. 2015;16(5):780-9. doi: 10.1080/15384047.2015.1026465. Epub 2015 Mar 16.

23.

Temporal regulation of cytokine mRNA expression by tristetraprolin: dynamic control by p38 MAPK and MKP-1.

Prabhala P, Bunge K, Rahman MM, Ge Q, Clark AR, Ammit AJ.

Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L973-80. doi: 10.1152/ajplung.00219.2014. Epub 2015 Feb 27.

24.

Role of dynamin in elongated cell migration in a 3D matrix.

Lees JG, Gorgani NN, Ammit AJ, McCluskey A, Robinson PJ, O'Neill GM.

Biochim Biophys Acta. 2015 Mar;1853(3):611-8. doi: 10.1016/j.bbamcr.2014.12.008. Epub 2014 Dec 10.

25.

Tristetraprolin and its role in regulation of airway inflammation.

Prabhala P, Ammit AJ.

Mol Pharmacol. 2015 Apr;87(4):629-38. doi: 10.1124/mol.114.095984. Epub 2014 Nov 26. Review.

26.

Role of mitogen-activated protein kinase phosphatase-1 in corticosteroid insensitivity of chronic oxidant lung injury.

Pinart M, Hussain F, Shirali S, Li F, Zhu J, Clark AR, Ammit AJ, Chung KF.

Eur J Pharmacol. 2014 Dec 5;744:108-14. doi: 10.1016/j.ejphar.2014.10.003. Epub 2014 Oct 12.

27.
28.

The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells.

Gurgis FM, Yeung YT, Tang MX, Heng B, Buckland M, Ammit AJ, Haapasalo J, Haapasalo H, Guillemin GJ, Grewal T, Munoz L.

Oncogene. 2015 May 28;34(22):2934-42. doi: 10.1038/onc.2014.225. Epub 2014 Aug 4.

PMID:
25088200
29.

TLR2 activation causes tachyphylaxis to β2 -agonists in vitro and ex vivo: modelling bacterial exacerbation.

Alkhouri H, Rumzhum NN, Rahman MM, FitzPatrick M, de Pedro M, Oliver BG, Bourke JE, Ammit AJ.

Allergy. 2014 Sep;69(9):1215-22. doi: 10.1111/all.12449. Epub 2014 Jul 3.

PMID:
24862376
30.

Regulation of pulmonary inflammation by mesenchymal cells.

Alkhouri H, Poppinga WJ, Tania NP, Ammit A, Schuliga M.

Pulm Pharmacol Ther. 2014 Dec;29(2):156-65. doi: 10.1016/j.pupt.2014.03.001. Epub 2014 Mar 20. Review.

PMID:
24657485
31.

Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids.

Rahman MM, Alkhouri H, Tang F, Che W, Ge Q, Ammit AJ.

PLoS One. 2014 Mar 19;9(3):e92466. doi: 10.1371/journal.pone.0092466. eCollection 2014.

32.

The NLRP3 inflammasome: role in airway inflammation.

Im H, Ammit AJ.

Clin Exp Allergy. 2014 Feb;44(2):160-72. doi: 10.1111/cea.12206. Review.

PMID:
24118105
33.

Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogen-activated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1.

Che W, Parmentier J, Seidel P, Manetsch M, Ramsay EE, Alkhouri H, Ge Q, Armour CL, Ammit AJ.

Am J Respir Cell Mol Biol. 2014 Feb;50(2):358-68. doi: 10.1165/rcmb.2013-0208OC.

PMID:
24032470
34.

The nucleotide-binding domain and leucine-rich repeat protein-3 inflammasome is not activated in airway smooth muscle upon toll-like receptor-2 ligation.

Hirota JA, Im H, Rahman MM, Rumzhum NN, Manetsch M, Pascoe CD, Bunge K, Alkhouri H, Oliver BG, Ammit AJ.

Am J Respir Cell Mol Biol. 2013 Oct;49(4):517-24. doi: 10.1165/rcmb.2013-0047OC.

PMID:
23614732
35.

Long-acting β2-agonists increase fluticasone propionate-induced mitogen-activated protein kinase phosphatase 1 (MKP-1) in airway smooth muscle cells.

Manetsch M, Rahman MM, Patel BS, Ramsay EE, Rumzhum NN, Alkhouri H, Ge Q, Ammit AJ.

PLoS One. 2013;8(3):e59635. doi: 10.1371/journal.pone.0059635. Epub 2013 Mar 22.

36.

Glucocorticoid insensitivity as a source of drug targets for respiratory disease.

Ammit AJ.

Curr Opin Pharmacol. 2013 Jun;13(3):370-6. doi: 10.1016/j.coph.2013.02.001. Epub 2013 Feb 19. Review.

PMID:
23434363
37.

Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells.

Che W, Manetsch M, Quante T, Rahman MM, Patel BS, Ge Q, Ammit AJ.

Biochim Biophys Acta. 2012 Oct;1823(10):1658-65. doi: 10.1016/j.bbamcr.2012.06.011. Epub 2012 Jun 25.

38.

Pro-inflammatory and immunomodulatory functions of airway smooth muscle: emerging concepts.

Xia YC, Redhu NS, Moir LM, Koziol-White C, Ammit AJ, Al-Alwan L, Camoretti-Mercado B, Clifford RL.

Pulm Pharmacol Ther. 2013 Feb;26(1):64-74. doi: 10.1016/j.pupt.2012.05.006. Epub 2012 May 24. Review.

PMID:
22634303
39.

Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition.

Allen JC, Seidel P, Schlosser T, Ramsay EE, Ge Q, Ammit AJ.

J Allergy (Cairo). 2012;2012:307838. doi: 10.1155/2012/307838. Epub 2012 Feb 19.

40.

Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement.

Alrashdan YA, Alkhouri H, Chen E, Lalor DJ, Poniris M, Henness S, Brightling CE, Burgess JK, Armour CL, Ammit AJ, Hughes JM.

Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L1118-27. doi: 10.1152/ajplung.00232.2011. Epub 2012 Mar 2.

41.

Corticosteroids and β₂-agonists upregulate mitogen-activated protein kinase phosphatase 1: in vitro mechanisms.

Manetsch M, Ramsay EE, King EM, Seidel P, Che W, Ge Q, Hibbs DE, Newton R, Ammit AJ.

Br J Pharmacol. 2012 Aug;166(7):2049-59. doi: 10.1111/j.1476-5381.2012.01923.x.

42.
43.

TLR2 ligand engagement upregulates airway smooth muscle TNFα-induced cytokine production.

Manetsch M, Seidel P, Heintz U, Che W, Hughes JM, Ge Q, Sukkar MB, Ammit AJ.

Am J Physiol Lung Cell Mol Physiol. 2012 May 1;302(9):L838-45. doi: 10.1152/ajplung.00317.2011. Epub 2012 Jan 13.

44.

MKP-1: a negative feedback effector that represses MAPK-mediated pro-inflammatory signaling pathways and cytokine secretion in human airway smooth muscle cells.

Manetsch M, Che W, Seidel P, Chen Y, Ammit AJ.

Cell Signal. 2012 Apr;24(4):907-13. doi: 10.1016/j.cellsig.2011.12.013. Epub 2011 Dec 19.

PMID:
22200679
45.

β2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers.

Niimi K, Ge Q, Moir LM, Ammit AJ, Trian T, Burgess JK, Black JL, Oliver BG.

Am J Physiol Lung Cell Mol Physiol. 2012 Feb 1;302(3):L334-42. doi: 10.1152/ajplung.00163.2011. Epub 2011 Nov 18.

46.

IκBα glutathionylation and reduced histone H3 phosphorylation inhibit eotaxin and RANTES.

Seidel P, Roth M, Ge Q, Merfort I, S'ng CT, Ammit AJ.

Eur Respir J. 2011 Dec;38(6):1444-52. doi: 10.1183/09031936.00129610. Epub 2011 Jun 30.

47.

Estradiol stabilizes the 105-kDa phospho-form of the adhesion docking protein NEDD9 and suppresses NEDD9-dependent cell spreading in breast cancer cells.

Bradshaw LN, Zhong J, Bradbury P, Mahmassani M, Smith JL, Ammit AJ, O'Neill GM.

Biochim Biophys Acta. 2011 Feb;1813(2):340-5. doi: 10.1016/j.bbamcr.2010.11.018. Epub 2010 Dec 8.

48.

Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle.

Munoz L, Ramsay EE, Manetsch M, Ge Q, Peifer C, Laufer S, Ammit AJ.

Eur J Pharmacol. 2010 Jun 10;635(1-3):212-8. doi: 10.1016/j.ejphar.2010.02.037. Epub 2010 Mar 9.

PMID:
20226180
49.

Development of inhalable formulations of anti-inflammatory drugs to potentially treat smoke inhalation injury in burn victims.

Thai A, Xiao J, Ammit AJ, Rohanizadeh R.

Int J Pharm. 2010 Apr 15;389(1-2):41-52. doi: 10.1016/j.ijpharm.2010.01.014. Epub 2010 Jan 18.

PMID:
20080165
50.

Proteasomal inhibition upregulates the endogenous MAPK deactivator MKP-1 in human airway smooth muscle: mechanism of action and effect on cytokine secretion.

Moutzouris JP, Che W, Ramsay EE, Manetsch M, Alkhouri H, Bjorkman AM, Schuster F, Ge Q, Ammit AJ.

Biochim Biophys Acta. 2010 Mar;1803(3):416-23. doi: 10.1016/j.bbamcr.2009.12.007. Epub 2010 Jan 1.

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