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Items: 12


Orchestrating single-cell analysis with Bioconductor.

Amezquita RA, Lun ATL, Becht E, Carey VJ, Carpp LN, Geistlinger L, Martini F, Rue-Albrecht K, Risso D, Soneson C, Waldron L, Pagès H, Smith ML, Huber W, Morgan M, Gottardo R, Hicks SC.

Nat Methods. 2019 Dec 2. doi: 10.1038/s41592-019-0654-x. [Epub ahead of print] Review.


ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates.

Guan T, Dominguez CX, Amezquita RA, Laidlaw BJ, Cheng J, Henao-Mejia J, Williams A, Flavell RA, Lu J, Kaech SM.

J Exp Med. 2018 Apr 2;215(4):1153-1168. doi: 10.1084/jem.20171352. Epub 2018 Feb 15.


Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity.

Perry CJ, Muñoz-Rojas AR, Meeth KM, Kellman LN, Amezquita RA, Thakral D, Du VY, Wang JX, Damsky W, Kuhlmann AL, Sher JW, Bosenberg M, Miller-Jensen K, Kaech SM.

J Exp Med. 2018 Mar 5;215(3):877-893. doi: 10.1084/jem.20171435. Epub 2018 Feb 7.


Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response.

Laidlaw BJ, Lu Y, Amezquita RA, Weinstein JS, Vander Heiden JA, Gupta NT, Kleinstein SH, Kaech SM, Craft J.

Sci Immunol. 2017 Oct 20;2(16). pii: eaan4767. doi: 10.1126/sciimmunol.aan4767.


Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8+ T Cell Terminal Differentiation and Loss of Multipotency.

Gray SM, Amezquita RA, Guan T, Kleinstein SH, Kaech SM.

Immunity. 2017 Apr 18;46(4):596-608. doi: 10.1016/j.immuni.2017.03.012. Epub 2017 Apr 11.


Immunology: The chronicles of T-cell exhaustion.

Amezquita RA, Kaech SM.

Nature. 2017 Mar 9;543(7644):190-191. doi: 10.1038/nature21508. Epub 2017 Feb 22. No abstract available.


NK Cell Responses Redefine Immunological Memory.

Adams NM, O'Sullivan TE, Geary CD, Karo JM, Amezquita RA, Joshi NS, Kaech SM, Sun JC.

J Immunol. 2016 Oct 15;197(8):2963-2970. Review.


IL-17 Promotes Neutrophil-Mediated Immunity by Activating Microvascular Pericytes and Not Endothelium.

Liu R, Lauridsen HM, Amezquita RA, Pierce RW, Jane-Wit D, Fang C, Pellowe AS, Kirkiles-Smith NC, Gonzalez AL, Pober JS.

J Immunol. 2016 Sep 15;197(6):2400-8. doi: 10.4049/jimmunol.1600138. Epub 2016 Aug 17.


Autoreactive T Cells from Patients with Myasthenia Gravis Are Characterized by Elevated IL-17, IFN-γ, and GM-CSF and Diminished IL-10 Production.

Cao Y, Amezquita RA, Kleinstein SH, Stathopoulos P, Nowak RJ, O'Connor KC.

J Immunol. 2016 Mar 1;196(5):2075-84. doi: 10.4049/jimmunol.1501339. Epub 2016 Jan 29.


The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection.

Dominguez CX, Amezquita RA, Guan T, Marshall HD, Joshi NS, Kleinstein SH, Kaech SM.

J Exp Med. 2015 Nov 16;212(12):2041-56. doi: 10.1084/jem.20150186. Epub 2015 Oct 26.


Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.

Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM.

Nat Immunol. 2015 Aug;16(8):871-9. doi: 10.1038/ni.3224. Epub 2015 Jul 6.


IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity.

Cui G, Staron MM, Gray SM, Ho PC, Amezquita RA, Wu J, Kaech SM.

Cell. 2015 May 7;161(4):750-61. doi: 10.1016/j.cell.2015.03.021.

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