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Items: 1 to 50 of 64

1.

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.

Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N.

J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.

2.

Systematic discovery of antiphage defense systems in the microbial pangenome.

Doron S, Melamed S, Ofir G, Leavitt A, Lopatina A, Keren M, Amitai G, Sorek R.

Science. 2018 Mar 2;359(6379). pii: eaar4120. doi: 10.1126/science.aar4120. Epub 2018 Jan 25.

3.

Quantitative species-level ecology of reef fish larvae via metabarcoding.

Kimmerling N, Zuqert O, Amitai G, Gurevich T, Armoza-Zvuloni R, Kolesnikov I, Berenshtein I, Melamed S, Gilad S, Benjamin S, Rivlin A, Ohavia M, Paris CB, Holzman R, Kiflawi M, Sorek R.

Nat Ecol Evol. 2018 Feb;2(2):306-316. doi: 10.1038/s41559-017-0413-2. Epub 2017 Dec 18.

PMID:
29255297
4.

Intracellular signaling in CRISPR-Cas defense.

Amitai G, Sorek R.

Science. 2017 Aug 11;357(6351):550-551. doi: 10.1126/science.aao2210. No abstract available.

PMID:
28798118
5.

Communication between viruses guides lysis-lysogeny decisions.

Erez Z, Steinberger-Levy I, Shamir M, Doron S, Stokar-Avihail A, Peleg Y, Melamed S, Leavitt A, Savidor A, Albeck S, Amitai G, Sorek R.

Nature. 2017 Jan 26;541(7638):488-493. doi: 10.1038/nature21049. Epub 2017 Jan 18.

6.

Repeat Size Determination by Two Molecular Rulers in the Type I-E CRISPR Array.

Goren MG, Doron S, Globus R, Amitai G, Sorek R, Qimron U.

Cell Rep. 2016 Sep 13;16(11):2811-2818. doi: 10.1016/j.celrep.2016.08.043.

7.

Natural selection underlies apparent stress-induced mutagenesis in a bacteriophage infection model.

Yosef I, Edgar R, Levy A, Amitai G, Sorek R, Munitz A, Qimron U.

Nat Microbiol. 2016 Apr 18;1(6):16047. doi: 10.1038/nmicrobiol.2016.47.

8.

Novel bifunctional hybrid small molecule scavengers for mitigating nerve agents toxicity.

Amitai G, Gez R, Raveh L, Bar-Ner N, Grauer E, Chapman S.

Chem Biol Interact. 2016 Nov 25;259(Pt B):187-204. doi: 10.1016/j.cbi.2016.04.036. Epub 2016 Apr 27.

PMID:
27129421
9.

CRISPR-Cas adaptation: insights into the mechanism of action.

Amitai G, Sorek R.

Nat Rev Microbiol. 2016 Feb;14(2):67-76. doi: 10.1038/nrmicro.2015.14. Epub 2016 Jan 11. Review.

PMID:
26751509
10.

CRISPR adaptation biases explain preference for acquisition of foreign DNA.

Levy A, Goren MG, Yosef I, Auster O, Manor M, Amitai G, Edgar R, Qimron U, Sorek R.

Nature. 2015 Apr 23;520(7548):505-510. doi: 10.1038/nature14302. Epub 2015 Apr 13.

11.

Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification.

Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radić Z.

J Med Chem. 2014 Feb 27;57(4):1378-89. doi: 10.1021/jm401650z. Epub 2014 Feb 7.

12.

Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.

Radić Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Duggan BM, Ajami D, Rebek J, Taylor P.

Biochem J. 2013 Feb 15;450(1):231-42. doi: 10.1042/BJ20121612.

13.

Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates.

Radić Z, Sit RK, Garcia E, Zhang L, Berend S, Kovarik Z, Amitai G, Fokin VV, Barry Sharpless K, Taylor P.

Chem Biol Interact. 2013 Mar 25;203(1):67-71. doi: 10.1016/j.cbi.2012.08.014. Epub 2012 Sep 4.

14.

PanDaTox: a tool for accelerated metabolic engineering.

Amitai G, Sorek R.

Bioengineered. 2012 Jul-Aug;3(4):218-21. doi: 10.4161/bioe.20431. Epub 2012 Jun 18.

15.

Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.

Radić Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2012 Apr 6;287(15):11798-809. doi: 10.1074/jbc.M111.333732. Epub 2012 Feb 16. Erratum in: J Biol Chem. 2012 Jun 1;287(23):19337.

16.

A vast collection of microbial genes that are toxic to bacteria.

Kimelman A, Levy A, Sberro H, Kidron S, Leavitt A, Amitai G, Yoder-Himes DR, Wurtzel O, Zhu Y, Rubin EM, Sorek R.

Genome Res. 2012 Apr;22(4):802-9. doi: 10.1101/gr.133850.111. Epub 2012 Feb 1.

17.

Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging.

Cochran R, Kalisiak J, Küçükkilinç T, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2011 Aug 26;286(34):29718-24. doi: 10.1074/jbc.M111.264739. Epub 2011 Jul 5.

18.

New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.

Sit RK, Radić Z, Gerardi V, Zhang L, Garcia E, Katalinić M, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2011 Jun 3;286(22):19422-30. doi: 10.1074/jbc.M111.230656. Epub 2011 Apr 4.

19.

Spontaneous proton transfer to a conserved intein residue determines on-pathway protein splicing.

Pereira B, Shemella PT, Amitai G, Belfort G, Nayak SK, Belfort M.

J Mol Biol. 2011 Feb 25;406(3):430-42. doi: 10.1016/j.jmb.2010.12.024. Epub 2010 Dec 23.

20.

Negative school perceptions and involvement in school bullying: a universal relationship across 40 countries.

Harel-Fisch Y, Walsh SD, Fogel-Grinvald H, Amitai G, Pickett W, Molcho M, Due P, de Matos MG, Craig W; Members of the HBSC Violence and Injury Prevention Focus Group.

J Adolesc. 2011 Aug;34(4):639-52. doi: 10.1016/j.adolescence.2010.09.008. Epub 2010 Dec 17.

PMID:
21168202
21.

Psychosocial outcomes related to subjective threat from armed conflict events (STACE): Findings from the Israeli-Palestinian cross-cultural HBSC study.

Harel-Fisch Y, Radwan Q, Walsh SD, Laufer A, Amitai G, Fogel-Grinvald H, Abdeen Z.

Child Abuse Negl. 2010 Sep;34(9):623-38. doi: 10.1016/j.chiabu.2009.12.007.

PMID:
20663554
22.

Self-targeting by CRISPR: gene regulation or autoimmunity?

Stern A, Keren L, Wurtzel O, Amitai G, Sorek R.

Trends Genet. 2010 Aug;26(8):335-40. doi: 10.1016/j.tig.2010.05.008. Epub 2010 Jul 1.

23.

Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation.

Küçükkilinç T, Cochran R, Kalisiak J, Garcia E, Valle A, Amitai G, Radić Z, Taylor P.

Chem Biol Interact. 2010 Sep 6;187(1-3):238-40. doi: 10.1016/j.cbi.2010.03.050. Epub 2010 Apr 9.

24.

Decontamination of chemical and biological warfare agents with a single multi-functional material.

Amitai G, Murata H, Andersen JD, Koepsel RR, Russell AJ.

Biomaterials. 2010 May;31(15):4417-25. doi: 10.1016/j.biomaterials.2010.02.004. Epub 2010 Mar 2.

PMID:
20199807
25.

Polyurethane-based leukocyte-inspired biocidal materials.

Amitai G, Andersen J, Wargo S, Asche G, Chir J, Koepsel R, Russell AJ.

Biomaterials. 2009 Nov;30(33):6522-9. doi: 10.1016/j.biomaterials.2009.08.027. Epub 2009 Sep 4.

PMID:
19733392
26.

Modulation of intein activity by its neighboring extein substrates.

Amitai G, Callahan BP, Stanger MJ, Belfort G, Belfort M.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11005-10. doi: 10.1073/pnas.0904366106. Epub 2009 Jun 17.

27.

Characterization of asymmetric fluorogenic phosphonates as probes for developing organophosphorus hydrolases with broader stereoselectivity.

Amitai G, Adani R, Limanovich O, Teitlboim S, Yishay S, Tveria L, Yacov G, Meshulam H, Raveh L.

Chem Biol Interact. 2008 Sep 25;175(1-3):249-54. doi: 10.1016/j.cbi.2008.05.036. Epub 2008 Jun 6.

PMID:
18588863
28.

IBU-octyl-cytisine, a novel bifunctional compound eliciting anti-inflammatory and cholinergic activity, ameliorates CNS inflammation by inhibition of T-cell activity.

Nizri E, Irony-Tur-Sinai M, Lavon I, Meshulam H, Amitai G, Brenner T.

Int Immunopharmacol. 2007 Sep;7(9):1129-39. Epub 2007 Apr 27.

PMID:
17630191
29.

Latent evolutionary potentials under the neutral mutational drift of an enzyme.

Amitai G, Gupta RD, Tawfik DS.

HFSP J. 2007 May;1(1):67-78. doi: 10.2976/1.2739115/10.2976/1. Epub 2007 May 21.

30.
31.

Trans protein splicing of cyanobacterial split inteins in endogenous and exogenous combinations.

Dassa B, Amitai G, Caspi J, Schueler-Furman O, Pietrokovski S.

Biochemistry. 2007 Jan 9;46(1):322-30.

PMID:
17198403
32.

Novel approaches to treatment of autoimmune neuroinflammation and lessons for drug development.

Nizri E, Irony-Tur-Sinai M, Grigoriadis N, Abramsky O, Amitai G, Brenner T.

Pharmacology. 2007;79(1):42-9. Epub 2006 Nov 30. Review.

33.

Asymmetric fluorogenic organophosphates for the development of active organophosphate hydrolases with reversed stereoselectivity.

Amitai G, Adani R, Yacov G, Yishay S, Teitlboim S, Tveria L, Limanovich O, Kushnir M, Meshulam H.

Toxicology. 2007 Apr 20;233(1-3):187-98. Epub 2006 Oct 13.

PMID:
17129656
34.

Directed evolution by in vitro compartmentalization.

Miller OJ, Bernath K, Agresti JJ, Amitai G, Kelly BT, Mastrobattista E, Taly V, Magdassi S, Tawfik DS, Griffiths AD.

Nat Methods. 2006 Jul;3(7):561-70. No abstract available.

PMID:
16791215
35.

Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase.

Amitai G, Gaidukov L, Adani R, Yishay S, Yacov G, Kushnir M, Teitlboim S, Lindenbaum M, Bel P, Khersonsky O, Tawfik DS, Meshulam H.

FEBS J. 2006 May;273(9):1906-19.

36.

Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning.

Amitai G, Adani R, Fishbein E, Meshulam H, Laish I, Dachir S.

Chem Biol Interact. 2005 Dec 15;157-158:361-2.

PMID:
16498717
37.
38.

Muscarinic modulations of neuronal anticholinesterase responses.

Salmon A, Erb C, Meshorer E, Ginzberg D, Adani Y, Rabinovitz I, Amitai G, Soreq H.

Chem Biol Interact. 2005 Dec 15;157-158:105-13. Epub 2005 Nov 11.

PMID:
16289123
39.

Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning.

Amitai G, Adani R, Fishbein E, Meshulam H, Laish I, Dachir S.

J Appl Toxicol. 2006 Jan-Feb;26(1):81-7.

PMID:
16167317
40.

Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments.

Nizri E, Adani R, Meshulam H, Amitai G, Brenner T.

Neurosci Lett. 2005 Mar 7;376(1):46-50. Epub 2004 Dec 8.

PMID:
15694272
41.

The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components.

Farías GG, Godoy JA, Vázquez MC, Adani R, Meshulam H, Avila J, Amitai G, Inestrosa NC.

Neurobiol Dis. 2005 Feb;18(1):176-83.

PMID:
15649708
42.

Network analysis of protein structures identifies functional residues.

Amitai G, Shemesh A, Sitbon E, Shklar M, Netanely D, Venger I, Pietrokovski S.

J Mol Biol. 2004 Dec 3;344(4):1135-46.

PMID:
15544817
43.

Protein splicing and auto-cleavage of bacterial intein-like domains lacking a C'-flanking nucleophilic residue.

Dassa B, Haviv H, Amitai G, Pietrokovski S.

J Biol Chem. 2004 Jul 30;279(31):32001-7. Epub 2004 May 18.

44.

Distribution of split DnaE inteins in cyanobacteria.

Caspi J, Amitai G, Belenkiy O, Pietrokovski S.

Mol Microbiol. 2003 Dec;50(5):1569-77.

45.

Protein splicing of inteins with atypical glutamine and aspartate C-terminal residues.

Amitai G, Dassa B, Pietrokovski S.

J Biol Chem. 2004 Jan 30;279(5):3121-31. Epub 2003 Oct 30.

46.

Degradation of VX and sulfur mustard by enzymatic haloperoxidation.

Amitai G, Adani R, Hershkovitz M, Bel P, Rabinovitz I, Meshulam H.

J Appl Toxicol. 2003 Jul-Aug;23(4):225-33.

PMID:
12884405
47.

Nasal midazolam as a novel anticonvulsive treatment against organophosphate-induced seizure activity in the guinea pig.

Gilat E, Goldman M, Lahat E, Levy A, Rabinovitz I, Cohen G, Brandeis R, Amitai G, Alkalai D, Eshel G.

Arch Toxicol. 2003 Mar;77(3):167-72. Epub 2002 Dec 6.

PMID:
12632257
48.

Distribution and function of new bacterial intein-like protein domains.

Amitai G, Belenkiy O, Dassa B, Shainskaya A, Pietrokovski S.

Mol Microbiol. 2003 Jan;47(1):61-73.

49.

Determination of therapeutic doses of bisquaternary oximes in large animals.

Chen R, Raveh L, Zomber G, Rabinovitz I, Cohen G, Adani R, Amitai G.

J Appl Toxicol. 2001 Jul-Aug;21(4):285-91.

PMID:
11481661
50.

Fine-tuning an engineered intein.

Amitai G, Pietrokovski S.

Nat Biotechnol. 1999 Sep;17(9):854-5. No abstract available.

PMID:
10471922

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