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Items: 9


Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives.

Onambele LA, Riepl H, Fischer R, Pradel G, Prokop A, Aminake MN.

Int J Parasitol Drugs Drug Resist. 2015 Apr 17;5(2):48-57. doi: 10.1016/j.ijpddr.2015.03.002. eCollection 2015 Aug.


Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents.

Ettari R, Pinto A, Tamborini L, Angelo IC, Grasso S, Zappalà M, Capodicasa N, Yzeiraj L, Gruber E, Aminake MN, Pradel G, Schirmeister T, De Micheli C, Conti P.

ChemMedChem. 2014 Aug;9(8):1817-25. doi: 10.1002/cmdc.201402079. Epub 2014 Jun 11.


Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors.

Tschan S, Brouwer AJ, Werkhoven PR, Jonker AM, Wagner L, Knittel S, Aminake MN, Pradel G, Joanny F, Liskamp RM, Mordmüller B.

Antimicrob Agents Chemother. 2013 Aug;57(8):3576-84. doi: 10.1128/AAC.00742-12. Epub 2013 May 20.


Changes in the transcriptome of the malaria parasite Plasmodium falciparum during the initial phase of transmission from the human to the mosquito.

Ngwa CJ, Scheuermayer M, Mair GR, Kern S, Brügl T, Wirth CC, Aminake MN, Wiesner J, Fischer R, Vilcinskas A, Pradel G.

BMC Genomics. 2013 Apr 15;14:256. doi: 10.1186/1471-2164-14-256.


The proteasome of malaria parasites: A multi-stage drug target for chemotherapeutic intervention?

Aminake MN, Arndt HD, Pradel G.

Int J Parasitol Drugs Drug Resist. 2012 Jan 9;2:1-10. doi: 10.1016/j.ijpddr.2011.12.001. eCollection 2012 Dec. Review.


Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy.

Aminake MN, Mahajan A, Kumar V, Hans R, Wiesner L, Taylor D, de Kock C, Grobler A, Smith PJ, Kirschner M, Rethwilm A, Pradel G, Chibale K.

Bioorg Med Chem. 2012 Sep 1;20(17):5277-89. doi: 10.1016/j.bmc.2012.06.038. Epub 2012 Jun 29.


Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast.

Aminake MN, Schoof S, Sologub L, Leubner M, Kirschner M, Arndt HD, Pradel G.

Antimicrob Agents Chemother. 2011 Apr;55(4):1338-48. doi: 10.1128/AAC.01096-10. Epub 2011 Jan 18.


Antiplasmodial thiostrepton derivatives: proteasome inhibitors with a dual mode of action.

Schoof S, Pradel G, Aminake MN, Ellinger B, Baumann S, Potowski M, Najajreh Y, Kirschner M, Arndt HD.

Angew Chem Int Ed Engl. 2010 Apr 26;49(19):3317-21. doi: 10.1002/anie.200906988. No abstract available.


The origin of malignant malaria.

Rich SM, Leendertz FH, Xu G, LeBreton M, Djoko CF, Aminake MN, Takang EE, Diffo JL, Pike BL, Rosenthal BM, Formenty P, Boesch C, Ayala FJ, Wolfe ND.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14902-7. doi: 10.1073/pnas.0907740106. Epub 2009 Aug 3.

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