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Molecular characterization of carbapenem-resistant Klebsiella pneumoniae ST14 and ST512 causing bloodstream infections in ICU and surgery wards of a tertiary university hospital of Verona (northern Italy): co-production of KPC-3, OXA-48, and CTX-M-15 β-lactamases.

Piccirilli A, Perilli M, Piccirilli V, Segatore B, Amicosante G, Maccacaro L, Bazaj A, Naso L, Cascio GL, Cornaglia G.

Diagn Microbiol Infect Dis. 2020 Mar;96(3):114968. doi: 10.1016/j.diagmicrobio.2019.114968. Epub 2019 Dec 13.


Inhibition of the transcriptional repressor LexA: Withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials.

Bellio P, Mancini A, Di Pietro L, Cracchiolo S, Franceschini N, Reale S, de Angelis F, Perilli M, Amicosante G, Spyrakis F, Tondi D, Cendron L, Celenza G.

Life Sci. 2020 Jan 15;241:117116. doi: 10.1016/j.lfs.2019.117116. Epub 2019 Nov 29.


Identification of CTX-M-15 and CTX-M-27 in Antibiotic-Resistant Gram-Negative Bacteria Isolated from Three Rivers Running in Central Italy.

Piccirilli A, Pompilio A, Rossi L, Segatore B, Amicosante G, Rosatelli G, Perilli M, Di Bonaventura G.

Microb Drug Resist. 2019 Sep;25(7):1041-1049. doi: 10.1089/mdr.2019.0016. Epub 2019 Apr 17.


Kinetic Profile and Molecular Dynamic Studies Show that Y229W Substitution in an NDM-1/L209F Variant Restores the Hydrolytic Activity of the Enzyme toward Penicillins, Cephalosporins, and Carbapenems.

Piccirilli A, Brisdelli F, Aschi M, Celenza G, Amicosante G, Perilli M.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02270-18. doi: 10.1128/AAC.02270-18. Print 2019 Apr.


Cerium oxide nanoparticles as potential antibiotic adjuvant. Effects of CeO2 nanoparticles on bacterial outer membrane permeability.

Bellio P, Luzi C, Mancini A, Cracchiolo S, Passacantando M, Di Pietro L, Perilli M, Amicosante G, Santucci S, Celenza G.

Biochim Biophys Acta Biomembr. 2018 Nov;1860(11):2428-2435. doi: 10.1016/j.bbamem.2018.07.002. Epub 2018 Jul 17.


TEM-184, a Novel TEM-Derived Extended-Spectrum β-Lactamase with Enhanced Activity against Aztreonam.

Piccirilli A, Perilli M, Amicosante G, Conte V, Tascini C, Rossolini GM, Giani T.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00688-18. doi: 10.1128/AAC.00688-18. Print 2018 Sep.


A Kinetic Study of the Replacement by Site Saturation Mutagenesis of Residue 119 in NDM-1 Metallo-β-Lactamase.

Marcoccia F, Mercuri PS, Galleni M, Celenza G, Amicosante G, Perilli M.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e02541-17. doi: 10.1128/AAC.02541-17. Print 2018 Aug.


P174E Substitution in GES-1 and GES-5 β-Lactamases Improves Catalytic Efficiency toward Carbapenems.

Piccirilli A, Mercuri PS, Galleni M, Aschi M, Matagne A, Amicosante G, Perilli M.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01851-17. doi: 10.1128/AAC.01851-17. Print 2018 May.


Exploring the role of L209 residue in the active site of NDM-1 a metallo-β-lactamase.

Marcoccia F, Leiros HS, Aschi M, Amicosante G, Perilli M.

PLoS One. 2018 Jan 2;13(1):e0189686. doi: 10.1371/journal.pone.0189686. eCollection 2018.


Interaction of carbapenems and β-lactamase inhibitors towards CTX-M-15 and CTX-M-15G238C mutant.

Sabatini A, Brisdelli F, Celenza G, Marcoccia F, Colapietro M, Tavío MM, Piccirilli A, Amicosante G, Perilli M.

J Glob Antimicrob Resist. 2017 Sep;10:95-100. doi: 10.1016/j.jgar.2017.04.004. Epub 2017 Jul 12.


SOS response in bacteria: Inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein.

Bellio P, Di Pietro L, Mancini A, Piovano M, Nicoletti M, Brisdelli F, Tondi D, Cendron L, Franceschini N, Amicosante G, Perilli M, Celenza G.

Phytomedicine. 2017 Jun 15;29:11-18. doi: 10.1016/j.phymed.2017.04.001. Epub 2017 Apr 8.


Protolichesterinic acid enhances doxorubicin-induced apoptosis in HeLa cells in vitro.

Brisdelli F, Perilli M, Sellitri D, Bellio P, Bozzi A, Amicosante G, Nicoletti M, Piovano M, Celenza G.

Life Sci. 2016 Aug 1;158:89-97. doi: 10.1016/j.lfs.2016.06.023. Epub 2016 Jun 27.


BlaB-15, a new BlaB metallo-β-lactamase variant found in an Elizabethkingia miricola clinical isolate.

Colapietro M, Endimiani A, Sabatini A, Marcoccia F, Celenza G, Segatore B, Amicosante G, Perilli M.

Diagn Microbiol Infect Dis. 2016 Jun;85(2):195-7. doi: 10.1016/j.diagmicrobio.2015.11.016. Epub 2015 Nov 17.


Kinetic Studies on CphA Mutants Reveal the Role of the P158-P172 Loop in Activity versus Carbapenems.

Bottoni C, Perilli M, Marcoccia F, Piccirilli A, Pellegrini C, Colapietro M, Sabatini A, Celenza G, Kerff F, Amicosante G, Galleni M, Mercuri PS.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):3123-6. doi: 10.1128/AAC.01703-15. Print 2016 May.


Kinetic Study of Laboratory Mutants of NDM-1 Metallo-β-Lactamase and the Importance of an Isoleucine at Position 35.

Marcoccia F, Bottoni C, Sabatini A, Colapietro M, Mercuri PS, Galleni M, Kerff F, Matagne A, Celenza G, Amicosante G, Perilli M.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2366-72. doi: 10.1128/AAC.00531-15. Print 2016 Apr.


Ceftaroline in vitro activity against methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococci: a short report from Italy.

Segatore B, Setacci D, Marcoccia F, Amicosante G.

J Chemother. 2017 Apr;29(2):118-121. doi: 10.1179/1973947815Y.0000000070. Epub 2016 Jul 25. No abstract available.


Identification of New Natural CphA Metallo-β-Lactamases CphA4 and CphA5 in Aeromonas veronii and Aeromonas hydrophila Isolates from Municipal Sewage in Central Italy.

Bottoni C, Marcoccia F, Compagnoni C, Colapietro M, Sabatini A, Celenza G, Segatore B, Maturo MG, Amicosante G, Perilli M.

Antimicrob Agents Chemother. 2015 Aug;59(8):4990-3. doi: 10.1128/AAC.00628-15. Epub 2015 May 18.


Interaction between lichen secondary metabolites and antibiotics against clinical isolates methicillin-resistant Staphylococcus aureus strains.

Bellio P, Segatore B, Mancini A, Di Pietro L, Bottoni C, Sabatini A, Brisdelli F, Piovano M, Nicoletti M, Amicosante G, Perilli M, Celenza G.

Phytomedicine. 2015 Feb 15;22(2):223-30. doi: 10.1016/j.phymed.2014.12.005. Epub 2014 Dec 19.


OXA-23 carbapenemase in multidrug-resistant Acinetobacter baumannii ST2 type: first identification in L'Aquila Hospital (Italy).

Perilli M, Sabatini A, Pontieri E, Celenza G, Segatore B, Bottoni C, Bellio P, Mancini A, Marcoccia F, Brisdelli F, Amicosante G.

Microb Drug Resist. 2015 Feb;21(1):97-101. doi: 10.1089/mdr.2014.0056. Epub 2014 Oct 2.


Kinetic study of the effect of histidines 240 and 164 on TEM-149 enzyme probed by β-lactam inhibitors.

Perilli M, Mancini A, Celenza G, Bottoni C, Bellio P, Sabatini A, Di Pietro L, Brisdelli F, Segatore B, Amicosante G.

Antimicrob Agents Chemother. 2014 Oct;58(10):6294-6. doi: 10.1128/AAC.02950-14. Epub 2014 Aug 4.


Emergence of blaKPC-3-Tn4401a in Klebsiella pneumoniae ST512 in the municipal wastewater treatment plant and in the university hospital of a town in central Italy.

Perilli M, Bottoni C, Pontieri E, Segatore B, Celenza G, Setacci D, Bellio P, Strom R, Amicosante G.

J Glob Antimicrob Resist. 2013 Dec;1(4):217-220. doi: 10.1016/j.jgar.2013.07.002. Epub 2013 Aug 20.


Curcumin inhibits the SOS response induced by levofloxacin in Escherichia coli.

Bellio P, Brisdelli F, Perilli M, Sabatini A, Bottoni C, Segatore B, Setacci D, Amicosante G, Celenza G.

Phytomedicine. 2014 Mar 15;21(4):430-4. doi: 10.1016/j.phymed.2013.10.011. Epub 2013 Nov 17.


On the structural affinity of macromolecules with different biological properties: molecular dynamics simulations of a series of TEM-1 mutants.

Giampaolo AD, Mazza F, Daidone I, Amicosante G, Perilli M, Aschi M.

Biochem Biophys Res Commun. 2013 Jul 12;436(4):666-71. doi: 10.1016/j.bbrc.2013.06.013. Epub 2013 Jun 12.


Prevalence of quinolone resistance determinant qnrA6 among broad- and extended-spectrum beta-lactam-resistant Proteus mirabilis and Morganella morganii clinical isolates with sul1-type class 1 integron association in a Tunisian Hospital.

Mahrouki S, Perilli M, Bourouis A, Chihi H, Ferjani M, Ben Moussa M, Amicosante G, Belhadj O.

Scand J Infect Dis. 2013 Aug;45(8):600-5. doi: 10.3109/00365548.2013.795657. Epub 2013 Jun 9.


R164H and V240H replacements by site-directed mutagenesis of TEM-149 extended-spectrum β-lactamase: kinetic analysis of TEM-149H240 and TEM-149H164-H240 laboratory mutants.

Perilli M, Celenza G, Mercuri PS, Galleni M, Pellegrini C, Segatore B, Amicosante G.

Antimicrob Agents Chemother. 2013 Feb;57(2):1047-9. doi: 10.1128/AAC.01268-12. Epub 2012 Nov 26.


Carbapenem-resistant Klebsiella pneumoniae harbouring blaKPC-3 and blaVIM-2 from central Italy.

Perilli M, Bottoni C, Grimaldi A, Segatore B, Celenza G, Mariani M, Bellio P, Frascaria P, Amicosante G.

Diagn Microbiol Infect Dis. 2013 Feb;75(2):218-21. doi: 10.1016/j.diagmicrobio.2012.10.008. Epub 2012 Nov 13.


Antibacterial activity of selected metabolites from Chilean lichen species against methicillin-resistant staphylococci.

Celenza G, Segatore B, Setacci D, Perilli M, Brisdelli F, Bellio P, Piovano M, Garbarino JA, Amicosante G, Nicoletti M.

Nat Prod Res. 2013;27(17):1528-31. doi: 10.1080/14786419.2012.730043. Epub 2012 Oct 2.


Chromosomal blaCTX-M-₁₅ associated with ISEcp1 in Proteus mirabilis and Morganella morganii isolated at the Military Hospital of Tunis, Tunisia.

Mahrouki S, Belhadj O, Chihi H, Mohamed BM, Celenza G, Amicosante G, Perilli M.

J Med Microbiol. 2012 Sep;61(Pt 9):1286-9. doi: 10.1099/jmm.0.039487-0. Epub 2012 Jun 8.


Cytotoxic activity and antioxidant capacity of purified lichen metabolites: an in vitro study.

Brisdelli F, Perilli M, Sellitri D, Piovano M, Garbarino JA, Nicoletti M, Bozzi A, Amicosante G, Celenza G.

Phytother Res. 2013 Mar;27(3):431-7. doi: 10.1002/ptr.4739. Epub 2012 May 25.


Evaluations of the Effects of Extremely Low-Frequency Electromagnetic Fields on Growth and Antibiotic Susceptibility of Escherichia coli and Pseudomonas aeruginosa.

Segatore B, Setacci D, Bennato F, Cardigno R, Amicosante G, Iorio R.

Int J Microbiol. 2012;2012:587293. doi: 10.1155/2012/587293. Epub 2012 Apr 2.


In vitro antimicrobial activity of pannarin alone and in combination with antibiotics against methicillin-resistant Staphylococcus aureus clinical isolates.

Celenza G, Segatore B, Setacci D, Bellio P, Brisdelli F, Piovano M, Garbarino JA, Nicoletti M, Perilli M, Amicosante G.

Phytomedicine. 2012 May 15;19(7):596-602. doi: 10.1016/j.phymed.2012.02.010. Epub 2012 Mar 27.


In vitro interaction of usnic acid in combination with antimicrobial agents against methicillin-resistant Staphylococcus aureus clinical isolates determined by FICI and ΔE model methods.

Segatore B, Bellio P, Setacci D, Brisdelli F, Piovano M, Garbarino JA, Nicoletti M, Amicosante G, Perilli M, Celenza G.

Phytomedicine. 2012 Feb 15;19(3-4):341-7. doi: 10.1016/j.phymed.2011.10.012. Epub 2011 Nov 25.


Persistence of TEM-52/TEM-92 and SHV-12 extended-spectrum β-lactamases in clinical isolates of Enterobacteriaceae in Italy.

Perilli M, Segatore B, Mugnaioli C, Celenza G, Rossolini GM, Stefani S, Luzzaro F, Pini B, Amicosante G.

Microb Drug Resist. 2011 Dec;17(4):521-4. doi: 10.1089/mdr.2011.0059. Epub 2011 Oct 4.


First report from Italy of blaVIM-1 and blaTEM-1 genes in Pseudomonas putida and Acinetobacter baumannii isolated from wastewater.

Perilli M, Pellegrini C, Celenza G, Bellio P, Segatore B, Amicosante G.

J Chemother. 2011 Jun;23(3):181-2. No abstract available.


Occurrence of class 1 and 2 integrons in resistant Enterobacteriaceae collected from a urban wastewater treatment plant: first report from central Italy.

Pellegrini C, Celenza G, Segatore B, Bellio P, Setacci D, Amicosante G, Perilli M.

Microb Drug Resist. 2011 Jun;17(2):229-34. doi: 10.1089/mdr.2010.0117. Epub 2011 Jan 26.


Expression of matrix metalloproteinase-9 (MMP-9) in human midpregnancy amniotic fluid and risk of preterm labor.

Di Ferdinando A, Patacchiola F, Perilli MG, Amicosante G, Carta G.

Clin Exp Obstet Gynecol. 2010;37(3):193-6.


QnrB9 in association with TEM-116 extended-spectrum beta-lactamase in Citrobacter freundii isolated from sewage effluent: first report from Italy.

Forcella C, Pellegrini C, Celenza G, Segatore B, Calabrese R, Tavio MM, Amicosante G, Perilli M.

J Chemother. 2010 Aug;22(4):243-5.


Characterization of quinolone resistance in Escherichia coli strains of animal origin from Italy.

Forcella C, Alessiani A, Perilli M, Zilli K, Di Giannatale E, Amicosante G.

J Chemother. 2010 Jun;22(3):165-8.


Preliminary investigations into fluoroquinolone resistance in Escherichia coli strains resistant to nalidixic acid isolated from animal faeces.

Alessiani A, Di Giannatale E, Perilli M, Forcella C, Amicosante G, Zilli K.

Vet Ital. 2009 Oct-Dec;45(4):521-7. English, Italian.


Infections with VIM-1 metallo-{beta}-lactamase-producing enterobacter cloacae and their correlation with clinical outcome.

Falcone M, Mezzatesta ML, Perilli M, Forcella C, Giordano A, Cafiso V, Amicosante G, Stefani S, Venditti M.

J Clin Microbiol. 2009 Nov;47(11):3514-9. doi: 10.1128/JCM.01193-09. Epub 2009 Sep 9.


Prolonged bacteraemia caused by VIM-1 metallo-beta-lactamase-producing Proteus mirabilis: first report from Italy.

Falcone M, Perilli M, Mezzatesta ML, Mancini C, Amicosante G, Stefani S, Venditti M.

Clin Microbiol Infect. 2010 Feb;16(2):179-81. doi: 10.1111/j.1469-0691.2009.02781.x. Epub 2009 Jul 16.


Comment on: Redefining extended-spectrum beta-lactamases: balancing science and clinical need.

Bush K, Jacoby GA, Amicosante G, Bonomo RA, Bradford P, Cornaglia G, Garau J, Giamarellou H, Jarlier V, Martinez-Martinez L, Miriagou V, Palzkill T, Pascual A, Rodriguez-Baño J, Rossolini GM, Sougakoff W, Vatopoulos A.

J Antimicrob Chemother. 2009 Jul;64(1):212-3; author reply 213-5. doi: 10.1093/jac/dkp104. Epub 2009 Mar 24. No abstract available.


Identification of bla(IMP-22) in Pseudomonas spp. in urban wastewater and nosocomial environments: biochemical characterization of a new IMP metallo-enzyme variant and its genetic location.

Pellegrini C, Mercuri PS, Celenza G, Galleni M, Segatore B, Sacchetti E, Volpe R, Amicosante G, Perilli M.

J Antimicrob Chemother. 2009 May;63(5):901-8. doi: 10.1093/jac/dkp061. Epub 2009 Mar 6.


Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity.

Zampieri M, Passananti C, Calabrese R, Perilli M, Corbi N, De Cave F, Guastafierro T, Bacalini MG, Reale A, Amicosante G, Calabrese L, Zlatanova J, Caiafa P.

PLoS One. 2009;4(3):e4717. doi: 10.1371/journal.pone.0004717. Epub 2009 Mar 5.


Evidence for qnrB1 and aac(6')-Ib-cr in CTX-M-15-producing uropathogenic Enterobacteriaceae in an Italian teaching hospital.

Perilli M, Forcella C, Celenza G, Frascaria P, Segatore B, Pellegrini C, Amicosante G.

Diagn Microbiol Infect Dis. 2009 May;64(1):90-3. doi: 10.1016/j.diagmicrobio.2009.01.009. Epub 2009 Feb 26.


First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy.

Rossolini GM, Luzzaro F, Migliavacca R, Mugnaioli C, Pini B, De Luca F, Perilli M, Pollini S, Spalla M, Amicosante G, Toniolo A, Pagani L.

Antimicrob Agents Chemother. 2008 Nov;52(11):4023-9. doi: 10.1128/AAC.00707-08. Epub 2008 Sep 22.


Natural D240G Toho-1 mutant conferring resistance to ceftazidime: biochemical characterization of CTX-M-43.

Celenza G, Luzi C, Aschi M, Segatore B, Setacci D, Pellegrini C, Forcella C, Amicosante G, Perilli M.

J Antimicrob Chemother. 2008 Nov;62(5):991-7. doi: 10.1093/jac/dkn339. Epub 2008 Aug 27.


Class I integron-borne bla(VIM-1) carbapenemase in a strain of Enterobacter cloacae responsible for a case of fatal pneumonia.

Perilli M, Mezzatesta ML, Falcone M, Pellegrini C, Amicosante G, Venditti M, Stefani S.

Microb Drug Resist. 2008 Mar;14(1):45-7. doi: 10.1089/mdr.2008.0765.


E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates.

Perilli M, Celenza G, De Santis F, Pellegrini C, Forcella C, Rossolini GM, Stefani S, Amicosante G.

Antimicrob Agents Chemother. 2008 Mar;52(3):915-9. Epub 2007 Dec 26.


Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy.

Venturelli A, Tondi D, Cancian L, Morandi F, Cannazza G, Segatore B, Prati F, Amicosante G, Shoichet BK, Costi MP.

J Med Chem. 2007 Nov 15;50(23):5644-54. Epub 2007 Oct 23.


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